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1 mparator, suggesting nonadaptive mutational "fragility".
2 eat contractions downstream of Fcy1, but not fragility.
3 ta1-integrin underlies Kindler syndrome skin fragility.
4 ication, and prevents repeat instability and fragility.
5 ound tumor resistance due to Treg functional fragility.
6 intracellular calcium, and elevated osmotic fragility.
7 are prone to replication stress and telomere fragility.
8 tion of yeast RNaseH genes and caused repeat fragility.
9 ynthesis as a potential therapeutic point of fragility.
10 c variation based on replication-derived DNA fragility.
11 derlie genetic diseases typified by cellular fragility.
12 ce, identifying immune-independent beta cell fragility.
13 transplantation as a countermeasure to bone fragility.
14 acterized by progressive muscle weakness and fragility.
15 plex environments outside factories is their fragility.
16 results in leading strand-specific telomere fragility.
17 e HIV-1 capsid protein (CA) exhibits extreme fragility.
18 :osteoclast (OB:OC) ratio and increased bone fragility.
19 enging because of its small size and extreme fragility.
20 characterized this in terms of their kinetic fragility.
21 liquid, demonstrating a structural basis for fragility.
22 and clinical features of trauma-induced skin fragility.
23 mportant component of bone strength and bone fragility.
24 echanism involving reduced myofiber membrane fragility.
25 n have failed to optimize networks and avoid fragility.
26 driving force for crystallization and liquid fragility.
27 embryos present with growth delay and tissue fragility.
28 posure impairs bone metabolism and increases fragility.
29 d by membrane protein oxidation and membrane fragility.
30 ree energy landscape--is a good predictor of fragility.
31 banding decreases OS rigidity, reducing its fragility.
32 to OS radius, so that thinner OS have lower fragility.
33 lications for the care of patients with bone fragility.
34 cytoskeleton organization, resulting in skin fragility.
35 ns relying on inactivity to explain skeletal fragility.
36 losa, characterized by life-threatening skin fragility.
38 generating secondary structure-mediated DNA fragility, advancing our understanding of mechanisms und
39 FANC pathway are characterized by chromosome fragility, altered mutability, and abnormal regulation o
41 fect in two unrelated girls with severe bone fragility and a clinical diagnosis of osteogenesis imper
43 sion by elevating miR-155 increased telomere fragility and altered the structure of metaphase chromos
44 ic dermatoses characterized by mucocutaneous fragility and blister formation, inducible by often mini
45 gnificantly decreased the rate of CAG repeat fragility and contractions in the rnh1Deltarnh201Delta b
48 aim of this study is to investigate vascular fragility and endothelial glycocalyx (ECG) in images of
52 EL1 mutations displayed telomere shortening, fragility and fusion, and growth defects in culture.
55 pathological conditions, leading to skeletal fragility and increased marrow adiposity during aging, e
61 el, we show that histones induce erythrocyte fragility and lysis in a concentration-dependent manner.
65 ent with the clinical phenotypes of skeletal fragility and oligodontia in persons deficient for LRP5
67 it is not characterized by generalized bone fragility and presented with cataracts in the original f
70 isms, is extremely challenging, owing to the fragility and short lifetime of those edge structures.
72 unctional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of th
73 ization of NSPC RDCs reveals a basis of gene fragility and suggests potential impacts of DNA breaks o
75 , a linear relationship is found between the fragility and the energy scales of both the screened Cou
76 chanism for leading strand-specific telomere fragility and the first known role for FEN1 in leading s
77 s no correlation between promoter nucleosome fragility and the levels of histone modifications or his
78 We present an analytic scheme to connect the fragility and viscoelasticity of metallic glasses to the
81 ic cemento-osseous lesions of jawbones, bone fragility, and diaphyseal sclerosis of tubular bones.
84 with a special necessity by the complexity, fragility, and inaccessibility of intact nervous systems
86 mation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in he
91 , this versatility comes with a trade-off of fragility, as there exist numerous paths to altered sign
93 an inherited disorder characterized by skin fragility, blistering, and multiple skin wounds with no
95 mutation in two unrelated families with skin fragility, but cardiac findings highlighted age-dependen
96 ome is instrumental to understanding genomic fragility, but current methods are limited in versatilit
97 L1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to pr
98 th decreased bone density and increased bone fragility, but how this disease affects alveolar bone he
99 crease short-term variance creates ecosystem fragility by changing the boundaries of safe operating s
100 FEN1 limits leading strand-specific telomere fragility by processing RNA:DNA hybrid/flap intermediate
101 te alloys with tailored thermoelasticity and fragility by rationally tuning the chemical composition
103 e discount rate, the house lifetime, and the fragility can increase the economically optimal house el
105 n, (iii) five textural parameters: hardness, fragility, cohesiveness, springiness and adhesiveness an
106 r stirring conditions exhibited an increased fragility compared with fibrils formed quiescently after
108 , replication forks stall within the AT-rich fragility core of CFS, leading to dormant origin activat
109 Nrp1 dependency and the key drivers of Treg fragility could help to improve immunotherapy for human
110 ansepidermal water loss, enhanced corneocyte fragility, decreased dendritic epidermal T cells, and an
111 h3) endonuclease caused R-loop-dependent CAG fragility, defining an alternative function for this com
115 idermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven bliste
116 dermis, and its mutations cause a human skin fragility disorder coined recessive dystrophic epidermol
117 Cole-Carpenter syndrome is a severe bone fragility disorder that is characterized by frequent fra
119 molysis bullosa is a group of heritable skin fragility disorders with considerable morbidity and mort
120 phenotypic spectrum of human inherited skin fragility disorders, and we propose the addition of EBS
121 a phenotypically heterogeneous group of skin fragility disorders, is currently associated with mutati
124 etibial hyperpigmentation, skin and vascular fragility, easy bruising, and variable musculoskeletal s
125 ealth factors; child's size factors; child's fragility factors; socio-demographic background; obstetr
126 l through CDK9, providing potential nodes of fragility for therapeutic intervention, potentially dist
127 bone and muscle attenuation was 0.73 for any fragility fracture and 0.76 for hip fractures, respectiv
128 nd FRAX were 2.1, 1.9, 0.98, and 2.5 for any fragility fracture and 2.0, 2.5, 1.1, and 2.5 for femora
129 less than -2.0 taking exemestane, one had a fragility fracture and four had other fractures, whereas
130 postmenopausal women with osteoporosis and a fragility fracture and randomly assigned them in a 1:1 r
132 sin Z mRNA was significantly associated with fragility fracture in osteoporosis patients (P = 0.0018)
133 eases, often goes undetected until the first fragility fracture occurs, causing patient suffering and
134 improvement in BMD, or who have an incident fragility fracture on therapy, secondary causes of osteo
135 We used Cox regression models to assess fragility fracture risk factors including the VACS Index
137 rating characteristic curve (AUC) values for fragility fracture were 0.71, 0.65, 0.51, and 0.72 at 2
138 orosis defined by a clinical event, namely a fragility fracture, or with an osteoporotic BMD should a
139 menopausal women, patients with a history of fragility fracture, patients receiving chronic glucocort
146 re of -2.0 or more taking exemestane had two fragility fractures and two other fractures, those takin
150 train rates correlate with the occurrence of fragility fractures in osteoporosis, while improvements
153 sal women with (n = 22) and without (n = 22) fragility fractures were matched for age and body mass i
154 potential for screening patients at risk for fragility fractures, given the ease of implementation an
164 collagen mutations and characterized by bone fragility, frequent fractures in absence of trauma and g
165 of diabetic bone deterioration and increased fragility from the aspect of microdamage accumulation an
166 oxide value (PV)], textural (i.e., hardness, fragility, gumminess, chewiness, springiness, cohesivene
167 mpound pyridostatin (PDS) increases telomere fragility in BRCA2-deficient cells, suggesting that G4 f
168 elomeric 8-oxoG formation increased telomere fragility in cells lacking OGG1, the enzyme that removes
170 The structural underpinnings for skeletal fragility in coinfected women have not been characterize
174 dence that WNT1 mutations contribute to bone fragility in OI patients and demonstrates that the Wnt1(
175 epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging dat
178 f the ear and the tail epidermis, corneocyte fragility, increased transepidermal water loss, and loca
181 phthalmology RCTs through application of the Fragility Index (FI), a novel metric of the robustness o
197 s and increased aphidicolin-induced telomere fragility, indicating a role for RECQL1 in telomere main
198 two distinct phases of water and to extract fragility indices m = 14 for the low-density and m = 20-
202 ns, our results suggest that R-loop-mediated fragility is a mechanism that could cause DNA damage and
206 est that in C. elegans promoters, nucleosome fragility is in large part DNA-encoded and that it poise
207 we show that FEN1 depletion-induced telomere fragility is increased by RNA polymerase II inhibition a
210 We also show that IFNgamma-induced Treg fragility is required for response to anti-PD1, suggesti
213 ds additional light on the elusive structure-fragility link in glass-forming matter and provides a fi
218 results demonstrate that the sensitivity and fragility of algae to triclosan can be amplified with ti
220 Osteoporosis is associated with increased fragility of bone and a subsequent increased risk of fra
221 Ss also utilize MiDAS and to what extent the fragility of CFSs and RFSs arises by shared or distinct
228 in the epidermal barrier, although increased fragility of isolated corneocytes was demonstrated.
231 d tomography and biomechanics confirmed bone fragility of OVX-Diet rats, and quantitative RT-PCR reve
235 nterferon-gamma (IFNgamma), which drives the fragility of surrounding wild-type Tregs, boosts anti-tu
238 o limits protein evolvability because of the fragility of the interactions networks that maintain pro
239 n of temperature correlates with the kinetic fragility of the liquid, demonstrating a structural basi
241 nert surface to overcome the problems of the fragility of the microwire and the possible interference
243 of diseases characterized by blistering and fragility of the skin in response to mechanical trauma.
244 t is a simple closed-form expression for the fragility of the supercooled liquid metal in terms of fe
245 toelectronic devices has been limited by the fragility of the supramolecular structures used and the
246 lso attribute this different behavior to the fragility of the system, in combination with the very fa
253 version of the keratin intermediate filament fragility phenotype associated with epidermolytic ichthy
255 ome, a genetic disease characterized by skin fragility, photosensitivity, and increased risk of squam
256 ailure syndrome characterized by chromosomal fragility, progressive marrow failure, and cancer predis
258 esent new experimental evidence showing that fragility reflects the strength of the repulsive part of
259 is signature enables precise mapping of core fragility regions in known CFSs and identification of no
262 In muscular dystrophies, muscle membrane fragility results in a tissue-specific increase of dange
263 Substantial evidence shows that skeletal fragility should be considered among the complications a
268 Previous attempts to quantify robustness and fragility sought to understand how the functional connec
270 lease activity independently causes telomere fragility, suggesting a requirement of the SLX4 complex
271 epeats, which are associated with chromosome fragility, suggests sequence capture during repair of do
273 sition leads to a super-strong liquid of low fragility that dynamically controls collapse, before a s
274 undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in an
276 mechanical defects of the lamina and nuclear fragility, the gene expression model impairment of spati
278 yed 2 different mouse models of genetic skin fragility to assess the role of the basement membrane pr
279 re many and varied, ranging from atrophy and fragility to defective repair to deficient immunity and
280 mere loops (T loops) and suppresses telomere fragility to maintain the integrity of chromosome ends.
281 tes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telome
282 ing osmolarity, it results in a trade-off of fragility to non-natural oscillatory inputs that match t
283 examined a cohort of 362 families with skin fragility to screen for genetic mutations with next-gene
284 pe is characterized by mild generalized skin fragility, trauma-induced skin blistering since infancy,
285 cteristics of phage biology, with structural fragility under the high temperatures and acidic environ
291 ndence of Sigma(T) correlates with the glass fragility, we show that the validity of the Adam-Gibbs r
292 s characterized by pleiotropy and regulatory fragility, where deletion of individual cis-regulatory e
293 eriorated mechanical integrity and increased fragility, whereas the mechanisms are not fully understo
294 f liquids is frequently characterized by the fragility, which can be defined from the temperature dep
295 makes manufacturing errors more likely, and fragility, which makes postrelease damage more likely.
296 ecessive clinical picture that includes bone fragility with a moderately severe and progressive prese
297 stimulation can identify and help to repair fragilities within a signaling network, while using line
299 addition to a mutation associated with skin fragility/woolly hair syndrome, impair gap junction loca