ライフサイエンスコーパス: fragment

1 ation of a dominant negative truncated TRESK fragment.

2 vironment from the reducing transition metal fragment.

3 s stem forms only in the cleaved xbp-1 ncRNA fragment.

4 were mainly located on the surface of the Nt-fragment.

5 tize the 2-OMe-alpha-l-Rha-(1->2)-beta-l-Rha fragment.

6 ical stratification of communities in forest fragments.

7 gal glycan laminarin into readily analyzable fragments.

8 ing in pro-inflammatory low-molecular weight fragments.

9 formation between a large number of peptide fragments.

10 ated point clouds mimicking ideal ligands or fragments.

11 tracking of explosively generated hypersonic fragments.

12 ults in modulation of the abundance of their fragments.

13 presence of isotopes, adducts and in-source fragments.

14 to introduce new functionality and/or couple fragments.

15 ns and presence of retinal nerve fiber layer fragments.

16 atures for Abeta43, Abeta38, and short Abeta fragments.

17 e protein kinases (PASTA-eSTK) that sense PG fragments.

18 tructions involving the union of unsaturated fragments.

19 edium of cells expressing recombinant NOTCH3 fragments.

20 the all-ion fragmentation (CF(2))(n) related fragments.

21 rs drive expression of split Cre recombinase fragments.

22 11/20 aqueous samples along with shorter DNA fragments.

23 s they are enriched with fibers, rather than fragments.

24 single-base-pair change to insertion of DNA fragments.

25 ture and separation of the PEG tube into two fragments.

26 theory on rank orders in biology is somewhat fragmented.

27 Often, post-marketing research landscape is fragmented.

28 and retraction of their protrusions to avoid fragmenting.

29 is characterized by the capture of long DNA fragments (15-20 kb) by magnetic beads, after enzymatic

30 his position also yielded some 53-nucleotide fragments, 16 longer.

31 ons during the lag phase, whereas C-terminal fragments (20-32 and 26-32) showed limited involvement d

32 ers (neuron-specific enolase and cytokeratin fragment 21-1).

33 consistent with our recently reported fibril-fragmenting activity.

34 and the specificity in interaction with tRNA fragments advocate paramount importance toward understan

35 This is because ctDNA is a mix of fragmented alleles, and the contribution of different ca

36 ecifically, while in larger connected forest fragments along the northern riverbank genetic connectiv

37 Interestingly, UVPD fragments also indicated that the charge at the "unfoldi

38 and wide indel spectrum revealed by NGS and fragment analysis.

39 synthesis of a glycosylated interferon-gamma fragment and the chemokine-binding protein UL22A, respec

40 ent interventions for nurses and midwives is fragmented and lacks cohesion.

41 However, access to these predictors is fragmented and requires substantial effort to find them

42 We find that mitochondria are small and fragmented and translocate apically on microtubules and

43 it has become possible to separate antibody fragments and antibody-drug conjugate species in less th

44 C3 fragments and C5b-9 are deposited on TF1PIGAnull target

45 ommodates parallel nicking on orthogonal DNA fragments and enzymatic toehold creation that enables si

46 ents in Gl-L and Gd-L were similar, but more fragments and higher molecular mass bands were observed

47 While the overall properties of fragments and leads have remained constant, a number of

48 The results indicate that 78% of the fragments and only 33% of the fibers analyzed were plast

49 s niger was capable of solubilizing natural (fragments and powder) and synthetic struvite when incorp

50 nomes, estimating the completeness of genome fragments and removing flanking host regions from integr

51 y and diverse library containing nearly 4000 fragments and screening for target-specific binders with

52 Flow cytometry of dispersed tissue fragments and serial immunohistochemistry of paraffin-em

53 rs can be modulated by the coordinated metal fragments and that they can bind chloride 1 to 2 orders

54 l images confirm the presence of such porous fragments and the flat diurnal temperature profiles sugg

55 thase (cGAS) recognizing cytosolic chromatin fragments and then activating the stimulator of interfer

56 e assay, WISP1 promoted the growth of cancer fragments and upregulated tumor-promoting genes, such as

57 ative chemical ligation from smaller peptide fragments, and a high-throughput bacterial expression an

58 ank, structurally superimposes their adenine fragments, and detects the hydrogen bonds mediating the

59 ction of the Ps56 genome, cloning of several fragments, and resection of the fragments that retained

60 protein composed of a single chain variable fragment antibody conjugated with an elastin-like polype

61 s showed that tRNA halves and distinct Y RNA fragments are abundant in the extracellular space, inclu

62 ar consequences of these pathological NOTCH3 fragments are an important area for future investigation

63 requency (10 MHz) two subpopulations of cell fragments are distinguished.

64 ensure reconstitution of active Cre when all fragments are expressed in the same neuroblast.

65 Here, we demonstrate that these fragments are produced by RNase 1, a highly active secre

66 ts with a length between 140 and 180 bp) DNA fragments are recovered and sequenced on Illumina HiSeq

67 More than a million Okazaki fragments are synthesized, processed and joined during r

68 These fragments are then adjuvanted by a co-administered cell

69 emonstrates the role of phospholipid bilayer fragment as the key intermediate in the mechanism of lip

70 DropSynth can build thousands of gene-length fragments at >20% fidelity.

71 ransformation of these antibodies from small fragments at the discovery stage to full antibodies at t

72 RNA fragments attached to pUG tails with more than 16 perfec

73 Injections of the retrograde tracer fragment B of cholera toxin (CTb) were performed in the

74 functionalized small molecules suitable for fragment-based drug discovery and the cystic fibrosis C2

75 Fragment-based drug discovery is a strategy widely used

76 e used structure-based virtual screening and fragment-based drug discovery to identify compounds like

77 g an enhanced version of the popular Rosetta fragment-based protein structure prediction tool.

78 We show that microplastic fragments become relatively concentrated within the base

79 is subjected to proteolytic processing into fragments before being secreted to the CSF.

80 glaucoma patients demonstrate shorter, more fragmented bouts of physical activity throughout the day

81 rotein and that is cleaved into two discrete fragments by a clostripain-like protease called fragipai

82 or near native peptidoglycan precursors and fragments by Escherichia coli PBP1B, allowing us to (a)

83 ift assays to examine the binding of OLE RNA fragments by OapB and found that OapB recognizes a small

84 Remarkably, this fragment can be attached to any xylose unit.

85 Therefore, the Asn(81)-Asn(149) fragment can be considered as the site of IgE recognitio

86 rate that covalently tethered small molecule fragments can be used to stabilize specific oligomers du

87 reaten population stability as seen in other fragmented carnivore populations globally.

88 Consistently, both C(2)AB fragments cause a reduction in the membrane-bending modu

89 genetic approach that applies a cell-surface fragment complementation strategy, Split-TurboID, and id

90 he generation and nuclear import of a 30 kDa fragment comprising most of L1's C-terminal, intracellul

91 These functions of DRAIC mapped to the same fragment containing bases 701-905.

92 ata reveal a conserved mechanism for 5' tRNA fragment control of noncoding RNA biogenesis and, conseq

93 The strategy involves a late-stage fragment coupling between a tertiary carbon radical and

94 hat featured a carefully orchestrated tandem fragment coupling-annulation cascade.

95 udies including antigen-binding and neonatal fragment crystallizable (Fc) receptor (FcRn) binding dem

96 ife and blocking access of autoantibodies to fragment cystallizable gamma receptors (Fcgamma receptor

97 steine with a succinimide group in a peptide fragment derived from thioredoxin-1 (Trx-1) obtained via

98 Starting from a fragment derived lead compound, we have conducted struct

99 our approach involves creating a library of fragments derived from an open reading frame of interest

100 DNA fragments derived from the 5' region of SLC26A9-bearing

101 ent and broadly applicable approach to early fragment development.

102 ultiple physical contacts, a C-terminal CAL1 fragment directly binds a CENP-C cupin domain dimer.

103 The fragments discriminately bind to the interface of 14-3-3

104 assay, XACTLY, to interrogate the termini of fragmented DNA, information traditionally lost in standa

105 Comparison of both the fragment drift times and IR spectra with those of suitab

106 lattice contacts and therefore accessible to fragments during soaks.

107 the methods used to identify the two initial fragments either simultaneously or successively.

108 tact or sheds individual platelets or larger fragments (emboli).

109 he N-terminus, and the charge states of UVPD fragments enabled monitoring of charge migration to the

110 rization of UH154-11, a ferroan trachybasalt fragment enclosed in a Renazzo-type carbonaceous chondri

111 rase-mediated dUTP nick-end labeling and DNA fragment enzyme-linked immunosorbent assay.

112 Each metal(II) halide sheet represents a fragment excised from a single layer of the bulk solid s

113 We have previously described antibody fragments (FABs) that recognize activated betaarr1 upon

114 The antibody-binding crystallizable fragment (Fc) gamma receptors (FcgammaRs) are expressed

115 s revealed that a rarely seen crystallizable fragment (Fc) modification, N325 deamidation, exhibited

116 recently demonstrated that proteasomes could fragment filamentous aggregates into smaller entities, r

117 allows bacteria to internalize exogenous DNA fragments for the acquisition of new phenotypes such as

118 endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation.

119 w proteins recognize adenine: a planar rigid fragment found in the most common and ancient ligands.

120 ectron microscopy, we investigated 10 papyri fragments from J.-F.

121 embly errors, chimeras, and contamination by fragments from other genomes limit the value of these ge

122 ease of FAAs and appearance of small protein fragments from SDS-PAGE in dry-aged samples compared to

123 However, TDP1 can only process small peptide fragments from ssDNA ends, raising the question of how t

124 Amino acid fragments from such hydrated protein films are observed

125 rity of the red inks inscribed on 12 papyrus fragments from the Tebtunis temple library.

126 The protection was mediated by the Fc fragment functions of MR228.

127 tin channels, we further show that a soluble fragment generated from the N-terminal extracellular dom

128 the development of the fragment hits using a fragment growing strategy was employed, which led to the

129 Where populations are fragmented, habitat quantification is often the first st

130 energy supply, and flood protection but also fragment habitats of freshwater species.

131 Endangered due to small population sizes and fragmented habitats.

132 ers, and instead contains distal chromosomal fragments harboring CRC-driven enhancers.

133 Significant progress was made in developing fragment hit 7 into lead 23dd (>600-fold increase in act

134 sing a structure-based approach, we merged a fragment hit with the previously reported sulfonamide se

135 Noncovalent fragment hits revealed binding hotspots, while the coval

136 ry are described, and the development of the fragment hits using a fragment growing strategy was empl

137 lf-cleavage is constitutive and produces two-fragment holoreceptors that remain bound at the cell sur

138 uses are necessary for transmission, not the fragments identified by PCR.

139 Many of the mRNA fragments identified by peak calling correspond to annot

140 rate caused appearance of a 160 kDa myosin-4 fragment in SDS-PAGE, further decreased water-holding of

141 Viral expression of TrkB 1-486 fragment in the hippocampus of APP/PS1 mice facilitates

142 te that is readily generated, dispersed, and fragmented in the environment.

143 nd several peaks are observed for CA and its fragments in both the positive and negative modes.

144 hat the distribution patterns of the peptide fragments in Gl-L and Gd-L were similar, but more fragme

145 of the N-terminal (1-11) and central (12-19) fragments in interactions during the lag phase, whereas

146 tempt to identify substrates and proteolytic fragments in mouse and human plaque extracts.

147 lomeres creates a preponderance of chromatin fragments in the cytosol, which leads to a premature sen

148 umulation of immunostimulatory peptidoglycan fragments in the host cell cytosol.

149 biopsy analysis of circulating cell-free DNA fragments in the patients' blood can monitor clonality a

150 sts have observed small extrachromosomal DNA fragments in tumor cells, yet comprehensive examination

151 hosphorylates full-length and N-terminal HTT fragments in vitro (at S13/S16), in cells (at S13) and i

152 Further, kelp fragments increased pH and aragonite saturation and decr

153 Analysis of the breakpoint junction fragment indicated that these 67 kb heterozygous duplica

154 ECD fragments indicated unfolding started at the N-terminus,

155 of ontologies would not only make currently fragmented information about health risks from chemical

156 We hypothesise that, as the fragment insertion process focuses on the most challengi

157 ovalent tether and the nature of the protein-fragment interaction.

158 The isobarically labeled peptides are fragmented into sets of b- and y-ion clusters upon LC-MS

159 We have recently introduced a fragment ion indexing method and the MSFragger search en

160 and the principal component analysis of the fragment ion intensities of just two isomeric oligomer g

161 (3) spectra are consistent with the proposed fragment ion structures and mechanisms of formation.

162 Matching of data for intact and fragment ions against known values for 36 fully defined

163 fragmentation produced a greater variety of fragment ions and complementary ion pairs leading to mor

164 demonstrates the utility of highly reactive fragment ions for selective bond formation processes and

165 tool, we completely annotated 201 adduct and fragment ions from 10 metabolites.

166 lyze the intensity changes of the adduct and fragment ions from metabolites.

167 Tracking diagnostic lipid DB-position fragment ions in mouse pancreatic tissue with down to 10

168 However, this strategy does not consider fragment ions shifted by unknown modifications, preventi

169 d or formate-adducted GPLs yields diagnostic fragment ions spaced 24 Da apart.

170 cules and measures of exact masses of formed fragment ions, it could be concluded that some of these

171 ated ions of metabolites from the adduct and fragment ions.

172 erlapping isotope patterns of highly charged fragment ions.

173 tuted cis-2,8-dioxabicyclo[3.3.0]octan-3-one fragment is described.

174 be viewed as sp-hybridized and the [B-BO](-) fragment is isoelectronic to a carbyne (CR).

175 e cleavage site in this 1192-amino-acid-long fragment is located between amino acids 961-971.

176 action between the ferrocenes and the MCl(2) fragment is small and suggests that communication is med

177 emarkably, the average shape of natural rock fragments is cuboid.

178 "Piecing together" scroll fragments is like solving jigsaw puzzles with an unknown

179 m a combination of synthetic and recombinant fragments-is a burgeoning field of chemical biology that

180 delta and LigI that is critical for Okazaki fragment joining in vitro.

181 nges of nondiadromous fish species were more fragmented (less connected) (CI = 73 +/- 28%; mean +/- S

182 incorporation of fluorine into proteins and fragment libraries for drug discovery has become increas

183 this work, the screening and validation of a fragment library are described, and the development of t

184 versal NMR experiment, a rationally designed fragment library, and a sample composition optimized for

185 cies identifications of this rare and highly fragmented material.

186 he formation of long 5'-flaps during Okazaki fragment maturation, and that the essential function of

187 le DNA metabolic pathways, including Okazaki fragment maturation, replication of 'difficult-to-replic

188 me analyses of postmortem mRNA from a tissue fragment may determine unique molecular identifiers for

189 chanistic insight into how a unique collagen fragment may regulate ovarian cancer, but in addition ma

190 ometer and collision cross section values of fragments measured.

191 aps suggests that the unsaturated spiroketal fragment might be crucial to induce PP2A inhibition.

192 espan in C. elegans, and is accompanied by a fragmented mitochondrial network.

193 arent molecule transition state at which the fragment molecule was born.

194 to fragment peptides and proteins, providing fragments mostly similar to collisional activation.

195 In solution, the N-terminal fragment of ALIX-PRD is dynamically disordered.

196 trode surface and HT-2 toxin antigen binding fragment of antibody (anti-HT2 (10) Fab).

197 Previously, we used the scFv fragment of antibody 237 as a chimeric antigen receptor

198 trate that acutely introducing an N-terminal fragment of FMRP into BCs normalizes GABA release in the

199 udy, we sought to identify a minimal soluble fragment of HuCR1, which retains the complement regulato

200 were tested in NMRI mice transplanted with a fragment of mouse adenocarcinoma (MAC13).

201 amyloidogenic peptides, namely, the 106-126 fragment of prion protein (PrP(106-126)) and the human i

202 PAP(248-286) is a peptide fragment of prostatic acid phosphatase and has been repo

203 ntify plasma concentrations of an N-terminal fragment of tau (NT1) in a large, well-characterized coh

204 Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, i

205 cised ~ 15 kilobases of DNA that contained a fragment of the integrated vector sequence and the neigh

206 Next, a hexasaccharide fragment of the Pseudomonas aeruginosa exopolysaccharide

207 A1, A2, and A3 domains, an A1A2A3 tridomain fragment of VWF, plasmin-cleaved dimers of VWF, multimer

208 t that is thought to have assembled from the fragments of an ancient collision.

209 Fragments of bacterial peptidoglycan (muramyl peptides)

210 arify these relationships by studying larger fragments of cheetah mtDNA, both from an Indian cheetah

211 respond to OS via recognition of proteolytic fragments of chloroplastic ATP synthase, termed inceptin

212 a histolytica kills human cells by ingesting fragments of live cells until the cell eventually dies,

213 cbC-penDE complex and partial duplication of fragments of regulatory genes.

214 We assessed variation in fragments of the mitochondrial (mt) genes cytochrome c o

215 leaved form, as membrane-spanning C-terminal fragments of the proteins.

216 tures of the EV71 virion in complex with Fab fragments of these potent and protective antibodies reve

217 mensional structure in the presence of small fragments of tRNA (tRFs).

218 arvae and A. tonsa on DMS-infused fibers and fragments (P < 0.05).

219 appropriate basicity, we could suppress the fragment peaks and obtain a plain IMS spectrum for CA co

220 ical activity superior to that of the parent fragment peptide in vitro.

221 IRMPD) has been used in mass spectrometry to fragment peptides and proteins, providing fragments most

222 emerge and persist despite an intrinsically fragmented population structure.

223 t acquisition modes isolate and concurrently fragment populations of different precursors by cycling

224 of MMP-2, these filaments rapidly break into fragments prior to reassembling into spherical micelles.

225 those at CHG and CHH sites in P1, P2 and P3 fragments regardless of the CO(2) or N-fertilizer level.

226 g indicating a surface composed of an impact-fragmented regolith overlying basaltic lava flows.

227 or over 90% of the molecules with respect to fragment relative intensity and m/z.

228 Fragments released from the PG serve as fundamental reco

229 n, the biogenesis of these extracellular RNA fragments remains largely unexplored.

230 These fragments represent a starting point to develop ALAS2 in

231 umor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring throug

232 determined by PBE+D3 calculation, the phenyl fragment reveals strong pai-pai interaction for steric h

233 other RNase HI enzymes, RnhP incises Okazaki fragments, ribopatches, and a complementary RNA-DNA hybr

234 osed a novel algorithm to detect and restore fragmented ridges in incomplete fingerprints.

235 by precollisional coastwise transport of arc fragments rifted from the Congo/Tanzania cratonic nucleu

236 e into the lumen of small or large intestine fragments, robust phosphorescence intensity and lifetime

237 M204 and an engineered single-chain variable fragment (scFv) inhibited seeding by IL15-induced tau ol

238 A nonimmune, human single-chain variable fragment (scFv) phage display library was screened for b

239 ere, we report a human single-chain variable fragment (scFv), identified via yeast surface display, t

240 different chemical matter from an NMR-based fragment screen using selective methyl labeling.

241 Fragment screening offers an efficient approach to explo

242 Herein, we conducted an NMR-based fragment screening to identify additional chemical matte

243 amentous fungus and used in crystallo glycan fragment screening to reassemble the GPI-core glycan in

244 N-methyl pyridone series identified through fragment screening.

245 High-throughput screening and fragment-screening campaigns published between 2017 and

246 The evaluation of our fragment selection approach was conducted using an enhan

247 We conclude that pyrazine as a molecular fragment should not be perceived as a simple aromatic is

248 mutants carrying the transgenic ZmNLP5 cDNA fragment significantly increased the nitrate content in

249 hemispherical agar embedded with pencil lead fragments simulating as FBs.

250 he extraordinarily short nature of CMV cfDNA fragment size with a median length of 149 bp.

251 racterized by reduced anxiety-like behavior, fragmented social behavior, and altered ultrasonic vocal

252 indicated reduced migration on the strongly fragmented southern riverside.

253 ain (ABD) and a llama single-domain antibody fragment specific for mouse and human serum albumin.

254 al peptides (TCPs), including a major 11-kDa fragment (TCP96), are produced through cleavage by human

255 tissues and for specimens containing highly fragmented template DNA.

256 e a monomeric, glycan-engineered RBD protein fragment that is expressed at a purified yield of 214 mg

257 generates toxic N-terminal huntingtin (HTT) fragments that preferentially kill striatal neurons.

258 an be targeted in a differential manner with fragments that represent promising starting points for t

259 g of several fragments, and resection of the fragments that retained the exclusion phenotype allowed

260 For each fragment, the carbon-black pigment found in the ink is i

261 In contrast to the IgE Fc fragment, the IgE Fc in intact IgE is significantly less

262 soids, where circulating blood progressively fragments them into platelets.

263 despread deposition of complement-activation fragments throughout the sinusoids, elevated transaminas

264 udy, we have developed an HtrA1-blocking Fab fragment to test the therapeutic hypothesis that HtrA1 p

265 platform for multimerizing antibody and Fab fragments to enhance the capabilities of human therapeut

266 migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, not

267 we mined Quercus suber EST libraries for OSC fragments to use in a RACE PCR-based approach and cloned

268 and is capable of transporting peptidoglycan fragments (tri-diaminopimelic acid) in E. coli and in C.

269 that ensilication stabilizes tetanus toxin C fragment (TTCF), a component of the tetanus toxoid prese

270 htheria toxin from engineered intein-flanked fragments upon receptor-mediated delivery of one of them

271 hase liquid chromatography (LC)-MS, and then fragmented using electron-transfer/higher-energy collisi

272 f interest and enriching for the interacting fragments using a yeast two-hybrid reporter system.

273 t approach that unites the C1-C9 and C10-C22 fragments using Sonogashira coupling and Boland reductio

274 ections using a synthetic human single-chain fragment variable library.

275 entification of a high-affinity single-chain fragment variable region (scFv).

276 Depending on local constraints, this fragment variably formed new domains, partitioned existi

277 s that were liganded by Fab-epitope antibody fragments via atomic force microscopy.

278 Notably, a metal-phthalocyanine fragment was successfully incorporated into this Zr-MOL

279 amount of raw total RNA without enriching or fragmenting was also preliminary assessed.

280 33,953 subpockets annotated with their bound fragments was screened for local similarity to cavities

281 stoichiometry and stable isotopes per coral fragment, we found that nutrients from fish positively a

282 lls expressing a WT or S838A/T841A mutant RB fragment, we present evidence that deficiency for this p

283 the actual "pinholes." Focusing on the TMD2 fragment, we used synchrotron radiation-based circular d

284 vely opsonized with prophagocytic complement fragments, we find that this cell also escapes immune su

285 nine (up to 47%) and highly modified protein fragments were found in the processing waters, indicatin

286 Twenty fragments were identified as hits for Notum inhibition,

287 Various fluorine and Ln-containing high-mass fragments were observed in this experiment, including th

288 Known as tRFs, these fragments were reported for the first time only a decade

289 s hits for Notum inhibition, and 14 of these fragments were shown to bind in the palmitoleate pocket

290 ation between viable/necrotic cells and cell fragments, whereas phase information allows discriminati

291 gh the vast majority of sequences were small fragments, which highlights the challenge of assembling

292 Thus, masking the anti-CD3 Fab fragment with an anti-idiotypic mask and cleavage of the

293 -stranded overhangs, if present, on each DNA fragment with an overall accuracy between 80-90%.

294 length of <=80 bp) and mononucleosome-sized (fragments with a length between 140 and 180 bp) DNA frag

295 h indexing primers, the subnucleosome-sized (fragments with a length of <=80 bp) and mononucleosome-s

296 tyrosine sites that can be liganded by SuTEx fragments with site specificity in lysates and live cell

297 ransduced to express exon 1 huntingtin (HTT) fragments with variable length polyglutamine (polyQ) tra

298 Grafting of the Asn(81)-Asn(149) fragment within the primary structure of yeast cyclophil

299 issociation because glycan-retaining peptide fragments would not be required for localization.

300 While an N-terminal CAL1 fragment wraps around CENP-A/H4 through multiple physica