ライフサイエンスコーパス: fragmentation

1 brane deformation, DNA damage and chromosome fragmentation.

2 Results suggest habitat is at risk of fragmentation.

3 in the aging process, which is paralleled by fragmentation.

4 activation and simultaneously induces glycan fragmentation.

5 onserved in the gas phase prior to precursor fragmentation.

6 its show different stabilities under CID/HCD fragmentation.

7 f a mechanism different than Hsp104-mediated fragmentation.

8 erator establishing this link, for 2D and 3D fragmentation.

9 s, forest interior was prevalent with little fragmentation.

10 rse health outcomes associated with activity fragmentation.

11 tinal mitochondria from stress-induced hyper-fragmentation.

12 damage and hydroxyl radical-induced protein fragmentation.

13 opening followed by Coulomb repulsion-driven fragmentation.

14 d 1,4- hydride transfer processes as well as fragmentation.

15 tropical agriculture expansion and landscape fragmentation.

16 increases in smaller endotherms via habitat fragmentation.

17 protein whose disruption results in nuclear fragmentation.

18 o developing platelet-sized swellings during fragmentation.

19 go synapsis, which is followed by chromosome fragmentation.

20 ominated by secondary nucleation rather than fragmentation.

21 fluences on the energy of activation for ion fragmentation.

22 ds are isolated and trapped individually for fragmentation.

23 ns are imperiled due to human-caused habitat fragmentation.

24 n and S-metolachlor) displayed no cross-ring fragmentation.

25 associations between VF damage and activity fragmentation.

26 suppresses DRP1 expression and mitochondrial fragmentation.

27 te during C(alpha)-thioether bridge LC-MS/MS fragmentation.

28 triggers rapid and reversible mitochondrial fragmentation.

29 ors that govern its formation and subsequent fragmentation.

30 recycled through an unprecedented triflation/fragmentation.

31 metabolites and DRP1-dependent mitochondrial fragmentation.

32 ing in aryl-Ge or Me-Ge nucleophile-assisted fragmentations.

33 Increased rest fragmentation, a potential surrogate for sleep fragmenta

34 ic analyzes show that enhanced mitochondrial fragmentation accelerates wound closure via the upregula

35 -glycosites, indicating that collision-based fragmentation alone is not sufficient.

36 INSR knockdown triggers robust mitochondrial fragmentation, alterations in mitochondrial polarization

37 thropogenic modifications leading to habitat fragmentation and a higher genetic diversity and structu

38 egregation coincides with DREPP-dependent MT fragmentation and a partial loss of the ability to reorg

39 ing cytotoxic stress to induce mitochondrial fragmentation and apoptosis.

40 Circadian rest-activity rhythm fragmentation and attenuation and ultradian disorganizat

41 e sequence of each native DNA molecule after fragmentation and can capture the genomic landscape of c

42 the mitochondria induces both mitochondrial fragmentation and cell death following nitrogen starvati

43 or most downstream molecular analysis due to fragmentation and chemical modification.

44 collapse and are associated with chromosome fragmentation and chromothripsis, complex chromosome rea

45 b) investigated the combined impact of river fragmentation and climate change and (c) tested the rela

46 es and 1-naphthylamines and their subsequent fragmentation and cyclization.

47 ch has been undergoing an intense process of fragmentation and deforestation caused by human-made cha

48 Both fragmentation and discolouration of ocean plastics may o

49 demonstrate a rescue of aortic elastic fiber fragmentation and disorganization accompanied by a decre

50 (MALDI), combined with in-source decay (ISD) fragmentation and Fourier-transform ion cyclotron resona

51 latter being consistent with decreased sleep fragmentation and increased sleep duration for mice expo

52 ation of multivesicular bodies with vacuolar fragmentation and mistargeting of the vacuolar carboxype

53 nger, abrogated DRP1-dependent mitochondrial fragmentation and neurite degeneration.

54 ly reinforce the existing link between Golgi fragmentation and neurodegeneration but also demonstrate

55 ted protein 1 (DRP1)-dependent mitochondrial fragmentation and neuronal degeneration.

56 impacts of climate change, land use, habitat fragmentation and nitrogen pollution.

57 Tandem ring-opening fragmentation and olefination of dimedone establishes al

58 In this study, we have shown that, despite fragmentation and overexploitation, this species maintai

59 particulate are more susceptible to further fragmentation and particulate generation hazard than the

60 ymerase used in MDA is sensitive to template fragmentation and presence of sites with DNA damage that

61 the mitochondria where it induces organelle fragmentation and promotes cell death prior to its destr

62 oach relies on a three-dimensional molecular fragmentation and recombination scheme and the identific

63 The dynamics of domain fragmentation and redistribution are associated with SLE

64 , dendritic mitochondria underwent increased fragmentation and reduced positioning to dendritic spine

65 trongly indicate a mainly physical origin of fragmentation and regulation of platelet size in flow-ac

66 mechanical clamping and electrohydraulics in fragmentation and removal of refractory calculi.

67 that limited population size due to habitat fragmentation and repeated population bottlenecks, by in

68 a library generation workflow that leverages fragmentation and retention time prediction to build lib

69 s-induced OPA1 cleavage causes mitochondrial fragmentation and sensitizes cells to death.

70 cause of the influence of oxidation on MS/MS fragmentation and the large number of complex and only p

71 C=C double bonds (DBs) requires specialized fragmentation and/or functionalization methods.

72 ctrum of posttraumatic sequelae (to overcome fragmentation) and also perform in-depth biobehavioral e

73 ronidase expression and activity, hyaluronan fragmentation, and effacement of HA from the vessel wall

74 ere insomnia with delayed sleep onset, sleep fragmentation, and increased wakefulness.

75 Mutagenesis of Pro(81) abolished the fragmentation, and low pH and reducing conditions enhanc

76 ation, acetylcholine receptor (AChR) cluster fragmentation, and neuromuscular dysfunction.

77 xidative stress, DRP1-mediated mitochondrial fragmentation, and neuronal injury manifested by a reduc

78 Protein 3 (DLG3), resulting in Golgi complex fragmentation, and reduced protein glycosylation, leadin

79 entration, motility, morphology, volume, DNA fragmentation, and total motile sperm count) at 6 months

80 vity among bear subpopulations could further fragmentation, and ultimately threaten population stabil

81 In this study, enhanced in-source fragmentation annotation (eISA) was created by tuning th

82 MF) method, a method based on the systematic fragmentation approach, to predict, for the first time,

83 Landscape heterogeneity and fragmentation are key challenges for biodiversity conser

84 The anomeric alkoxyl radical beta-fragmentation (ARF) of carbohydrates possessing an elect

85 Specifically, a subject with a rest fragmentation at the 90th percentile showed a 57% increa

86 or pharmacologic activation of Golgi complex fragmentation blocks PDAC growth and metastasis similar

87 Irradiation negatively affected myofibrillar fragmentation, but samples irradiated at 9 kGy had (p <

88 , followed by tandem mass spectrometry (MS2) fragmentation by CID in the ion trap.

89 River fragmentation by dams, presenting physical barriers, can

90 a 52 ms SWIFT isolation, followed by in-cell fragmentation by ultraviolet photodissociation (UVPD).

91 Sequential fragmentations can be observed upon IR activation, which

92 chate samples, explaining 71% of the all-ion fragmentation (CF(2))(n) related fragments.

93 g rapid degradation through radical addition-fragmentation chain transfer (AFCT) reactions, to suppor

94 electron/energy transfer reversible addition-fragmentation chain transfer (PET-RAFT) polymerization i

95 amic moieties capable of reversible addition fragmentation chain transfer (RAFT) into photoinitiated

96 hich was synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization from

97 The reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-

98 of nanocapsules using a reversible addition-fragmentation chain transfer (RAFT) process without comp

99 omer retention in CID by exploring different fragmentation channels in glycans of increasing complexi

100 entrations (in the nanomolar range) and poor fragmentation characteristics hinder facile simultaneous

101 ell death (PCD) that is characterized by DNA fragmentation, chromatin condensation, cellular swelling

102 of proteins display a distinct and enhanced fragmentation, compared to their unmodified counterparts

103 Our data indicate that this fragmentation contributes to the activation of the mitoc

104 Hyaluronan fragmentation corresponded to hypoxic induction of the c

105 Increases in fragmentation due to future dams were especially high in

106 ese repeats slows fibrillation and increases fragmentation during aggregation.

107 Significant chromosomal replication and fragmentation during the resistance phase could provide

108 The fragmentation dynamics of the dication is unraveled by t

109 To get insight into the fragmentation dynamics, we use a theoretical approach co

110 tandem mass tag reagents but with increased fragmentation efficiency and signal.

111 We show excellent fragmentation efficiency for denatured peptides and prot

112 nstrumentation to the limit and generate low fragmentation-efficiency and low signal-to-noise-ratio s

113 Elevated mitochondrial fragmentation either in fzo-1 fusion-defective mutants o

114 We found that the cleavage product from this fragmentation event is released into the conditioned med

115 be differentiated by mobility-resolved MS/MS fragmentation experiments.

116 and homologous series evaluation, and MS/MS fragmentation experiments.

117 The elasto-hydrodynamic origin of the fragmentation explains the strong acceleration of platel

118 The resultant field induced fragmentation (FIF) spectra included residual intensitie

119 proteoform analysis, but achieving complete fragmentation for such precursor ions remains challengin

120 group, ablation delivered at AFN detected by fragmentation/fractionation of the endocardial electrogr

121 Biological and chemical DNA fragmentation generates DNA molecules with a variety of

122 Their fragmentation generates some small RNAs that are highly

123 ization yield and decreases ion-beam induced fragmentation, greatly improving the detection of biomol

124 ctical terms, the positive CFG decreases the fragmentation half-life of 2,5-dimethyl-tetrazole in ref

125 Such fragmentation has been reported to impact a small fracti

126 still some impediments to overcome, such as fragmentation, high costs, and questions around data own

127 that this increased choice leads to audience fragmentation, ideological segregation, and echo chamber

128 To study the protein fragmentation in a model and to confirm the assignment o

129 croglia, prevented LPS-induced mitochondrial fragmentation in neurons, and importantly, upregulated t

130 enance, we observed marked increase in Golgi fragmentation in primary fibroblasts derived from all af

131 Fragmentation in responsibility for drinking water contr

132 ly considered in light of accelerated forest fragmentation in the Amazon.

133 ntation (mean of 29.7% for percentage of DNA fragmentation in the folic acid and zinc group and 27.2%

134 e extent to which measurement of a sperm DNA fragmentation index (DFI) can predict sperm quality and

135 ted to examine the relationship between rest fragmentation index and incident heart failure.

136 tivity bout duration in minutes, with higher fragmentation indicating more transient, rather than sus

137 ensive understanding of how habitat loss and fragmentation influence genetic variation.

138 improved sequence coverage by combining ECD fragmentation integrated over multiple CIU intermediates

139 r particles within the stomach and promoting fragmentation into smaller plastic debris, which is then

140 n a single fragmentation window ensures that fragmentation is consistent when quantitation relies on

141 This ethanol-induced mitochondrial fragmentation is dependent on the mitochondrial fission

142 Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but act

143 obal species-level assessment of dam-induced fragmentation is lacking.

144 FXII-W268R/S544A reveals that intracellular fragmentation is largely dependent on autoactivation.

145 agmentation, a potential surrogate for sleep fragmentation, is independently associated with a higher

146 Electrospray ionization (ESI) in-source fragmentation (ISF) has traditionally been minimized to

147 We present a detailed in-source fragmentation (ISF) study based on the mechanisms of the

148 ve the catalytic stability by mitigating the fragmentation issue.

149 To prevent this fragmentation, its causes were examined via gas-phase io

150 le to allylic H-abstraction and further beta-fragmentation leading to dialkylpyridines as the ultimat

151 tient genomes are characterized by extensive fragmentation leading to overall fewer DCEs of smaller s

152 nts a substantial disease of recurrent sleep fragmentation, leading to intermittent hypoxia and subse

153 causing unpredictable capsulorhexis and lens fragmentation/liquefaction.

154 on targeted the neuromiocardial interface by fragmentation mapping (AF-Nests) using the velocity frac

155 Therefore, fragmentation may be the primary process controlling the

156 ameter is also helpful for rationalizing the fragmentation mechanism.

157 , when combined with a thorough study of the fragmentation mechanisms, constitutes an informative sou

158 sing information for deducing a set of photo-fragmentation mechanistic pathways for Ln(hfac)(3).

159 al energy surface determination, statistical fragmentation methods and molecular dynamics simulations

160 Two different fragmentation methods are employed, infrared multiphoton

161 Electron-based fragmentation methods have revolutionized biomolecular m

162 nation of easy-to-use criteria including QRS fragmentation might improve risk stratification.

163 particle shows that the continuous bisection fragmentation model is the main contributor to the fragm

164 amounts and were sequenced by sequential MS fragmentation (MS(n)).

165 Using in-source activation for nonspecific fragmentation of all precursors, functional group famili

166 from higher-energy C-trap dissociation (HCD) fragmentation of alpha2,3-sailoglycopeptides then genera

167 hat size, while secondary NPs originate from fragmentation of bigger debris.

168 Readmission to a different hospital leads to fragmentation of care.

169 ises testing and treatments over prevention, fragmentation of clinical care and public health service

170 asymmetric design that exhibits preferential fragmentation of cross-links over peptide backbones, a d

171 peroxide, UV, photosensitized reactions) and fragmentation of DNA in human spermatozoa.

172 generates fatty acyl carboxylate anions via fragmentation of ester bonds linking the fatty acyl subs

173 The fragmentation of HA by myeloid cells was mediated by the

174 r level, the POL2A defect is associated with fragmentation of heterochromatin.

175 our findings reveal gradual decompaction and fragmentation of higher-order chromatin structure as an

176 Fragmentation of homeostatic high molecular weight HA pr

177 knockout in YAC84Q mice alleviated excessive fragmentation of important synaptic proteins.

178 own and unknown proteoforms was performed by fragmentation of intact precursor ions.

179 ciation (UVPD) produces rich and informative fragmentation of intact protein ions, but in the case of

180 accounting for potential biases and reducing fragmentation of knowledge that can prevent effective en

181 generate strong reporter ions following HCD fragmentation of labeled peptides acquired on Orbitrap p

182 t the missing loss could be explained by the fragmentation of large aggregates into small particles,

183 Blood platelets are formed by fragmentation of long membrane extensions from bone marr

184 ondrial localization of Drp1, causing marked fragmentation of mitochondria.

185 In addition, ethanol exposure causes the fragmentation of mitochondrial networks aligned with myo

186 that the langoustine is responsible for the fragmentation of MPs already accumulated in sediments th

187 Fragmentation of natural environments as a result of hum

188 lly, we demonstrate native top-down backbone fragmentation of noncovalent protein complexes, leading

189 Here, we discovered site-specific fragmentation of NOTCH3 protein in pathologically affect

190 utation in the kinase gene dstyk that causes fragmentation of notochord vacuoles and a severe congeni

191 ergy deposition method that offers extensive fragmentation of peptides while leaving the glycosite in

192 Here, the fragmentation of photoexcited iso-propyl iodide and tert

193 that DNASE1L3 is an important player in the fragmentation of plasma DNA, which appears to act in a c

194 ellular DNase, DNASE1L3, plays a role in the fragmentation of plasma DNA.

195 Proteolytic fragmentation of polyglutamine-expanded ataxin-3 is a co

196 with habitat degradation has contributed to fragmentation of populations and a severe decline in its

197 In order to prevent or reduce the extent of fragmentation of saturated hydrocarbons upon APCI, and t

198 derstanding and contribute to the increasing fragmentation of science.

199 We tested whether fragmentation of sustained rest/activity patterns derive

200 Coupling of tumor and immune CNs, fragmentation of T cell and macrophage CNs, and disrupti

201 in connectedness among taxa, an increase in fragmentation of taxon co-occurrence networks, and a shi

202 here it leads to entanglement and ultimately fragmentation of the cell body.

203 The greater fragmentation of the circadian pattern of energy intake

204 Here, we assessed the degree of fragmentation of the occurrence ranges of ~10,000 lotic

205 d acyclic compounds through ring-opening and fragmentation of the parent butenolide ring.

206 een Trp and the pyridinium salt, followed by fragmentation of the pyridinium N-N bond and concomitant

207 ults obtained displayed many more cross-ring fragmentation of the pyrimidine ring compared to the pyr

208 opefully policy makers to reduce the current fragmentation of the standardization and regulatory body

209 s a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to sp

210 We further demonstrate how fragmentation of THF-doped DOM in APPI resolved subtle d

211 We formulated mass spectral fragmentations of lipids across 117 lipid subclasses and

212 s are widespread, the consequence of habitat fragmentation on genetic diversity, gene flow and geneti

213 inutes/day (P < 0.05) and 2% higher activity fragmentation (P < 0.05), but not with the number of act

214 e show that N-O homolysis is the most likely fragmentation pathway available to N-acyloxyamines, in c

215 ntation model is the main contributor to the fragmentation pathway of the catalyst particle as a whol

216 thermore, within the largest Ti clusters the fragmentation pathway was found to occur through both th

217 second, we determine the dominant molecular fragmentation pathways during soot formation.

218 This may be attributed to different fragmentation pathways enabled by allylic versus vinylic

219 ion of glycan isomers by providing different fragmentation pathways to generate informative, structur

220 pulses, which characteristically affects the fragmentation pattern observed in the mass spectra.

221 and sialylation drastically alter the MS(2) fragmentation pattern of glycopeptides in negative mode

222 The characteristic fragmentation pattern of phospholipids consisting of the

223 from spectra having similar retention time, fragmentation pattern, and the same precursor m/z and co

224 zation and quantifies the reproducibility of fragmentation patterns across samples.

225 tware library currently contains ~7 000 PFAS fragmentation patterns based on rules derived from stand

226 ivation, which do not only give rise to rich fragmentation patterns but also overcome low mass cutoff

227 ing the ISF conditions to generate in-source fragmentation patterns comparable with higher energy fra

228 showed similar sensitivity enhancements and fragmentation patterns compared to our previously report

229 d 210 times in positive mode), with the eISA fragmentation patterns consistent with METLIN for over 9

230 arnitines, we conducted in-depth analyses of fragmentation patterns of acylcarnitines and developed a

231 The identified unique mass fragmentation patterns of amino acids coupled to a multi

232 frontier strategy for generating informative fragmentation patterns of ions, especially for biologica

233 ods, due to identical exact mass and similar fragmentation patterns of the stereoisomers.

234 Moreover, the combined fragmentation patterns provide sufficient information to

235 GNPS performs auto-deconvolution of compound fragmentation patterns via unsupervised non-negative mat

236 as well as for studying relationships among fragmentation patterns, collision energies, structures,

237 tly enhance our understanding of the peptide fragmentation process and could improve peptide identifi

238 unked an erroneous assumption of a concerted fragmentation process for (OCP)(-) , rather than cycload

239 on of MS/MS, relies on a wavelength specific fragmentation process occurring on resonance with an IR

240 out, providing a better understanding of the fragmentation process.

241 ity as the biophysical mechanism behind this fragmentation process.

242 earch to result in three main distinct photo-fragmentation processes: (a) ligand-metal charge transfe

243 EID fragmentation produced a greater variety of fragment ion

244 hese brains indicated accumulation of NOTCH3 fragmentation products in the basement membrane, collage

245 iQA, were identified on the base of their MS fragmentation profile.

246 viduals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood ce

247 his treatment also significantly reduced the fragmentation rate and apoptotic index of blastocysts an

248 The corresponding fragmentation rate constants were translated into a vibr

249 ic methods to rely solely on collision-based fragmentation rather than electron-driven dissociation b

250 molecular ion abundances were maximized and fragmentation reactions minimized.

251 ) study based on the mechanisms of the major fragmentation reactions observed of diagnostic ions (DIs

252 is was accompanied by abnormal mitochondrial fragmentation, reduced adenosine triphosphate (ATP) leve

253 duct aminyl radicals are susceptible to beta-fragmentation, releasing alkyl radicals and affording im

254 abled us to separate and analyze CID and ECD fragmentation simultaneously.

255 The major issue is that the elution time and fragmentation spectra depend considerably on the equipme

256 n tandem mass spectrometry and the resulting fragmentation spectra were processed via a commercial so

257 twork to predict 2,497 compound classes from fragmentation spectra, including all biologically releva

258 y the library-based method of 2D ultraviolet fragmentation spectroscopy-mass spectrometry (2D UV-MS)

259 inker that remain on released peptides, each fragmentation spectrum can offer multiple independent op

260 Following MS2 fragmentation, SPS enables simultaneous isolation of the

261 tion profiles of transcribed regions, an RNA fragmentation step before biotin tagging was introduced,

262 luene and tetrahydrofuran (THF), including a fragmentation study of THF-doped riverine DOM using infr

263 Fragmentation takes place in a concerted asynchronous re

264 Various mass spectrometry (MS) based fragmentation techniques are powerful approaches for map

265 The development of various ionization and fragmentation techniques has been of key importance for

266 In-source fragmentation tests were conducted and experiments invol

267 (MALDI) combined with in-source decay (ISD) fragmentation that allows mapping of N- and C-terminal r

268 ently introduced a chemical approach for RNA fragmentation that we refer to as TT(chem)-seq.

269 s that combine collision- and electron-based fragmentation to characterize the number of O-glycosites

270 the availability of mobile protons, driving fragmentation to charge remote channels.

271 neration uses enzymatic rather than acoustic fragmentation to generate WGA-free whole-genome librarie

272 xplored the use of negative-mode MS(2)/MS(3) fragmentation to supplement current nanoLC-MS(2)-based s

273 ium of CADASIL brains, we mapped the site of fragmentation to the NOTCH3 N terminus at the peptide bo

274 However, APCI causes extensive fragmentation to these compounds, which impedes its effe

275 DNA fragmentation, TUNEL-positive neurons, cleaved caspase-3

276 Our results demonstrate significant fragmentation upstream and inside the TIMS tunnel that c

277 As habitat loss and fragmentation, urbanization, and global climate change a

278 d C-C insertions and eliminations, oxidative fragmentation using hypervalent iodine reagents, reactio

279 separate UV-induced products for subsequent fragmentation via low energy collision-induced dissociat

280 Fragmentation was assessed using previously validated in

281 Activity fragmentation was calculated as the reciprocal of the av

282 ime-of-flight regions of the instrument, and fragmentation was fast enough to be compatible with mobi

283 Accordingly, the extent of fragmentation was found to correlate with the proton aff

284 Fragmentation was not observed, or seen weakly, with ald

285 A statistically significant increase in DNA fragmentation was observed with folic acid and zinc supp

286 High efficiency of fragmentation was observed with single bond cleavage of

287 the spectrum and no further dissociation or fragmentation was observed.

288 QRS fragmentation was the only independent predictor of appr

289 Current levels of fragmentation were highest in the United States, Europe,

290 e habitat network that diminishes effects of fragmentation, which improves overall habitat quality an

291 the precursor ion radii are modulated before fragmentation, which results in modulation of the abunda

292 rotein 1 (DRP1) expression and mitochondrial fragmentation, which suppresses kindlin-2 mitochondrial

293 and pirimiphos-methyl) displayed cross-ring fragmentation while compounds with only aromatic hydroca

294 reactive stages with improved efficiency of fragmentation will be needed to extend the practice of r

295 yte and the isotope standard within a single fragmentation window ensures that fragmentation is consi

296 g several spectroscopic techniques, protease fragmentation with mass analysis, and EM.

297 ridin-1-yl (TEMPO), and subsequent oxidative fragmentation with MMPP.

298 higher energy collisional dissociation (HCD) fragmentation with the resulting MS3 fragments detected

299 This methodology of multiple CE fragmentation without merging spectral information can s

300 To this end, the fragmentation yields of fragile benzylpyridinium "thermo