ライフサイエンスコーパス: fratricide

1 ptide-specific lysis by neighboring T cells (fratricide).

2 e of residual CD7 expression and the ensuing fratricide.

3 l and malignant cells, leading to CAR T-cell fratricide.

4 he pancreas, resulting in Fas/Fas-L-mediated fratricide.

5 between CARTs and T-ALL blasts leads to CART fratricide.

6 ded protection from CD70 CAR T cell-mediated fratricide.

7 d bacteriocins A and B (CibAB) implicated in fratricide.

8 ility of cytotoxic lymphocytes to suicide or fratricide after degranulation.

9 and neoplastic T cells, undergo only limited fratricide and can be expanded long-term ex vivo.

10 age increase in load that is attributable to fratricide and determine the parameters that should be m

11 ic disruption of the CD7 gene prevented this fratricide and enabled expansion of CD7 CAR T cells with

12 ock out of CD38 to prevent antibody-mediated fratricide and enhance NK cell metabolic fitness.

13 CAR) T-cells targeting CCR9 are resistant to fratricide and have potent antileukemic activity both in

14 ve cytotoxicity and proliferation because of fratricide and not due to the absence of a 2B4-dependent

15 and some myeloid leukemias, produces robust fratricide and often requires additional mitigation stra

16 cell death in Th1/Th2 effectors include both fratricide and suicide.

17 Additionally, we address the phenomenon of fratricide and trogocytosis-associated exhaustion, which

18 cell recognition, activation, apoptosis and fratricide, and exhaustion.

19 ade lymphodepleting serotherapy, CAR7 T-cell fratricide, and graft-versus-host disease, respectively.

20 tion-associated genes related to competence, fratricide, and the transparent colony phenotype.

21 Here, we describe fratricide as the governing principle behind gelatinase

22 es additional gene modifications to overcome fratricide because of shared T-cell antigens on normal a

23 Fratricide between CD8(+) T lymphocytes is known to occu

24 ped a CD5-directed CAR that produces minimal fratricide by downmodulating CD5 protein levels in trans

25 We suggest that Tm-cell fratricide by Fas-mediated apoptosis results in a densit

26 We show that, surprisingly, fratricide can lead either to an increase or a decrease

27 Importantly, however, the fratricide conferred by SLAMF7-CAR T cells spares the SL

28 We do not observe fratricide during CD229 CAR T cell production, as CD229

29 2B4-mediated inhibition of NK-cell fratricide explains some of the paradoxes of 2B4 functio

30 it is not known what effect, if any, T-cell fratricide has on the course of infection.

31 ve HTLV-I-positive patients considered here, fratricide has probably caused an increase in equilibriu

32 tion and are susceptible to NK cell-mediated fratricide in a perforin- and NKG2D-dependent manner.

33 We also show that NK-NK fratricide in the absence of 2B4-CD48 interaction is dep

34 Fratricide killing, prevalent in wild-type cells, is cal

35 This process of glial 'fratricide' may provide a basis for the secondary propag

36 multiple turnovers, resulting in "molecular fratricide." N-bromoacetyltryptamine should serve as a u

37 ntigens may be limited by T cell aplasia and fratricide, necessitating "rescue" allogeneic hematopoie

38 of stationary phase cells mimics aspects of fratricide observed in enterococcal biofilms, where both

39 ets (RIP-Fas-L) as a result of Fas-dependent fratricide of beta-cells after transfer of diabetogenic

40 mic disruption of a target antigen overcomes fratricide of CAR T cells and establishes the feasibilit

41 nd malignant T cells, potentially leading to fratricide of CAR T cells or profound immunodeficiency.

42 In this study, we show fratricide of CD7 CAR T cells can be fully prevented usi

43 pping expression on healthy T cells leads to fratricide of CD7-CAR T cells, requiring additional gene

44 m APCs in an Ag-specific fashion, leading to fratricide of programmed death 1-expressing, neighboring

45 T cells and show that they induce selective fratricide of SLAMF7(+/high) NK cells, CD4(+) and CD8(+)

46 lls, failed to trigger a self-MHC-restricted fratricide of T cells, and was associated with toxicity

47 inuous CAR-mediated engagement, resulting in fratricide of trogocytic antigen-expressing NK cells (NK

48 t the qualitative and quantitative effect of fratricide on HTLV-I equilibrium proviral load.

49 We also investigate the effect of fratricide on the probability of viral clearance.

50 de-based CAR, which show evidence of minimal fratricide post activation/transduction and antigen-depe

51 Finally, we show that fratricide reduces the probability of viral clearance.

52 o T cell-bound HLA-I molecules, allowing for fratricide representation and activation.

53 Epitope-edited CD45 CAR T cells were fratricide resistant and effective against patient-deriv

54 CD1a-CARTs are fratricide resistant, persist long term in vivo (retaini

55 data support the therapeutic and safe use of fratricide-resistant CD1a-CARTs for relapsed/refractory

56 ukemia (T-ALL) by self-selecting for CD7(-), fratricide-resistant CD7 CAR T cells that were transcrip

57 WU-CART-007 is a CD7-targeting, allogeneic, fratricide-resistant chimeric antigen receptor T-cell pr

58 dings demonstrate the efficacy and safety of fratricide-resistant, allogeneic anti-CD70 CAR T cells t

59 ls were completely resistant to DARA-induced fratricide, showed superior persistence in immune-defici

60 lls and abating T cell activity by promoting fratricide T cell killing and T cell exhaustion.

61 atibility complexes and became the target of fratricide T cell killing, which was reversed by Tim-3 b

62 ver-infiltrating cells, pointing to death by fratricide that causes almost complete disappearance of

63 on of competence for transformation, such as fratricide, the kin-discriminatory killing of neighborin

64 We derive the conditions necessary for fratricide to cause a decrease in load and deduce that,

65 system prevented trogocytic antigen-mediated fratricide, while sparing activating CAR signaling again

66 athematical techniques to investigate T-cell fratricide with particular reference to HTLV-I infection