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2 pic surveillance is invasive, expensive, and fraught by issues of sampling bias and the subjective as
4 n nuclear imaging involves several ethically fraught components at different stages of the machine le
6 ngle marker to distinguish bacterial taxa is fraught even if some markers appear to be discriminative
10 isis, much attention has been devoted to the fraught question of how to allocate intensive care unit
12 hile generalisations about polyploids can be fraught, this evidence indicates that the breakdown of t
15 ue and perioperative management RAAA remains fraught with a high rate of death and complications.
16 ed over the helical scaffold such that it is fraught with a huge steric strain to undergo required bo
17 y to cross-couple secondary alkyl centers is fraught with a number of problems, including difficult r
18 th the most efficient regimens available, is fraught with a substantial proportion of failures to reo
19 ral percutaneous transluminal angioplasty is fraught with a substantial risk of restenosis and reinte
21 reviewing letters of recommendation are all fraught with bias, especially for individuals from group
22 ng reprogramming methodologies, however, are fraught with caveats, including a heavy reliance on vira
24 ly ill coronavirus disease 2019 patients was fraught with challenges and generated a strong feeling o
25 e management of anophthalmia in the child is fraught with challenges and nuances, the principal aim i
28 l solvothermal approach, while prevalent, is fraught with challenges such as complicated processes, e
29 Learning their structure and intricacies is fraught with challenges, and often side-stepped in favou
31 the transition to biodegradable packaging is fraught with challenges, including scalability, cost-eff
32 study showed that UHC is a complex process, fraught with challenges, many possible pathways, and var
37 tionships after termination of treatment are fraught with complexities and are the subject of ongoing
39 n the mainstay of care for IOI, their use is fraught with complications and side-effects, suggesting
40 rmanent extended-length tracheostomy that is fraught with complications including mucus plugging and
41 tro evaluation of colistin susceptibility is fraught with complications, due in part to the inherent
42 ing following third-degree burn injuries are fraught with complications, often resulting in long-term
43 rified the nature of PTLD, the literature is fraught with conflicting experience and outcomes with PT
44 or membrane proteins, the extrapolations are fraught with considerable uncertainty as the denaturants
48 Inferring the size of extinct animals is fraught with danger, especially when they were much larg
49 get genes, particularly in cancer, have been fraught with dead ends and context-specific functions.
50 m, but benchmarking and interpreting them is fraught with difficulties (need to compare them on a com
51 ichens, particularly the genus Lecanora, are fraught with difficulties arising from hidden diversity
52 inference of their parameters from data, are fraught with difficulties because the dynamics depends o
53 owever, all elements of informed consent are fraught with difficulties due to the unique nature of th
54 tive in releasing the drug rapidly, they are fraught with difficulties inherent in processing particu
55 However, use of the Tet-On system has been fraught with difficulties, including high background exp
56 this pre-biomineralization fossil record is fraught with difficulties, leading to controversial and
65 redicted mechanistic pathways is limited and fraught with difficulty, mainly as rapid proton transfer
70 irect links across phenotypic hierarchies is fraught with difficulty; we identify issues complicating
77 the randomized trials used for analysis are fraught with inconsistencies, including the availability
81 wever, machine learning in the microbiome is fraught with issues of reproducibility, driven in large
82 rge numbers of putative novel small proteins fraught with large fractions of false-positive predictio
84 e implementation of these maneuvers has been fraught with limited activity and lack of specificity.
85 odification may be helpful, but even this is fraught with limited efficacy and potential complication
86 considered a last resort leukemia treatment, fraught with limited success due to microbial infections
89 heless, any inter-trial comparison is always fraught with major difficulties, and an indirect compari
92 h studies of trauma system effectiveness are fraught with methodologic difficulties, several types of
93 idence base is limited, and most studies are fraught with methodologic limitations, including cross-s
98 liciting reliable responses from newborns is fraught with operational difficulties, and studies with
103 ic characters means that using these data is fraught with potential difficulties, leading to errors i
105 ool in the armoury against cancer, but it is fraught with problems due to its global systemic toxicit
106 st infection, and current drug therapies are fraught with problems, predominantly because of the prot
111 t of highly performant but "black box" AI is fraught with risk, and high-profile errors could damage
112 tration of such myeloablative transplants is fraught with risks, some of which are related to the int
117 c category guiding translational research is fraught with so many problems that the validity of resea
118 rican populations, but its implementation is fraught with substantial ethical governance risks that c
119 dard therapy for Wegener's granulomatosis is fraught with substantial toxicity and not always effecti
121 of HCV replication in extrahepatic sites is fraught with technical challenges, and in vitro systems
123 mary tumors, however, the analysis of LOH is fraught with technical problems that have limited its re
124 n in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age o
127 many effective choices, but as a class it is fraught with the risk of serious peptic ulcer disease an
128 C expression in hepatocellular carcinoma are fraught with the theoretical possibility of injuring adj
133 current treatment methods for KS and PEL are fraught with unwanted side effects and low efficiency, t
134 stimating IFTA are slow, labor-intensive and fraught with variability and sampling error, and are not