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1 version efficiency of 19.83% from 16.95% (BP-free).

2 nly about 0.2% of its overall area being ice-free.

3 edian follow-up, 94% versus 12% remained MRD free.

4 n "free" countries than in either "partially free" (~6.7%) or "not free" regimes (~4.8%).

5 ce of soft deodorized oils in EVOO: R1 (10 x free acidity/DAG(exp)) >= 0.23 and R2 (DAG(exp)-DAG(theo

6 s of 6 lysine and arginine-derived glycation free adducts were higher in patients with early decline

7 Label-free affinity electrochemical biosensors constructed wit

8 age-matched HTLV-1 carriers who remained ATL-free after a median of 10 years of follow-up.

9 ies that promote long-term immunosuppression-free allograft survival.

10 as catalytically active hexamers to generate free amino acids from human hemoglobin and are drug targ

11 ocado puree resulted in high levels of total free amino acids.

12 effect on bound-forms hydrolysis, being both free and bound forms equally affected by temperature.

13 In this study, free and bound phenolic acids (PAs) profile, betaine and

14 Extraction of free and bound phenols from millet in acidic and basic h

15 nd green) and under various conditions (cell-free and cell-based, two cell types).

16 torage (FS) on single and total polyphenols (free and conjugated) content and antioxidant activity (A

17 y developmental stages on canopy, yield, and free and glycoside-bound terpenes of the berry were inve

18 SONATA format is free and open for the community to use and build upon wi

19 ipyrad is a free and open source program written in Python.

20 ; then, the models were implemented into the free and open-source OPERA application to enable screeni

21 face within commercial software to integrate free and open-source/external scripts and tools, tailori

22 ective response rates and longer progression-free and overall survival than those with NMRs <5.75.

23 refractory patients, the median progression-free and overall survival times were not yet reached, wi

24 analysis and subsequent reports, progression-free and overall survival were significantly improved in

25 ity-vote model for opinion dynamics on scale-free and regular networks.

26 The label-free and sensitive detection of synthesis products from

27 This binder-free and straightforward strategy for electrode preparat

28 Taking full advantage of the chromatography-free and suppression-reducing features of this prototype

29 function [thyroid-stimulating hormone (TSH), free and total thyroxine (fT4, TT4) and triiodothyronine

30 onventionally raised mice compared with germ-free animals.

31 gy, we report crystal structures of salts of free anionic nucleobases and base pairs previously studi

32 We report a multiplex label-free antigen microarray on the Arrayed Imaging Reflectom

33 The first method is optimized for probe-free applications: Domains are directly distinguished fr

34 t ICIRD spectroscopy is a noninvasive, label-free approach for assessing conformational changes in re

35 Additionally, we find that an equation-free approach that does not presume a specific stock-rec

36 th pathways initially involve the release of free arachidonic acid after activation of the CB2 recept

37 sses explain the relationship between an ice-free Arctic and permafrost thawing before 0.4 Ma.

38 ffinity to PIPs we have developed a new cell free assay based on the ability of the receptor to preve

39 present Merqury, a novel tool for reference-free assembly evaluation based on efficient k-mer set op

40 tter vision, and all were considered disease free at last follow-up.

41 esophageal cancer surgery, and were disease-free at least 1 year postoperatively were asked to compl

42 in protoplasts, and direct quantification of free auxin levels suggest these irregularities are cause

43 lf-navigated "Koosh ball" 3D UTE sequence at free breathing (TE, 0.03 msec).

44 enerate synthetic MRI ventilation scans from free-breathing MRI (deep learning [DL] ventilation MRI)-

45 Filament-free, bulk-RRAM cells instead store analogue states usin

46 s monkeys, ARGX-117 dose-dependently reduces free C2 levels and classical pathway activity.

47 umulene moieties can allow access to unusual free carbene coordination geometries given the proper st

48 concepts and development of low-PGM and PGM-free catalysts are discussed.

49 y, aNHCs successfully accomplished the metal-free catalytic formylation of amides using CO(2) and the

50 RAC promotes PPARgamma/RXR signaling in cell-free, cellular, and in vivo settings.

51 between excitons, charge-transfer states and free charges.

52 ritical step towards manufacturing petroleum-free chemicals from lignocellulosic biomass.

53 ong the best performances reported for metal-free CO(2) reduction electrocatalysts.

54 The free concentration was subsequently used to extrapolate

55 ctures are normally determined under solvent-free conditions, the structures of solvated 2D COFs are

56 ho experienced movement-evoked pain and pain-free controls.

57 n Services use is more prevalent (~7.8%) in "free" countries than in either "partially free" (~6.7%)

58 hen compared with that observed with the POM-free Cp*Rh@UiO-67 catalyst and reached TONs as high as 1

59 1, hazard radio favoring CDAR, 0.094) of MRD-free CR.

60 Using host cell-free culture, progesterone was determined to have a dire

61 osition of CURC-muPLs outperformed multiple, free CURC applications.

62 ificant increase in the number of ventilator-free days (days alive and free of mechanical ventilation

63 rity margin for the difference in ventilator-free days at day 28 of -10%.

64 primary outcome was the number of ventilator-free days at day 28, with a noninferiority margin for th

65 Alive and Ventilator Free versus ventilator-free days score under various circumstances.

66 The "ventilator-free days" score, is an established composite that equat

67 The primary outcome was ventilator-free days, determined at 28 days after admission.Measure

68 f disease and/or its treatment with a gluten-free diet (GFD).

69 copic evaluation after 1-3 years on a gluten-free diet to evaluate improvements in villous atrophy.

70 According to the ideal-free distribution (IFD), individuals within a population

71 ls is also equipped with an efficient matrix-free divisive hierarchical spectral clustering different

72 nd whole-genome bisulfite sequencing of cell free DNA (cfDNA) and of matched metastatic tumor biopsie

73 lcytosine (5hmC) changes in circulating cell free DNA from a PDAC cohort (n = 64) in comparison with

74 Herein, a metal-free domino synthesis of Z-selective alpha,beta-diphenyl

75 A one-pot, metal-free, double cyclization for the synthesis of bicyclic 2

76 concentration than equivalent quantities of free drug.

77 itor-loaded liposomes is more effective than free drugs, non-targeted liposomes, and single-agent con

78 Disease duration, disease-free duration, previous injection number, microaneurysms

79 ls by simple switching between DESI, voltage-free EASI, or LTP ionization as well as to freely move t

80 en utilized as the sensing layer for reagent-free electrochemical AST.

81 Upon free electron-hole encounters at later times, both charg

82 eta) X-ray emission spectroscopy at an X-ray free-electron laser (FEL).

83 ontact transfer their energy to pre-existing free electrons in the semiconductor, without an equivale

84 xperiments show that protein-protein binding free energies are sensitive to the extent of methylation

85 on between two different crystal phases with free energies that depend on the crystal size.

86 ct of methylation on protein-protein binding free energies.

87 deeply inserted tryptophans that have lower free energy in the LD oil phase and positively charged r

88 de critical, detailed information on folding free energy landscapes, intermediates, and pathways.

89 provide useful mechanistic insights into the free energy of interaction between the monomers as well

90 electivity, and since KED is affected by the free energy of reaction and asynchronicity (factor eta)

91 ven docking model and including a systematic free energy perturbation (FEP) study.

92 ked morpholines, a modification motivated by free energy perturbation (FEP+) calculations.

93 However, we are not convinced that the free energy principle and Thinking Through Other Minds w

94 The linear free energy relationship accurately described the data c

95 elical hairpin domain HP2 and applied linear free energy relationship analysis to infer that the tran

96 rea (a neutral denaturant) alter the folding free energy remains indistinguishable whether proteins a

97 d is able to detect small changes in binding free energy with a sensitivity comparable to in vitro me

98 ces, the CB interface has the least area and free energy, in both capsids.

99 iffusion is due to an abrupt decrease in the free-energy barriers for lateral mobility of outer-spher

100 ons of advanced methods for sampling complex free-energy landscapes at near nonergodicity conditions

101 re are serious theoretical problems with the free-energy principle model, which are shown in the curr

102 through other minds creatively situates the free-energy principle within real-life cultural processe

103 esian brain hypothesis, as formalized by the free-energy principle, is ascendant in cognitive science

104 ded molecular dynamics and enhanced sampling free-energy simulations, we observed that the carboxyl s

105 at allow JGTA-S1 to fix N(2) and grow in a N-free environment; moreover, P. stutzeri dinitrogen reduc

106 in an asymmetric torsional potential, and a 'free' excited state in which FliJ undergoes rotational d

107 bit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such

108 d is stimulated by exposure to nonesterified free fatty acids at concentrations observed in obese sub

109 phospholipase A(2) (sPLA(2)) enzymes release free fatty acids, including arachidonic acid, and genera

110 Furthermore, fish-free feed had the highest degree of in-vitro protein hyd

111 mic force microscopy to yield nearly pinhole-free film growth while maintaining epitaxy and high crys

112 The increased demand for pesticide-free foods has also increased the search for healthier a

113 r in coreceptor-bound or coreceptor-unbound (free) forms, and we here present evidence that the two p

114 he extracorporeal circuit that increases the free fraction of a toxic drug and thereby increases its

115 strong and durable dental adhesives that are free from 2 symbolic methacrylate-based dental resins-2-

116 available in large volumes, it is typically free from protein contamination, and it is chemically co

117 resulted in constitutively active proteins, freed from autoinhibition and no longer influenced by ni

118 High-purity 69.69 mmol-H(2)/(dry-ash-free)g-brown seaweed is produced with a conversion as hi

119 on an inert support (SiO(2)) for the halide-free, gas phase carbonylation of methanol to AA.

120 work will be useful to better detect outlier-free genetic and epigenetic signatures in various comple

121 than in SPF mice, and winner B cells in germ-free germinal centres are enriched in 'public' clonotype

122 ges following soft tissue augmentation using free gingival grafts (FGG) at implant sites over a 3-mon

123 (sham) group (n = 27), palatal wounds, after free gingival grafts (FGG) harvest, received sham applic

124 R) technique is utilized for measuring label-free GPCR signal profiles.

125 of different levels of complexity: a context-free grammar generating sequences following a mirror str

126 gnostics, by making portable and electricity-free heating available at any location.

127 tructures of two distinct isoforms of ligand-free human karyopherin RanBP5 and investigate its global

128 The metal-free hydrofluorination of alkynes constitutes an attract

129 Free hydrogen (H(2)) is a basal energy source underlying

130 Our data demonstrate the existence of free hydroxyl groups in cutin and provide insight into h

131 Caries-free (ICDAS [International Caries Detection and Assessme

132 translate to distinct biological functions: free IgE initiated allergic inflammation through Fcepsil

133 Here we demonstrate the use of label-free imaging flow cytometry and deep learning to charact

134 Here, we investigate label-free immunosensing, using a quartz crystal microbalance

135 Despite Israel's having been declared polio-free in 1988, a routine sewage surveillance program dete

136 ble whether proteins are surface-attached or free in bulk solution.

137 This biomarker generalized to a drug-free independent cohort of melancholic MDD, and did not

138 PHgO(GT2a) increased cell-free infectivity of TR in both cell types, but spread in

139 d to produce and characterize a novel gluten-free ingredient from oat through sprouting at 18 degrees

140 ic imaging studies captured relatively noise-free input functions for kinetic modeling approaches.

141 and M-ILFs, respectively) as well as in GALT-free intestinal lamina propria (LP).

142 One is model-free learning, i.e., simple reinforcement of rewarded ac

143 ment for next-generation high-energy, cobalt-free Li-ion batteries.

144 -healing capabilities, development of "anode-free" Li batteries to minimize the interaction between L

145 energy applications of off-grid and battery-free lighting and sensing.

146 mitted over long distances through corrosion-free, lightweight fiber optic cables.

147 y processes across four major habitat types (free-living, particle-associated, biofilm on benthic sto

148 growth more effectively than treatment with free lysozyme.

149 ile evolving at a constant rate in a novelty-free manner, have merely become undetectable by search a

150 enotyping and infection diagnosis in a label-free manner.

151 Fat-free mass index (FFMI) and fat mass index (FMI) are supe

152 clear evidence of water stability in a lead-free metal halide perovskite, namely DMASnBr(3) , obtain

153 en, to be positively correlated with relapse-free, metastasis-free, or overall survival in breast can

154 of auxotrophic Salmonella infection in germ-free mice to show that live bacterial virulence factor-d

155 Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only c

156 f microbiota-replete mice compared with germ-free mice.

157 ies of the effects of fecal transfer in germ-free mice.

158 mutations; (iii) increased circulating cell-free mtDNA serum levels in both patients with biallelic

159 , the potential applications of these binder-free nanostructured electrodes in practical full-cell-co

160 ducing microorganisms with the antimicrobial free nitrous acid, which is generated in situ from calci

161 Among US veterans 75 years and older and free of ASCVD at baseline, new statin use was significan

162 In PESA participants (n = 4,184 subjects free of cardiovascular disease), PA was measured by wais

163 sionals Follow-up Study (1986-2016) who were free of CVD and cancer at baseline.

164 Bone marrow was microscopically free of disease, but molecular testing identified the sa

165 mber of ventilator-free days (days alive and free of mechanical ventilation) over 28 days.

166 was fast (<24 h) and this early response was free of naive IgG-SCs.

167 ng donors include patient survival, survival free of operative intervention, and data on complication

168 tracardiac pressure measurements in patients free of significant complications are incompletely descr

169 s Follow-up Study (HPFS; 1986-2016) who were free of T2D, cardiovascular disease, and cancer at basel

170 rmined by HPLC-MS analysis to be essentially free of toxic gossypol.

171 Rac1(flox/flox);PostnCre(+)) were completely free of tumors and had normal phospho-ERK activity compa

172 ely correlated with relapse-free, metastasis-free, or overall survival in breast cancer.

173 conductor involves the energy-dependent mean free path of the charge carriers and is affected by crys

174 ological activity, whereas the corresponding free peptide did not.

175 Differences in progression-free (PFS) and overall survival (OS) were evaluated usin

176 In sign-trackers, model-free phasic dopaminergic reward-prediction errors underl

177 ietary fibers, DPPH scavenging capacity, and free phenolics.

178 design of a redox stimuli activatable metal-free photosensitizer (aPS), also functioning as a pre-ph

179 is article introduces a gel-based separation-free point-of-care (POC) device for whole blood glucose

180 An effective method for transition-metal-free postfunctionalization of thiazolo[3,2-c][1,3,5,2]ox

181 easure the rate of failure to provide defect-free postoperative venous thromboembolism (VTE) chemopro

182 the method is also compatible with a silver-free protocol.

183 E)-2,4-octadienal), which did not occur with free PSO.

184 functionalize peptides and proteins through free-radical-mediated dechalcogenation.

185 ng the di-tert-butyl peroxide as a source of free radicals and a dehydrogenating agent.

186 bs X-rays during radiotherapy (RT), creating free radicals and local tumor damage, effectively boosti

187 Free-ranging African mammals are exposed to diverse IAV

188 use a long-term study with 106 GPS-collared free-ranging cheetahs (Acinonyx jubatus) to demonstrate

189 to facilitate spectroscopic investigations, free reactants could be activated the same way by the lo

190 g fluorescent proteins and demonstrate label-free readout on unlabeled Gram-negative and Gram-positiv

191 n in either "partially free" (~6.7%) or "not free" regimes (~4.8%).

192 ructure between states; DLS implements model-free response learning by learning associations between

193 LLPS in response to a rise in intracellular free RNA concentrations.

194 In test set 1, segmentation-free RNFL predictions were highly correlated with conven

195 d using dogs and are currently threatened by free-roaming dogs and their associated diseases.

196 ividual restoration of offset is crucial for free ROM in THA.

197 show these high conductivities are aided by free rotation of the NH(4) (+) units and significant gyr

198 In fact, although free rPrP(90-231) phase separated into large droplets, a

199 , and depended on injury severity (grade IV (free rupture) 20.9%).

200 ent (rho0) recipient cells following uridine-free selection, although exogenous mtDNA is lost from me

201 facile, general, and high throughput solvent-free self-assembly strategy to synthesize a series of MM

202 zed field-effect transistor (FET) as a label-free sensor for AIV detection in chicken serum.

203 raining datasets that hold the key for label-free single-cell analysis and, consequently, for differe

204 ng inflammatory cytokines expression whereas free Sino treatment did not demonstrate a significant ef

205 INDA/EXM 2.0 (commercial) and IDAC-Dose 2.1 (free) software.

206 opulations observed for these sugars both in free solution and bound to nonhydrolytic proteins, where

207 his afferent nerve, we further build a power-free spiking mechanoreceptor system with a passive piezo

208 f-of-principle study, we have utilized label-free spontaneous Raman spectroscopy to understand the st

209 The peptide-free state of these molecules is not well understood.

210 ution in the solvent to a completely solvent-free state, even at ambient conditions.

211 Alignment-free, stochastic models derived from k-mer distributions

212 coefficients for ligand-bound versus ligand-free structure performance show no statistically signifi

213 ctrospray ionization (DESI) MS for the label-free study of enzymatic reactions directly from the bioa

214 Intakes of free sugars were assessed at 1 and 2 y of age.

215 Nevertheless, no derivatization strategy for free sulfhydryl groups in tissue is known for MALDI MSI.

216 biomechanical degradation is found near the free surfaces and especially near the lesion, and the co

217 hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the opera

218 significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; P < .0

219 At 90 days, amputation-free survival (AFS) and Limb salvage (LS) were noticeabl

220 The 5-year disease-free survival (DFS) rates for patients with T-ALL random

221 al and distant recurrence (LR), (iv) disease free survival (DFS), (v) overall survival (OS).

222 ations (trunk-ratio) had a prolonged disease-free survival (DFS), regardless of the influence of clin

223 3.37 to 12.10; P < .001), decreased relapse-free survival (HR, 2.94; 95% CI, 1.84 to 4.69; P < .001)

224 sociated with 17 fewer months of progression-free survival (PFS) (95% confidence interval [CI] 5-29,

225 ere applied to predict patients' progression-free survival (PFS) and overall survival (OS).

226 Progression-free survival (PFS), OS, and adverse events were also as

227 adiographic characteristics with progression-free survival (PFS; by RECIST) were evaluated by Cox reg

228 tive Risk: 2.129, p < 0.0001) and recurrence-free survival (Relative Risk: 1.299, p < 0.0001) in pati

229 eported significant benefits in both relapse-free survival (RFS) and overall survival (OS) for high-d

230 gnosis for overall survival (OS) and relapse free survival (RFS) outcomes.

231 5-year overall survival (OS) and recurrence-free survival (RFS) were 82%, 57%, and 77%, 51%, respect

232 including overall survival (OS), recurrence-free survival (RFS), disease-specific mortality (DSM), a

233 At the time of final progression-free survival analysis and interim overall survival anal

234 riants were associated with worse transplant-free survival and longer times on the ventilator.

235 S11 due to its association with poor disease-free survival and promotion of aggressive phenotypes in

236 rvival, event-free survival, and progression-free survival and safety.

237 the effects of radiotherapy timing on event-free survival and subgroup interactions were combined us

238 The primary endpoint was progression-free survival assessed by intention to treat.

239 ve regimens have been used with poor disease-free survival at long-term follow-up.

240 nalysis of investigator-assessed progression-free survival at the overall survival database lock, med

241 em to derive a substantial long-term relapse-free survival benefit from targeted therapy (HR [versus

242 To confirm the stability of the relapse-free survival benefit, longer-term data were needed.

243 Taken together with the lack of progression-free survival benefit, these findings do not support rou

244 The primary endpoint was progression-free survival by independent review in the intention-to-

245 setting significantly prolonged progression-free survival compared with a fixed-duration treatment o

246 ere able to obtain updated results for event-free survival for 2153 patients recruited between Novemb

247 model to estimate probability of transplant-free survival from fetal diagnosis to age 6 years and po

248 y postpone resistance and extend progression-free survival in many cancer indications.

249 oureterectomy significantly improved disease-free survival in patients with locally advanced UTUC.

250 analysis (May 31, 2019), median progression-free survival in the intention-to-treat population was 8

251 ns and associated with divergent progression-free survival patterns.

252 Objective response rate and progression-free survival per investigator assessment were recorded.

253 l survival database lock, median progression-free survival remained significantly improved with ramuc

254 ars and postnatal restricted mean transplant-free survival time.

255 ) in the EZH2(WT) cohort; median progression-free survival was 13.8 months (10.7-22.0) and 11.1 month

256 Median progression-free survival was 13.93 months (95% CI 11.73-not evaluab

257 Median progression-free survival was 14.5 months (95% CI 12.5-17.7) in the

258 follow-up of 44 months (26-53), 4-year event-free survival was 59% (95% CI 48-73); 69% (54-87) in ado

259 The primary endpoint was recurrence-free survival, analysed in the per-protocol population.

260 Four-year event-free survival, relapse-free survival, and overall survival rates were 67.7% (95

261 plications on metastatic pattern, metastasis-free survival, and overall survival.

262 ndary endpoints were overall survival, event-free survival, and progression-free survival and safety.

263 We report on biochemical progression-free survival, freedom from non-protocol hormone therapy

264 The primary endpoints were event-free survival, overall response, and overall survival.

265 Four-year event-free survival, relapse-free survival, and overall surviv

266 associated with recurrence and lower disease-free survival.

267 were independent predictors of lower disease-free survival.

268 with overall survival and distant metastasis free survival.

269 its effectiveness for extending progression-free survival; however, these parameters were not predic

270 were 5-year locoregional control and disease-free-survival.

271 tions associated with a particle-attached or free-swimming lifestyle could reflect adaptation to vari

272 A convenient additive-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wi

273 esence of specific glucuronidase could yield free systemic quercetin in human body.

274 Both driven and force-free systems are analyzed.

275 ons for mNGS technology and other hypothesis-free testing methodologies that are in development.

276 e performed to infer phenome-wide effects of free testosterone on 461 outcomes in 161,268 males from

277 itlisted for LT with HEHE were identified by free-text entry.

278 germinal centres is markedly higher in germ-free than in SPF mice, and winner B cells in germ-free g

279 ulting in their continued turnover likely to free the NAD(+) molecules.

280 dentification of PG is noninvasive and label-free, the popularity of this approach has considerably s

281 Systemic free thiols are amenable to nutritional or therapeutic i

282 the agent's beliefs only when the agent was free to act on the ball and not when the agent was visib

283 The observed constant free to bound forms ratio showed that the temperature ra

284 n (IFD), individuals within a population are free to select habitats that maximize their chances of s

285 whereas antigenic methods are able to detect free toxin.

286 in the atmosphere as Mount Bachelor received free tropospheric air masses on certain nights during th

287 y estimating the probability of complication-free tumour under different treatment protocols.

288 on, and refined the model to R (work) and R (free) values of 17.4% and 20.9%, respectively.

289 tcomes between patients treated with polymer-free versus durable polymer DES.

290 We evaluated power of Alive and Ventilator Free versus ventilator-free days score under various cir

291 irus and 3- to 6.2-fold-lower growth of cell-free virus.

292 he molecular size of the probe molecule, the free volume element size probability distribution was de

293 cted to local structural fluctuations of the free volume elements.

294 the best established experimental measure of free volume.

295 d different motor-learning tasks, i.e. model-free vs. model-based learning tasks, and their possible

296 entify reasons for failure to provide defect-free VTE chemoprophylaxis, and (3) examine patient- and

297 o traumatic brain injury with a closed-head, free-weight drop method.

298 Here we describe a reference-free workflow for diploid de novo genome assembly that c

299 germ line" hypothesis by generating germline-free zebrafish Danio rerio and testing the effect of the

300 The barrel-free zone receives topographically ordered input from th