ライフサイエンスコーパス: free acid

1 d hydrolyze the CoA thioester to release the free acid.

2 also cleaved the thioester bond to give the free acid.

3 2)-G and PGE(2)-EA less efficiently than the free acid.

4 terial was its carboxylate salt form not its free acid.

5 ion compared to direct administration of the free acid.

6 ence for the alcohols and aldehydes over the free acids.

7 It has low activity against the free acids.

8 s the dramatic difference in potency between free acid 17 and its methyl ester 21 (IC50 > 200 microM)

9 The prodrug 4r was converted to free acid 5r in vitro in mouse plasma and in vivo.

10 atients in the LTE transitioned to tafamidis free acid 61 mg (bioequivalent to tafamidis meglumine 80

11 Both synthetic LXA(4) and 15-epi-LXA(4) as free acids activate recombinant human LXA(4) receptor (A

12 over a 3-wk period, both misoprostol and its free acid-active metabolite 5C-30695 significantly reduc

13 tector signal as a function of micrograms of free acid added were demonstrated in the presence of the

14 ble with this protocol; (3) lactonization of free acids, affording gamma-, delta-, or epsilon-lactone

15 thermodynamic solid-state form of diclofenac free acid and an intriguing conversion to liquid verapam

16 The method allows the use of free acid and dextran-conjugated dyes.

17 In contrast, 10 nM latanoprost free acid and fluprostenol caused membrane depolarizatio

18 leukotriene A4 methyl ester, leukotriene A4 free acid and GSH were 7.6 microM, 3.6 microM and 1.6 mM

19 ve inhibitor for ibuprofen oxidation in both free acid and ibuprofen ester form.

20 as the aspartyl side chain shuttles between free acid and peracid forms.

21 ansferase (COMT; EC 2.1.1.68) methylates the free acids and caffeoyl CoA 3-O-methyltransferase (CCoAO

22 ons and low-abundance acyl neutral losses as free acids and ketenes.

23 -selective (ONO-AE1-259, AH13205, butaprost-free acid) and EP4 -selective (L-902,688, TCS251) agonis

24 M1, trans-unoprostone isopropyl, latanoprost free acid, and fluprostenol were studied on Ca(2+)-activ

25 es which include combinations of monoesters, free acids, and amines, some of which are inhibitors of

26 vity, serum liver enzymes, adipokines, fatty free acids, and high-sensitivity C-reactive protein (hsC

27 optimized workflow for automated sonication-free acid-assisted proteome (ASAP) extraction from FFPE

28 Cytoplasmic ATP free-acid ([ATP](i)), but not the MgATP complex, activat

29 vior between the Lewis acid-base adducts and free acid-base pairs is examined.

30 hough the native CTL epitope terminates as a free acid, both tetrasubstituted peptides only function

31 n was still decreased by 70% relative to the free acid case.

32 The two regimens were ceftiofur crystalline-free acid (CCFA) administered to either one or all steer

33 effects of injectable ceftiofur crystalline-free acid (CCFA) versus in-feed chlortetracycline on the

34 indicate that this lipid, in contrast to its free-acid counterpart, acts as a peroxisome proliferator

35 atives bound significantly better than their free acid counterparts, suggesting that the state of met

36 process readily delivered the Fmoc-protected free acid derivatives of AHMOD ((2S)-amino-(6R)-hydroxy-

37 ever, there are only a handful of reports of free-acid-directed beta-methylene C(sp(3))-H activation,

38 allows selective quantitation of the desired free acid drug forms without significant interferences f

39 thout decomposition, avoid the production of free acid during acylation reactions, and can be used un

40 between common cationic peptides and low Mw free acid end-group poly(lactic-co-glycolic acids) (PLGA

41 , relative distribution of ester aliphatics, free acid end-groups and free hydroxyl groups, different

42 a, a fixed monthly dose of nedosiran 160 mg (free acid; equivalent to 170 mg sodium salt) in adults w

43 reasing masses were detected and assigned to free acids, esters and polyesters with up to eight units

44 has been successful in remineralizing resin-free, acid-etched dentin, with evidence of intrafibrilla

45 Orally consumed 3.42 g free-acid (FA-HMB) HMB (providing 2.42 g of pure HMB) ex

46 ifferentiated using this method; the salt-to-free acid form conversion ranged between less than the l

47 fter the dye ester has been converted to the free acid form in the cytoplasm.

48 ause the volatility of a drug present in its free acid form is typically much higher than that of its

49 In a complementary fashion, the free acid form of 3-phosphonofluorescein does not cross

50 s linked to active efflux of the hydrophilic free acid form of BCECF from the MRP-overexpressing cell

51 ESI/QMS studies of the free acid form of low molecular weight poly(carboxylic a

52 slices gave indications that Zinquin in its free acid form was able to diffuse across the plasma and

53 onding dimethyl ester suggests that only the free-acid form of glutamine effectively inhibits ANR act

54 (TDMS) for the detection and quantitation of free acid forms in pharmaceutical drug products formulat

55 with control (0.015% ethanol in DMEM) or the free acid forms of bimatoprost (0.01 or 0.1 microg/mL),

56 ng the concentration of both the anionic and free acid forms of the Meldrum's adduct 6 in real time.

57 d with 5-6-fold higher affinities than their free acid forms.

58 ll four substrates with a preference for the free acid forms.

59 safety, and tolerability of two lenacapavir free acid formulations administered by ventrogluteal int

60 the acid binding almost completely depletes free acid from the deblocking solution.

61 ond the unit cell parameters to positions of free acid groups and included water molecules.

62 substrates are transported as CoA esters or free acids has been a matter of debate.

63 show that inhibition is competitive for the free acid ibuprofen substrate, no doubt because this sub

64 erally been supposed that pABA exists as the free acid in plant cells and that it moves between organ

65 s may be deprotected in one step to give the free acids in quantitative yields.

66 s of bimatoprost, latanoprost, and their C-1 free acids indicate that latanoprost, but not bimatopros

67 ensitivity of the method was demonstrated at free acid levels of 0.6% w/w (6 microg absolute mass).

68 Latanoprost-free acid (LFA)-treated NTM cells were analyzed for OPN

69 leic (LA) acids in different chemical forms (free acids, methyl esters and homogeneous triacylglycero

70 ng with PGE2, PGE2 methyl ester, misoprostol-free acid, misoprostol, and sulprostone suggested that a

71 n CEM cell cultures-the bispivaloyloxymethyl free acid monophosphonate prodrug exhibited some activit

72 The hydrolysis of dehydrodiferulates to free acids occurs in two discrete steps, one involving d

73 The free acid of acetic acid and the imidazolium ion showed

74 The free acids of these compounds also served as the best ac

75 e conversion of salt to its original form of free acid or base-disproportionation-can have a drastic

76 ly occur via two parallel pathways involving free acids or their coenzyme A (CoA) esters.

77 ays with 10 microg/mL of either latanoprost (free acid) or prostaglandin F(2alpha) ethanolamide and c

78 NA), perfluoro-2-propoxypropanoic acid (GenX Free Acid), perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulf

79 sugar, sucrose, water insoluble solids, ash, free acid, pH, HMF contents, electrical conductivity and

80 all polymers but does not always release the free acid product.

81 e energy of formation of this complex from a free acid, pyridine, and a carboxylic acid dimer to be a

82 much more potent PPARalpha ligands than the free acids, resulting in altered PPARalpha conformation

83 -chain alpha-keto acids to the corresponding free acids results in the formation of ATP via substrate

84 ion; A0 = absorbance of the sensor in a salt-free acid solution) was found, and the current approach

85 e of the formulations (low molecular weight, free acid terminated) exhibited the same mechanism in vi

86 ycerols or acyl-CoA esters to the respective free acids that are required for GLUT4 transport vesicle

87 ods not only in their bound form but also as free acids that can be extracted from non-hydrolyzed sam

88 d on the concentration of ceramide; only the free acid was formed if the truncated ceramide was absen

89 The free acids were analyzed in a negative-ion mode, whereas

90 s of bimatoprost, latanoprost, and their C-1 free acids were determined by liquid chromatography and

91 Free acids were obtained by acid hydrolysis of the amide

92 ostone isopropyl ester, and their respective free acids were shown to be FP agonists in the h-TM cell