ライフサイエンスコーパス: free base

1 ed osmotic pump (initial dose 2.0 mg/kg/day, free base).

2 of the adenine can be rescued by adding the free base.

3 in the periplasm and enters the cell as the free base.

4 tabolism that bind only small nucleosides or free bases.

5 talyzed coupling steps to assemble the final free base 1 in high yield and regioselectivity.

6 lubility and bioavailability compared to the free base, 1.

7 nt acid treatment provided the corresponding free-base 10(3)-(2-hydroxyethyl)benzochlorin, which upon

8 d to nicotine (4.5 mg/kg per day of nicotine free base, 15 to 22 days via osmotic minipump).

9 Photolysis of metalated (Cu and Ni) and free base 2-diazo-3-oxochlorins within a frozen matrix (

10 Specifically, monomeric free-base (2H-P) and Zn-metalated (Zn-P) porphines (P) w

11 To overcome these limitations, a synthetic free base 3,13-dibromobacteriochlorin (BC-Br(3)Br(13)) h

12 Iodination or bromination of a free base 5,10-diaryloxochlorin gave a mixture of produc

13 d two, three or four doses of 2.5 mg/kg MPTP free base administered subcutaneously at 2-h intervals.

14 Compared to the free-base analogue, these complexes showed a remarkable

15 tral features that closely resemble those of free base analogues of chlorophyll b.

16 metalated derivatives than the corresponding free-base analogues to produce the corresponding excited

17 mers with fixed orientation, compared to the free-base analogues, the related mono- and di-Zn(II) com

18 The excited-state dynamics of the purine free base and 9-methylpurine are investigated using expe

19 synthesis of a pyrimidine nucleoside from a free base and a nonactivated sugar in a plausible prebio

20 Altogether four free base and four zinc chlorins have been prepared.

21 A new class of redox-active free base and metalloporphyrins fused with the 1,3-dithi

22 Crystal structures of free base and monoprotonated form are discussed.

23 Free base and N-oxides were observed by this method.

24 , is consistent with the pK(a) values of the free base and not the sulfate salt form of the drug.

25 Free base and Pd porphyrin derivatives of horseradish pe

26 l shifts (Deltadelta > 90 ppm) between their free base and protonated forms.

27 osides and 2'-deoxypurine nucleosides to the free base and ribose (or 2'-deoxyribose) 1-phosphate.

28 s been employed to prepare several arrays of free base and zinc porphyrins.

29 extensive fluorescence quenching in both the free base and Zn dyads is associated with an extremely r

30 sis of 2'-deoxypurine ribonucleosides to the free bases and 2-deoxyribose 1-phosphate.

31 each of which is distinguished by different free bases and protonation states.

32 raaryl- and beta-octaethylchlorins, as their free bases and zinc complexes, now fully delineate the t

33 Free bases and Zn complexes fluoresce with quantum yield

34 according to the Periodic Table, describing free-base and main-group element corrole derivatives, th

35 Shifts in the resonance Raman lines of free-base and metalated porphyrins bound to the wild-typ

36 ro-diporphyrins and triporphyrins, including free-base and metalloporphyrin hetero dimers.

37 The synthesis and chiral resolution of free-base and Ni(II) complexes of a number of derivative

38 he relative stereostructures of a variety of free-base and Ni(II) complexes of these morpholinochlori

39 morpholino-substituents, which differ in the free-base and Ni(II) complexes, and in the monoalkoxy, b

40 a facile approach for the preparation of the free-base and the related Zn(II) benzochlorins containin

41 Free-base and zinc(II) porphyrins bearing either one, tw

42 -tolylmagnesium bromide, providing access to free-base and Zn complexes.

43 The free-base and Zn-containing dyads were subjected to exte

44 phines (P) were employed to form square-type free-base and Zn-functionalized tetramers on Ag(100).

45 f 12 explicit H-bonding waters around the Sp free bases; and (4) reevaluation of calculated specific

46 ms for nonplatinum group metal catalyst (PGM free) based anion exchange membrane water electrolyzers

47 a monoprotonated form and the corresponding free bases appeared to be relatively unstable.

48 We recommend that the community adopt PCR-free-based approaches to reduce PCR bias that affects ca

49 selectivity of unprotected azadiene in metal-free base-assisted hetero-Diels-Alder reaction is exploi

50 provided two atropisomers 5a and 5b for the free base at equilibrium (1:2.3 at room temperature in C

51 s allowed the first structural analysis of a free base azuliporphyrin to be conducted.

52 ubstituted bacteriochlorin (HBC-type), and a free base B,D-tetradehydrocorrin (TDC-type).

53 ture of two free base bacteriochlorins and a free base B,D-tetradehydrocorrin.

54 afforded a readily separable mixture of two free base bacteriochlorins and a free base B,D-tetradehy

55 Altogether 22 free base bacteriochlorins have been prepared.

56 tion spectra typical of bacteriopheophytins (free base bacteriochlorophylls), with a strong near-infr

57 base or their protonated analogues, with the free base being more strongly associated with the chiral

58 n, which upon a sequence of reactions gave a free-base benzochlorin bearing a carboxylic acid functio

59 coupled-cluster calculations proved that the free base BHPs, although highly symmetric, exhibited the

60 The free-base bromoporphyrins also were coupled with tri-n-b

61 ylase removes 5-methylcytosine from DNA as a free base, but its involvement in this process is unknow

62 deamination of cytosine to uracil, using the free base C, its nucleosides, and nucleotides as substra

63 The free base carbaporphyrin and carbachlorin, and the nicke

64 The free base carbasapphyrins were unstable but the monoprot

65 In the free-base case, this regioselectivity can be explained u

66 An efficient one-pot metal-free, base-catalyzed method has been developed for the r

67 onfirmed the aromatic characteristics of the free-base, cationic, and anionic structures.

68 easily demetalated to give the corresponding free base chlorin.

69 The reduction of a free-base chlorin generally forms a bacteriochlorin (BC)

70 Two free base chlorins have been prepared wherein each chlor

71 n the absorption maximum (637-655 nm for the free base chlorins, 606-628 nm for the zinc chlorins) an

72 all found to be severely ruffled whereas the free-base chromophores are more planar.

73 We report that free-base cocaine administered in volatile form to the f

74 ay structures of the Cu complex with C60 and free-base complexes with C70 and a pyrrolidine-derivatiz

75 of H2TTFP(2+) (1200 GM) was obtained for the free base compound, a value that is much higher than tho

76 ve a limited binding capacity with a maximum free base content of 0.7 eq/L, which corresponds to a so

77 cal molecules using a model system involving free-base coproporphyrin (COP) complexed with horse hear

78 ented here is a first crystal structure of a free-base corrole anion, derived from tris(p-cyanophenyl

79 nd geometric properties of surface-supported free-base corrole molecules.

80 The first example of covalently linked free-base corrole-fullerene dyads is reported.

81 Free-base corroles have long been known to be acidic, re

82 with concentrated sulfuric acid yielded the free-base cyanobenzochlorins in major quantity along wit

83 nalogous dependence is also observed for the free-base derivative, with the exocyclic ring-containing

84 n various ways (e.g., both labeled and label-free based detection).

85 moiety, and liberation of the corresponding free-base dipyrrin.

86 fullerene triplets are formed only with the free base dyad in toluene, where triplet formation from

87 Quenching is also observed in the free base dyad, where 1P(H2)-Sp(o) and P(H2)-1Sp(o) exch

88 In toluene, the lifetimes of the free base dyads are 600-790 ps compared to 10.1 ns for t

89 phyrin (ZnP) dyads were made by treating the free base dyads with zinc acetate.

90 er ear of live mice to achieve specific, DNA-free base editing in vivo.

91 lexes into mammalian cells, establishing DNA-free base editing.

92 (UNG), an enzyme normally involved in error-free base excision repair.

93 e zinc oxochlorins (Phi(f) = 0.030-0.047) or free base (Fb) oxochlorins (Phi(f) = 0.13-0.16) are comp

94 mprised of five zinc (Zn) porphyrins and one free base (Fb) porphyrin (cyclo-Zn(5)FbU) while the othe

95 pectively; and the output unit consists of a free base (Fb) porphyrin.

96 s have been synthesized in which the zinc or free base (Fb) porphyrins are joined by a 4,4'-diphenyle

97 The arrays contain alternating Zn and free base (Fb) porphyrins or all Zn porphyrins.

98 ate energy transfer from a zinc chlorin to a free-base (Fb) chlorin occurs with a rate constant of (1

99 crossing efficiency, with QY(ISC) ~ 80% for free-base (FB) cores, which can be increased to about 92

100 nsity of 0.27 W cm(-) (2), outperforming the free-base Fe counterpart.

101 Comparative studies with a free-base Fe porphyrrole catalyst (E(onset) 0.97 V(RHE))

102 d Fe atoms, which is absent in the reference free-base Fe-porphyrrole.

103 tation of a pellet containing 25 mg morphine free base for 4 days or by injecting morphine (20 mg/kg,

104 llography, with the alpha,beta-isomer as the free base form and the alpha,alpha-isomer as the zinc co

105 The most stable optimized structures for the free base form of both the macrocycles showed absolute p

106 pH-dependence studies confirm that the free base form of imidazole is the rescue agent.

107 he observed pK(a) values associated with the free base form of paromomycin are lower in magnitude tha

108 ant, the minor one has the alpha-amino group free base form of SAM reacting with the protonated imine

109 ther to the partitioning of the circulating, free base form of the drug into subcutaneous fat.

110 ealed a signal corresponding to the soluble, free base form of the drug.

111 oncentrated CDCl(3) solutions of the neutral free base form of this prodiginine derivative.

112 potentials can be tuned by metalation of the free base form, H2TTFP.

113 Addition of base gave the unstable free base form, while pyrrolidine formed an unstable add

114 bind to the enzyme with its imidazole in the free base form.

115 dlB in its zwitterionic state and not in the free-base form as had been previously suggested.

116 This porphyrinoid was nonaromatic in the free-base form but showed significant diatropicity upon

117 to Lys47; hence, this residue exists in the free-base form for catalysis.

118 irst 57 patients to be enrolled received the free-base form of rociletinib (150 mg once daily to 900

119 ng from 780 to 880 m(2)/g was synthesized in free-base form via the reaction of meso-tetrakis(pentafl

120 The free base forms of the catalysts are characterized by fo

121 These results establish that the free base forms of these imidazoles facilitate HRP turno

122 The free base forms of thia- and selenaazuliporphyrins both

123 phyrins(1.2.1) proved to be very stable, the free base forms were unstable and could not be isolated.

124 minant contribution to reaction by the amine-free base forms, the only species found to bind to the e

125 CT) injection in comparison to its sunitinib free base formulation.

126 in dyads in distinct metalation states (zinc/free base, free base/zinc) were prepared by Sonogashira

127 This process represents a ligand-free, base-free, and recyclable catalyst along with an i

128 protein efficiently liberates 8-oxoGua as a free base from the damaged DNA substrate.

129 a method for separating glycosylase-released free bases from oligonucleotides and DNA followed by GC-

130 -cyclo-2'-deoxyguanosine (cyclo-dG), and the free base guanine (Gua).

131 -Oxo-7,8-dihydroguanine (8-oxoG, or OG) as a free base has been widely considered as a biomarker for

132 nd compared: two for the pyridine-containing free base hosts and two for encapsulated F(-) complexes

133 on the leading reaction of formaldehyde with free bases: hydroxymethylation of cytosine amino groups.

134 emission of fluorescence equal to that of a free base in all three positions.

135 estive vacuole (DV) and is only present as a free base in nonpolar ones, such as the host's and paras

136 ty at ambient temperature and degradation to free base in vivo.

137 mic exposure in rats to nicotine (0.17 mg/kg free base) increases the ratio of DA neuronal currents m

138 h 5,7-dihydroxytryptamine (5,7-DHT; 3 microg free base) into both the dorsal and median raphe, which

139 entafluorophenyl)porphyrin to all isomers of free base isobacteriodilactones using the oxidant cetylt

140 ) that received daily MPTP injections (15 mg free base/kg body weight, s.c.) for 6 consecutive days e

141 administering nicotine (approximately 1.5 mg free base/kg/day), we found a significant increase of ni

142 Zn(II) or Cr(III) metalation of the free-base ligand shifted the equilibrium to the single d

143 lly shifted absorption bands compared to the free base macrocycle.

144 s produced higher ratings of appeal (salt vs free-base mean difference effect estimate: b = 12.0; 95%

145 A facile one-pot metal-free, base-mediated formal [3 + 2] and [4 + 2] dearomati

146 eport the direct and selective conversion of free base meso-tetrakis(pentafluorophenyl)porphyrin to a

147 d by the antenna chromophores is 80% for the free base molecule and 96% for the zinc analogue.

148 on (C(max)) in brain following inhalation of free-base nicotine E-cig vapor was 19% and 15% lower rel

149 Mean C(max) with C-cigs and free-base nicotine E-cigs were greater in females relati

150 These results suggest that while E-cigs with free-base nicotine formulation can deliver nicotine rapi

151 d exposure to e-cigarette puffs with salt vs free-base nicotine formulations appeared to increase pro

152 Salt vs free-base nicotine formulations produced higher ratings

153 Alkaline free-base nicotine is bitter and a respiratory irritant.

154 11)C]nicotine-labeled vapor from E-cigs with free-base nicotine or C-cig smoke in a randomized order.

155 cotine is less aversive upon inhalation than free-base nicotine, and many ECIG manufacturers have beg

156 among never smokers unaccustomed to inhaling free-base nicotine.

157 Model-free-based NMR dynamics studies have been undertaken for

158 dministered in salt (benzoic acid added) and free-base (no benzoic acid) nicotine formulations with c

159 human alkyltransferase is inactivated by the free base O6-benzylguanine, raising the possibility that

160 d not differ from P140A in reaction with the free base O6-benzylguanine.

161 ion, some of the DNA cleavages seen with the free base of 19a (compound 18c) in the presence of top1

162 trocytosine (NitroC), 2-pyrimidinone (P; the free base of zebularine) and 6-methylfuranopyrimidinone

163 e model has refined to give R-work 19.2 %, R-free (based on 5 % of the data) 23.0 %.

164 would have been wrongly classified as tumor-free based on gross tumor measurement.

165 biosensor for HbA1c detection which is label-free based on the impedance measurement, and it features

166 d whether schools self-designated as "peanut-free" based on policies.

167 idazole (14)N nucleus in enzyme-bound versus free base-on cob(II)alamin shows an enhanced delocalizat

168 contrast, the addition of porphyrin (either free base or metalated) to E287Q is substoichiometric, a

169 Analytes can be complexed as either the free base or their protonated analogues, with the free b

170 ne anchors, covalently linked to porphyrins (free base or Zn), were prepared and characterized.

171 of mono- and dioxabacteriochlorins, as their free bases or Zn(II) complexes, were determined by singl

172 the UV-vis absorption spectrum, addition of free-base or metalated porphyrins to wild-type ferrochel

173 onic cigarette (ECIG) liquids can exist in a free-base or protonated (or "salt") form.

174 from liquid solutions that contained either free-base or protonated nicotine at 15 mg/g concentratio

175 IG is independent of whether the nicotine is free-base or protonated, however the liquid vehicle has

176 ophile, the imidates can react either as the free-base or the hydrochloride salt in a telescoped proc

177 erent diameter ((n,m) = (6,5) and (7,6)) and free-base or zinc porphyrin bearing peripheral positive

178 The free base oxacarbaporphyrin and the palladium derivative

179 The free base oxacarbaporphyrin reacted with Pd(OAc)(2) in D

180 The free base oxodibenziphlorins were rather unstable in sol

181 n covalently linked to a zinc (PZn) and to a free-base (P(H2)) porphyrin.

182 (VG), resulting in four different solutions (free-base/PG, free-base/VG, protonated/PG, and protonate

183 rconnected pathways involving methylation of free bases, phospho-bases, or phosphatidyl-bases.

184 ree base porphyrin) transmission unit, and a free base phthalocyanine output unit for studies in arti

185 tion, leading to the subsequent formation of free base phthalocyanine.

186 adding a Ag atom from the probe to a single free-base phthalocyanine molecule adsorbed on Ag(111).

187 nthesis, and avoidance of the poorly soluble free base porphine.

188 ive coupling mechanism between unsubstituted free-base porphine units yielding dimers, trimers, and l

189 The crystal structure of a free base porpholactone N-oxide carrying the N-oxide on

190 d current densities have been calculated for free-base porphynoids using the gauge including magnetic

191 inequivalent sites [zinc porphyrin (Zn) and free base porphyrin (Fb)] give an upper limit of approxi

192 ipheral Zinc porphyrins (ZnPs) and a central free base porphyrin (H2P)-all rigidly linked to each oth

193 The molecular triad consists of a free base porphyrin (P) linked to both a C(60) electron

194 y arranging the zinc-porphyrin (ZOR) and the free base porphyrin (POR) donors in an energetically fav

195 ds were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)-Zn(i + 6)), and highly ef

196 methane, DDQ oxidation) afforded the desired free base porphyrin in yield comparable to that obtained

197 electrochemically oxidized and the attached free base porphyrin is photoexcited.

198 in current were observed with a monolayer of free base porphyrin or palmitic acid.

199 dioic acid group at the meso-position of the free base porphyrin rotates with rate constant 5 s(-1) (

200 ent of the resulting meso-acetal-substituted free base porphyrin to gentle acidic hydrolysis yields t

201 ay via a mixed cyclization involving the bis(free base porphyrin) and 4-tert-butylphthalonitrile, and

202 s consisting of a perylene input unit, a bis(free base porphyrin) transmission unit, and a free base

203 porphyrin is readily demetalated to give the free base porphyrin.

204 demetalation, affording Zn-pbp-Fb where Fb = free base porphyrin.

205 The encapsulation of a free-base porphyrin [5,10,15,20-tetrakis(1-methyl-4- pyr

206 Unexpectedly, the free-base porphyrin binds C60 more strongly than the met

207 a meso-meso linked oxovanadium(IV) porphyrin-free-base porphyrin dimer.

208 rs indicate quenching of the S1 state of the free-base porphyrin in all benzoquinone-containing dendr

209 timized wave function of the monosubstituted free-base porphyrin intermediate carrying a bromine atom

210 periments reveal that photoexcitation of the free-base porphyrin leads to picosecond triplet state fo

211 r facile in situ encapsulation of a cationic free-base porphyrin, and the alpha-cage of our (In-imida

212 a molecular light absorber, in the form of a free-base porphyrin, coupled to a Co3O4 nanoparticle cat

213 first example of a stable cis tautomer of a free-base porphyrin, the long-postulated intermediate of

214 unit is not similarly isolated in the corner free-base porphyrin-2,3,7,8-tetraone [C-(P-tetraone)2H].

215 R spectra of the radical anions derived from free-base porphyrin-2,3-dione [(P-dione)2H] and porphyri

216 A series of rigid polyphenylene, free-base porphyrin-containing dendrimers terminated wit

217 b3g) and 3(au, b3g) electronic states of the free-base porphyrin.

218 Altogether seven new aldehydes, eight free base porphyrins and eight zinc porphyrins have been

219 inc porphyrins at the termini and 1, 2, or 3 free base porphyrins at the core.

220 A new approach for the synthesis of free base porphyrins bearing one or two (cis or trans) m

221 d the zincated porphyrins (the corresponding free base porphyrins did not undergo dimerization).

222 On the other hand, catalytic properties of free base porphyrins have been less explored.

223 The free base porphyrins in the tetrad and pentad are joined

224 yrins in each array are attached to the core free base porphyrins via 1,4-diphenylethyne linkers.

225 The free-base porphyrins 5-bromo-10,20-diphenylporphyrin and

226 The corresponding halogenated free-base porphyrins also underwent the cross-coupling r

227 The free-base porphyrins are stable under conditions of wate

228 -histidine-tagged peptides and proteins, and free-base porphyrins coated on AFM probes, can be chelat

229 Tessellation of nine free-base porphyrins into a 3 x 3 array is accomplished

230 Free-base porphyrins were converted to metalloporphyrins

231 rporating respectively Zn(II) porphyrins and free-base porphyrins, is reported.

232 lding microporous MOFs containing accessible free-base porphyrins, it is noteworthy that the LbL grow

233 H(2)SO(4) to afford free-base porphyrins, which on zinc insertion using Zn(O

234 xes give similar SHG signals to those of the free-base porphyrins, while exhibiting no detectable two

235 owed Soret and Q-band absorptions typical of free-base porphyrins.

236 Furthermore, the label-free based proteomics results indicated that 62 upregula

237 s greatly upshifted relative to those of the free-base protoporphyrin in solution.

238 RR data on the binding of free-base protoporphyrin IX and its metalated complexes

239 Similarly for free-base protoporphyrin, the natural substrate of ferro

240 e isolated in a monoprotonated form, and the free bases proved to be somewhat unstable.

241 T must recognize the guanine in tRNA and the free base queuine or preQ(1) to catalyze this exchange.

242 e-Q(0)) intermediate, but mammals import the free base, queuine, obtained from the diet or the intest

243 es [8, 25, and 75 microg/kg/injection (inj), free base], rats responded approximately equally for any

244 tautomer of a variety of substituted amidine free bases reacts with nitric oxide (NO) to produce comp

245 irect injection of approximately 4 microgram free base, resulted in dopamine overflow with a maximum

246 s and nucleosides than for the corresponding free bases, revealing an unprecedented effect of ribosyl

247 analysis that included patients who received free-base rociletinib at a dose of 900 mg twice daily or

248 e non-interlocked components, and brings the free base rotaxanes into the basicity realm of phosphaze

249 observed when bis(3-pyridyl)-functionalized free-base salen-type ligand was employed in the reaction

250 t(OTf)(2) with bis(4-pyridyl)-functionalized free-base salen-type ligands.

251 lation of the corresponding hitherto elusive free base secochlorin bisaldehyde.

252 ere readily demetalated and separated as the free base species.

253 rate of reaction with O(6)-benzylguanine, a free base substrate, as on the repair of methylated DNA.

254 The reaction sequence is applicable to the free base systems as well as their Zn(II), Ni(II), Pd(II

255 anufacturing of mRNA vaccines relies on cell-free based systems that are easily scalable and flexible

256 l delivery of three forms of TAF, namely TAF free base (TAF(fb)), TAF fumarate salt (TAF(fs)), and TA

257 The crystal structure of a free base tetraarylporphyrin N-oxide demonstrates the de

258 hose of zinc tetraphenylporphyrin (ZnTPP) or free base tetraphenylporphyrin (FbTPP), respectively.

259 Indeed, we have found that free base tetraphenylporphyrin (H2TPP) is an efficient p

260 t lengths, while a zinc tetraphenylporphyrin free base tetraphenylporphyrin dyad constitutes the mini

261 n acid additives that change nicotine from a free-base to a protonated salt chemical form, which coul

262 , by the deposition of atomic silicon onto a free-base TPP layer on a Ag(100) surface under ultrahigh

263 ) complexes of triphyrin(2.1.1) by refluxing free base triphyrin(2.1.1)s with PCl(3) in a mixture of

264 nthesis involved oxidative heterocoupling of free base tris-aryl-p-aminophenyl porphyrins with a p-am

265 g in four different solutions (free-base/PG, free-base/VG, protonated/PG, and protonated/VG).

266 Although nicotine formulation (free-base vs. protonated or salt) in electronic cigarett

267 ave a monocation in chloroform, although the free base was generated in 5% Et(3)N-chloroform.

268 an intriguing conversion to liquid verapamil free base were observed upon disproportionation of the r

269 Free bases were of limited stability.

270 n elevation of T(g) compared to lumefantrine free base, with the largest increase in T(g) observed wi

271 ontinuous administration of nicotine (4.5 mg free base x kg(-1) x day(-1)) for 1 and 7 days led to in

272 distinct metalation states (zinc/free base, free base/zinc) were prepared by Sonogashira coupling re

273 cofacial motif previously demonstrated with free-base, Zn(II), and Ni(II) porphyrins.