ライフサイエンスコーパス: free form

1 DNA binding (delta = 1080 vs 110 GM for the free form).

2 r Wolinella succinogenes (novel, glutaminase-free form).

3 concentrations, >80% of FXIII-A2 existed in free form.

4 ma approximately 1% of FXIII-A2 should be in free form.

5 associated with PSII supercomplexes or in a free form.

6 nd better storage stability, compared to the free form.

7 a protease and its zymogen precursor in the free form.

8 geted construct or the therapeutics in their free form.

9 rm and water gives 3 in its uncomplexed, ion-free form.

10 on of its precursor arachidonic acid (AA) in free form.

11 e conformations are present in the substrate-free form.

12 the water/hydroxide ligand in the substrate-free form.

13 120% more cholesterol, predominately in the free form.

14 nformational entropy observed in the calcium-free form.

15 efficient H(2) supply on demand in a bubble-free form.

16 erates it in the dark, is inactive in cation-free form.

17 chemical analytes with label-based or label free form.

18 ipids, and they are subsequently released in free form.

19 h the inhibitor marimastat and the inhibitor-free form.

20 t stabilizes target Rabs in their nucleotide-free form.

21 d solubility in the high-density lipoprotein-free form.

22 unusually stable peptide-containing beta(2)m-free form.

23 of the hinges are reversed in the nucleotide-free form.

24 poB100-containing lipoproteins but also in a free form.

25 yeast cells in both its Ca2+-bound and Ca2+-free form.

26 n prostate tissues was found to exist in the free form.

27 ther depletion of zinc, presumably in a zinc-free form.

28 nd most adipose cholesterol is stored in its free form.

29 a shorter period of time comparing with its free form.

30 n the lignan macromolecule and slightly in a free form.

31 late in the lignan macromolecule and/or in a free form.

32 and human CFTR in the dephosphorylated, ATP-free form.

33 sed on mitochondrial DNA (mtDNA) in the cell free form.

34 oducing typical amyloid fibrils in its lipid-free form.

35 roteins but is also released from cells in a free form.

36 erified forms were more stable than were the free forms.

37 elf, at high resolution in DNA-bound and DNA-free forms.

38 of a lack of sufficient information on their free forms.

39 0 nm) was observed for both Na(+)-bound and -free forms.

40 in solution in both Cu(II)-bound and Cu(II)-free forms.

41 may hydrolyze to their potent unconjugated, 'free' forms.

42 cterium Methanocaldococcus jannaschii in its free form (2.2 A resolution) and bound to the S-adenosyl

43 and not significantly changed compared with free form (34.3mmol/L and 387.2mmol/Lmin), respectively,

44 res of CobA are reported here: its substrate-free form, a complex of CobA with MgATP, and a ternary c

45 ) anoxic storage brings about an increase of free forms, a strong decrease in the percentage of bonde

46 L1 loop, disordered in the structure of the free form, adopts a highly specific conformation to form

47 envelope trimer, in protein nanoparticle or "free" forms after primary immunization.

48 In the free form, all PDKs phosphorylated site 1, and PDK4 had

49 on by NMR, its exchange with the NMR-visible free form allows for its indirect characterization.

50 Taken together, our results suggest that the free form, although different from the bound state, shar

51 NO2-FA were detected in vivo in a free form, although it is assumed that they may also be

52 es it at a rate of 3.0 min(-1) in the ligand-free form and 4.3 min(-1) in the estriol-bound form, des

53 New atomic structures of vSET in the free form and a ternary complex with S-adenosyl homocyst

54 oteins can be prepared in an inactive, metal-free form and activated by exogenous Zn(2+).

55 carboxylation reaction, have been solved in free form and bound to its substrate pyruvate, product o

56 1 TAR RNA (taum approximately 18 ns) both in free form and bound to the ligand argininamide (ARG).

57 tures of the C-terminal domain of EB1 in the free form and complexed with a small molecule.

58 tral parameters of the new spin-label in its free form and covalently attached to an amino acid cyste

59 Treatment of platelets with CD increases the free form and enhances vWF binding.

60 that the domain is poorly structured in its free form and folds upon binding to DNA.

61 HglS to 1.1 angstrom resolution in substrate-free form and in complex with 2OA.

62 of BlaI from Staphylococcus aureus, both in free form and in complex with 32 bp of DNA of the mec op

63 teria Aquifex aeolicus (AaBPL) in its ligand-free form and in complex with biotin and ATP.

64 uctures of MGL from Bacillus sp. H257 in its free form and in complex with different substrate analog

65 e present crystal structures of Hsp47 in its free form and in complex with homotrimeric synthetic col

66 Crystal structures of RalA in the free form and in complex with its effectors, Sec5 and Ex

67 e was crystallographically determined in the free form and in complex with lysozyme.

68 ently, different states of Cas1-Cas2, in its free form and in complex with protospacer DNAs, were sol

69 The structure of MecI, also in free form and in complex with the bla operator, has been

70 -II from the fungi Aspergillus fumigatus, in free form and in complex with the inhibitor fructosyl-th

71 integrin-like domains, both in the inhibitor-free form and in complex with the inhibitor marimastat.

72 ture of Saccharomyces cerevisiae KMO, in the free form and in complex with the tight-binding inhibito

73 the crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or wi

74 DEK is secreted in both a free form and in exosomes, vesicular structures in which

75 howed that (125)I-labeled SAA, both in lipid-free form and in reconstituted HDL particles, functions

76 e solved the x-ray crystal structures of its free form and its complex with the active site inhibitor

77 ructure of the HCN2 channel CNBD in the cAMP-free form and mapped on it the TRIP8b interaction site.

78 apid exchange between Put that exists in the free form and Put found in acid soluble conjugate forms.

79 the nocardicin thioesterase domain in ligand-free form and reacted with a structurally precise fluoro

80 myces cerevisiae Vps4 in both the nucleotide-free form and the ADP-bound form provide the first struc

81 imilarities between the NMR structure of the free form and the crystal structure of the TGFbeta-bound

82 ng water molecule is misaligned, in both the free form and the inhibitor-bound double mutant.

83 ures of the human CRFR1 ECD, one in a ligand-free form and two in distinct CRF-bound states.

84 nd explore its antimycobacterial activity in free form and using nanoparticles-based delivery systems

85 synovial macrophages was observed both in a free form and via exosomes.

86 DEK is secreted by synovial macrophages in a free form and via exosomes.

87 nactive and open/active conformations in the free form and when bound to bona fide Py-tract RNA ligan

88 s of P450 2B4 are reported for the substrate-free form and when bound to the substrates, benzphetamin

89 seradish peroxidase (HRP) isoenzyme C in the free form and when ligated to a variety of small organic

90 NAT(L) were solved at 1.95 angstroms (ligand-free form) and 2.75 angstroms (acyl-CoA complex), showin

91 depends on the presence of this protein in a free form, and alterations in P123 processing abolish th

92 d the crystal structures of PLCgamma1-SH3 in free form, and bound to a 10-mer peptide containing this

93 of the Cd(2+) H185G enzyme in its substrate-free form, and in complex with PEP, and PEP plus A5P.

94 med by the PGK domains already in its ligand-free form, and substrate binding is not required to enab

95 Phenolic compounds were found mainly in free form, and values ranged between 544.1 and 1508.3 mg

96 cus elongatus and Synechocystis sp. in their free forms, and in complex with the nicotinamide coenzym

97 r in coreceptor-bound or coreceptor-unbound (free) forms, and we here present evidence that the two p

98 n that has been shown to kill Aa in its iron-free form (apo) and reduce binding to host cells in its

99 t kinetic folding studies of DBD in its Zn2+-free form (apoDBD) and in the presence of various concen

100 Soft materials featuring both 3D free-form architectures and high stretchability are high

101 nist analogues of somatostatin (SRIF) in the free form are described.

102 ylhexan-1-ol, 3-S-cysteinylhexan-1-ol) whose free forms are responsible for appreciated tropical-like

103 37 100 ns investigating the LC13 TCR in its free form as well as in complex with HLA-B*08:01 and dif

104 ort the first structure of CRBP1 in a ligand-free form as well as ultra-high resolution structures of

105 high levels of the disaccharide trehalose in free form as well as within various immunologically rele

106 , its structure was solved in the nucleotide-free form, as well as in the presence of product, GDP.

107 ystal structure of this mutant solved in the free form at 1.55 A resolution reveals an inactive confo

108 homodimeric cation-dependent MPR in a ligand-free form at pH 6.5.

109 n complex was 3.8% and 33% higher than their free forms at 0-300 degrees C and 300-600 degrees C rang

110 structure of R.marinus Cel12A in the ligand-free form (at 1.54 angstroms) and structures of RmCel12A

111 sent the crystal structure of DtpA in ligand-free form (at 3.30 angstrom resolution) and in complex w

112 locations: at the primary septum, largely in free form, at the mother-bud neck, partially linked to b

113 We found that the free form BoNT/A maintains a pH-independent conformation

114 seen, which leads us to conclude that in the free form, both stem 2 and parts of stem 3 are formed an

115 Here we show that most cytokines are not in free form but appear associated with exosomes that are d

116 transported from the lung to the spleen in a free form but by B cells.

117 tingly, printor selectively binds to the ATP-free form but not to the ATP-bound form of torsinA, supp

118 lled substrate-binding site in the substrate-free form, but oppositely, toward the proposed proton de

119 pproaches give similar models for the ligand-free form, but the ligand-bound models differ for the tw

120 hat are synthesized and secreted in the iron-free form by microorganisms.

121 synthesized N protein in a monomeric and RNA-free form by the viral phosphoprotein P that plays the r

122 In their free form, cis-antheraxanthin degraded 30-fold faster wh

123 -bound form and (ii) as a protease in Zn(2+)-free form, commissioning it to perform multiple function

124 rgest conformational change, in its unbound (free) form, correlate with the experimentally observed s

125 Only encapsulated rapamycin, not the free form, could induce immunological tolerance.

126 However, because microelectronic devices use free-form design principles, the insertion point of self

127 nd the nonclassical Ag HLA-F, expressed as a free form devoid of peptide, physically and functionally

128 switch II region stabilising the nucleotide-free form differentiate these pathways.

129 bstrate-bound structures, with the substrate-free form dominating, but with varying displacements of

130 The metal-free form, (DPA-C(2))(2)-TPPS(3) (1), where DPA is dipic

131 Similarly to the free form, encapsulated yeast successfully completed the

132 r p53 may therefore exist in the folded zinc-free form, especially when tumorigenic mutations are pre

133 We previously showed that free-form essential amino acids acutely stimulate muscle

134 l particles, the Q-bound form, but not the Q-free form, established the NADH-linked respiratory activ

135 ll essential amino acids were present in the free form, except methionine.

136 tral player is the ATPase Get3, which in its free form exists as a dimer.

137 omputational topology design (CTD) and solid free-form fabrication (SFF) have made it possible to cre

138 After the extraction of the free forms (FB1, FB2), the residue was subjected to an a

139 Compared with free form, fibrinogen-bound IL-1beta stimulated increase

140 affinities of its Ca(2+)-bound versus Ca(2+)-free form for the effector enzyme.

141 ability of apoA-I to be liberated in a lipid-free form from HDL.

142 f stable cell adherent complexes whereas its free form functions as a transcription factor that regul

143 sensor from canine NCX1, but not the Ca(2+)-free form, has been reported, although the molecular mec

144 bound nitric oxide complex and the substrate-free form have been determined revealing a substrate-fre

145 A new method for a free-form, high-density, material-independent, and high-

146 dented in microbial metabolism and, in their free form, highly toxic to living organisms.

147 The structure of the free form HIV gp120, critical for therapeutic agent deve

148 The exact location of the 'free' form, however, has never been determined.

149 In the free form, HRP assumes two distinct spectroscopic confor

150 different from the previously reported P-CAB-free form, illustrating a common conformational change i

151 in chains of elastin, have now been found in free form in human urine.

152 s a potent antioxidant recently found in the free form in olive oil and table olives.

153 (84.0%) and Met (75.8%) were found to be in free form in the fruiting body, in contrast with the myc

154 is found in both a cell-bound form and cell-free form in the host during an infection.

155 ructure of SpeG from V. cholerae in a ligand-free form in three different conformational states: open

156 ver, we found that the majority of tSC is in free form in trout mucus and free tSC is able to directl

157 eme-binding PAS domain in the ferric, ligand-free form, in comparison to the previously determined cy

158 ctures were determined for GH20C in a ligand-free form, in complex with the N-acetylglucosamine and N

159 on of these oxysterols to the ARPE19 cell in free form indicated that 7kCh is the most cytotoxic of t

160 the biomimetic complexes in the FeCu and Cu-free forms indicates that, in the regime of rapid electr

161 nd dsRNA in the complex are similar to their free forms, indicating little or no structural change in

162 TS, which is intrinsically disordered in its free form, interacts strongly with PP1 in a highly exten

163 ocytic/endocytic pathways and is exported in free form into the cytosol, becoming available for activ

164 ere the crystal lattice of the target in the free form is such that large portions of the interacting

165 tential for DNA-bound SoxR compared with the free form is thus reconciled based on a high-energy conf

166 conformation of this segment in the peptide-free form is unknown.

167 at Mg2+-bound form of GCAP-1, not its cation-free form, is the true activator of RetGC-1 under physio

168 eity compared to similar practices used with free form L-5-MTHF and FA, respectively.

169 ical metamaterials that not only features 3D free-form lattice architectures but also poses ultrahigh

170 ts a highly twisted geometry relative to its free form, leading to the emergence of an emissive trans

171 ed in the periplasm, the precise location of free-form Lpp has never been determined.

172 For decades, it has been widely assumed that free-form Lpp is associated with bound-form.

173 Our results indicate that free-form Lpp spans the outer membrane and is surface-ex

174 ere allowed to choose preferred testing in a free-form manner.

175 arotenoids were found to be present in their free form (no carotenoid esters were detected).

176 olled manner and along an ad-hoc arbitrarily free-form, non-rastered path.

177 Intriguingly, the free form NTNHA-A adopts pH-dependent conformational cha

178 t remarkably converts the high-density guest-free form of a well-known organic host (p-tert-butylcali

179 Comparison of the free form of ACPs (NMR structures of fren ACP and the Ba

180 IFT27 directly interacts with the nucleotide-free form of ARL6.

181 bound kappaB DNA structures reveals that the free form of both classes approximates ideal B-form DNA

182 The percentage of the free form of BP-3 in urine was used in the determination

183 A significantly lower percentage of the free form of BP-3 was found in urine from the U.S. popul

184 The Ca(2+)-free form of calmodulin (apoCaM) often appears inert, mo

185 The Ca(2+)-free form of CaM (apoCaM) is already pre-associated with

186 gations indicate that local depletion of the free form of DOX, even at the kinetic stage, is negligib

187 of protein synthesis but dependent on a tRNA-free form of eEF1A.

188 release and binds tightly to the nucleotide-free form of exocytic but not endocytic Rab GTPases.

189 inflammation, we used a membrane-bound cell-free form of FasL (mFasL-vesicle preparation (VP)).

190 the activation of the cyclase by the Ca(2+)-free form of GCAP-2 and the inhibition of retGC basal ac

191 It is known that apolactoferrin, the iron-free form of human lactoferrin, can kill many species of

192 d IGF-binding protein 3 (IGFBP3) so that the free form of IGF-1 could be released from the IGF-1.IGFB

193 r, promising results were achieved using the free form of inulinase from A. niger (77.19% of GF2; 14.

194 Crystal structures of the ligand-free form of KstR show variability in the position of th

195 obiology, Cowles et al. demonstrate that the free form of Lpp is an integral OM protein whose C-termi

196 ve solved the x-ray structure of a substrate-free form of lysine-5,6-aminomutase from Clostridium sti

197 epitope recognized by MEM-265 in the peptide-free form of major histocompatibility complex II DR1 bet

198 dy has identified an enzyme specific for the free form of Met-(R)-O, fRMsr, through proteomic analysi

199 ntly found that thionein, the reduced, metal-free form of metallothionein, could function as a reduci

200 For example, the free form of MMP-1 was found to have a K(D) of 34.6 nM f

201 with L and mediates the association with the free form of N and with the ribonucleoprotein is not cle

202 phosphatase activity predominantly onto the free form of one of the proteins making up the split kin

203 While preventing the free form of p53 from accessing its cognate sites, sumoy

204 In vitro studies suggest that the nucleotide-free form of PilB assumes the active signaling conformat

205 BioW for biotin synthesis indicates that the free form of pimelic acid is an intermediate in biotin s

206 interacts preferentially with the nucleotide-free form of Rab-RP1, and this interaction involves Clar

207 miniscent of the structure of the nucleotide-free form of Ras in complex with Sos.

208 Degradation of the free form of RNase R also requires tmRNA-SmpB, but this

209 Spo13 binds preferentially to the nucleotide-free form of ScSec4 and facilitates nucleotide exchange

210 The X-ray crystal structure of the substrate free form of Staphylococcus aureus UDP-N-acetylenolpyruv

211 cally competent 'closed' state in the ligand-free form of the enzyme adenylate kinase.

212 zyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decrea

213 In contrast, the free form of the enzyme, which is deleterious to cells,

214 exchange reaction required to regenerate the free form of the enzyme.

215 also found to be disordered in the substrate-free form of the enzyme.

216 L) spectroscopy to compare opsin, the ligand-free form of the GPCR rhodopsin, with opsin containing t

217 found in association with the open, peptide-free form of the HLA-B8 H chain.

218 igh resolution solution NMR structure of the free form of the MptpA LMW-PTP.

219 pes place LIN-42 in opposition to the ligand-free form of the nuclear receptor DAF-12, which indirect

220 ent assembly in vitro was 22 nt for the zinc-free form of the protein and 16 nt for the zinc-bound fo

221 The drug-free form of the protein is similar in overall fold to t

222 lution NMR structure of the inactive calcium-free form of the protein.

223 K1-ATP complex phosphorylates the nucleotide-free form of the S6K1 alpha II kinase and (ii) initial b

224 F Envs, which was not observed with the cell-free form of the same virus.

225 Na(+) binding to the glutamate-free form of the transporter generates a high affinity b

226 scence in situ hybridization showed that the free form of the transpoviron replicates within the gian

227 e apoptosis-mediating anticancer effect than free form of these proteins and 5-FU.

228 The soluble free form of this domain is a 10 alpha-helix bundle.

229 The free form of YmoA shows collective microsecond-milliseco

230 Free forms of CML, CEL, and Ndelta-(5-hydro-5-methyl-4-i

231 NADH-free forms of CtBPs cooperated with the p53-binding part

232 ctures of both the choline-bound and choline-free forms of CutC and have discovered that binding of c

233 by further interactions of the complex with free forms of either native or non-native T-synthase.

234 global demand for cost-effective, pollution-free forms of energy conversion.

235 Nucleotide-free forms of G alpha subunits were typically very sensi

236 balance of membrane skeleton-associated and free forms of GPIb-IX.

237 Ca(2+)-free forms of guanylyl cyclase-activating proteins (GCAP

238 s with both dominant negative and nucleotide free forms of H and NRas, but not with the corresponding

239 ctral tuning in the chloride-bound and anion-free forms of halorhodopsin from Natronobacterium pharao

240 each other and more similar to the substrate-free forms of homologs than to the substrate-bound forms

241 the balance of peptide-occupied and peptide-free forms of MHC class II at the cell surface.

242 Alkaline hydrolysis allowed to release free forms of phenolics and to confirm (chromatographica

243 ciation is an inherent property of the lipid-free forms of several exchangeable apolipoproteins, incl

244 changes in the molar fractions of bound and free forms of SG, the approach provides an unprecedented

245 cessible surfaces of the iron-bound and iron-free forms of the N-terminal lobe of human serum Tf at b

246 disclose the structural architecture of the free forms of thrombin and prethrombin-2, consistent wit

247 ens, H. pylori preferentially binds the iron-free forms of transferrin and lactoferrin, which limits

248 These sites were occluded in the E2 (Ca(2+)-free) form of the enzyme, consistent with mutual protect

249 rentiate between complexed and unencumbered (free) forms of cyclopentyne, but those involving spirodi

250 s photonic crystal-based color filters, onto free-form optical elements and curved surfaces.

251 ables instant 3D optical zoom-in imaging, 3D free-form optical microsurgery, and 3D visualization and

252 rs and all of them had a carbonyl group in a free form or as hemiacetal.

253 ithrombin inhibition of factor Xa, either in free form or assembled into the prothrombinase complex d

254 mc directly interacts specifically in either free form or covalently bound to solid supports with den

255 cultured cells when applying the drug in the free form or in a delivery system.

256 g crystal structures of Importin-beta in its free form or in complex with nuclear localization signal

257 or bacterial infection and is present in its free form or is conjugated to cellular proteins.

258 ss of carbene, however they are found in the free form or ligated to only a few d-block ions.

259 sly reported SaDHNA structures in its ligand-free form (PDB entry 1DHN) and in complex with HP (PDB e

260 Our results show that, in its free form, pol X can exist in two stable conformations t

261 y have not been detected unesterified in the free form, presumably because of their marked reactivity

262 thesized as a membrane-bound protein while a free-form prostasin is secreted into the culture medium.

263 MutS, which can be isolated in a nucleotide-free form, purified MutS E694A contains 1.0 mol of bound

264 single-shot fast spin-echo images by tracing free-form regions of interest on individual consecutive

265 nged the galloylated form of catechin to its free form, releasing gallic acid and increasing the anti

266 The anion is isolated in its free form, representing a new "anti-van't Hoff/Le Bel" c

267 lo- and apo-metalloproteins (metalbound and -free forms, respectively) by CBB G-250 dye and employing

268 e D-bound, epothilone B-bound, and substrate-free forms, respectively, are the first crystal structur

269 exists in the predominantly metal-bound and free forms, respectively.

270 nd quercetin were detected in only bound and free-form, respectively.

271 On the other hand, the structure of the free form reveals a collapse of the 215-217 strand that

272 n structure of the C191A/C220A mutant in the free form reveals a conformation similar to the Na+-free

273 of the FMN-bound wild type form with the FMN-free form reveals a significant conformational differenc

274 includes restrictions based on field values, free-form SQL queries and combined queries on multiple t

275 The relevance of this conformation to the free form structure and the pathway for conformational c

276 DMPs are created as free-form text and describe the data and tools employed

277 ally recognize anatomical entity mentions in free-form text have been introduced.

278 ng in their analysis because these notes are free-form texts and the writing formats and styles vary

279 s molecule can be sublimed to afford a guest-free form that displays the unexpected transport of mole

280 . naeslundii existed predominantly in a cell-free form, that a small amount of the activity was cell

281 In the solvent-free form, the diffusion of small quantities of iodine v

282 In the substrate-free form, the Fe-Cys stretching mode was detected at 34

283 In its free form, the protein undergoes a microsecond exchange

284 ermotoga neapolitana adenylate kinase in the free form (TNAK) and inhibitor-bound form (TNAK*Ap5A) we

285 ntibody (LT3015) Fab fragment in its antigen-free form to 2.15 A resolution and in complex with two L

286 lized, human uPAR (H47C/N259C) in its ligand-free form to 2.4 A and in complex with amino-terminal fr

287 shifts from an alpha helix in the substrate-free form to a pi helix in the substrate-bound form.

288 nal switch in DNA from a loose duplex in the free form to a single-strand, tightly folded hairpin con

289 e pathway for conformational change from the free form to the CD4-bound structure is discussed in det

290 ts position in the previously reported P-CAB-free form, to a location proximal to the P-CAB binding s

291 Monolignol glucosides accumulate in a free form up to 9.85mg/g dry matter at the early develop

292 be based only on the determination of their free form using LC-MS/MS.

293 el d 1 to induce mast cell activation in its free form versus displayed on VLPs and we performed alle

294 were present in urine, and the proportion of free form was inversely related to the total concentrati

295 zyme adenylate kinase (AdK) in its substrate-free form, we compared a range of protein transition pat

296 crystal structure of BchL in the nucleotide-free form where a conserved, flexible region in the N-te

297 ndothelial differentiation on day 3 in label-free form, whereas flow cytometry and fluorescent micros

298 nd to the cell's peptidoglycan layer, and a 'free-form', which is not.

299 structural definition of uPAR in its ligand-free form, which represents one of the biologically acti

300 ignificant structural rearrangement from its free form while the protein shows smaller but significan