ライフサイエンスコーパス: free radical

1 rogen abstraction (HA) from Ch by a reactive free radical.

2 the electroactivity of a persistent organic free radical.

3 exceptionally clean and efficient source of free radicals.

4 r behaviour in response to the generation of free radicals.

5 may also participate in the inactivation of free radicals.

6 umor tissue prevents the formation of oxygen free radicals.

7 position of the loaded initiator to generate free radicals.

8 owed us to determine the ability to scavenge free radicals.

9 zed to detoxify methylglyoxal and neutralize free radicals.

10 lity to UV irradiation induced generation of free radicals.

11 ely and exclusively without the formation of free radicals.

12 cal is formed at O3-atom upon scavenging the free radicals.

13 ucture of starch granules, and generation of free radicals.

14 ts against oxidative degradation of foods by free radicals.

15 suggesting the dominance of oxygen-centered free radicals.

16 oaches but compensating for the diffusion of free radicals.

17 significant capacity to inhibit DPPH and NO free radicals.

18 antioxidant activity as tested by different free radicals.

19 the activity lifetime and the resistance to free radicals.

20 compromised, fueling into a vicious cycle of free radicals.

21 +)) radical, as well as the stable nitroxide free radical 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-o

22 exhibited the highest scavenging activity of free radicals (78.8%).

23 namely, 1,1-diphenyl-2picrylhydrazyl (DPPH) free radical ability and ferric reducing antioxidant pot

24 y combining the merits of solid supports and free radical activated glycan sequencing (FRAGS) reagent

25 The free-radical-activated glycan-sequencing reagent (FRAGS)

26 is suggested for the anthocyanins scavenging free radical activity by hydrogen transfer.

27 which are therefore a valuable tell-tale for free radical activity in the cell's lipidome.

28 Glycation and increased free radical activity underlie the pathogenesis of diabe

29 This review covers free radical additions, which are initiated by the forma

30 reaction between NO and the thiol produces a free radical adduct RSNOH(*), which reacts with a second

31 Free radical alkane chlorination is an important industr

32 Total phenolics, flavonoids, ABTS free radical and hydroxyl radicals scavenging and anti-i

33 rboxylates and halide initiators in both the free radical and iodine degenerative transfer controlled

34 ng the di-tert-butyl peroxide as a source of free radicals and a dehydrogenating agent.

35 s interface, which will consequently release free radicals and accelerate organic chemical degradatio

36 It plays an essential role neutralizing free radicals and acting as enzyme co-factor in several

37 resent the link between resonance-stabilized free radicals and carbonaceous nanoparticles generated i

38 bs X-rays during radiotherapy (RT), creating free radicals and local tumor damage, effectively boosti

39 e infiltrating cells then release cytokines, free radicals and other factors that contribute to renal

40 phagosomal cytotoxic reactive species (i.e., free radicals and oxidants) by activated macrophages and

41 t (13)C NMR and EPR spectra of the nitroxide free radicals and the oxoammonium salts, along with TEMP

42 ractions had the largest capacity to capture free radicals, and the lowest peroxide values, conjugate

43 background to, and theoretical knowledge on, free radicals; and then proceeds to review studies that

44 Some free radicals are stable enough to be isolated, but most

45 polymers, a highly reactive surface, rich in free radicals arising from deposition/treatment specific

46 The free-radical arylation of H-phosphinates and related com

47 There is a growing interest in free radicals as therapeutic agents for antimicrobial ap

48 e examined the ability of MB-gCs to scavenge free radicals as well as their influence on mitochondria

49 determined by 2,2-diphenyl-1-picrylhydrazyl free radical assay and the electrochemical index concept

50 that it is capable of protecting cells from free radical attacks.

51 basis of these results, we propose plausible free radical-based mechanisms for the C-C bond coupling

52 stage, hydrogen atom transfer (HAT)-mediated free radical bond formations (C20-C2 and C20-OH, respect

53 nes may not confer strong protection against free radicals but nevertheless, their positive influence

54 a gelatinization process indicating that the free radical by-products from CP are able to disrupt the

55 fferent studies have shown that detection of free radicals by ESR spin trapping provides useful infor

56 Consequent inflammation produces free radicals by mitochondria thus causing lipid peroxid

57 astid division proteins, revealing that this free radical can mimic transcriptional changes typically

58 The production of oxygen free radicals catalysed by non-haem iron was investigate

59 of FA, the amount of the blue-green-colored free-radical cation (ABTS+) was reduced.

60 consistent with the formation of diffusively free radical cations (1, NMe-1).

61 including (i) covalent cross-linking (e.g., free radical chain polymerization, click cross-linking,

62 Results were consistent with a free radical chain scission mechanism, supported by meas

63 This free-radical chain mechanism shows that Ni does not clea

64 s associated with photo-cross-linking (e.g., free-radical chain polymerization, thiol-ene, photomedia

65 Autoxidation is an autocatalytic free-radical chain reaction responsible for the oxidativ

66 lic network of peroxy-hydroperoxide-mediated free-radical chain reactions.

67 (CNPs) have been demonstrated to neutralize free radical chemical species associated with many life-

68 to be an intrinsic stereochemical feature of free radical chemistry as can be seen in traditional rad

69 illustrates the defining characteristics of free radical chemistry, beginning with its rich and stor

70 use of rapid, mild and operationally simple free-radical chemistry performed on recombinantly expres

71 ble conditions, which exploit unusual carbon free-radical chemistry, and use them to form Cbeta-Cgamm

72 ecule is paramagnetic and exists in air as a free radical, constrained from reacting aggressively wit

73 enzyme in mammalian cells, having one of two free radical-containing subunits called R2 and p53R2.

74 chondria remain damaged and vicious cycle of free radicals continues to self-propagate.

75 ng glutathione regeneration and consequently free-radical control.

76 Free radical cyclization of (2-bromophenyl)pyrrolyl-1,2,

77 te olefin 2, effecting a transannular C20-C2 free radical cyclization of a challenging substrate with

78 sosomal destabilization, cell viability, and free radical damage were analyzed.

79 mosquitoes use to avoid ammonia toxicity and free radical damage.

80 In this setting, NADPH oxidase, a source of free radicals, decreased in the myocardium of conditione

81 mers while multiple hyaluronidases or tissue free radicals degrade these into smaller bioactive fragm

82 the stronger oxidant AgBF4 formed the metal-free radical dication L(.2+) .

83 yl-trithiocarbonate group, which initiated a free radical dissociation process.

84 , antioxidant activity by the capture of the free radical DPPH and ferric reduction ability (FRAP).

85 henolic hydrogen atom transfer to the stable free radical DPPH.

86 tivity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazo

87 g assays: (i) 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging; (ii) 2,2,6,6-tetramethyl

88 and scavenging activities against different free radicals (DPPH, ABTS(+), O(2)(-), ROO).

89 -Hb complex was postulated to be a source of free radicals during TLF-1 lysis.

90 Environmentally Persistent Free Radicals (EPFRs) are newly discovered, long-lived s

91 radicals known as environmentally persistent free radicals (EPFRs) have been found to exist on the su

92 ployed to measure environmentally persistent free radicals (EPFRs) in the total particulate matter (T

93 the formation of environmentally persistent free radicals (EPFRs).

94 EPR studies exhibited a higher amount of free radicals for fructose than the other sugars, and mo

95 atalytic conversion of inorganic chlorine to free radical form on ubiquitous sulfate-water aerosols;

96 e stress (OXINOS), defined by an increase in free radical formation and corresponding decrease in vas

97 Electron spin resonance indicates free radical formation during irradiation, which might i

98 a Caco-2/HT-29 intestinal barrier, inhibited free radical formation in muscle and liver cells.

99 while retarding desorption of and capturing free radicals formed at the cathode, resulting in enhanc

100 metallic species, which helps to protect the free radicals from side reactions.

101 he type of cheese, and which might be due to free radicals from the radiolysis of proteins.

102 A method for the generation of free radicals from thiazolinium salts upon photocatalyti

103 he real-time detection of intracellular NO-a free radical gas-has been difficult, and surrogate marke

104 O) is a fascinating and important endogenous free-radical gas with potent antimicrobial, vasodilating

105 Free radicals generated by UV-light irradiation of a fro

106 vel strategy that employs oxygen-independent free radicals generated from a polymerization initiator

107 igh altitude has an independent influence on free radical generation and the resultant oxidative stre

108 Rac1 and p22(phox) knockdown abrogated free radical generation by TGF-beta1 in HK-2 cells, cons

109 can dissociate the effects of intravesicular free radical generation on spontaneous neurotransmission

110 acutely probe the effects of intravesicular free radical generation on synaptic vesicles that fuse s

111 llular energy utilization, inflammation, and free radical generation, especially in the brain and hea

112 chain dysfunction with subsequent increasing free radical generation.

113 islands also serve as the reactive sites for free radical generation.

114 cell proliferation, and motility, as well as free radical generation.

115 Addition of AAPH, a free radical generator, was able to increase filipin sta

116 Persistent free radicals have become indispensable in the synthesis

117 Free radical imbalance is associated with several chroni

118 inactivate Fe(2+) ions that otherwise induce free radicals impacting gluconeogenesis in the liver.

119 Excessive production of paramagnetic free radicals in nonhippocampus brain tissue can be meas

120 The generation, accumulation and decay of free radicals in six varieties of cheese, irradiated (0-

121 complex antioxidant mechanism for scavenging free radicals in wolfberries oxidative stress response.

122 oxidant compounds towards limiting amount of free radical (in this article, DPPH) would reflect their

123 Anticancer modalities based on oxygen free radicals, including photodynamic therapy and radiot

124 to review studies that have employed various free radical-incorporated drug delivery systems as an ap

125 egies that can potentiate the application of free radical-incorporated drug delivery systems for inhi

126 ge for reactions of inactivation of selected free radicals indicate that catecholic colonic metabolit

127 ibbs free energies of reactions with various free radicals indicate that syn-DHCA and syn-DHFA, colon

128 dition of transcriptional regulation between free radical induced signalling and nitrogen regulation

129 on <10kDa) exerted protective effect against free-radical induced cytotoxicity in Caco-2 and HepG2 ce

130 emulsions (20% v/v) were exposed to iron or free radical initiated oxidation.

131 ier mechanism through a resonance-stabilized free radical intermediate (C(18)H(13)).

132 wed the identification of a key diprotonated free-radical intermediate, which was implicated in a rem

133 rized in fungi, in which enzymes that create free radical intermediates are used to degrade this mate

134 of carboxylic acids is a versatile route to free radical intermediates for chemical synthesis.

135 Free radical intermediates most likely differentiate thi

136 nvolves a targeted ring annulation involving free radical intermediates.

137 ged reaction barriers, resonantly stabilized free-radical intermediates, and methodical ring annulati

138 ged reaction barriers, resonantly stabilized free-radical intermediates, and systematic ring annulati

139 s proceeding via carbanionic and open-shell (free radical) intermediates.

140 s proceeding via carbanionic and open shell (free radical) intermediates.

141 responsible for the conversion of superoxide free radicals into hydrogen peroxide and oxygen, is know

142 Cis lipids can be converted by thiols and free radicals into trans lipids, which are therefore a v

143 inus of glycans in which a localized nascent free radical is generated upon collisional activation an

144 pe fuels further 'inflammatory storms', with free radicals leading to further DNA damage.

145 The interaction of proteins with free radicals leads, among other types of damages, to th

146 which were effective in reducing the oxygen free radical level.

147 In the AS model, abnormally high free radical levels were observed in dorsal and ventral

148 The rate-determining step in free radical lipid peroxidation is the propagation of th

149 reversion of the quadricyclanes occurs via a free radical mechanism with very little contribution fro

150 itant oxidation at the gamma-position, via a free radical mechanism.

151 this C-C bond formation proceeding through a free radical mechanism.

152 ating that GDGT cyclization occurs through a free radical mechanism.

153 oxidants that serve to initiate the enzyme's free-radical mechanism.

154 control fungal, aflatoxin B(1) (AFB(1)) and free radicals mediated deterioration of stored maize sam

155 functionalize peptides and proteins through free-radical-mediated dechalcogenation.

156 We recently communicated that the free-radical-mediated oxidation (autoxidation) of choles

157 Specifically, two unprecedented muoniated free radicals, MesP(.) -CMu(Me)(2) (1 a, minor product)

158 The free radical-neutralizing vitamin B(12)-analog cobinamid

159 The free radical nitric oxide (NO(*)) exerts biological effe

160 n and production of micromolar levels of the free radical nitric oxide in neighboring beta-cells.

161 ell expression of iNOS and production of the free radical nitric oxide.

162 molecular dialogue between isoprene and the free radical NO Proteins belonging to the photosynthetic

163 Reaction of [Cu(II)]-C6F5 with the free radical NO(g) results in C-N bond formation to give

164 entration and distribution of nitrogen oxide free radicals (NO(x)).

165 ultracold collision dynamics of the hydroxyl free-radical OH with Sr atoms leading to quenching of OH

166 When handled carefully, these reactive free radicals open doors to the controllable surface fun

167 can also convert light energy into cytotoxic free radicals or heat, allowing for effective cancer pho

168 nce (ESR) spectroscopy measures paramagnetic free radicals, or electron spins, in a variety of biolog

169 plex behavior of the important environmental free radical oxidant NO(3)(*) in its reactions with alip

170 ed amino acids is correct as regards various free radicals, particularly oxygen-derived peroxyl radic

171 oceed via mechanisms involving enzymatic and free radical pathways.

172 hesizing unnatural polymers in cells through free radical photopolymerization using a number of bioco

173 It is remarkable that free radical polymerization chemistry can take place wit

174 This intermediate is understood to initiate free radical polymerization of acrylic monomers, thereby

175 ith two terminal olefin structures has great free radical polymerization potential, according to its

176 thesized via sequential polycondensation and free radical polymerization reactions.

177 ed porous organic polymer (POP) using simple free radical polymerization techniques to prepare a cost

178 th lauryl methacrylate via a simple one-step free radical polymerization to produce a "self-plasticiz

179 ts such as PAA with rGO, and VS-PANI through free radical polymerization using methylene bis-acrylami

180 as other complexes preferred redox-initiated free radical polymerization.

181 the utility of these monomers in controlled free radical polymerization.

182 The tip is fabricated using the free radical polymerization.

183 ion (MagLev) to characterize the kinetics of free-radical polymerization of water-insoluble, low-mole

184 reported, which are synthesized by a facile free-radical polymerization using branched and amphiphil

185 mide) covalently bound to graphene oxide via free-radical polymerization.

186 Both the activity of lipoxygenase and the free radical populations in PPIs were positively related

187 The free radical precursor generates a nascent free radical

188 SS-FRAGS comprises a solid support, free radical precursor, disulfide bond, pyridyl, and hyd

189 In contrast with typical free radical precursors, semiconductors generate single

190 we develop a multifunctional solid-supported free radical probe (SS-FRAGS) that enables glycan enrich

191 metabolites than reactive oxygen species and free radical processes (the "usual suspects").

192 es by tert-butyl hydroperoxide that occur by free radical processes provide access to carboxylic acid

193 Nitric oxide (NO) is a toxic free radical produced by neutrophils and macrophages in

194 s show that the active reducing agent is the free radicals produced by benzoins under elevated temper

195 ally, spermine neutralized off-target oxygen free radicals produced by NADPH oxidase-1 (Nox1)(3,6) th

196 e juice may prevent neuronal damage from the free radicals produced during normal metabolism.

197 The free radicals produced in this way are highly effective

198 These chemicals stimulate free radical production and disrupt microtubules in neur

199 ant food antioxidants considerably decreased free radical production and lipid oxidation but not prot

200 ong the CA1 dorsal-ventral axis of excessive free radical production as measured by Quest MRI, and re

201 e quinone pool is the primary determinant of free radical production by SDH.

202 s using a variety of succinate oxidation and free radical production data.

203 n barrier and reaches mitochondrial sites of free radical production.

204 ore effective than those designed to enhance free radical production.

205 m 3.5 to 6.5 poorly affected the kinetics of free radical production.

206 in expression was due to myoglobin-dependent free-radical production, leading to the oxidation and de

207 By further exploring O(2) 's free radical 'quantum quirkiness', including emergent (q

208 ogen (PG) were synthesized on Cu foils via a free radical reaction at growth temperatures of 230-300

209 of interest in new transformations based on free radical reactivity has meant that numerous choices

210 eased muscle NADH content, and higher muscle free radical release measured in vivo using pMitoTimer r

211 ischemia, inflammation, excitotoxicity, and free-radical release, contribute to neural tissue damage

212 Some of the free radical releasing systems highlighted include polym

213 rol the release of the therapeutic ranges of free radicals required for different applications, inclu

214 dicals dimerize, but the colored, air-stable free radicals return upon heating.

215 on and compounds were measured based on DPPH free radical savenging activity, oxygen radical absorban

216 tective approaches-normobaric hyperoxia, the free radical scavenger alpha-phenyl-butyl-tert-nitrone (

217 Through the assessment of a free radical scavenger and an anti-inflammatory endocann

218 yses that have been employed to evaluate the free radical scavenger capacity of carotenoid molecules

219 These effects were mitigated by the free radical scavenger N-acetylcysteine, which also reve

220 Furthermore, myocardial expression of free radical scavenger superoxide dismutase 1 and aldehy

221 Melatonin, an endogenous free radical scavenger synthesized by neuronal mitochond

222 g an activation of glutathione and ascorbate free radical scavenger systems.

223 nt with N-acetyl-l-cysteine (NAC), an oxygen free radical scavenger, led to a reduction in the FoxO1

224 Significantly, treatment with an oxygen free radical scavenger, N-acetyl-l-cysteine (NAC), atten

225 nfluenced by the presence of the less potent free radical scavengers gallic and caffeic acids.

226 Free radical scavengers have failed to improve patient o

227 The mitochondrially enriched electron and free radical scavengers JP4-039 and XJB-5-131 improved R

228 ects in WT C. elegans Supporting this model, free radical scavengers suppressed the Rhizobium-induced

229 The most potent free radical scavengers that we tested for in the wine s

230 ll wine samples were found to be less potent free radical scavengers.

231 tematic study was undertaken to evaluate its free radical scavenging ability and anti-apoptotic activ

232 of intracellular GSH levels, suggesting that free radical scavenging ability may be responsible for t

233 ains is correlated with high antioxidant and free radical scavenging activities measured under the FR

234 Total phenolic content (TPC), DPPH free radical scavenging activity (DPPH), degree of hydro

235 termination of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (DPPH-RSA) in food is r

236 henols, ascorbic acid, catalase activity and free radical scavenging activity during storage.

237 metric assays, GB total phenolic content and free radical scavenging activity were found to be 59.91

238 otal phenolics, ascorbic acid, anthocyanins, free radical scavenging activity), polyphenoloxidase enz

239 pies related to three possible mechanisms of free radical scavenging activity, namely HAT, SET-PT and

240 Antioxidant activity was tested by free radical scavenging against 2,2-diphenyl-1-picrylhyd

241 prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limit

242 To achieve this, free radical scavenging antioxidant, Trolox was conjugat

243 metal chelator antioxidants e.g. EDTA, than free radical scavenging antioxidants e.g. gallic acid.

244 total phenolic acids, reducing abilities and free radical scavenging capacities, in response to an in

245 nolics, anthocyanins, proanthocyanidins, and free radical scavenging capacity were analysed.

246 MS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging capacity were used to measure fl

247 Interestingly, Folin-Ciocalteu index and free radical scavenging capacity, measured with three di

248 ds were used to assess antioxidant activity, free radical scavenging capacity, protein-bound carbonyl

249 In the research, two methods were used: free radical scavenging DPPH (microM Trolox) and the red

250 nd 1H(+)/1e(-) (phenoxyl radical--> quinone) free radical scavenging mechanisms of quercetin and its

251 erent reaction paths of double (2H(+)/2e(-)) free radical scavenging mechanisms was estimated.

252 ated using beta-carotene bleaching (BCB) and free radical scavenging method DPPH and compared with bu

253 m mechanical DFT calculations suggested that free radical scavenging was likely mediated by the sulfu

254 tochondrial fission, a response abolished by free radical scavenging with N-acetylcysteine (NAC) and

255 content, total antioxidant activity and DPPH free radical scavenging.

256 tection, structural support, coloration, and free radical scavenging.

257 l to contribute to health benefits by direct free radical scavenging.

258 Chelating and free radicals scavenging activities of extra virgin oliv

259 peels oleoresin, TPO, exhibited competitive free radicals scavenging activity with synthetic antioxi

260 one showing potent thrombolytic activity and free radicals scavenging power, in addition to nontoxici

261 polyCA presented the highest antioxidant and free radical-scavenging activity based on DPPH, ABTS and

262 ins, allowing representative measurements of free radical-scavenging capacity (DPPH) and trolox equiv

263 s, nonenzymatic browning (NEB), and the DPPH free radical-scavenging capacity of fresh red Capsicum (

264 Additionally, appending a stable free radical (SFR) allows the study of how an unpaired s

265 gradation system substantially decreased the free radical signals and decreased the Fe(II) content.

266 Although free radical species contribute to COD removal, anodes d

267 The cascade is mediated by organocopper and free radical species, and amounts to the first known [1+

268 as it is able to scavenge different types of free radical species, showing strong neuroprotection and

269 piezoelectric ZnO nanoparticles to generate free-radical species that initiate chain-growth polymeri

270 O2) or singlet molecular oxygen, rather than free-radical species, perform major second messenger fun

271 neration of both neutral and charged organic free-radical species.

272 to whether our data may form the basis for a free radical substituent constant, sigmaQ*, analogous to

273 a strong role for oxidative stress caused by free radicals, such as reactive oxygen species (ROS), in

274 able of producing significant amounts of the free radical superoxide.

275 Nitric oxide (NO) is an important free radical synthesized and released by brain cells.

276 This peptidomimetic/free radical system is a potentially excellent template

277 Amorphous carbons contain persistent free radicals that may play a role in observed redox rea

278 eactions of lipid peroxidation (enzymatic or free radical), the reactive nature of the products forme

279 Free radical theory of aging hypothesizes that oxygen-de

280 greatly increases the local concentration of free radicals, thereby strongly influencing particle gro

281 ted with thiol-functionalized nanogels via a free radical thiol-ene reaction.

282 Since free-radical thiol-ene polymerization is not inhibited b

283 substituted alkene with a hindered secondary free radical to form a bond and quaternary center adjace

284 alogue, is employed to probe the addition of free radicals to the P=C bond of a phosphaalkene.

285 introduced by site-directed mutagenesis) as free-radical trapping 'tags' for downstream modification

286 In ferroptosis, iron-mediated free radicals trigger lipid peroxidation under condition

287 om stabilization of the intermediate allylic free radical two sites for oxidative product formation a

288 days is equivalent to decades of exposure to free radicals under physiological conditions.

289 quercetin itself, able to deactivate various free radicals, under different biological conditions.

290 with two pendant, chiral nitronyl nitroxide free radical units.

291 e free radical precursor generates a nascent free radical upon collisional activation and thus simult

292 d glycation endproducts (AGEs) together with free radicals via autoxidation of glucose and Amadori pr

293 udied cinnamic acid derivatives may scavenge free radicals via double processes by involvement of cat

294 The oxidations generated by these free radicals were estimated on myofibrils prepared from

295 Stable organic free radicals were observed in the N2 system with g fact

296 metal-hydride species to an alkene to form a free radical, which is responsible for subsequent bond f

297 s and/or insufficient ability for scavenging free radicals, which could contribute to PD pathogenesis

298 tween Fe(2+) and H(2) O(2) generating active free radicals, which likely cause degradation of the cat

299 Nitric oxide () is a free radical with a wide range of biological effects, bu

300 -invasively measures excessive production of free radicals without an exogenous contrast agent.