ライフサイエンスコーパス: frequenin

1 tic expression of the Ca(2+) binding protein frequenin.

2 cleotide exchange factor at 64C (RhoGEF64c), Frequenin 2 (Frq2), Prip, and CG1093 that are involved i

3 Frequenin, a Ca(2+)-binding protein, has previously been

4 ave examined the effect of overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase

5 Frequenin, also known as neuronal calcium sensor-1 (NCS-

6 The Drosophila protein frequenin and its mammalian homolog neuronal Ca2+ sensor

7 munohistochemical analysis demonstrates that frequenin and Kv4.2 channel proteins are coexpressed in

8 We conclude that frequenin, and by inference, phosphatidylinositol 4-kina

9 in expression, occluded by overexpression of frequenin, and is selective to N-type Ca(2+) channels.

10 determined that the differential effects of frequenin are mediated by means of the Kv4 N terminus.

11 proteins (e.g. recoverin, neurocalcins, and frequenin) are expressed at highest levels in excitable

12 n Pik1 is a hydrophobic alpha-helix and that frequenins bind to one side of this alpha-helix.

13 Frq1 belongs to the recoverin/frequenin branch of the EF-hand superfamily and regulate

14 Overexpression of frequenin did not affect postendocytic trafficking steps

15 ficity for Kv4 currents is suggested because frequenin does not modulate Kv1.4 or Kv3.4 currents.

16 frequenin in motoneurons, and inhibition of frequenin expression or activity prevents the synaptic a

17 Ca(2+) currents is blocked by inhibition of frequenin expression, occluded by overexpression of freq

18 onservation between Saccharomyces cerevisiae frequenin (Frq1) and human NCS-1 is also reflected at th

19 Yeast frequenin (Frq1), a small N-myristoylated EF-hand protei

20 Adenoviral-mediated overexpression of frequenin had no effect on early Golgi transport of memb

21 Frequenin has negligible effects on Kv4.1 current inacti

22 GDNF enhances the expression of frequenin in motoneurons, and inhibition of frequenin ex

23 at of Frq1 in S. cerevisiae and, hence, that frequenins in general may serve as regulators of certain

24 CS-1 (neuronal calcium sensor-1, also termed frequenin) in 3T3L1 adipocytes strongly inhibited insuli

25 Frequenin increases Kv4.2 current amplitudes (partly by

26 Here, we provide direct evidence that frequenin is a potent and specific modulator of Kv4 chan

27 provide strong support for the concept that frequenin may be an important Ca(2+)-sensitive regulator

28 Frequenin/NCS-1 has been shown to enhance exocytotic act

29 kly expressed in human PFs, whereas DPP6 and frequenin (neuronal calcium sensor-1) were enriched.

30 Frq1 (frequenin orthologue) also is essential for viability an

31 Endogenous frequenin was identified in these cells by polymerase ch

32 s severely inhibited in cells overexpressing frequenin, whereas basolateral delivery of the polymeric