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1 ted levels of the PFK-1 allosteric activator fructose 2,6-bisphosphate.
2 evented binding and allosteric activation by fructose 2,6-bisphosphate.
3 ence and presence of the allosteric effector fructose 2,6-bisphosphate.
4 ut is with both ATP and fructose-6-P or with fructose-2,6-bisphosphate.
5 bited the IGF-1-induced increase in cellular fructose-2,6-bisphosphate.
6 atase, catalyzes synthesis and hydrolysis of fructose 2, 6-bisphosphate.
7 tase, catalyzes synthesis and degradation of fructose 2, 6-bisphosphate.
8 ng reaction with the physiological substrate fructose-2, 6-bisphosphate.
9 rom; K(a) for Mg(2+), 0.34-0.76 mm; K(i) for fructose-2,6-bisphosphate, 0.11-0.61 microm; and IC(50)
10        Raising the cellular concentration of fructose-2,6-bisphosphate, a potent effector of the dire
11 FKFB3), the pro-glycolytic enzyme that forms fructose-2,6-bisphosphate, a powerful allosteric activat
12                                   Binding of fructose-2,6-bisphosphate also significantly increased t
13 ts glycolysis by reducing cellular levels of fructose-2,6-bisphosphate, an activator of glycolysis an
14                  By controlling the level of fructose-2,6-bisphosphate, an allosteric activator of th
15          4 6-fold decreases in Ki values for fructose 2,6-bisphosphate and 5-9-fold decreases in the
16                The two sites for activators, fructose 2,6-bisphosphate and AMP or ADP, have evolved f
17 dent and was enhanced by forced elevation of fructose 2,6-bisphosphate and by additional xylitol-deri
18 te, and that inhibition could be reversed by fructose 2,6-bisphosphate and cyclic AMP, a high-affinit
19 filled by the O2 phosphate of the substrate, fructose-2,6-bisphosphate, and subsequently, the phospho
20 e absent in FBPases of organisms that employ fructose 2,6-bisphosphate as a regulator.
21 inant human and zebra fish enzymes hydrolyze fructose-2,6-bisphosphate as well as fructose-1,6-bispho
22                                       [2-32P]Fructose 2,6-bisphosphate binding experiments also sugge
23                               Increasing the fructose-2,6-bisphosphate concentration over a 15-fold r
24 ux, consistent with the observed decrease in fructose-2,6-bisphosphate concentration.
25                         Also, the effects of fructose-2, 6-bisphosphate concentrations on fructose-1,
26 d) a normal ATP/ADP ratio, and (e) unchanged fructose 2,6 bisphosphate content.
27  apo and holo tetramers show that binding of fructose 2,6-bisphosphate cools the enzyme and reduces d
28 te and the Ki for the competitive inhibitor, fructose 2,6-bisphosphate, decreased by as much as 4- an
29 c flux is the relatively recently discovered fructose-2,6-bisphosphate (F-2,6-P2), an allosteric acti
30 iated L6 rat myotubes increased synthesis of fructose 2,6-bisphosphate (F2,6BP), a positive allosteri
31 FKFB3 and increased synthesis of its product fructose 2,6-bisphosphate (F2,6P2).
32 y, the levels of both PFKFB3 and its product fructose-2,6 bisphosphate (F2,6BP), an allosteric modula
33 tion of the allosteric glycolytic activator, fructose-2,6-bisphosphate (F2,6BP).
34 ) control glycolytic flux via their product, fructose-2,6-bisphosphate (F26BP), which activates 6-pho
35 l-product complexes of the Trp57 mutant with fructose 2,6-bisphosphate (F26P(2)) causes similar decre
36                              The addition of fructose 2,6-bisphosphate (F26P(2)) has no effect on the
37 rating amounts of the heterotropic activator fructose 2, 6-bisphosphate (F26P2) gives no change in th
38                                              Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric
39 ogenesis, being inhibited synergistically by fructose 2,6-bisphosphate (Fru-2,6-P(2)) and AMP.
40                  PFK-2 controls the level of fructose 2,6-bisphosphate (Fru-2,6-P(2)), an important r
41    Here we examine the physiological role of fructose 2,6-bisphosphate (Fru-2,6-P2 ) during photosynt
42 this study, we investigated (a) the roles of fructose 2,6-bisphosphate (Fru-2,6-P2) and ribose 1,5-bi
43 he generally accepted metabolic concept that fructose 2,6-bisphosphate (Fru-2,6-P2) inhibits gluconeo
44                                              Fructose 2,6-bisphosphate (fru-2,6-P2) is a signalling m
45                       The effects of AMP and fructose 2,6-bisphosphate (Fru-2,6-P2) on porcine fructo
46                                              Fructose 2,6-bisphosphate (Fru-2,6-P2) plays an importan
47 ase), catalyzes synthesis and degradation of fructose 2,6-bisphosphate (Fru-2,6-P2).
48                                       beta-D-Fructose-2,6-bisphosphate (Fru-2,6-P(2)) is an important
49 rease in its catalytic ability to synthesize fructose-2,6-bisphosphate (Fru-2,6-P(2)), the key glycol
50 f beta-D-fructose- 6-phosphate (Fru-6-P) and fructose-2,6-bisphosphate (Fru-2,6-P2) at distinct activ
51 is, we analyzed the effect of amino acids on fructose-2,6-bisphosphate (Fru-2,6-P2) metabolism.
52 roperties support the view that the level of fructose 2,6-bisphosphate in leaves is determined by the
53            The steady state concentration of fructose 2,6-bisphosphate in turn depends on the activit
54 e 6-phosphofructo-2-kinase and production of fructose 2,6-bisphosphate, in the hearts of mPDK1(-/-) m
55         The Ki for the competitive inhibitor fructose 2,6-bisphosphate increased 3- and 5-fold in Arg
56                                 The K(i) for fructose 2,6-bisphosphate increases approximately 20- an
57 s a possible evolutionary predecessor to AMP/fructose 2,6-bisphosphate inhibition in mammalian FBPase
58                                              Fructose 2,6-bisphosphate is a powerful allosteric regul
59 A in the liver and demonstrate that elevated fructose 2,6-bisphosphate is essential for recruitment o
60 increased levels of the allosteric regulator fructose-2,6-bisphosphate, leading to increased glycolyt
61 se in hepatic fat oxidation, increased liver fructose 2,6-bisphosphate level, and reductions in lacta
62 crease in mRNA level over a 15-fold range in fructose-2,6-bisphosphate level.
63 e mRNA were unchanged by the manipulation of fructose-2,6-bisphosphate level.
64                     TIGAR expression lowered fructose-2,6-bisphosphate levels in cells, resulting in
65    Seven days after virus injection, hepatic fructose-2,6-bisphosphate levels increased significantly
66 rmal lung fibroblasts showed that iPFK-2 and fructose-2,6-bisphosphate levels increased specifically
67 ucokinase mRNA and protein levels as well as fructose-2,6-bisphosphate levels were increased in aLivG
68 ficient of 2), synergistic with both AMP and fructose 2,6-bisphosphate, noncompetitive with respect t
69 y identified mechanism whereby the levels of fructose 2,6-bisphosphate promote mitochondrial PDK4 lev
70 ve identified the origins of the citrate and fructose 2,6-bisphosphate sites.
71 lycolysis in adipocytes via the synthesis of fructose-2,6-bisphosphate that was significantly downreg
72 -2), regulator of the glycolysis-stimulating fructose-2,6-bisphosphate, was among human HeLa cell pro
73 Km for fructose 1,6-bisphosphate, and Ki for fructose 2,6-bisphosphate were comparable for the mutant
74 lites, such as fructose 1,6-bisphosphate and fructose 2,6-bisphosphate, which are known allosteric ac
75              Pfk2 catalyzes the synthesis of fructose-2,6-bisphosphate, which acts as a potent allost
76 element in its mRNA and functions to produce fructose-2,6-bisphosphate, which is a powerful allosteri
77 iation constants of fructose-6-phosphate and fructose-2,6-bisphosphate, which were 29 +/- 3 and 2.1 +
78 t was counteracted by selective depletion of fructose 2,6-bisphosphate with a bisphosphatase-active k