ライフサイエンスコーパス: fucosylation

1 human alpha-1-acid-glycoprotein (for antenna fucosylation).

2 nnose residues and a Glc-Fuc disaccharide (O-fucosylation).

3 R5 proteolysis is promoted by SPY-mediated O-fucosylation.

4 ylation while its absence signifies antennae fucosylation.

5 ly leads to ambiguous assignment of N-glycan fucosylation.

6 he only linkage found in human N-glycan core fucosylation.

7 factor 1-alpha (HNF1A) as a key regulator of fucosylation.

8 unrecognized general defect in N-glycan core fucosylation.

9 ing Fcgamma receptor, independent of Fc core-fucosylation.

10 is, rather than differences in levels of XyG fucosylation.

11 ha(1,3)fucosyltransferase FucT-VII-dependent fucosylation.

12 carbohydrate core-2 branching or alpha(1,3)-fucosylation.

13 ligosaccharides, as well as a high degree of fucosylation.

14 are triantennary and trisialylated with core fucosylation.

15 redominantly influenced by Ag density and Ab fucosylation.

16 FcgammaR-blocking cytophilic Abs, and 5) Ab fucosylation.

17 iates, which was followed by stereoselective fucosylation.

18 on ADCC was dependent on the status of core fucosylation.

19 ralog of host OGT, is required for nuclear O-fucosylation.

20 -glycan is essential for FUT8-catalyzed core fucosylation.

21 enzyme, significantly increased Treg surface fucosylation (66% vs 8%).

22 modification of Notch receptors by O-linked fucosylation, a reaction that is catalyzed by protein O-

23 se of sialylation alpha2-6, poly-LacNAc, and fucosylation, all known epitopes found in different tumo

24 escence (0-9 years) the levels of alpha(1-3)-fucosylation, alpha(2-3)-sialylation, and galactose sulf

25 osylation, suggesting that the level of core fucosylation also depends on the nature of the recombina

26 g the Lewis[x] determinant), alpha(1,6)-core fucosylation and a bisecting GlcNAc residue.

27 w for quantitative site-specific analysis of fucosylation and apply it to a comparison of hemopexin (

28 A pre-requisite for both core alpha1,6-fucosylation and beta1,4-galactosylation is the presence

29 a-galactose and are more diverse with higher fucosylation and better interaction with DC-SIGN [DC-spe

30 t human glycoprotein to determine changes in fucosylation and changes in sialylation that were in ver

31 35c1 overexpression causes elevated N-linked fucosylation and disrupts embryonic patterning in a tran

32 nique will allow dynamic imaging of cellular fucosylation and facilitate studies of fucosylated glyco

33 alyses showed that the IgG-Fc glycoform with fucosylation and fully galactosylation was an independen

34 During maturation (9-18 years) the levels of fucosylation and galactose sulfation continue to increas

35 in primary rat hepatocytes can increase core fucosylation and induce additional glycoform alterations

36 Secretion of ADAMTS17 requires O-fucosylation and its autocatalytic activity does not dep

37 o modification of host glycans by increasing fucosylation and mannose content, while decreasing sialy

38 Notch activity is regulated by both O-fucosylation and O-glucosylation, and Notch receptors co

39 Amounts of core fucosylation and of triantennary glycans increased subst

40 of antibodies with different combinations of fucosylation and sialylation and performed side-by-side

41 hypoxia also results in increased levels of fucosylation and sialylation.

42 axy8 exhibits increased XyG fucosylation and the occurrence of XyG fragments not pre

43 us to identify the SmFucTs involved in core fucosylation and the synthesis of complex antennary glyc

44 transporter, slc35c1 that promotes terminal fucosylation and thereby limits Wnt activity.

45 of GSP-6' and GSP-6" to P-selectin required fucosylation and, to a lesser extent, sialylation as wel

46 triantennary GlcNAc branching, and alpha1,6-fucosylation) and augmented by Asn(347) NeuAc-type sialy

47 h is here validated with human IgG (for core fucosylation) and human alpha-1-acid-glycoprotein (for a

48 the sequences with terminal sialylation and fucosylation, and addition of LacNAc repeat structures.

49 Commensal bacteria induce epithelial fucosylation, and epithelial fucose is used as a dietary

50 s of bi- and triantennary, core and terminal fucosylation, and mono- to trisialylation.

51 selectin ligand expression, general cellular fucosylation, and normal postnatal physiology is achieve

52 ith respect to the extent of branching, core fucosylation, and the abundance of poly-N-acetyllactosam

53 a virtually complete deficiency of cellular fucosylation, and variable frequency of intrauterine dem

54 Thus, rapid IEC fucosylation appears to be a protective mechanism that u

55 ng defects associated with enhanced N-linked fucosylation are due to diminished canonical Wnt signali

56 rotein sialylation and alpha-1,6-linked core fucosylation are observed following activation of the be

57 As increases in sialylation and fucosylation are prominent among cancer-associated modif

58 ms that regulate the induction of epithelial fucosylation are unknown.

59 last menstrual period, indicating more core fucosylation as well as possible changes in branching of

60 ransporter (NST2) resulted in loss of MIC2 O-fucosylation, as detected by an antibody against the Glc

61 lectin: (i) those having a single alpha1-->3 fucosylation at internal GlcNAcs but not at the penultim

62 cNAc and (ii) those having double alpha1-->3 fucosylation at internal GlcNAcs, excluding the penultim

63 plantation mouse embryo, as well as alpha1,3-fucosylation at multiple internal GlcNAc of unbranched p

64 rms at the N187 site of HPX, absence of core fucosylation at N882 and N911 sites of CFH, or a higher

65 ort here a detailed study of the effect of O-fucosylation at Ser-60 on the structure of FVII EGF-1, i

66 ng of complex-type N-linked glycans +/- core fucosylation but does not process oligomannose- or hybri

67 In addition, the alpha1-3,-4 fucosylation, but not the terminal sialylation, assists

68 have evolved for the inhibition of in vitro fucosylation, but they are not applicable for in vivo us

69 (r) Fucosylation by alpha 1,2-L-FT of the galactosyl residue

70 SGL-1, including sialylation, sulfation, and fucosylation by alpha 1,3-fucosyltransferase(s) (FucT),

71 We unravel the mechanistic basis for fucosylation by AtFUT1 with a multipronged approach invo

72 abilized mucins post translationally through fucosylation by FUT8, as the knockdown of FUT8 resulted

73 acceptor substrate could facilitate the core fucosylation by FUT8.

74 f which contain the consensus sequence for O-fucosylation by protein O-fucosyltransferase 2 (POFUT2).

75 -Fuc are important for tachyzoite fitness, O-fucosylation by TgSPY is not essential.

76 The importance of core fucosylation can be seen in the complex pathological phe

77 eins, demonstrating that complex patterns of fucosylation can modulate glycan recognition.

78 Notch receptors are modified by O-fucosylation catalyzed by protein O-fucosyltransferase 1

79 In vivo, two B mAb-Ds with 77-81% fucosylation cleared red cells and prevented D-immunisat

80 ADAMTS9 showed that 9 of 12 TSRs with the O-fucosylation consensus sequence carried the Glucosebeta1

81 We investigated whether a lack of fucosylation consequent to loss of GDP-fucose synthesis

82 inner olfactory nerve layer, suggesting that fucosylation contributes to OB development.

83 In addition, the degree of anti-HPA-1a fucosylation correlated positively with the neonatal pla

84 nterfere with selectin-mediated recognition, fucosylation could negatively regulate siglec binding.

85 s, yielded a human cDNA that complements the fucosylation defect in the Lec13 cell line.

86 gnaling during development, and shows milder fucosylation defects than those observed in mice unable

87 We studied a mouse model of fucosylation deficiency (Fx-/- mice) and mice with the f

88 Fucosylation deficiency altered the composition of the f

89 onsequent to a molecular mechanism driven by fucosylation deficiency and/or HES1-loss.

90 In mice, fucosylation deficiency leads to colitis and adenocarcin

91 We show that fucosylation-deficient Lec13 Chinese hamster ovary cells

92 By contrast, fucosylation-deficient myeloid progenitors are insensiti

93 matopoietic stem cells deficient in cellular fucosylation display decreased frequency and defective r

94 n of three other highly conserved sites of O-fucosylation does not have detectable effects.

95 In the absence of fucosylation, dysplasia appeared and progressed to adeno

96 Glycoprotein fucosylation enables fringe-dependent modulation of sign

97 sylation in FX(-/-) mice identifies cellular fucosylation events as essential concomitants to fertili

98 We found that core fucosylation exerted a significant adverse effect on Fcg

99 The results of enforced fucosylation for 22 patients enrolled in the trial were

100 Consistent with very low endogenous fucosylation, forced fucosylation of intact WEHI-3 cells

101 ised by the presence of outer-arm alpha(1,3)-fucosylation (forming the Lewis[x] determinant), alpha(1

102 ation (FUT8) and downregulation of alpha-1,2 fucosylation (FUT1, FUT2) were identified as features of

103 Upregulation of core fucosylation (FUT8) and downregulation of alpha-1,2 fuco

104 of two enzymes involved in alpha-1,6 linked fucosylation, GDP-mannose 4, 6-dehydratase (Gmds) and to

105 High fucosylation (>89%) of mouse-human heterohybridoma (HH)

106 , the presence of a bisecting GlcNAc or core-fucosylation had little effect on the affinity of Fc to

107 Elevated core fucosylation has also been identified in several human c

108 nositol (GPI) anchors and N-glycosylation, O-fucosylation has been recently reported in key sporozoit

109 Enhanced fucosylation has been suggested as a marker for serologi

110 Fucosylation has profound effects on the expression and

111 G1 monoclonal antibodies with reduced glycan fucosylation have been shown to improve antibody-depende

112 While sialylation and fucosylation have predominated the focus of cancer-assoc

113 AT5) and a known regulator of plasma protein fucosylation (HNF1A).

114 To study how changes in fucosylation impact embryonic development, we up-regulat

115 w Fc structures arising from sialylation and fucosylation impact immunity, focusing on responses to v

116 Core fucosylation impacted L1CAM cleavage and the ability of

117 The mur2 mutation eliminates xyloglucan fucosylation in all major plant organs, indicating that

118 911 sites of CFH, or a higher degree of core fucosylation in CFH compared to HPX, but we did not iden

119 t a valuable tool for studying the role of O-fucosylation in ECM synthesis and remodeling, and will b

120 on hypotheses regarding roles of xyloglucan fucosylation in facilitating xyloglucan-cellulose intera

121 Conditional control of fucosylation in FX(-/-) mice identifies cellular fucosyl

122 l for rapid recognition of antenna from core fucosylation in glycans detected with low abundances.

123 m, via O-GlcNAcylation in mammals, but via O-fucosylation in higher plants.

124 nables systematic imaging of sialylation and fucosylation in live zebrafish embryos at distinct devel

125 A pilot study of fucosylation in liver cirrhosis of the HCV and NASH etio

126 nterparts, revealed a consistent increase in fucosylation in liver disease with significant site- and

127 (FUT8), the only enzyme catalyzing alpha1,6-fucosylation in mammals, has been observed in several ma

128 ed intestinal epithelial Fut2 expression and fucosylation in mice.

129 novel and broad role of l-fucose and protein fucosylation in plant immunity.

130 offer new insight into the role of alpha1,3 fucosylation in prostate cancer development.

131 ne a critical role for N-glycosylation and O-fucosylation in the biosynthesis of punctin-1.

132 vitro and identifies a requirement for Notch fucosylation in the expression of Notch ligand binding a

133 ew insights into the mechanism of xyloglucan fucosylation in the Golgi.

134 can be identified by the concentration of 2'-fucosylation in their milk.

135 ich we show are both substrates for N-linked fucosylation in zebrafish embryos.

136 h respect to sialylation, mannosylation, and fucosylation, in normal, pancreatitis, and cancer sera.

137 The target fucosylation inhibitor (1) was synthesized from readily

138 nd feasibility of a novel strategy, enforced fucosylation, intended to improve engraftment after dono

139 Fucosylation is a common modification, and its site in g

140 O-fucosylation is a common posttranslational modification

141 Furthermore, these results suggest O-fucosylation is a mechanism by which proteins involved i

142 he enzymes (fucosyltransferases) involved in fucosylation is a recurrent theme in modern glycoscience

143 Fucosylation is an important feature of protein N-glycos

144 Here we show that increased core fucosylation is associated with de-differentiation of pr

145 In particular, the level of core-fucosylation is critical to several Fc mediated biologic

146 O-Fucosylation is essential for receptor function, and elo

147 d CR/Nodal signaling assays, indicating that fucosylation is functionally important for CR to facilit

148 Together these findings indicate that O-fucosylation is functionally significant for secretion o

149 of N-glycans is reduced severely, protein O-fucosylation is generally unaffected.

150 Fucosylation is important for the function of many prote

151 O-Fucosylation is mediated by protein O-fucosyltransferase

152 Cell surface fucosylation is required for T3SS2-dependent killing, an

153 dition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an alpha-1,6-fucosyltransf

154 hich are conditionally deficient in cellular fucosylation, is consequent to loss of Notch-dependent s

155 Both fucosylation isoforms of sPSGL-1 bound to sP-selectin.

156 Disruption of intestinal fucosylation led to increased susceptibility to infectio

157 t studies have described changes in the core-fucosylation level of PSA between PCa patients and healt

158 dhesion and spreading in vitro, as well as N-fucosylation level of the endometrium in pregnant mice.

159 ion of IgG1 monoclonal antibodies with lower fucosylation levels and thus improve the ADCC of these p

160 increased alpha1,2-, alpha1,3- and alpha1,6-fucosylation levels by up-regulating N-fucosyltransferas

161 on like anti-D Ig (>60%) together with lower fucosylation (<60%) as safe features of mAb-Ds for media

162 he amino acids responsible for site-specific fucosylation map near the GDP-fucose-binding site.

163 broad perspective, these data suggest that O-fucosylation may be a widespread post-translational modi

164 t transfusion), indicating that the level of fucosylation may be antigen dependent and/or related to

165 he rs78060698 variant, through regulation of fucosylation may control intestinal host-microbial inter

166 Co-administration with MSCs or ex vivo fucosylation may enhance utility of CD34(+) cells in cel

167 ads us to propose an atypical water-mediated fucosylation mechanism facilitated by an H-bonded networ

168 Rat YB2/0 mAb-Ds with <50% fucosylation mediated more efficient ADCC and clearance

169 Notch activity can be modulated by O-fucosylation (mediated by protein O-fucosyltransferase-1

170 The molecular mechanism, however, by which fucosylation mediates these processes remains largely el

171 ce and highlights the specific importance of fucosylation, most likely through its effect on the abil

172 the glycopeptide from normal SKP1 and from a fucosylation mutant, followed by matrix-assisted laser d

173 the extracellular domain of the receptor: O-fucosylation, O-glucosylation, and O-GlcNAcylation.

174 he quantification of the outer arm and total fucosylation of 12 fucosylated glycoforms of 9 glycopept

175 The fucosylation of a Notch1 EGF repeat fragment that occurs

176 nduced Notch signaling were reduced, and the fucosylation of a Notch1 fragment was also decreased.

177 wis x (17) was synthesized via the enzymatic fucosylation of a precursor displayed in the plate.

178 We found markedly decreased levels of core fucosylation of anti-HPA-1a-specific IgG1 from FNAIT pat

179 mucin core 2 can proceed even after alpha1,3 fucosylation of beta1,6-linked LacNAc.

180 We found that inadequate alpha1-3 fucosylation of CB CD34(+) cells, particularly CD34(+)CD

181 These observations suggest that alpha1-3 fucosylation of CB cells might be a simple and effective

182 this defect appears related to low levels of fucosylation of cell surface molecules that are responsi

183 Inhibition of fucosylation of cell wall polysaccharides also affected

184 us, inhibition of Notch-Serrate binding by O-fucosylation of EGF12 might be needed in certain context

185 ven orally to mice, 2-fluorofucose inhibited fucosylation of endogenously produced antibodies, tumor

186 l step of Lex biosynthesis is the alpha(1,3)-fucosylation of GlcNAc in a terminal Galbeta(1-->4)GlcNA

187 (d) On C-3 or C-4 fucosylation of GlcNAc, both types 1 and 2 lost activity

188 The fucosylation of glycans leads to diverse structures and

189 ification is needed to confirm that enhanced fucosylation of HPX and CFH may serve as an indicator of

190 Core fucosylation of IgG is a "safety switch" reducing ADCC,

191 Nevertheless, forced fucosylation of intact cells did not significantly augme

192 -fucosynthase and fucoligase for direct core fucosylation of intact N-glycoproteins.

193 ith very low endogenous fucosylation, forced fucosylation of intact WEHI-3 cells or murine neutrophil

194 itionally, alpha1,2-, alpha1,3- and alpha1,6-fucosylation of integrin alphaVbeta3, a critical endomet

195 Fucosylation of intestinal epithelial cells, catalyzed b

196 rements requires sulfation, sialylation, and fucosylation of ligands.

197 istently associated with increased outer arm fucosylation of majority of the analyzed proteins.

198 These findings support ex vivo fucosylation of multipotent CD34(+) CB cells as a clinic

199 fucosyltransferase (FUT8) catalyzes the core fucosylation of N-glycans in the biosynthesis of glycopr

200 nt roles in directing the branching and core fucosylation of N-glycans in vivo.

201 Ic patients suggested that although terminal fucosylation of N-glycans is reduced severely, protein O

202 NAc2, suggesting that FUT8 can catalyze core fucosylation of N-glycans lacking an alpha1,3-arm GlcNAc

203 first report of in vitro FUT8-catalyzed core fucosylation of N-glycans lacking the alpha1,3-arm GlcNA

204 The core fucosylation of N-glycans on glycoproteins is catalyzed

205 Core fucosylation of N-glycoproteins plays a crucial role in

206 es of the young (MODY) would display altered fucosylation of N-linked glycans on plasma proteins and

207 Core fucosylation of N-linked oligosaccharides (GlcNAcbeta1,

208 in humans, requires sialylation and alpha1,3-fucosylation of neutrophils.

209 ose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch

210 art through processes controlled by O-linked fucosylation of Notch receptors.

211 the catalytic domain of SPY abolishes the O-fucosylation of PRR5.

212 fects and mechanisms accounting for impaired fucosylation of selectin ligands and defective selectin

213 density, although a marked elevation in the fucosylation of Ser-linked glycans compared with Thr-lin

214 ceptor (TLR) ligands causes rapid alpha(1,2)-fucosylation of small intestine epithelial cells (IECs)

215 The results show that the outer arm fucosylation of the A2G2F1 glycoform of the VDKDLQSLEDIL

216 Previous studies suggest that O-fucosylation of the epidermal growth factor-like (EGF) r

217 Fucosylation of the innermost GlcNAc of N-glycans by fuc

218 The in vitro fucosylation of the nonglycosylated FVII EGF-1 was achie

219 This phenomenon is linked to changes in the fucosylation of the O chain, which was concomitant with

220 Fucosylation of the polylactosamine sequences on complex

221 Whereas in the double mutant core alpha1,3-fucosylation of the proximal N-acetylglucosamine was abo

222 Fucosylation of the resulting compounds by a recombinant

223 ls revealed that galactosylation rather than fucosylation of the side chains is essential for mainten

224 ned to stipules and pollen grains leading to fucosylation of the walls of these cell types in the mur

225 3 and G817R in TSR6), and S641L eliminated O-fucosylation of TSR3.

226 These results, indicating that O-fucosylation of TSRs is required for efficient processin

227 fut2 gene-trap lines, we demonstrated that O-fucosylation of TSRs was essential for restricting epith

228 charides and glycoproteins demonstrated that fucosylation of xyloglucans and of N-linked glycans is f

229 In view of the influence of outer-arm fucosylation on carbohydrate recognition processes in ge

230 e split mutation introduced a new site for O-fucosylation on EGF repeat 14 of the Notch extracellular

231 FNG to inhibit JAG1-NOTCH2 activation, and O-fucosylation on EGF9 was important for trafficking of bo

232 However, sites of O-fucosylation on Notch that influence Notch activation ha

233 Corroborating the inhibitory role of fucosylation on receptor recognition, adhesion of the me

234 Previously, O-fucosylation on Ser or Thr mediated by the endoplasmic r

235 s with this mutation are caused by loss of O-fucosylation on TSR3 and impaired ADAMTSL2 secretion.

236 Either alpha1,3 fucosylation or 6-O-sulfation of the GlcNAc moiety reduc

237 We investigated whether O-fucosylation or Fringe-mediated elongation of O-fucose o

238 lass, presentation, opsonization density, Fc fucosylation, or mutation.

239 The high degree of sulfation and fucosylation parallels the modifications observed previo

240 oteins with O-fucose; here we describe the O-fucosylation pathway in the nucleocytosol of a eukaryote

241 To elucidate the GnT I-independent core fucosylation pathway, we generated a stable HEK293S GnT

242 e responsible for the GnT I-independent core fucosylation pathway.

243 , implicating a clear GnT I-independent core fucosylation pathway.

244 Furthermore, the fucosylation pattern of PSGL-1 can affect its affinity f

245 In the context of a wild-type fucosylation phenotype, we find that the Notch ligands s

246 om several laboratories has indicated that O-fucosylation plays an important role in ligand mediated

247 dependent killing, and genetic inhibition of fucosylation prevents membrane insertion of the T3SS2 tr

248 ntly builds on our understanding of the core fucosylation process.

249 rences are responsible for the site-specific fucosylation properties of each enzyme.

250 studies demonstrated that the site-specific fucosylation properties of these enzymes could be revers

251 ese two enzymes have distinct "site-specific fucosylation" properties.

252 GDP-fucose (GDP-Fuc), the precursor for all fucosylation reactions, in the blood stages of Plasmodiu

253 that the metabolite may be used for further fucosylation reactions.

254 o prepare activated L-fucose derivatives for fucosylation reactions.

255 We also observed that core fucosylation reduced the activity of GnT-IV toward the b

256 receptivity, as well as the regulation of N-fucosylation remains unclear.

257 and, commensurately, cell surface alpha(1,3)-fucosylation reveals that acceptor sialyllactosaminyl gl

258 with bisecting GlcNAc, sialic acid, and core fucosylation showed significant differences in HCC serum

259 In contrast, in the absence of fucosylation, sialylation did not adversely impact ADCC.

260 ular weight of the chains, and the levels of fucosylation, sialylation, and sulfation remain fairly c

261 Sialylation in the context of core fucosylation significantly decreased ADCC in a cell-base

262 For example, core fucosylation significantly decreases antibody-dependent

263 This O-fucosylation site did not meet the proposed consensus se

264 Unexpectedly, one additional O-fucosylation site was found in the disintegrin domain.

265 -like domain and the presence of a consensus fucosylation site within all EGF-CFC family members sugg

266 osylated form even for the residues near the fucosylation site.

267 cFuc disaccharide at high stoichiometry at O-fucosylation sites and variable mannose stoichiometry at

268 We identified 7 O-fucosylation sites in the thrombospondin (TSP) type 1 re

269 ating that arabinosyl residues represent the fucosylation sites on these molecules.

270 ons occur within the TSRs and two lie near O-fucosylation sites.

271 has been successfully employed for assigning fucosylation, such strategies are often too cumbersome,

272 eceptor led to approximately 30% and 3% core fucosylation, suggesting that the level of core fucosyla

273 s in HA specificity, such as preferences for fucosylation, sulfation and sialylation at positions 2 (

274 hD) and platelet Ags frequently have reduced fucosylation that enhances their pathogenicity.

275 ,6-Trifluorofucose (1) is a new inhibitor of fucosylation that has been demonstrated to allow the pre

276 in mice conditionally deficient in cellular fucosylation that is attributable to a loss of Notch-dep

277 The relevance of gut fucosylation to human diseases also is discussed.

278 ycans, sialylation (mono-, di-, and tetra-), fucosylation (tri-, core, and outer arm), and galactosyl

279 application toward the rapid verification of fucosylation types in a therapeutic protein (Rituximab).

280 Thus, the fucosylations unveil a proliferation-dependent switch in

281 was efficient in detection of N-glycan core fucosylation using lectin blotting and lectin ELISA assa

282 lines (B) was similar to anti-D Ig although fucosylation varied, affecting ADCC activity.

283 dition of fucose to the diet, which restored fucosylation via a salvage pathway.

284 that IL-22RA1 signaling promotes intestinal fucosylation via induction of the fucosyltransferase Fut

285 ryonic development, we up-regulated N-linked fucosylation via over-expression of a key GDP-Fucose tra

286 This increase in core fucosylation was associated with increased levels of two

287 ther enzyme) demonstrated that site-specific fucosylation was defined within a 40-amino acid segment

288 Unexpectedly, only small amounts of terminal fucosylation was found in diantennary complex-type N-gly

289 To test the functional consequences of Ab fucosylation, we produced V-gene-matched recombinant ant

290 ecifically, whereas alpha2,6-sialylation and fucosylation were not.

291 st to the FNAIT patients, no changes in core fucosylation were observed for anti-HLA antibodies in re

292 , including N-glycosylation, sialylation and fucosylation, were observed between early and late time

293 n a receptive endometrium by up-regulating N-fucosylation, which is a potential useful biomarker to e

294 these FX-deficient cells exhibited defective fucosylation, which is required for Notch signaling.

295 fucosylated N-glycans rapidly verifies core fucosylation while its absence signifies antennae fucosy

296 iabetic CD34(+) cells manipulated by ex vivo fucosylation with ASC-101.

297 ne example of which being the association of fucosylation with mesenchymal subtype.

298 be achieved on human CAR T-cells by surface fucosylation, with resultant robust E-selectin binding u

299 937 lymphoma cells, the glycosides decreased fucosylation without affecting sialylation.

300 tions to GlyCAM-1, together with appropriate fucosylation, yields enhanced rolling ligands for both p