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3 resent high-resolution cryo-EM structures of full-length 5-HT(3A)R in complex with palonosetron, onda
5 d for reactivity to two types of antibodies, full-length 7S IgY and 5.7S IgY, which has a truncated F
6 eceptor gene, in enhancing expression of the full-length 7TM mMOR-1 through a chaperone-like function
10 rillizing Abeta (1-30) peptide recapitulates full-length Abeta stereoselective cellular uptake, allow
13 main dimerization interface in all variants, full-length AfGcHK variants bearing the Y15A or Y15G sub
18 cases revealed increased phosphorylation of full-length amyloid precursor protein and its associated
20 Our results provide the first glimpse of a full-length and functional BAX(O), revealing structural
21 ng by evaluating the taxonomic resolution of full-length and mini-barcodes and to determine a thresho
23 se 1 (TBK1), that efficiently phosphorylates full-length and N-terminal HTT fragments in vitro (at S1
24 dentification to analyze the interactomes of full-length and truncated forms of RAG1 in pre-B cells.
27 ar multipole moments and charge asymmetry of full-length antibodies instead of only localized charges
28 ple preparation procedure applicable to both full-length antibody therapeutics and antibody-antigen c
31 d toward the local Wnt cue in CRC cells with full-length APC, but not if APC was truncated or deplete
32 neration of sAPPbeta and increased levels of full-length APP (flAPP), indicative of reduced processin
34 fold higher affinity (30 nM) compared to the full-length aptamer (124 nM), with a limit of detection
36 o ARSi and genetic chances and expression of full length AR (AR-FL) vs. AR-V7 were evaluated in a ser
38 tably, the humanized mice expressed both the full-length AS3MT that catalyzes iAs methylation and the
42 t when expressed alone in HEK293F cells, the full-length beta3-subunit forms trimers in the plasma me
43 e variant-gene-disease associations from the full-length biomedical literature and designs an evidenc
44 erage (88-99%) in the HDX-MS experiments for full-length BM3 and its component domains in both the li
50 uncover a range of conformational effects in full-length BTK induced by a panel of active site inhibi
51 g the compact autoinhibitory conformation of full-length BTK, shifting the conformational ensemble aw
52 f p73 alternative splicing and show that the full-length C terminus of p73 is essential for hippocamp
54 e five exon 5-associated seven transmembrane full-length carboxyl terminal variants, MOR-1B1, MOR-1B2
60 tical role of this motif in the context of a full-length channel chimera, Nav1.9-Ct49aa(Nav1.7), whic
67 of domain-based contact prediction with the full-length contact prediction improved the performance
71 microscopy structure of CsgG in complex with full-length CsgF shows that the 33 N-terminal residues o
72 e kinase (CKB) bound to ASB9-ELOB/C, and for full-length CUL5 bound to the RING protein, RBX2, which
74 overy of the geometry of the complex between full-length CXCR4, a prototypical CXC receptor and drive
78 erentiation with TGF-beta and 1,25diOHvitD3, full-length Dicer became abundant together with varying
80 trophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in ske
82 by inhibiting the proteolytic processing of full-length Drosophila Ci or mammalian Gli proteins to n
91 ich targets only viral maturation, but lacks full-length Env and Gag immunogens, can prevent intravag
92 ociated urethritis; for a subset of samples, full-length env genes were generated for sequence analys
94 o substantiate this finding, we analyzed the full-length FERM domain and a series of truncated FERM c
95 tics of fibronectin fragment FNIII(8-14) and full-length fibronectin (FN) on CH(3)-, OH-, COOH-, and
97 erization of split pairs of FRB or FKBP with full-length FKBP or FRB, respectively, by rapamycin.
100 ing to classify because the minimal level of full-length (FL) transcripts required for normal functio
101 Despite that, the actin-bundling site in the full-length (FL) villin protein remains unidentified.
102 ransfection, we show increased levels of the full-length GAA transcript, acid-alpha-glucosidase prote
105 specific T cell activity was observed in the full-length gB protein and mRNA-LNP groups, though not i
106 were administered 3 sequential doses of the full-length gB protein with an MF59-like squalene-based
108 -electron microscopy structures of the human full-length GB1-GB2 heterodimer: one structure of its in
113 Here, we present Cryo-EM structures of the full-length GlyR protein complex reconstituted into lipi
114 lar dynamics simulations of fusion between a full-length hemagglutinin proteoliposome and a lipid bil
117 constructed from the various segments of the full-length hIAPP peptide; however, only a few have thei
121 letely prevents in vitro phase separation of full-length hnRNPA2 and aggregation of the disease-assoc
122 LINE-1s, as well as increased expression of full-length hominid-specific LINE-1s that produce bidire
124 ufficient to cause inclusion formation since full-length HTT and HTTex1 with expanded polyQ are both
125 with expanded polyQ are both toxic although full-length HTT remains diffuse while HTTex1 forms inclu
127 e recombinant expression and purification of full-length human FMRP, FXR1P, and FXR2P from Escherichi
128 ution, peptide-free crystal structure of the full-length human GLP-1R in an inactive state, which rev
129 tions in vitro into phase-separated forms of full-length human hnRNPs (TDP-43, FUS, hnRNPA2) and thei
130 we compare the effects of expressing mutant full-length human HTT (fl-mHTT) to the effects of mutant
131 Here, we report a solution structure of the full-length human Orc6 (HsOrc6) alone and in a complex w
132 e, we developed a mouse model by inserting a full-length human PRSS1R122H gene, the most commonly mut
133 ity of KB105, a gene therapy vector encoding full-length human TGM1, to deliver functional human TGM1
136 220 OR open reading frames, 20 of which are full length, intact OR genes, and found a large ratio of
137 en made in understanding the architecture of full-length ion channels and the structural and biophysi
138 ic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the fun
139 that addresses both challenges for targeted full-length isoform sequencing applications using collec
142 overall efficiency of chitin degradation by full-length Jd1381 depended on its chitinase and LPMO ac
143 the distinct disease mutation which reshapes full-length kinase conformations, affecting their activi
144 rovides additional mechanistic insights into full-length kinase functions by reporting protein-protei
146 , and live-cell imaging, we demonstrate that full-length kindlins can oligomerize (self-associate) in
148 Here we report a crystal structure of the full-length LCI1 membrane protein to reveal LCI1 structu
150 However, direct evidence for RSPO-bound, full-length LGR5 interacting with these E3 ligases in wh
151 the target amplicons demonstrated that both full-length library (565 bp) and mini-barcodes (193 bp)
156 5)N-(15)N J-couplings of (15)N His37-labeled full length M2 (M2FL) protein from Influenza A virus emb
158 from > 19,000 protein-coding genes, abundant full-length, mature tRNAs and other structured small non
159 in the mitochondrial membrane, competes with full-length Mcl-1 protein with regards to its antiapopto
160 l1(DeltaIEC) mice); these mice and mice with full-length Mcl1 (controls) were raised under normal or
163 in Mecp2R294X mice was sufficient to elicit full-length MeCP2 protein expression in peripheral tissu
167 erization through disulfide formation of the full-length mini-protein and show the coiled-coil region
168 current anti-miRNA (antimiR) reagents target full length miRNAs, here we investigate novel nanopartic
171 Here we show that m(6)A can be mapped in full-length mRNAs transcriptome-wide and reveal the comb
181 re, we report the first crystal structure of full-length nsp10 from the arterivirus PRRSV, which has
182 s, Arg111His, Phe112Tyr, and Ala115Val (AgRP full-length numbering), were incorporated into the pepti
184 Taking advantage of long reads spanning the full length of mRNA transcripts, we provide support for
189 ur real time single molecule measurements of full length p53 tetramers binding DNA reveal the paramet
190 pressed UBQLN2 selectively lowered levels of full-length pathogenic HTT but not of HTT exon 1 fragmen
193 erization of a secreted, soluble, and stable full-length PfCSP (containing 4 NVDP and 38 NANP repeats
195 ded Gly-zipped TMD2/TMD2 dimer), and for the full-length pinholin protein before being triggered (Gly
202 mpact of PGRN mutations on the processing of full-length prosaposin to individual saposins, which are
204 s substrate and the crystal structure of the full-length protein at 1.85 angstrom resolution revealed
205 licing can increase endogenous expression of full-length protein by preventing naturally occurring no
206 ed glycans in the S1 subunit compared to the full-length protein could indicate differences in the gl
207 ical 2-dimensional (2D) crystal lattice, but full-length protein crystallizes multiple orders of magn
208 o its size and complexity, expression of the full-length protein has been difficult, leading to focus
209 relate the experimentally observed yield of full-length protein in the FPA assay to the force exerte
210 found that although the dimerization of the full-length protein is preserved via the kinase domain d
211 nts show that the inter-domain linker in the full-length protein promotes oligomerization and thus ma
213 which the arrested protein is converted into full-length protein with a Bell model of force-induced r
214 ion of three Pfs48/45 proteins including the full-length protein, the 6C domain fragment and the 6C d
215 -196 C1 PrP construct, in the absence of the full-length protein, were susceptible to Delta(Spont) pr
219 however, have largely focussed on refolding full-length proteins from artificially induced denatured
221 n NMR-based approach to monitor oxidation in full-length proteins under denaturing conditions, as dem
222 and on real datasets from droplet-based and full-length protocols, and show that it yields biologica
226 consisting of Rab5, RabGDI and a complex of full length Rabex5/Rabaptin5 was necessary to pattern Ra
227 has been resolved(16), the structure of the full-length receptor and its transmembrane signalling me
228 ocyte glycoprotein epitope MOG(35-55) or the full-length recombinant human MOG protein, the latter re
229 uorescence energy transfer assay against the full-length recombinant protein kinase PfCLK3, and 11 an
230 veloped and does not require strain-specific full-length reference antigens or antibodies; instead, s
236 , IgG, and IgM indirect ELISAs to detect the full-length S protein or S receptor-binding domain (S-RB
237 ith SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in >3.1 and >3.7 log(10)
238 reater than either IgM or IgA titers for S1, full-length S, and S-RBD in the overall population.
240 apped the in vivo RNA-RNA interactome of the full-length SARS-CoV-2 genome and subgenomic mRNAs.
241 2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1
242 dified mRNA (mRNA-LNP) vaccines encoding the full-length SARS-CoV-2 spike protein or the spike recept
247 re, using next-generation sequencing of near-full-length single HIV-1 genomes and corresponding chrom
248 and the final DNA boosters delivered a near-full-length SIVmac239 genome capable of assembling nonin
252 candidates from Novavax, which is based on a full-length spike protein formulated in polysorbate 80 d
254 accine that encodes the prefusion stabilized full-length spike protein of the severe acute respirator
256 which encodes a membrane-anchored SARS-CoV-2 full-length spike, stabilized in the prefusion conformat
263 re than half of the transcript isoforms lack full-length support and instead rely on inference from s
265 Here, we present a crystal structure of a full-length talin head in complex with the beta3-integri
267 cs to generate libraries of natively paired, full-length TCRalphabeta clones, from millions of primar
270 domain), formed upon proteolytic cleavage of full-length TDP-43 in the nucleus and subsequent transpo
271 cifically modulate the enzymatic activity of full-length TDP1 while not affecting the activity of a t
272 formed insoluble inclusions that sequestered full-length TDP43 via preserved N-terminal interactions.
273 an N-terminally truncated TET1 protein and a full-length Tet1 (Tet1(FL) ) transcript encoding canonic
274 338-nucleotide protein-free RNA structures: full-length Tetrahymena ribozyme, hc16 ligase with and w
276 e immunity, and determine the structure of a full-length TIR-STING fusion from the Pacific oyster Cra
280 rimental evidence showed both a reduction in full-length transcript levels and an increase in levels
281 ion of the silencing cassette results in the full-length transcript of 901 nucleotides containing a 2
284 in alternative transcript identification of full-length transcripts in short-read RNA-Seq data, whic
285 function tolerates substantial reduction in full-length transcripts, helping to determine the pathog
286 y 120-fold and annotate it using 6.5 million full-length transcripts, thus improving our understandin
289 yme, hc16 ligase with and without substrate, full-length Vibrio cholerae and Fusobacterium nucleatum
291 ere we studied the interactions of activated full-length vinculin with actin and the way it regulates
292 iral RNA after ART discontinuation with near full-length viral DNA from peripheral blood and lymph no
293 entally validated epitopes sequences on 3985 full-length viral genomes revealed 19 highly conserved e
294 r retroviruses, HIV-2 packages two copies of full-length viral RNA during virus assembly and efficien
295 y of Yorkie WW domains interactions with the full-length Warts PPXY domain, and numerous PPXY motif v
296 ans complementation of heterokaryons using a full-length wild-type allele of the CpRbp1 gene resulted
299 he cryo-electron microscopy structure of the full-length WzmWzt transporter from Aquifex aeolicus bou
300 his antiterminator activity may help produce full-length Xist RNA while rendering the Xist locus resi