ライフサイエンスコーパス: full-length protein

1 ore quantitative and structural studies with full length protein.

2 s of the kinase domain in the context of the full length protein.

3 tute the presumed biological function of the full-length protein.

4 and nuclear localization, compared with the full-length protein.

5 on, trimerization, and porin function by the full-length protein.

6 (NB2a) cells, as well as the structure of a full-length protein.

7 ubstrate proteins to a similar degree as the full-length protein.

8 counts for over half of the stability of the full-length protein.

9 gene that controls expression of soluble and full-length protein.

10 eutralizing properties in the order of CCL26 full-length protein.

11 al frameshift required for production of the full-length protein.

12 with substantially weaker affinity than the full-length protein.

13 than by altering the coding sequence of the full-length protein.

14 conditions should ideally be done using the full-length protein.

15 her substrates with the same affinity as the full-length protein.

16 omain that inhibits adhesion mediated by the full-length protein.

17 ng to derive distance constraints across the full-length protein.

18 thereby permitting expression of functional full-length protein.

19 red to be stable fragments of their original full-length protein.

20 wo short protein isoforms in addition to the full-length protein.

21 nctional, despite SCRC encoding a functional full-length protein.

22 n that has the same membrane topology as the full-length protein.

23 hin the conserved TNF-homology domain of the full-length protein.

24 regulatory functions similar to those of the full-length protein.

25 restrict the conformational landscape of the full-length protein.

26 mpanied by marked cytotoxicity, requires the full-length protein.

27 nts appear to be proteolytic products of the full-length protein.

28 ndividual transmembrane (TM) domains and the full-length protein.

29 K1 and NK1 were more stable than the native, full-length protein.

30 (or are likely to bind) the ligand within a full-length protein.

31 allosteric interaction studies that use the full-length protein.

32 port similar to that of cells expressing the full-length protein.

33 he stability and DNA binding affinity of the full-length protein.

34 spliced isoform of ACTN4 than it does in the full-length protein.

35 hagocytosis, which was not a property of the full-length protein.

36 gher enzymatic activity as compared with the full-length protein.

37 -angle X-ray scattering experiments with the full-length protein.

38 ated mass shifts consistent with that of the full-length protein.

39 i3 fragment that opposes the activity of the full-length protein.

40 he interactions of NmerA and the Core in the full-length protein.

41 y beta-catenin binding domain present in the full-length protein.

42 intractable to X-ray crystallography in the full-length protein.

43 ion by BAK in the membrane without using the full-length protein.

44 me rearrangements in the cytoskeleton as the full-length protein.

45 niquely to the structure and function of the full-length protein.

46 inding and redox properties exhibited by the full-length protein.

47 ctin with essentially the same properties as full-length protein.

48 esult from nuclear activity of overexpressed full-length protein.

49 ics of individual DBDs in the context of the full-length protein.

50 ability to stabilize both isolated NBD1 and full-length protein.

51 of titin truncation versus deficiency of the full-length protein.

52 ion of the affected gene and production of a full-length protein.

53 fication influences a disordered region of a full-length protein.

54 c ribosomal readthrough of PTCs to produce a full-length protein.

55 on may contribute to light activation of the full-length protein.

56 cal for GAG-dependent oligomerization of the full-length protein.

57 ion codon (PTC) and prevent the formation of full-length protein.

58 rmination at a PTC to restore synthesis of a full-length protein.

59 model for the regulation of activity in the full-length protein.

60 e to the lack of a complete structure of the full-length protein.

61 osphorylated and non-phosphorylated forms of full-length proteins.

62 lain altered properties of the corresponding full-length proteins.

63 the double mutant cycle data obtained on the full-length proteins.

64 es remained limited, as is the case for many full-length proteins.

65 egy that allows for mapping the interface of full-length proteins.

66 ally for high affinity association of intact full-length proteins.

67 ct the substrate selectivity of HDAC8 toward full-length proteins.

68 DPCs containing full-length proteins (11-28 kDa) or a 23-mer peptide blo

69 s using (15)N relaxation dispersion NMR: the full-length protein (6-stranded beta-sheet sandwiched be

70 g exon 8 (Traf3DE8) that, in contrast to the full-length protein, activates ncNFkappaB signaling.

71 Tetrameric full-length protein aggregated at similar rates and kine

72 1 RRM domain specifically binds poly(A), the full-length protein also binds poly(U).

73 NCX1 full-length protein and a 75-kDa NCX1 fragment along wit

74 forms of the transcription factor GATA1 (the full-length protein and a shorter form).

75 asma membrane and endosomes that exists as a full-length protein and a truncated form of Ctr1 lacking

76 tyricum, consisting of a complex between the full-length protein and an N-terminally truncated C-term

77 t subcellular distribution compared with the full-length protein and enhanced deISGylation activity i

78 r bacterial species that are targeted by the full-length protein and in addition was able to lyse som

79 ni were intrinsically disordered in both the full-length protein and its complex with a 20-residue sp

80 result in the final localization of both the full-length protein and its major Deltapsi-dependent cle

81 solution structure and activity of both the full-length protein and its Ntd-truncated mutant (RapADe

82 as they are likely less immunogenic than the full-length protein and more convenient to produce.

83 Zn(2+)/Cd(2+)-ATPase could be isolated as a full-length protein and the ATPase activity was increase

84 n overexpressed in HeLa cells, both the MST1 full-length protein and the MST1 kinase domain (MST1-NT)

85 m-exchange mass spectrometry analysis of the full-length protein and through SA-induced disruption of

86 conformational and kinetic behaviors of the full-length protein and, even in absence of the pilin do

87 ttering to obtain solution structures of the full-length proteins and a series of deletion mutants.

88 onnexin mutants were translated into stable, full-length proteins and assembled into GJs when express

89 Purified recombinant full-length proteins and kinase domain constructs differ

90 Sufu into the MEFs stabilizes Gli2 and Gli3 full-length proteins and rescues Gli3 processing.

91 However, 15% of LARPs were full-length proteins and we confirmed several candidates

92 mational sampling properties of the DNA-free full-length protein, and in particular about the bHLH do

93 n structure with the periplasmic part of the full-length protein, and is capable of binding substrate

94 (C5-C10) had effects similar to those of the full-length protein, and it bound actin more tightly tha

95 membrane conductance regulator mRNA, restore full-length protein, and reestablish functional chloride

96 ased levels of LXR-independent SREBP-2 mRNA, full-length protein, and SREBP-2 active cleavage product

97 1, which either replaces or coexist with the full-length protein, and that restoring of DBC1 is requi

98 rate selectivity in the context of peptides, full-length proteins, and protein-nucleic acid complexes

99 tches, relative sizes of binding patches and full-length proteins, and the exploration of obligate an

100 al of this technology is to employ peptides, full-length proteins, antibodies, and small molecules to

101 proteins; in addition, concentrations of the full-length protein are reduced in comparison to those i

102 Use of stable isotope-labeled full-length proteins as an internal standard prior to mu

103 s substrate and the crystal structure of the full-length protein at 1.85 angstrom resolution revealed

104 y we determined the crystal structure of the full-length protein at 2.05 A resolution.

105 t interact with the C-terminal domain in the full-length protein at pH 4.

106 ing natural messenger RNA (mRNA) into active full-length proteins at temperatures up to 65 degrees C

107 otein-level, where functions are assigned to full-length proteins based on overall similarities.

108 revealed that the mutant AR aggregates as a full-length protein, becoming proteolyzed to a smaller f

109 actin monomers but only weakly, whereas the full-length protein binds two actin monomers with high a

110 Mosaics and Con-S Envs expressed as full-length proteins bound well to a number of neutraliz

111 expressed HERV-K envelopes not only makes a full-length protein but also specifically interacts with

112 esterol increased levels of SREBP-1 mRNA and full-length protein but did not change levels of cleaved

113 ow that both Dnmt3L(s) and Dnmt3L(o) produce full-length proteins but that the Dnmt3L(at) transcripts

114 lize the fragment in a manner similar to the full-length protein, but some other fragments lacking th

115 d HrcA from chlamydiae, we only detected the full-length protein, but we found that endogenous HrcA h

116 EFs) can restore the levels of Gli2 and Gli3 full-length proteins, but not those of their repressors,

117 ome of the isolated MeCP2 domains and in the full-length protein by binding to DNA.

118 e stop codons resulting in the production of full-length protein by interfering with ribosomal proofr

119 licing can increase endogenous expression of full-length protein by preventing naturally occurring no

120 target is the ribosome and that it produces full-length protein by promoting insertion of near-cogna

121 A recognition and structural analysis of the full-length protein by X-ray crystallography and small a

122 foundation for understanding recognition of full-length proteins by HDACs.

123 antibiotics have been proposed for restoring full-length proteins by readthrough of PTC.

124 We find that full-length protein can still be made when stalling afte

125 which provided clusters of the interfaces of full-length protein chains as a means of identifying bio

126 These data suggest that the AR is toxic as a full-length protein, challenging the notion of polygluta

127 onstruction methods merely identified 21% of full-length protein-coding transcripts from H. sapiens.

128 ences in the lipid binding properties of the full-length protein compared to its PH domain.

129 ugh the P152Lp53 DBD alone bound to DNA, the full-length protein completely lacked binding ability at

130 53) impaired nucleation and fibril growth of full-length protein, confirming that these segments part

131 C1 domain alone (Kd = 8.2 +/- 1.1 nm for the full-length protein containing all four mutations), and

132 domains, originally selected from Pfam, and full-length proteins containing their homologous domains

133 ed glycans in the S1 subunit compared to the full-length protein could indicate differences in the gl

134 ical 2-dimensional (2D) crystal lattice, but full-length protein crystallizes multiple orders of magn

135 elements that lead to the production of the full-length protein, CsoS2B, and a truncated protein, Cs

136 Thus, in the context of the full-length protein, DeltaF508 mutation causes detectabl

137 the arrangements of the PCM subunits in the full-length protein dimer in solution differ significant

138 been no published structural studies on the full-length protein due to proteolysis of its C-terminal

139 0-aa sequence derived from SPARC that mimics full-length protein effects.

140 e unbiased discovery of interactions between full-length proteins encoded by a library of 'prey' ORFs

141 To answer these questions, we studied 16 full-length protein equivalents of pseudogenes.

142 chaperone activity comparable to that of the full-length protein, even when monomer dissociation is r

143 r crystal structures show that, although the full-length protein exclusively forms nine-subunit assem

144 dimers to a single monomer conformation, the full-length protein exists in numerous conformational fa

145 to mRNA defects and to a strong reduction in full-length protein expression.

146 The full-length protein forms trimers and larger complexes,

147 RTC to effectively restore the expression of full-length protein from a nonsense-mutant allele.

148 near-cognate tRNA, leading to synthesis of a full-length protein from otherwise defective mRNA.

149 Importantly, only the full-length protein from the first group is a bona fide

150 terations also result in dissociation of the full-length protein from the ribosome.

151 however, have largely focussed on refolding full-length proteins from artificially induced denatured

152 n suppressing drugs that allow expression of full-length proteins from mutated genes with premature i

153 o its size and complexity, expression of the full-length protein has been difficult, leading to focus

154 mains of PutA are known, a structure for the full-length protein has not previously been solved.

155 n of each histidine to copper binding in the full-length protein has not.

156 /2 are autoinhibited such that the purified, full-length proteins have significantly less Rab35 bindi

157 protocols indicate alternate interactions of full-length proteins; HCN1 can interact with protocadher

158 ion of the peroxidase-like domain or, in the full-length protein, heterodimeric interactions with a m

159 , and Ac1-103 fibrils efficiently seeded the full-length protein, highlighting their importance in pa

160 P15) nearly recapitulate the features of the full-length protein (i.e., partition constants, molecula

161 precise informations on binding surfaces of full-length proteins, identifying sequential (linear) or

162 can be used as part of a strategy to restore full-length protein in a variety of genetic diseases.

163 entified retroviral envelope gene encoding a full-length protein in all simians under purifying selec

164 sors required the biosynthesis of the entire full-length protein in continuity, as it did not occur w

165 d provide an atomistic representation of the full-length protein in the form of a conformational ense

166 relate the experimentally observed yield of full-length protein in the FPA assay to the force exerte

167 ondary structures of the 3 fragments and the full-length protein in the presence and absence of Ca2+

168 tations also impeded self-interaction of the full-length protein in vivo, as measured by yeast-two hy

169 metry by measuring the binding curves of the full-length proteins in living cells.

170 in vitro-transcribed/translated peptides and full-length proteins in mammalian cell lysates coimmunop

171 to investigate the dynamic properties of the full-length proteins in solution during the various asse

172 alidated the interface in the context of the full-length proteins in solution.

173 ed and employed biophysical approaches using full-length proteins in the budding yeast system.

174 ificity characteristics of the corresponding full-length proteins in their native cellular context.

175 The advantages of BRET include expressing full-length proteins in their native environment that ha

176 ydrolyzable thioacetyl-lysine (ThioAcK) into full-length proteins in vitro, mediated by flexizyme.

177 alleles responded to treatment and produced full length protein, in some cases more than 50% relativ

178 g the first 40 N-terminal amino acids of the full-length protein including the transactivation and Md

179 editing during sexual reproduction to encode full-length proteins, including the ortholog of yeast Am

180 designs can disrupt the fibril formation of full-length proteins, including those, such as tau prote

181 mulated higher ATP hydrolysis rates than the full-length protein, indicating that binding to MinD is

182 e loosely associated with chromatin than the full-length proteins, indicating a conserved function fo

183 igosaccharide binding fold recapitulates the full-length protein interaction specificity for the TERT

184 hese results demonstrate that insertion of a full-length protein into non-CDR loops of antibodies pro

185 generate bifunctional antibodies by grafting full-length proteins into constant region loops of a ful

186 isolation are known to be inactive, and the full length protein is required for its function.

187 Parkin R42P full length protein is trafficked poorly to ER and stabl

188 show that a misfolding lesion in NBD1 of the full-length protein is a prerequisite for functional res

189 suggests that coordination of Cd(2+) in the full-length protein is consistent with a three- or four-

190 rnative translation initiation, but only the full-length protein is essential for gene variation.

191 eyond intradomain misfolding, folding of the full-length protein is further slowed by the formation o

192 VirB4 domain purifies as a monomer, but the full-length protein is observed in a monomer-dimer equil

193 The results show that the full-length protein is predominantly monomeric, whereas

194 found that although the dimerization of the full-length protein is preserved via the kinase domain d

195 nctional AQP4, the surface expression of the full-length protein is reduced.

196 into its stable native structure before the full-length protein is released from the ribosome.

197 he capsule operon with similar affinity, and full-length protein is required for specificity.

198 d when either the V(L) or C(L) domain in the full-length protein is severely destabilized (i.e., wher

199 The full-length protein is toxic to bacteria when taken up t

200 g post-translational modifications (PTMs) in full-length proteins is a challenge, especially in the c

201 -terminal regions or the architecture of the full-length proteins is available.

202 but how this relates to the function of the full-length proteins is unclear.

203 d of associating ontological terms only with full-length proteins, it sometimes makes more sense to a

204 The crystal structure of full-length protein kinase C betaII was determined at 4.

205 f N. crassa DGAT2 were tested: the predicted full-length protein (L-NcDGAT2) and a shorter form (S-Nc

206 nt prematurely terminates translation of the full-length protein, leaving the identity of the "enhanc

207 inity and salt dependence as compared to the full-length protein, likely indicative of a more suitabl

208 Here, we report that both the full-length protein, Ma1, and its naturally occurring tr

209 is, which also suggested that binding by the full-length protein may involve both monomers and small

210 cular-weight protein, a vaccine based on the full-length protein may not be feasible.

211 CDD incorporates several protein domain and full-length protein model collections, and maintains an

212 mRNA containing a premature stop codon, the full length protein negatively regulates its production

213 their homologue from Naegleria gruberi, the full-length protein NgTET1, are distributive in both che

214 eptide, 47YGRKKRRQRRR57, which can transduce full-length proteins not only across the cell membrane b

215 synthetase 1b gene that encodes the inactive full-length protein (Oas1b-FL).

216 domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respective

217 cting models from electron microscopy of the full-length protein, one of which proposes that the doma

218 stinct forms of ICP34.5 in infected cells: a full-length protein, one shorter form sharing the N term

219 N-P gene position of the rHPIV1 vector as a full-length protein or as a chimeric form with its TMCT

220 rom the first or second gene position as the full-length protein or as a chimeric protein with its tr

221 as codon optimized and expressed either as a full-length protein or as an engineered chimeric form in

222 ransposase MuA, which is not observed in the full-length protein or in the assembled transpososome in

223 ular dynamics simulations performed with the full-length protein or with the transmembrane segments w

224 We demonstrate that, like the full-length protein, overexpression of Hfe proteins lack

225 conformation, helping to rationalize how the full-length protein participates in multiple steps of DN

226 For the full-length protein, prephenate, the product of the CM r

227 nts show that the inter-domain linker in the full-length protein promotes oligomerization and thus ma

228 The wild-type, full-length protein, purified from bacteria, binds duple

229 Rather, the full-length protein rapidly samples many different confo

230 we quantitatively compare the binding of the full-length protein (Redbeta(FL)) and the N-terminal dom

231 carry the biological information encoded in full-length proteins remain underdeveloped.

232 Interestingly, full-length protein remained inactive in E. coli peripla

233 ; however, the molecular architecture of the full-length protein remains unknown.

234 he phosphodegron, when incorporated into the full-length protein, result in increased levels of const

235 ve PINK1, and the consequent accumulation of full-length protein, results in mitochondrial abnormalit

236 Our measurements on the full-length protein reveal a distinct role of the C-term

237 scattering data and a modeling study of the full-length protein, revealed a homodimer comprising a c

238 NMR analysis of the full-length protein reveals that the two PHD fingers of

239 diverse ubiquitin-binding domains (UBDs) in full-length proteins, selective recognition of chains wi

240 Mutation of these interface positions in the full-length proteins showed that these interactions were

241 lagging edge membrane when coexpressed with full-length protein, showing that CynA clustering is med

242 Data analysis revealed that full length protein standards have the broadest quantita

243 a fluorophore as well as the purified native full-length protein substrates p53 and acetyl-CoA synthe

244 atalyzed deacetylation of singly-acetylated, full-length protein substrates, revealing that HDAC8 sub

245 t activation of SIRT1 with native peptide or full-length protein substrates, whereas they do activate

246 HDAC8 substrate selectivity for peptides and full-length proteins suggest that HDAC8 substrate prefer

247 L, is more resistant to degradation than the full length protein, suggesting that sites on the C-term

248 viral large envelope protein but not to the full-length protein, suggesting a need for proteolytic c

249 erence band was absent in the spectra of the full-length protein, suggesting that the isolated sensor

250 free protein synthesis kit that is active in full-length protein synthesis and (ii) the relative acti

251 ts quantitative estimation of the effects on full-length protein synthesis of various additions, subt

252 but requires a conformational change in the full-length protein that is promoted by autophosphorylat

253 rm lacking the transactivation domain of the full-length protein that modulates total p53 activity an

254 After validating their ability to produce full-length proteins that localize to photoreceptor conn

255 ion of three Pfs48/45 proteins including the full-length protein, the 6C domain fragment and the 6C d

256 Compared with the activity of the full-length protein, the C-terminal helicase domain had

257 In the full-length protein, the C2A domain does not undergo mem

258 is highly dynamic, but in the context of the full-length protein, the dynamics is lost when the PDZ d

259 real-time monitoring of the expression of a full-length protein, the green fluorescent protein varia

260 In the full-length protein, the N-terminal helix is aligned nea

261 c finger (TZF) domain, in the ability of the full-length protein to bind to AREs within the tumor nec

262 Hit peptides are tested against the full-length protein to identify the best binder.

263 olecular mechanism for the adaptation of the full-length protein to increasing lipid load during chol

264 n isolation as well as in the context of the full-length protein to reveal that the Ub binding proper

265 and the use of protein fragments rather than full-length proteins to better resolve specific protein

266 oth the DBL domains and the parasite-derived full-length proteins to erythrocytes, which has implicat

267 MP correlated with that of the corresponding full-length proteins to induce apoptosis in the absence

268 me marker LC3 in osteoblasts, but unlike the full-length protein, trNbr1 fails to complex with activa

269 In contrast with full-length protein, truncated ASCC1 did not reduce the

270 Like the full-length protein, truncated langerin exists as a stab

271 n NMR-based approach to monitor oxidation in full-length proteins under denaturing conditions, as dem

272 2+ and HA determined by FTIR showed that the full-length protein undergoes slight conformational chan

273 ies cannot replicate the key features of the full-length proteins used in cellular studies.

274 eta conformational transition of RfaH in the full-length protein using a dual-basin structure-based m

275 acterize the structural architecture of both full-length proteins utilizing negative stain electron m

276 cus immunodominance compared to the case for full-length protein vaccination.

277 of repeat-specific Abs compared to a nearly full-length protein vaccine (FL-CSP).

278 al production of a non-glycosylated, soluble full-length protein vaccine immunogen.

279 indicating that another APP fragment or the full-length protein was likely responsible for maintaini

280 cated form of this enzyme suggested that the full-length protein was required for correct lipid subst

281 GFP and MCT12:214Delta-GFP revealed that the full-length protein was trafficked to the plasma membran

282 SH3 domain including a linker region of the full length protein), we observe a large temperature dep

283 In studying the full-length protein, we also have uncovered that IpaH fa

284 Using these data and mutational analysis of full-length proteins, we pinpoint three amino acids in T

285 cific truncation and partial cleavage of the full-length protein were employed to further characteriz

286 s amino-acid-specific-labeled samples of the full-length protein were prepared and mixed, so that onl

287 separate domains of both species and of the full-length proteins were modeled.

288 -196 C1 PrP construct, in the absence of the full-length protein, were susceptible to Delta(Spont) pr

289 s residues critical for the stabilization of full-length proteins when the PAS domain is present.

290 ite for GCAP1 with similar affinities as the full-length protein, whereas GCAP2 did not bind to this

291 EGFR isoform I is the full-length protein, whereas isoforms II-IV are shorter

292 he established biochemical activities of the full-length protein, while the carboxy-terminal 143 resi

293 bset of PPI interfaces without depleting the full-length protein will be valuable for structure-funct

294 which the arrested protein is converted into full-length protein with a Bell model of force-induced r

295 amined the interaction of Puma BH3 domain or full-length protein with Bak by surface plasmon resonanc

296 ransported to the cell surface via T9SS as a full-length protein with its CTD intact, independently o

297 The crystal structure of the full-length protein with prephenate bound and the accomp

298 hieve reversible immobilization of bioactive full-length proteins with good spatial and temporal cont

299 d TprI are highly thermostable, endowing the full-length proteins with impressive conformational stab

300 Furthermore, full-length proteins with these mutations decrease SID-1