ライフサイエンスコーパス: fully functional

1 ze AUXIN SIGNALING F-BOX (AFB) receptor, was fully functional.

2 ransfer to other pathogens where it could be fully functional.

3 ing inactive and trimers and tetramers being fully functional.

4 RPE grafts until demonstrating that they are fully functional.

5 y ICCS, indicating that these iNKT cells are fully functional.

6 Nrdp1 for degradation is properly folded and fully functional.

7 ved keratinocytes, suggesting that they were fully functional.

8 ction, translation in the apicoplast must be fully functional.

9 recruited to the centromeres, which remained fully functional.

10 read-through proteins that are partially or fully functional.

11 to evade the host immune response and remain fully functional.

12 , indicating that the D620N VPS35 protein is fully functional.

13 Shortened H proteins were not fully functional.

14 indicating that the NK cell populations were fully functional.

15 ochondrial tRNAs must be processed to become fully functional.

16 We report fully functional, 3D integrated complementary metal-oxid

17 e a phosphodeficient mutant at this site was fully functional, a phosphomimetic mutant displayed impa

18 3D-wPAT has three layers of fully functional acoustic transducer arrays.

19 Thus, the levels of the naturally expressed, fully functional, active cellular MT1-MMP enzyme are rou

20 It is increasingly apparent that fully functional adipose tissue can be cardioprotective

21 diac chamber is crucial for development of a fully functional adult heart.

22 s and the cells do not appear to mature into fully functional adult motor neurons.

23 We conclude that the production of fully functional AID protein by U-CLL and M-CLL cells co

24 E(1) represents a fully functional allele with a coding DNA sequence (CDS)

25 ized composite allografts (VCAs) can restore fully functional anatomic units in patients with limb am

26 -infected mice during the priming phase were fully functional and able to clear Pneumocystis infectio

27 Under these conditions, both enzymes are fully functional and are bound to VhuD in substoichiomet

28 The eluted tubulin is fully functional and can be efficiently assembled into m

29 hCG-generated Tregs were fully functional and could confer tolerance when adoptiv

30 d that recycling of internalized nAChRs into fully functional and denervated synapses was promoted by

31 ull-length RTKs require protein that is both fully functional and free from contaminating proteins.

32 The recruited DCs were fully functional and in a more advanced stage of maturat

33 cient myotubes, derived from myoblasts, were fully functional and mirrored the pathological features

34 Peptide synthesis was used to create a fully functional and monomeric PLB mutant with a spin la

35 This cofactor was fully functional and reconstituted the catalytic activit

36 pses formed during early development are not fully functional and respond poorly to presynaptic actio

37 We found that the complex is fully functional and that the stoichiometry of Rho* to G

38 The induced APOBEC3B enzyme is fully functional and therefore may exert mutational effe

39 ion channel pores of the P2X receptors were fully functional and unaltered by the receptor interacti

40 Nanostraw-treated cells were fully functional and viable, with no impairment in their

41 Nanobodies are the smallest fully functional antigen-binding antibody fragments poss

42 Here, we show that a fully functional antiviral CD8(+) T-cell response can be

43 By whole cell recording, these fusions are fully functional as CRAC channels.

44 hannels formed from concatenated dimers were fully functional as indicated by agonist-induced Ca(2+)

45 The expanded population was fully functional as judged by IFN-gamma production and M

46 ontaining only one active site cysteine were fully functional as repressors and still responded, albe

47 ne, encoding the wildtype mTert protein, was fully functional, as a mESC line with homozygous hmTert

48 l stability of BN, the ionic conduits remain fully functional at temperatures up to 90 degrees C.

49 red at -47 and -59, respectively, and NAC is fully functional at these promoters.

50 ild-type rat P2X2 expressed in Drosophila is fully functional (ATP EC(50) 8.7 uM), and that screening

51 hesized that optimal T cell priming requires fully functional B cells.

52 this effect was ablated in mice that lacked fully functional B cells.

53 erahertz (THz) electromagnetic spectrum as a fully-functional bandwidth, the development of a family

54 in the deficient in vitro maturation towards fully functional beta-cells.

55 The presence of a fully functional beta-glycoform together with the activi

56 This kinase is fully functional biochemically and in cells, and is rapi

57 ered, disulfide cross-linked ClpB hexamer is fully functional biochemically, suggesting that ClpB deo

58 ide the necessary tools to produce the first fully functional bioengineered livers for organ transpla

59 Their interactions not only serve to support fully functional blood vessels but also can regulate ves

60 We demonstrate fully functional blue light-emitting diodes (LEDs) by gr

61 This interaction requires fully functional BRCA1 as a mutant BRCA1 protein is unab

62 Second, the Calvin cycle is not fully functional, but RubisCO continues to fix CO2 and s

63 ; these nascent synapses subsequently become fully functional by 2 h after Sema4D treatment.

64 ans-splicing in Escherichia coli generated a fully functional C31 integrase.

65 This reconstituted system was fully functional, capable of translating natural messeng

66 from prepubescent primates can maintain the fully functional capacity of spermatogonia to produce sp

67 Here we report the development of fully functional CaV2.2 constructs containing inserted s

68 Fully functional CD8(+) T cell memory is highly dependen

69 cell help is essential for the generation of fully functional CD8(+) T cells during the primary respo

70 n the transition of genetic information to a fully functional cell.

71 nn at centrosomes has become synonymous with fully functional centrosomes in Drosophila melanogaster.

72 ransfer, but the relevance of avalanches for fully functional cerebral systems has been controversial

73 omerization but could not form a pore with a fully functional channel.

74 ical measurements on these same samples show fully functional channels, even without the presence of

75 The presented research reports a fully functional chemical-detection principle, addressin

76 ot sufficient for root, or leaf, growth, but fully functional chloroplasts are necessary and sufficie

77 ore extensive role for RFX TFs in generating fully functional cilia.

78 he fabrication, understanding and control of fully functional circuits at the single-molecule level c

79 prokaryotic tryptophan transporter TnaT to a fully functional Cl(-)-dependent form by a single point

80 ely after ecdysis until the formation of the fully functional club and unveil an unusual development

81 romolecular template to the formation of the fully functional club.

82 associates with the viral DNA ends to form a fully functional concerted integration intermediate.

83 a pharmacological blocker and when CFTR was fully functional.Conclusions: Enhancing the activity of

84 lytical ultracentrifugation, we found that a fully functional construct of caveolin-1 (Cav1(62-178))

85 D124V and H80R SOD1 proteins appear to have fully functional copper-binding sites, inductively coupl

86 d recall ability have less diAcH3 than their fully functional counterparts, indicating that the diAcH

87 Here, we present a fully functional Cu(A) center designed in a structurally

88 thin the cell, resulting in the secretion of fully functional cytokines.

89 e differentiation of naive CD8+ T cells into fully functional cytolytic effector cells and mediated t

90 usively showed that dld-II and lldEFG encode fully functional d-and l-LDH enzymes, which catalyze the

91 on of CD41 and CD45 followed by emergence of fully functional definitive HSCs.

92 Surprisingly, both photosystems are fully functional despite their carotenoid-binding sites

93 t accompany post-natal differentiation where fully functional differentiated cell types with limited

94 pression of a set of genes necessary for the fully functional, differentiated beta cell state, wherea

95 A fully functional DNA repair proteome for removing harmfu

96 ethylated CpG dyads in the DNA of cells with fully functional Dnmt and Tet proteins.

97 emissions trends emphasize the importance of fully functional DPFs.

98 She describes her health as good, is fully functional, drives, has had no falls, and provides

99 A fully functional, easy to set up server is provided as a

100 We show that a fully functional endocannabinoid system is present in pr

101 macroscale preform is thermally drawn into a fully functional energy-storage fiber.

102 e presence of fabK, a gene encoding a second fully functional enoyl-ACP reductase.

103 Although development of a fully functional ENS is required for gastrointestinal mo

104 the acinetobactin gene cluster, is the only fully functional entB ortholog present in ATCC 19606(T).

105 raphy in LSO-IC projections, suggesting that fully functional ephrin-B2 reverse signaling is required

106 ral and targeted to prevent the emergence of fully functional escape variants.

107 ed expression system that enables display of fully functional eukaryotic proteins while preventing te

108 Microfluidic features remained fully functional even after prolonged exposure to nonpol

109 cles with a capacitance of 25 F g(-1) and is fully functional even at compressions up to 75%.

110 In contrast, a fully functional EWS/FLI mutant (Mut9, which retains app

111 Remarkably, such flexible MTJs are fully functional, exhibiting a TMR ratio as high as 190%

112 Thus, this work implicates a fully functional exocyst complex as a component of the c

113 Tissue Tregs were fully functional, expanded independently of IL-33, and l

114 an trigger AP activation in individuals with fully functional factor H.

115 hat then must 'decide' to differentiate into fully functional fat cells is critical to our understand

116 fferent ribosomal proteins (RPs) can produce fully functional first-stage larvae, with similar develo

117 Using a fully functional fluorescent version of Arabidopsis thal

118 aterials is key to rendering these materials fully functional for a range of potential applications,

119 ss-of-function mutations in recA, which were fully functional for maize (Zea mays) transformation and

120 P dephosphorylation, and gene looping but is fully functional for mRNA 3'-end processing.

121 cherichia coli was expressed and purified in fully functional form and demonstrated to bind Cu(I) wit

122 5:R345W membrane trafficking is perhaps in a fully functional form.

123 o Th17-like and Th1-like cells but also into fully functional Foxp3(+) induced regulatory T cell-like

124 the final product contains greater than 90% fully functional FOXP3(+) Tregs.

125 deficiency that results from the absence of fully functional Fpn1.

126 Here we describe fully functional GABAergic communication within rodent p

127 se (NIK) is essential for the formation of a fully functional gammadelta T cell compartment.

128 The absence of fully functional GCase leads to the accumulation of its

129 utive modules arising from an uninterrupted, fully functional gene in the entomopathogenic bacterium

130 demonstrate that CD10 identifies a subset of fully functional germinal center TFH in normal secondary

131 Ejaculate success requires fully functional germline (sperm) and soma (seminal flui

132 Using a fully functional, GFP-tagged EGL-4, we show here that pr

133 heteromerize with another protein to form a fully functional glucose polymer receptor.

134 ts expression is needed for the formation of fully functional GSVs.

135 nt pK(a) for the self-cleavage reaction in a fully functional hairpin ribozyme with a unique 8azaA at

136 support for gene/metabolite annotation and a fully functional heatmap builder.

137 ly remodeled bone, mature vasculature, and a fully functional hematopoietic compartment.

138 nits GABA(B1a), GABA(B1b), and GABA(B2) form fully functional heteromeric GABA(B(1a,2)) and GABA(B(1b

139 ed to the Fc region of human IgG, creating a fully functional homodimer (or "lysibody") with high-aff

140 it is the hope that the hurdle of obtaining fully functional HSCs in a laboratory setting will be ov

141 vertible to fully human antibodies) and have fully functional humoral immune systems indistinguishabl

142 articular detail was exploited to assemble a fully functional hybrid DNA-protein nanostructure in a b

143 However, existing HumAb mice do not have fully functional immune systems, perhaps because of the

144 fortunately, existing HumAb mice do not have fully functional immune systems, perhaps because of the

145 nt human MC line, ROSA(KIT WT), expressing a fully functional immunoglobulin E (IgE) receptor.

146 Q in bo(3) from E. coli has been shown to be fully functional, implying that the positive charge of t

147 enhancement of TFH and GC B cells is already fully functional in 3-wk-old infant mice, which were ful

148 we also finally prove that the BM in pigs is fully functional in adult animals and that B lymphogenes

149 ied TRPV1, however, was recently shown to be fully functional in artificial liposomes in the absence

150 Phospho-IIF is fully functional in binding to free pol II and is able t

151 gB cytodomain mutants and show that they are fully functional in cell-cell fusion at shorter coincuba

152 The ability to generate fully functional iN cells from aged organisms will be pa

153 existing in a latent state, this complex was fully functional in eliciting SMAD-dependent signaling.

154 While Bst-IF2 is fully functional in formation of E. coli 70SIC, relative

155 Interestingly, mouse SDC1 is also fully functional in mediating HCV attachment when expres

156 to a D173A active site mutant, Exo1-E109K is fully functional in mismatch-provoked excision and repai

157 Moreover, the IL-7-induced pathway was fully functional in naive T cells from elderly and young

158 Importantly, the mutated NDK5 that appeared fully functional in ndk5 cells elicited a dominant-negat

159 oaches were taken to establish that FHL-2 is fully functional in P. atrosepticum and is the major sou

160 The LG3 domain from Marchantia polymorpha is fully functional in P. patens, whereas angiosperm sequen

161 eptor (MLA1) from monocotyledonous barley is fully functional in partially immunocompromised dicotyle

162 However, it is fully functional in regulated genes encoding iron uptake

163 ng synV derivative was constructed, which is fully functional in Saccharomyces cerevisiae under all c

164 terminal 24 amino acids (pHA-UL3825-331) was fully functional in suppressing cell death during infect

165 owed improved telomeric localization and was fully functional in terms of chromosome end protection b

166 The mutant protein is fully functional in that it can both stabilize PopB and

167 TRPV1 is fully functional in the absence of phosphoinositides, ar

168 ctivators is relatively intact, and they are fully functional in the Lhx3 complex and V2 interneuron

169 active in cellular metabolism could still be fully functional in the replication complexes.

170 support STING signaling, although they were fully functional in the TLR3 pathway.

171 clock, and many other peripheral clocks, are fully functional in this model allows the assignment of

172 resentation and activation signals to become fully functional in this model of Pneumocystis infection

173 and other nuclear gene groups appears to be fully functional in this mutant, indicating that a block

174 hich the order of the domains is reversed is fully functional in vitro and in vivo.

175 y, IL-10/IL-35 double-deficient T(regs) were fully functional in vitro and in vivo.

176 d by HemQ remains to be characterized, to be fully functional in vitro it requires the presence of a

177 ITPA-P32T is also fully functional in vivo in model organisms as determine

178 itionally, we show that Cbl-b(-/-) Tregs are fully functional in vivo, further suggesting that the re

179 lone (J6CF), which we previously found to be fully functional in vivo, was replication incompetent in

180 hway undergoes autocatalysis normally and is fully functional in vivo.

181 s is the time needed for the cells to become fully functional in vivo.

182 RP3 enhanced ASC speck formation, leading to fully functional inflammasomes and caspase-1 activation.

183 Thus, proper development of fully functional iNKT cells is constrained by a limited

184 tories had appropriate technical competency, fully functional instrumentation, and suitable reagents

185 Fully functional integrated circuits of digital and anal

186 We show that the purified protein is a fully functional ion channel with properties akin to the

187 B100 Tg (human APOB100 transgenic) mice with fully functional LDLr, despite increased levels of plasm

188 he A. tumefaciens biotin protein ligase is a fully functional ligase that has no role in regulation o

189 cal, and other 3D shapes and integrated into fully functional light-trapping PV devices.

190 ivation, we obtained cryo-EM structures of a fully functional, light-activated Rho-G(T) complex in th

191 d PI-MECs displayed all of the properties of fully functional lobular progenitors including giving ri

192 step toward the ultimate goal of generating fully functional lungs in vitro, these results suggest t

193 Here we report that a fully functional lysine-less mutant of an inner nuclear

194 telets are capable of generating and storing fully functional lysosomal enzymes and can also lead to

195 ologically relevant drug-binding site in the fully functional M2(21-61) is S31 in the TM pore.

196 o-EM can be used to investigate complete and fully functional macromolecular complexes in different f

197 the authors found activated Rho proteins in fully functional macrophages that hypersecreted inflamma

198 H, containing monohydroxylated betaTrp57, to fully functional MADH by catalyzing the insertion of a s

199 , indicating that processing is required for fully functional maturation of P30.

200 onserved endonuclease complex that generates fully functional mature tRNAs.

201 here the isolation and characterization of a fully functional megacomplex composed of a phycobilisome

202 otein of interest into a coherent pattern of fully functional membrane proteins on the surface of an

203 This method enables the manufacturing of a fully-functional microfluidic device in a few hours, wit

204 uring process to produce fully assembled and fully functional millimeter-scale tools.

205 ed mutation, alphaL260P, in the context of a fully functional mini-spectrin.

206 Platelets also contain fully functional miRNA machinery, and certain miRNA leve

207 t is subsequently processed to release three fully functional miRNAs.

208 symmetries across genome topography revealed fully functional mismatch and transcription-coupled repa

209 rol efflux capacity, and anti-miR33 required fully functional mitochondria to enhance ABCA1-mediated

210 the earliest diverging eukaryotes that have fully functional mitochondria.

211 of tethered chromosomes being dependent on a fully functional mitotic apparatus.

212 face beta-strand is sufficient to generate a fully functional monomer.

213 f extrinsic Ca(2+) to those cells containing fully functional NCX/GM1: differentiated NG108-15 and C6

214 melanocortinergic phenotype and maintains a fully functional neuronal POMC phenotype throughout adul

215 o reprogram human astrocytes in culture into fully functional neurons.

216 by apoptosis but is gradually replaced by a fully functional new growth plate from progenitor stem c

217 that Plasmodium cells evolved not to have a fully functional NGD pathway.

218 nase mechanism and allow reconstruction of a fully functional nitrogenase from the "skeleton" enzyme,

219 plicable methods to produce large numbers of fully functional NK cells is a critical step to maximize

220 e last eukaryotic common ancestor (LECA) had fully functional NPCs.

221 tor, but it compromises the formation of the fully functional nucleoprotein complex.

222 Thus, a fully functional, ongoing, antigen-specific CTL response

223 NA regulatory network to specify and produce fully functional oocytes.

224 in the differentiation of preosteoblasts to fully functional osteoblasts.

225 mpared to control BALB/c mice, which express fully functional P2X(7) receptors.

226 In summary, a fully functional PA and a minimum of adenylate cyclase a

227 ce and technology towards the development of fully functional paper devices in diagnostics and drug d

228 sive regulatory changes can rapidly assemble fully functional pathways in microbes.

229 itecture holds the key to the realization of fully functional photonic-integrated circuits.

230 Significantly, both isoforms form fully functional photopigments.

231 A fully functional placenta is critical for a successful p

232 netic program that establishes and maintains fully functional POMC neurons remains to be explored.

233 ate with anti-flu Ab responses, indicating a fully functional population.

234 ugh HlyC is known to activate proHlyA into a fully functional pore-forming toxin, HlyA.

235 expression of human Alix in the absence of a fully functional PPPY late domain partially rescued both

236 in budding is amplified in the absence of a fully functional PPPY motif.

237 However, fully functional practical thermoelectric coolers have n

238 We confirmed the involvement of MED25 for fully functional preinitiation complex recruitment and t

239 However, fully functional primary hepatocytes remain difficult to

240 This work presents the first fully functional, printed coils for 1.5- and 3-T clinica

241 nteraction of p30 with a PA28gamma retaining fully functional proteasome activity is required for p30

242 bodies that are subsequently used to produce fully functional protein by an in vitro refolding proces

243 Fully functional protein microarrays, with monolayer arr

244 A number of fully functional proteins have been identified to exist

245 The delivery of fully functional proteins to infected cells upon virion

246 the functional interaction with L to form a fully functional RdRP.

247 idelines for preparation and handling of the fully functional receptor suitable for a wide array of d

248 We have developed a fully functional recombinant PVM strain with a fluoresce

249 sphonate instead of the natural phosphate in fully functional, reconstituted bacterial ribosomes.

250 Fully functional RecQL5 requires both helicase activity

251 hese results describe a novel route by which fully functional regulatory elements can arise rapidly f

252 til donor organs are available and, at best, fully functional replacement organs.

253 vector stably expressed 17-77 mug ml(-1) of fully functional rhesus eCD4-Ig for more than 40 weeks,

254 Furthermore, we found fully functional RIPK1 kinase activity-independent necro

255 Our results show that fully functional root amyloplasts are not sufficient for

256 iate complex (RPi) before the formation of a fully functional RPo.

257 cardiac precursors able to mature and form a fully functional SAN-like tissue.

258 tivity assays indicated that QUAD opsin is a fully functional scramblase.

259 In the present work, we show that fully functional self-organized TiO(2) nanotube layers c

260 culture system can generate large numbers of fully functional sensory cells which could be used to in

261 Remarkably, deletion of the leader yielded a fully functional SfIAP with dramatically increased prote

262 rily divergent from higher plants, but has a fully functional silencing machinery including microRNA

263 uch "eyeball" cameras, including examples of fully functional silicon devices capable of collecting r

264 combined with dA-dT and dG-dC, it provides a fully functional six-letter genetic alphabet.

265 ps that have been taken towards delivering a fully functional solar fuels generator, which have explo

266 planted in patients, in vitro formation of a fully functional solid organ at a translatable scale has

267 omosome alignment during metaphase and for a fully functional spindle assembly checkpoint response.

268 (1), which is key to maintaining the pool of fully functional stem cells, not only in the brain but a

269 stem to the chick embryo and find that it is fully functional, suggesting that this strategy is gener

270 The immediate availability of fully functional synapses upon formation supports an age

271 Fully functional T cells are necessary for the maintenan

272 rm-free (GF) mice, ablation of the otherwise fully functional T reg cells resulted in a systemic auto

273 This failure to prime a fully functional T(CD8(+)) response results from a reduc

274 ecreted by P. syringae and is required for a fully functional T3SS.

275 or enhanced infant responses but induces few fully functional TFH cells, which are mostly follicular

276 Once blood circulation becomes fully functional, the embryonic head no longer produces

277 However, despite the vls system being fully functional, the spirochete fails to evade anti-Bor

278 nthesis and mutagenesis of UV radiation were fully functional, those of a site-specific 1,N(6)-etheno

279 ipheral IL-7 deficiency in the presence of a fully functional thymus, and we document a critical requ

280 behavior and development of thymocytes in a fully functional thymus, we developed transgenic reporte

281 l phosphoSH3C-SH3N unit in which the SH3N is fully functional to bind polyproline type II ligands and

282 g 72 h ambient storage, neutrophils remained fully functional to migrate towards chemical cues and ma

283 ces and discusses the challenges of creating fully functional transplantable liver grafts with this w

284 c (TrkB(F616A)) mice that express mutant but fully functional TrkB receptors.

285 he first multimixing stopped-flow study on a fully functional truncated variant of human peroxidasin

286 We further reveal that state transitions are fully functional under these conditions and that PsbS is

287 pressing the SMG7 K66E-knockin mutant retain fully functional UPF1-mediated NMD.

288 We demonstrate that the full-length PKS is fully functional upon rigidification of the ACP domain,

289 demonstrate that B cells from these mice are fully functional: upon transfer to congenic, wild type m

290 s library to in vitro selection and obtained fully functional variants with deletions of up to 18 ami

291 Establishment of a fully functional vasculature is complex and requires a n

292 ess that is essential for the formation of a fully functional vasculature.

293 Thus, the unusual V225d cag architecture was fully functional via conserved elements, but the natural

294 gmatic mutations-F45L, V209M and F220C-yield fully functional visual pigments that bind the 11-cis re

295 ion performance and speed, availability of a fully functional web-interface and state-of-the-art meth

296 nce genes and the induction mechanism remain fully functional when transferred to heterologous bacter

297 The sensors were fully functional with excellent selectivity to interferi

298 ences that encode elements that appear to be fully functional with intact open reading frames and oth

299 CaiT-D288A was fully functional with kinetic parameters similar to the

300 Here we have reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPAS