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1 ibition of fumarate hydratase (also known as fumarase).
2 nase, complex II, complex IV, aconitase, and fumarase.
3  by inactivating succinate dehydrogenase and fumarase.
4 ve also been seen in delta-crystallin and in fumarase.
5 sa possesses at least two and possibly three fumarases.
6 ral tumour suppressors such as p53, BAP1 and fumarase(4-7).
7                                              Fumarase A was overproduced.
8 hogluconate dehydratase, glutamate synthase, fumarase A, and FNR) and membrane-bound proteins (NADH d
9                          Fumarate hydratase (fumarase), a vulnerable component of the citric acid cyc
10 um1Delta) lacking succinate dehydrogenase or fumarase activities.
11 ur mutants produced 1.7- to 2.6-fold-greater fumarase activity and 1.7- to 2.3-greater amounts of alg
12 espite displaying similar reductions in both fumarase activity and malate content as observed in toma
13                                     In vivo, fumarase activity fell to < 5% when cells were aerated;
14                                            A fumarase activity stain revealed that P. aeruginosa poss
15                                        Total fumarase activity was at least approximately 1.6-fold gr
16 ly resulting from absent or severely reduced fumarase activity, with currently unknown functional con
17 ferric chloride, demonstrated an increase in fumarase activity.
18 R was also used to randomly recombine CM and fumarase, an unrelated but also alpha-helical protein.
19 th mitochondrial succinate dehydrogenase and fumarase and activate the cytosolic ATP-citrate lyase in
20 are marked increases in transcripts encoding fumarase and fumarate reductase, enzymes putatively requ
21 n be synthesized from fumarate by the enzyme fumarase and further oxidized to oxaloacetate by malate
22  reactivities for members of large aspartase/fumarase and pyridoxal 5'-phosphate-dependent enzyme fam
23 te oxidase, sarcosine oxidase and mixture of fumarase and sarcosine oxidase were used for monitoring
24 ases show no sequence similarity to class-II fumarases and are of different evolutionary origin.
25 ble metabolic signaling of the DDR, in which fumarases and different metabolites are recruited regard
26 g argininosuccinate lyase, delta-crystallin, fumarase, and aspartase.
27  detected for ADP-glucose pyrophosphorylase, fumarase, and phosphoglucose isomerase activity.
28 atriuretic peptide receptor C, mitochondrial fumarase, and the 3',5'-cyclic nucleotide phosphodiester
29 atalytic efficiencies, such as chymotrypsin, fumarase, and urease, can be accurately and precisely es
30                            The activities of fumarase- and manganese-cofactored superoxide dismutase
31  exposed to super-oxide at pH 6.5, cytosolic fumarase B was damaged.
32 e reductase (encoded by the frdABCD operon), fumarase B, which generates fumarate from malate, and th
33 new Mtb inhibitory compounds that target Mtb-fumarase by binding to a nonconserved allosteric site is
34 n of the iron-sulfur proteins, aconitase and fumarase, by accumulated cytoplasmic NO.
35  elevated levels of one major transcript and fumarase C and manganase-cofactored SOD activity, sugges
36                                              Fumarase C catalyzes the stereospecific interconversion
37    The recent three-dimensional structure of fumarase C from Escherichia coli has identified a bindin
38 n-regulated, tricarboxylic acid cycle enzyme fumarase C is essential for optimal alginate production
39                     The crystal structure of fumarase C with beta-(trimethylsilyl)maleate, a cis subs
40 otease,PrpL protease, exotoxin A, as well as fumarase C, Mn-dependent superoxide dismutase SodA, a fe
41 ater molecule may play an active role in the fumarase-catalyzed reaction.
42                                   The enzyme fumarase catalyzes the reversible hydration of fumarate
43 due His141, which is highly conserved in all fumarase class II enzymes and forms a charge relay with
44 numbering), acts as the general base in most fumarase class II superfamily members.
45 gions, which are moderately conserved in the fumarase class II superfamily, from three respective mon
46  PpCMLE is a homotetramer and belongs to the fumarase class II superfamily.
47 through M484, while the recombinant form, RY-fumarase, consists of residues S27 through L485.
48 additional crystallographic structures using fumarase crystals with bound inhibitors and poor substra
49          Fumaric aciduria (fumaric acidemia, fumarase deficiency) is a rare inborn error of metabolis
50               Furthermore, we found that the fumarase-dependent intracellular signaling of the B. sub
51 The crystal structure of the native form, NY-fumarase, encompasses residues R22 through M484, while t
52 parisons with other members of the aspartase-fumarase enzyme family, and the necessity for chemically
53      Whereas the resulting library contained fumarase fragments in many contexts before functional se
54 r both native and recombinant forms of yeast fumarase from Saccharomyces cerevisiae have been complet
55 provided by malate addition did not occur in fumarase (fum-1), glyoxylate shunt (gei-7), succinate de
56 acid fumaric acid, mediated by the cytosolic fumarase FUM2, is essential for cold acclimation of meta
57 e FH gene cause the deficiency of the enzyme fumarase (fumarate hydratase, EC 4.2.1.2) which result i
58                                     Class-II fumarases (fumarate hydratase, FH) are dual-targeted enz
59        Strikingly, here we show that E. coli fumarase functions are distributed between class-I fumar
60 ine mutations of the fumarate hydratase (FH, fumarase) gene are found in the recessive FH deficiency
61               Escherichia coli harbors three fumarase genes: class-I fumA and fumB and class-II fumC
62 of this so-called B site of Escherichia coli fumarase had little effect on the overall initial rate k
63 (trimethylsilyl)maleate, a cis substrate for fumarase, has led to the discovery of the second site or
64 hanges in the active site of fumarase (yeast fumarase II) that occur when fumarate is converted to ma
65 o-2-hydroxypropionate, a strong inhibitor of fumarase in its carbanion form, is competitive with both
66 erference to down-regulate the expression of fumarase in potato (Solanum tuberosum) under the control
67 ositive bacterium Bacillus subtilis class-II fumarase, in addition to its role in the tricarboxylic a
68                        The rates of PFOR and fumarase inactivation are similar, suggesting that super
69                    The reaction catalyzed by fumarase is critical for cellular energetics as a part o
70                                              Fumarase is distributed between two compartments of the
71      A key challenge in the targeting of Mtb fumarase is its similarity to the human homolog, which s
72 erium tuberculosis (Mtb) fumarate hydratase (fumarase) is a highly conserved essential protein that s
73 the dual function of the ancient prokaryotic fumarase, led to its subsequent distribution into differ
74 rotein that shares an active site with human fumarase, making active site inhibition equally cytotoxi
75 nthase, aconitase, isocitrate dehydrogenase, fumarase, malate dehydrogenase, and succinate dehydrogen
76 levated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydro
77                           Here, we show that fumarase of the model prokaryote Bacillus subtilis (Fum-
78      In vitro analysis demonstrated that the fumarase of the succinate-propionate pathway contains an
79  are measured using alcohol dehydrogenase or fumarase plus malic dehydrogenase reactions, respectivel
80                A catalytic mechanism for the fumarase reaction that can account for the kinetic behav
81  active site has been a major mystery of the fumarase reaction.
82 with lactate oxidase, sarcosine oxidase, and fumarase/sarcosine oxidase in the three sensing channels
83 activity invariably contained a CM core with fumarase sequences found only at the termini or in one l
84  and fumB and class-II fumC Notably, class-I fumarases show no sequence similarity to class-II fumara
85 odeling based on the known structures in the fumarase superfamily, including argininosuccinate lyase,
86 highly conserved regions within the class II fumarase superfamily.
87  the inactivation of the [4Fe-4S]-containing fumarases that otherwise occurs in the sodA sodB strain.
88                           Recycling of yeast fumarase to permit repetition of its reaction chemistry
89  We report the discovery of fumC, encoding a fumarase, upstream of the sodA gene, encoding manganese
90                      As a comparison, native fumarase was crystallized in the presence of the competi
91 ich participate in the DDR, and the class-II fumarase, which participates in respiration.
92 se functions are distributed between class-I fumarases, which participate in the DDR, and the class-I
93 as been demonstrated by studying crystalline fumarase with the bound competitive inhibitors-citrate a
94                Changes in the active site of fumarase (yeast fumarase II) that occur when fumarate is