ライフサイエンスコーパス: fumarate reductase

1 n using the MQ pool to fuel a membrane-bound fumarate reductase.

2 ve redox partners, flavocytochrome c3 (Fcc3) fumarate reductase.

3 more advantageous than nitrate reductase or fumarate reductase.

4 CymA(sol) efficiently reduces S. oneidensis fumarate reductase.

5 H61M and H61A mutant forms of the Shewanella fumarate reductase.

6 ochrome bd, and by fumarate, a substrate for fumarate reductase.

7 sm for fumarate reduction in the respiratory fumarate reductases.

8 benzyl viologen-linked hydrogenase (12.2 U), fumarate reductase (13.1 U), and diaphorase (109.7 U) ac

9 Fumarate reductase (24.5 U) displayed the highest activi

10 the enzyme resulted in a strain that lacked fumarate reductase activity and was unable to grow with

11 gold electrodes as a functional array whose fumarate reductase activity as viewed by direct electroc

12 Both enzymes contributed to the total fumarate reductase activity in vitro.

13 The fumarate reductase activity of both mutant enzymes can b

14 onversion of malate into succinate through a fumarate reductase activity that was detected in mitocho

15 Mutants lacking either nitrate reductase or fumarate reductase also had major colonization defects.

16 rate must be reduced to succinate by soluble fumarate reductase and the mitochondrial electron transp

17 fumarate and succinate, QFR is a much better fumarate reductase, and SQR is a better succinate oxidas

18 es revealed that formate dehydrogenase H and fumarate reductase are important A. actinomycetemcomitan

19 oreductase, complex II) and Escherichia coli fumarate reductase are remarkably similar.

20 el of these dual sites of quinone binding in fumarate reductase, as well as the nature of the substit

21 pping domain (Thr-A234 to Thr-A244 in quinol:fumarate reductase) begins at the interdomain hinge and

22 n transport between formate and fumarate via fumarate reductase by suppressor membrane fractions.

23 under microaerophilic conditions, the quinol:fumarate reductase can be utilized.

24 ate that periplasmic nitrate reductase, like fumarate reductase, can function in anaerobic respiratio

25 The integral membrane protein fumarate reductase catalyzes the final step of anaerobic

26 C. jejuni encodes enzymes annotated as a fumarate reductase (Cj0408 to Cj0410) and a succinate de

27 te transmits its effect to the motor via the fumarate reductase complex (FrdABCD), shown to bind to F

28 o replace the function of menaquinone in the fumarate reductase complex, and it enables A. succinogen

29 Fumarate reductase consists of four subunits that contai

30 aspartase) and an SR-11 DeltafrdABCD mutant (fumarate reductase), deficient in the ability to run the

31 These are fumarate reductase (encoded by the frdABCD operon), fuma

32 creases in transcripts encoding fumarase and fumarate reductase, enzymes putatively required to conve

33 ydrogenase flavoprotein (sdha-2), or soluble fumarate reductase F48E8.3 RNAi knockdown worms.

34 al photosynthetic systems utilizing either a fumarate reductase (FccA) for the solar-driven hydrogena

35 n both bacterial succinate dehydrogenase and fumarate reductase flavoprotein subunits and of SDHAF2 i

36 actor requirement of the unusual periplasmic fumarate reductase found in Shewanella.

37 cherichia coli through interactions with the fumarate reductase (Frd) electron transport complex.

38 cherichia coli through interactions with the fumarate reductase (Frd) electron transport complex.

39 Of these, fumarate reductase (Frd) is notable both for its high tu

40 uctase (narGHJI) gene expression and repress fumarate reductase (frdABCD) gene expression when no nit

41 rL-dependent nitrate reductase (narGHJI) and fumarate reductase (frdABCD) gene expression.

42 dAB), used during aerobic cell growth, and a fumarate reductase (frdABCD), dimethyl sulfoxide/trimeth

43 me contained genes encoding a heterotrimeric fumarate reductase, FrdCAB, with homology to the fumarat

44 deletion event between two tandemly arranged fumarate reductase (FRDg and FRDm2) genes to produce a c

45 hanism for fumarate reduction by the soluble fumarate reductase from Shewanella frigidimarina involve

46 nation of the X-ray structure of the soluble fumarate reductase from Shewanella frigidimarina shows t

47 ucture to the cytochrome c domain of soluble fumarate reductases from Shewanella sp.

48 The crystal structure of intact fumarate reductase has been solved at 3.3 angstrom resol

49 s idea, mutants lacking nitrate reductase or fumarate reductase have extreme colonization defects.

50 ese studies were extended to four mutants of fumarate reductase, impaired by single amino acid substi

51 lted in ca. 20-fold-lower levels of mRNA for fumarate reductase, inhibiting fumarate reduction and fa

52 Although fumarate reductase is not associated with any proton-pum

53 In the complex II homolog quinol:fumarate reductase, it has been demonstrated that menaqu

54 formate dehydrogenase via menaquinones to a fumarate reductase located at the cytoplasmic face of th

55 zyme is similar in structure and function to fumarate reductase (menaquinol-fumarate oxidoreductase [

56 trains lacking nitrate reductase outcompeted fumarate reductase mutants once the nitrate concentratio

57 ol in the presence of Casamino Acids or in a fumarate reductase-negative strain growing with glycerol

58 rate reductase, FrdCAB, with homology to the fumarate reductase of Wolinella succinogenes and the suc

59 Escherichia coli quinol-fumarate reductase operates with both natural quinones,

60 A prominent exception was the fumarate reductase Osm1, known to reside in mitochondria

61 Here we show that the fumarate reductase Osm1, which facilitates electron tran

62 to be even more potent inhibitors of E. coli fumarate reductase, particularly when acting in the dire

63 in several eukaryotic species that utilize a fumarate reductase pathway for anaerobic respiration, an

64 in several helminth parasites that utilize a fumarate reductase pathway.

65 ere lower in ETRA-153, as were the levels of fumarate reductase protein and transcript.

66 against the membrane-embedded protein quinol/fumarate reductase (QFR) from Wolinella succinogenes, a

67 been characterized, either in SQR or quinol:fumarate reductase (QFR) in situ.

68 or catalysis by the diheme-containing quinol:fumarate reductase (QFR) of Wolinella succinogenes.

69 e:ubiquinone oxidoreductase (SQR) and quinol:fumarate reductase (QFR) participate in aerobic and anae

70 The quinol-fumarate reductase (QFR) respiratory complex of Escheric

71 al structures of Escherichia coli menaquinol:fumarate reductase (QFR), a complex II superfamily membe

72 e Escherichia coli Complex II homolog quinol:fumarate reductase (QFR, FrdABCD) catalyzes the intercon

73 esidues, Lys-B228 and Glu-C29, at the quinol-fumarate reductase quinone binding site in reactions wit

74 membrane quinol oxidases, cytochrome bd and fumarate reductase redox cycle demethylmenaquinone, and

75 are surprisingly different from the soluble fumarate reductase structures.

76 e show that flavinylation of a member of the fumarate reductase subfamily allows this enzyme to recei

77 that is completely conserved throughout the fumarate reductase/succinate dehydrogenase family of enz

78 utants that lacked NADH dehydrogenase II and fumarate reductase, the most oxidizable components of th

79 from one that is predominantly a menaquinol-fumarate reductase to one that is essentially only funct

80 suggests that RQ is an electron carrier of a fumarate reductase-type complex II in this MRO.

81 We show that removal of soluble fumarate reductase unexpectedly increases health span in

82 The anaerobic respiratory enzyme fumarate reductase uses a flavoprotein subunit that is h

83 rements of site-specific mutations of quinol:fumarate reductase variants show that ubiquinone reducti

84 FeS subunits of succinate dehydrogenase and fumarate reductase, were deleted singly and in combinati

85 n Gln is in the target position and a better fumarate reductase when Glu is present.

86 Fumarate reductase, which is proficient in succinate oxi

87 These results suggest that fumarate reductase, which normally runs in the reductive

88 c respiration rather than the related enzyme fumarate reductase, which produces high levels of ROS.