ライフサイエンスコーパス: fumonisin

1 rates confirming exposure to aflatoxins and fumonisins.

2 to contribute to pathologies associated with fumonisins.

3 resultant mutant lost the ability to produce fumonisins.

4 the role of Fum14p in the esterification of fumonisins.

5 FUM14 is required for the esterification of fumonisins.

6 method for the quantitative determination of fumonisins.

7 the negative health and economic impacts of fumonisins.

8 hich emission was correlated with absence of fumonisins.

9 and 94.4% for all the mycotoxins, except for fumonisins.

10 nd FB2 contents in silage were due to hidden fumonisins.

11 lerable daily intake (PMTDI) recommended for fumonisins.

12 g them, N-(deoxy-D-fructos-1-yl)-FB4 and two fumonisin A4 isomers are herein reported for the first t

13 following inoculation of maize kernels, and fumonisin accumulation was analyzed by high-performance

14 Exposure to fumonisin alone or coexposure with aflatoxins may contri

15 HL-60 and the transfectants was abrogated by fumonisin, an inhibitor of ceramide generation, and by t

16 The effects of GEO on fumonisin and ergosterol production were evaluated at co

17 s, subsequently inhibiting the production of fumonisins and ergosterol.

18 flatoxins and ochratoxin, and 2.0ngL(-1) for fumonisins and neosolaniol.

19 Fusarium moniliforme toxins (fumonisins) and Alternaria alternata lycopersici (AAL) t

20 oor child health and development: aflatoxin, fumonisin, and deoxynivalenol.

21 tion of the mycotoxin FB1 in foods, the anti-fumonisin antibody was conjugated to the large subunit o

22 Aflatoxin and fumonisin are toxic food contaminants.

23 Fumonisins are a family of carcinogenic secondary metabo

24 Fumonisins are a group of mycotoxins found in various fo

25 Fumonisins are a group of polyketide-derived mycotoxins

26 Fumonisins are mycotoxins produced by Fusarium species t

27 Fumonisins are polyketide-derived mycotoxins produced by

28 Fumonisins are secondary metabolites of the fungus Fusar

29 Fumonisins are sphingolipid-like mycotoxins that cause s

30 gus produces several mycotoxins of which the fumonisins are the most toxic.

31 a Farber disease patient in the presence of fumonisin B (1), the conversion to NBD-ceramide was redu

32 A 2-h pretreatment of Jurkat cells with fumonisin B(1) (100 microm), a specific inhibitor of CoA

33 Fumonisin B(1) (FB(1)) is a mycotoxin that inhibits cera

34 Fumonisin B(1) (FB(1)), FB(2), and alternariol monomethy

35 C(6)-ceramide, fumonisin B(1) (FB(1)), or etoposide was used to initiat

36 The tricarballylic acid (TCA) units of fumonisin B(1) (FB(1); accounting for 70 % of fumonisin

37 sphorylation of SR proteins was inhibited by fumonisin B(1) and by overexpression of glucosylceramide

38 , alpha- and beta-zearalenol and fumonisins (fumonisin B(1) and fumonisin B(2)) through mashing and w

39 ns grown for 3 weeks in culture in 20 microM fumonisin B(1) develop dendrites, axons, and synaptic te

40 f fumonisin contamination) can be removed by fumonisin B(1) esterase (FE, EC 3.1.1.87) providing a bi

41 s of the sphingolipid biosynthesis inhibitor fumonisin B(1) has been achieved.

42 These data demonstrate that fumonisin B(1) protects against toxin-induced synaptic b

43 ceramide synthesis (l-cycloserine) and CerS (fumonisin B(1)) in cell viability assays.

44 In this work the ability to predict fumonisin B(1)+B(2) contents in corn meal using an FT-NI

45 Fumonisin B(1), an inhibitor of ceramide synthase, and g

46 The increase in ceramide was inhibited by fumonisin B(1), an inhibitor of ceramide synthase, but n

47 tor of serine palmitoyltransferase (SPT), or fumonisin B(1), an inhibitor of ceramide synthase, retar

48 Fumonisin B(1), an inhibitor of ceramide synthesis, sign

49 cord cell cultures grown in the presence of fumonisin B(1), an inhibitor of ganglioside synthesis.

50 pressed by inhibitors of ceramide synthesis, fumonisin B(1), myriocin, and l-cycloserine, and 4-HPR t

51 When cells were treated with 5-50 microm fumonisin B(1), the cellular level of ceramide decreased

52 5 ng/mL for aflatoxin B(1) and 1.0 ng/mL for fumonisin B(1), with dynamic ranges extending up to 5.0

53 to control cultures, tetanus toxin added to fumonisin B(1)-treated cultures does not block potassium

54 Supplementing fumonisin B(1)-treated cultures with mixed brain ganglio

55 ent with the inhibitor of ceramide synthase, fumonisin B(1).

56 chieved in maize for both aflatoxin B(1) and fumonisin B(1).

57 de synthase is inhibited by the fungal toxin fumonisin B(1).

58 nation of two mycotoxins, aflatoxin B(1) and fumonisin B(1).

59 earalenol and fumonisins (fumonisin B(1) and fumonisin B(2)) through mashing and wort boiling was stu

60 expressing wild type PAK1 with sphingosine, fumonisin B, or sphingomyelinase, all of which are able

61 /kg), diacetoxyscirpenol (<LOQ - 91 mug/kg), fumonisin B1 (<LOQ - 95 mug/kg), fumonisin B2 (<LOQ), fu

62 The specific inhibitor of ceramide synthase, fumonisin B1 (50 microM), was able to suppress H(2)O(2)-

63 glycol-dimethacrylate), PA-EGDMA) to remove fumonisin B1 (FB1) and fumonisin B2 (FB2) from model sol

64 The inhibitory effect on fumonisin B1 (FB1) and fumonisin B2 (FB2) production was

65 eaf tissues with a PCD-inducing fungal toxin fumonisin B1 (FB1) and increased sensitivity to heat sho

66 essment of two highly concerning mycotoxins (fumonisin B1 (FB1) and ocratoxin A (OTA)) has successful

67 ell cultures exposed to mycotoxin stress via fumonisin B1 (FB1) application.

68 e report that PCD triggered by the mycotoxin fumonisin B1 (FB1) can be suppressed by PTI in Arabidops

69 In this study, fumonisin B1 (FB1) consumption was assessed through dete

70 n of sphingolipid synthesis by the mycotoxin fumonisin B1 (FB1) disrupts axonal growth in cultured hi

71 e of the mycotoxins deoxynivalenol (DON) and fumonisin B1 (FB1) in industrial beers.

72 The fungal toxin fumonisin B1 (FB1) induces apoptosis-like programmed cel

73 Fumonisin B1 (FB1) is a carcinogenic mycotoxin produced

74 Fumonisin B1 (FB1) is a food-borne mycotoxin produced by

75 Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide

76 rabidopsis tissues but can be upregulated by fumonisin B1 (FB1) treatment and pathogen infection.

77 nd sensitivity to the PCD-inducing mycotoxin fumonisin B1 (FB1) were increased by ssSPTa overexpressi

78 we assessed GTP mitigation on biomarkers of fumonisin B1 (FB1), a class 2B carcinogen, in blood and

79 Fumonisin B1 (FB1), a programmed cell death-eliciting to

80 Interestingly, fumonisin B1 (FB1), an inhibitor of the salvage pathway,

81 hain ceramide levels, which was inhibited by fumonisin B1 (FB1), and not by myriocin (MYR).

82 mmunoassay (FNanoBiT assay) for detection of fumonisin B1 (FB1), based on the binding of two subunits

83 are targets for inhibition by the mycotoxin fumonisin B1 (FB1).

84 induced by mycotoxins ochratoxin A (OTA) and fumonisin B1 (FB1).

85 ome immunoanalysis) for the detection of the fumonisin B1 (FmB1).

86 ne governing the production of the mycotoxin fumonisin B1 (fum1) among 121 random ascospore progeny f

87 in adducts (AF-alb) using ELISA, and urinary fumonisin B1 (UFB1) using liquid chromatography-mass spe

88 YPC1p suppressed the inhibition of growth by fumonisin B1 albeit more modestly.

89 nd AtORM2 displayed increased sensitivity to fumonisin B1 and an accompanying strong increase in LCBs

90 suitable screening tool for the analysis of Fumonisin B1 and B2 in food samples.

91 bition of the de novo biosynthesis of SLs by fumonisin B1 and beta-chloro-L-alanine completely abroga

92 E C-LIKE 1 serves as a convergence point for fumonisin B1 and extracellular ATP signalling, and funct

93 Good specificity toward fumonisin B1 and its structural analog, fumonisin B2, wa

94 educed sensitivity to PCD-inducing mycotoxin fumonisin B1 as well as oxidative stress inducers, where

95 Although fumonisin B1 blocked ceramide production and increased s

96 as based on the following: 1) the ability of fumonisin B1 but not myriocin to inhibit ceramide format

97 Nevertheless, fumonisin B1 but not myriocin was able to protect from T

98 se findings suggest that dietary exposure to fumonisin B1 could adversely affect folate uptake and po

99 because inhibition of ceramide synthase with fumonisin B1 decreased apoptosis in lyase-overexpressing

100 The ceramide synthase inhibitor fumonisin B1 did not affect AA-induced ceramide producti

101 his is the first report of the occurrence of fumonisin B1 in commercial samples of polished rice from

102 preparation method for the determination of fumonisin B1 in rice was optimised using a strategy of s

103 pe microarray was applied to the analysis of fumonisin B1 in spiked maize and wheat samples.

104 Fumonisin B1 induced cell cycle arrest in the G1 phase i

105 Fumonisin B1 inhibited both the ceramide increase and th

106 ls basally and in response to UV-C, but only fumonisin B1 inhibited cell death, suggesting the presen

107 Ceramide analogues bypassed fumonisin B1 inhibition to initiate apoptosis directly.

108 The addition of fumonisin B1 or AAL toxin, TA, to CV-1 cells induced the

109 Inhibition of ceramide formation by fumonisin B1 or down-regulation of PKCdelta potentiated

110 lls treated with ceramide synthase inhibitor fumonisin B1 or glucosylceramide synthase inhibitor 1-ph

111 h ceramide synthesis inhibitors myriocin and fumonisin B1 or siRNA silencing of CerS6 prevented C16-c

112 Inhibition of ceramide synthesis by fumonisin B1 overcame the defect in PKC phosphorylation

113 paired kernel colonization, but the ratio of fumonisin B1 per unit growth was not significantly reduc

114 Inhibition of ceramide synthase with fumonisin B1 prevented p53 reactivation induced by GCS s

115 nd, inhibition of ceramide accumulation with fumonisin B1 restored the ability of PMA to induce trans

116 ition of de novo synthesis using myriocin or fumonisin B1 resulted in decreased overall cellular cera

117 Exposure to fumonisin B1 suppressed PHOSPHOLIPASE C-LIKE 1 expressio

118 gulation of CYP2C11 when added alone or with fumonisin B1 to block acylation of the exogenous sphingo

119 nor facilitative transport was inhibited by fumonisin B1 treatment, indicating that the effect of sp

120 array-based immunoassay for the detection of fumonisin B1 using a novel mimotope selected by phage di

121 was immobilized onto epoxy-glass slides, and fumonisin B1 was detected in a competitive binding inhib

122 is, since ceramide synthase inhibition (with fumonisin B1) had no effect.

123 sitive on-site quantification of fumonisins (fumonisin B1+fumonisin B2) in maize has been developed.

124 nes encoding all three proteins responded to fumonisin B1, a cell death-activating mycotoxin.

125 The inclusion of fumonisin B1, a ceramide synthase inhibitor, blocked PSC

126 in the ceramides was partially decreased by Fumonisin B1, a ceramide synthase inhibitor.

127 was dependent on ceramide synthesis, because fumonisin B1, a ceramide synthetase inhibitor, blocked t

128 amide without FFA induced DNA laddering, but fumonisin B1, a ceramide synthetase inhibitor, completel

129 de novo biosynthesis was similar to that of fumonisin B1, a classical inhibitor of ceramide synthase

130 Fumonisin B1, a dihydroceramide synthase inhibitor, exag

131 CS activation was obligatory, since fumonisin B1, a fungal pathogen that acts as a specific

132 ction was investigated in Caco-2 cells using fumonisin B1, a mycotoxin that inhibits the biosynthesis

133 However, addition of fumonisin B1, a selective ceramide synthase inhibitor, a

134 ed sphingosine by ceramide synthase, we used fumonisin B1, a specific inhibitor of ceramide synthase.

135 Treatment with fumonisin B1, a specific natural inhibitor of ceramide s

136 and that LASS1 in HeLa cells is sensitive to fumonisin B1, an in vitro inhibitor of (dihydro)ceramide

137 sphinganine by a second method (addition of fumonisin B1, an inhibitor of ceramide synthase) also re

138 Both fumonisin B1, an inhibitor of ceramide synthase, and ISP

139 ion induced by S1P was completely blocked by fumonisin B1, an inhibitor of ceramide synthase, but onl

140 Fumonisin B1, an inhibitor of ceramide synthase, prevent

141 16)-ceramide in SW480 cells was inhibited by fumonisin B1, an inhibitor of ceramide synthases (CerS).

142 in arachidonate signaling was detected since fumonisin B1, an inhibitor of de novo ceramide synthesis

143 y was not inhibited in vitro and in cells by fumonisin B1, an inhibitor of the CoA-dependent ceramide

144 nd okadaic acid, ceramide synthase inhibitor fumonisin B1, and ROS scavenger N-acetylcysteine (NAC).

145 gnificant variables for the determination of fumonisin B1, and then, a central composite rotatable de

146 25.0 ppb of aflatoxin A2, and 1229.4 ppb of fumonisin B1, any of these mycotoxins were detected in i

147 termination of ten mycotoxins (ochratoxin A, fumonisin B1, fumonisin B2, deoxynivalenol, fusarenon-X,

148 of ceramide production by the fungal toxin, fumonisin B1, impaired TCR-induced interleukin (IL)-2 pr

149 sphingolipid biosynthesis, L-cycloserine and fumonisin B1, prevented the observed accumulation of the

150 Myriocin and fumonisin B1, specific inhibitors of key enzymes (serine

151 Fumonisin B1, the N-acyl-sphinganine dehydrogenase (e.g.

152 ivity is CoA-independent and is resistant to fumonisin B1, thus explaining why YPC1 was cloned as a f

153 presence of the ceramide synthase inhibitor fumonisin B1, which inhibited apoptosis by 18%-81% (medi

154 Conversely, fumonisin B1, which inhibits the biosynthesis of endogen

155 Conversely, fumonisin B1, which selectively inhibits ceramide syntha

156 the programmed cell death-inducing mycotoxin fumonisin B1, with an accompanying reduced accumulation

157 d (aflatoxins, ochratoxin A, deoxynivalenol, fumonisin B1, zearalanone, T-2 and HT-2 toxin) and emerg

158 of PHOSPHOLIPASE C-LIKE 1 were resistant to fumonisin B1-induced death.

159 B1, thus explaining why YPC1 was cloned as a fumonisin B1-resistant gene.

160 52 and PHOSPHOLIPASE C-LIKE 1 was altered in fumonisin B1-resistant salicylic acid induction-deficien

161 ular ceramide levels and Abeta generation in fumonisin B1-treated cells.

162 hest LOD (15) and LOQ (50) were reported for fumonisin B1.

163 de novo ceramide biosynthesis, myriocin and fumonisin B1.

164 s whose overexpression bestows resistance to fumonisin B1.

165 y of SL synthesis, beta-chloro-L-alanine and fumonisin B1.

166 competitive inhibitor of ceramide synthase, fumonisin B1.

167 wn risk factors may be caused by exposure to fumonisin B1.

168 ctions in the Arabidopsis stress response to fumonisin B1.

169 hest LOD (15) and LOQ (50) were reported for fumonisin B1.

170 bilization, which was blocked exclusively by fumonisin B1.

171 lead to cell death, which were inhibited by fumonisin B1.

172 im of this study was to evaluate the fate of fumonisins B1 (FB1) and B2 (FB2) during industrial dry-m

173 The stability of Fumonisins B1 and B2 (FB1, FB2) was studied and the effe

174 termined to be effective for quantitation of fumonisins B1 and B2 in feed.

175 simultaneous extraction and determination of fumonisins B1 and B2 in maize.

176 derivatization is a suitable alternative for fumonisins B1 and B2 quantitation in corn-based feeds.

177 (aflatoxins B1, B2, G2 and G1, ochratoxin A, fumonisins B1 and B2) in beers.

178 Among all mycotoxins studied, fumonisins B1 was the most widely distributed in analyse

179 nivalenol, zearalenone, sterigmatocystin and fumonisins B1, B2 and B3.

180 oth the wild type and the dorn1 mutants from fumonisin-B1 toxicity, suggesting that different ATP rec

181 91 mug/kg), fumonisin B1 (<LOQ - 95 mug/kg), fumonisin B2 (<LOQ), fumonisin B3 (<LOQ), T2 (<LOQ) and

182 , PA-EGDMA) to remove fumonisin B1 (FB1) and fumonisin B2 (FB2) from model solutions and red wine.

183 inhibitory effect on fumonisin B1 (FB1) and fumonisin B2 (FB2) production was significant at GEO con

184 s with immobilised L-thyroxine, glucosamine, fumonisin B2 or biotin as template, can demonstrate comp

185 e quantification of fumonisins (fumonisin B1+fumonisin B2) in maize has been developed.

186 n B1) and 15mugL(-1) (for deoxynivalenol and fumonisin B2).

187 ten mycotoxins (ochratoxin A, fumonisin B1, fumonisin B2, deoxynivalenol, fusarenon-X, T-2 and HT-2

188 ward fumonisin B1 and its structural analog, fumonisin B2, was observed, together with negligible cro

189 B1 (<LOQ - 95 mug/kg), fumonisin B2 (<LOQ), fumonisin B3 (<LOQ), T2 (<LOQ) and zearalenone (<LOQ).

190 chratoxin A, diacetoxiscyrpenol (DAS), three fumonisins, beauvericin (BEA), deoxynivalenol (DON), 15-

191 sm to regulate vegetative growth, virulence, fumonisin biosynthesis and stress response in F. vertici

192 mutant exhibited severe defects not only in fumonisin biosynthesis but also vegetative growth and co

193 polyketide synthase gene (FUM1) required for fumonisin biosynthesis.

194 monisins, confirming the key role of FUM1 in fumonisin biosynthesis.

195 to host and environmental stimuli to trigger fumonisin biosynthesis.

196 In Fusarium, fumonisin biosynthetic genes (FUM) are clustered, and th

197 ied, as did the effects on the production of fumonisins, but at >/=300 mug/mL of REO, these processes

198 Whereas fungi damage plants, fumonisins cause disease both to cattle breedings and hu

199 However, the three forms of fumonisins collected in all fractions amounted to 183%,

200 Fumonisin concentrations from samples measured by MINA w

201 ants generated are no longer able to produce fumonisins, confirming the key role of FUM1 in fumonisin

202 Fumonisins contain a highly reduced, acyclic 18-carbon c

203 Fumonisins contain two tricarballylic esters that are cr

204 fungus that produces the harmful mycotoxins fumonisins, contaminates worldwide a broad range of crop

205 lation between cancer and food suggests that fumonisin contamination rather than aflatoxin is the mos

206 umonisin B(1) (FB(1); accounting for 70 % of fumonisin contamination) can be removed by fumonisin B(1

207 al a potential biocontrol strategy to reduce fumonisin contamination.

208 associated with a safer product in terms of fumonisin contamination.

209 At present, fumonisin determination is performed using costly and de

210 ation between child growth and aflatoxin and fumonisin exposure in Tanzania.

211 B(4) to the tricarballylic esters-containing fumonisins, FB(3) and FB(4), respectively, when incubate

212 gbw/day for the sum of (DON+3-ADON+15-ADON), fumonisins (FB1+FB2+FB3), the sum of (T2+HT-2), NIV and

213 d the occurrence of deoxynivalenol (DON) and fumonisins (FBs) in malting barley.

214 effect of nixtamalization on the content of fumonisins (FBs), hydrolysed (HFBs) and partially hydrol

215 zearalenone, alpha- and beta-zearalenol and fumonisins (fumonisin B(1) and fumonisin B(2)) through m

216 and ultrasensitive on-site quantification of fumonisins (fumonisin B1+fumonisin B2) in maize has been

217 allows a fast and reliable determination of Fumonisin in beer samples with recovery rate of 87-105%.

218 d is comparable to HPLC for the detection of fumonisins in corn, animal feeds, and human foods.

219 ysed (HFBs) and partially hydrolysed (PHFBs) fumonisins in maize was investigated at laboratory-scale

220 nd PHFBs reduction, due to the solubility of fumonisins in water during the steeping process, but did

221 this FE is likely capable of detoxifying any fumonisin indicating its potential applicability in food

222 ked by myriocin inhibition of SPT as well as fumonisin inhibition of the ceramide synthases, suggesti

223 HFB(4), which are biosynthetic precursors of fumonisins lacking the tricarballylic esters, were detec

224 In the endosperm, cornmeal and grits fumonisin levels decreased from 60 to 95%.

225 trial dry-milling can contribute to reducing fumonisin levels in corn products intended for human con

226 Fumonisin levels in cornmeal and grits were below the ma

227 robic conditions for 7days have shown higher fumonisin levels than those not exposed to air.

228 flatoxin promotes hepatocellular cancer, and fumonisin may promote esophageal cancer.

229 Fusarium verticillioides produces fumonisin mycotoxins during colonization of maize.

230 , a major fungal pathogen of maize, produces fumonisins, mycotoxins of global food safety concern.

231 oduced by inhibition of ceramide synthase by fumonisins, mycotoxins produced by Fusarium moniliforme,

232 ungus also produces carcinogenic mycotoxins, fumonisins on infested maize.

233 volatile organic compounds (VOCs) emitted by fumonisin-producing (wild-type) and nonproducing (mutant

234 s ethyl 3-methylbutanoate reduced growth and fumonisin production in wild-type F. verticillioides, sh

235 Thus, the inhibition of fungal biomass and fumonisin production was dependent on the concentration

236 growth of F. verticillioides and subsequent fumonisin production.

237 d that Gbeta protein FvGbb1 directly impacts fumonisin regulation but not other physiological aspects

238 h) were tested, with all polymers exhibiting fumonisin removal capacities (monitored by LC-MS).

239 on small cereals that produce aflatoxins and fumonisins, respectively, while directly competing with

240 Fumonisin-specific antibody was used to isolate mimotope

241 are not frequently studied in milk, such as fumonisins, sterigmatocystin or ochratoxin B.

242 , ochratoxin A, zearalenone, deoxynivalenol, fumonisins, T-2 and HT-2 toxins, fusarenone X, diacetoxy

243 on made available forms of matrix-associated fumonisins that were then converted to their hydrolysed

244 lites were tentatively identified, including fumonisins their modified forms (i.e. hydrolysed, acylat

245 Law limits set fumonisins tolerable daily intake with respect to severa

246 Moreover, blocking ORMDL induction with fumonisin treatment resulted in significantly greater in

247 ing mycotoxins (ochratoxins, aflatoxins, and fumonisins) using DBS/DSS and VTS assays.

248 A limit of detection of 2.5 mugL(-1) for fumonisins was achieved, with an analytical working rang

249 The occurrence of masked fumonisins was also investigated.

250 The recovery values for fumonisins were between 42.1% and 64.6%.

251 Fumonisins were concentrated in the germ and pericarp at

252 ollected from each year, all of six examined fumonisins were detected with very high prevalence (from

253 Fumonisins were reduced by between 50 and 100 per cent d

254 und in peanut, maize, rice, and cassava) and fumonisins, which occur primarily in maize.