ライフサイエンスコーパス: function

1 levels of insulin sensitivity and beta-cell function.

2 ment can provide valuable insight into their function.

3 ce that this modification can affect protein function.

4 key transcription factors ensures beta-cell function.

5 ngly understood to be important for cellular function.

6 nner that is dependent upon intact lysosomal function.

7 es and for the experimental testing of nasal function.

8 xpected effects on electrical and mechanical function.

9 lular processes depend on proper spliceosome function.

10 concentration was best fit by a logarithmic function.

11 rly ketamine exposure on brain structure and function.

12 ern statistical approaches by the likelihood function.

13 sthma control questionnaire (ACQ-6) and lung function.

14 sment of primate trophoblast development and function.

15 a key regulator of regulatory T (Treg) cell function.

16 ecruiting NF2 to the ICD to modulate cardiac function.

17 ions of specialized metabolite structure and function.

18 unity changes, including loss of species and function.

19 y cells showed near complete loss of protein function.

20 s ECs, and are important for proper neuronal function.

21 tained body mass despite variation in immune function.

22 ions can lead to profound changes in protein function.

23 estin-1 is necessary and sufficient for this function.

24 and release, implying additional steps in IB function.

25 , if charge transfer can be coupled with RNA function.

26 that stiffens the tissue and impairs ocular function.

27 codon optimality in BRCA1 can attenuate its function.

28 c differences in lactation, diet, and immune function.

29 cardium and corresponding decline in cardiac function.

30 mutation-induced changes to genuine loss of function.

31 ut impairment of hemodynamics or right heart function.

32 such as benzoyl-leucyl-leucine (Bz-LL), for function.

33 rence in the genome or essentiality for cell function.

34 cing that establish immune cell identity and function.

35 ional modification that can regulate protein function.

36 overexpression model to study its regulatory function.

37 licated in IL-17 signaling or nervous system function.

38 into the catalytic mechanism of this cryptic function.

39 d in the appropriate cellular compartment to function.

40 ical organization that may constrain network function.

41 ing a wide range of physiological states and functions.

42 egeneration and in vivo restoration of organ functions.

43 itial steps of ribosome biogenesis and other functions.

44 le enzymes that serve a range of biochemical functions.

45 ntax is different, suggesting discriminatory functions.

46 eometries that may be customizable for novel functions.

47 expression, suggesting general GATA cofactor functions.

48 stinct metabolic requirements and biological functions.

49 d convergent epigenomes, transcriptomes, and functions.

50 , indicating two distinct but interdependent functions.

51 to molecules with diverse shapes, sizes and functions.

52 of HeRs, suggesting their diverse biological functions.

53 ic control of enhancers that modify neuronal functions.

54 ed into complex circuits, form systems-level functions.

55 eveloping molecular assemblies/processes for functions.

56 mpact of metastatic bone disease on physical functioning.

57 ng of their interactive effects on ecosystem functioning.

58 lute insulin secretion but impairs beta-cell function, 2) causes insulin resistance, and 3) reduces m

59 nductivity (~11 670 S cm(-1) ) and high work function (~5.1 eV), which are achieved by combining a si

60 in vivo and in vitro studies supporting this function, a mechanistic understanding of how Msp1 extrac

61 Consistent with being loss-of-function alleles, we show using patients' primary fibrob

62 DNA ADP-ribosyl glycohydrolase, DarG(Mtb) ), functions along with its cognate toxin Rv0059 (DNA ADP-r

63 ells (ie, FOXP3), resulting in impaired Treg function and autoimmunity.

64 B levels, directly correlated with sarcomere function and can be used to predict TNNT2 variant pathog

65 Further exploration of LRO function and carboxylesterase homologs in C. elegans and

66 results show that Dw2 modulates endomembrane function and cell division during sorghum internode grow

67 by pharmacological inhibition of the eIF4G1 function and chemogenetic inhibition of neuronal activit

68 e resource for investigating human astrocyte function and dysfunction in health and disease.

69 he effects of rare SERPINA1 variants on lung function and emphysema phenotypes in subjects with signi

70 iated with a paradoxical mitochondrial hyper-function and increased oxidative stress, possibly result

71 rized pathological tissue integrity, barrier function and metabolic stability over time.

72 RNAs are involved in neuroplasticity, immune function and neurorestoration.

73 of depression, at both the level of synaptic function and protein expression.

74 lactic and therapeutic RDV improve pulmonary function and reduce lung viral loads and severe lung pat

75 targets for selective manipulation of CD11b function and reduction of PMN-associated tissue damage i

76 ns open new and interesting questions on the function and regulation of the E/I balance.

77 the condition-dependent expression of immune function and stress response.

78 iary geometry, but also maintains control in function and structural evolution.

79 Here, we investigated the function and structural organization of the protein coro

80 duct of lipid peroxidation) on mitochondrial function and structure was assessed in HL1 murine cardio

81 established effects on CFTR trafficking and function and suggested novel roles of EGR1 and SGK1 in t

82 ts implication in the pathogenesis of immune function and the development of CF lung disease.Methods:

83 espite these fluctuations is crucial to cell function and viability.

84 Human disturbances alter the functioning and biodiversity of many ecosystems.

85 g healing by balancing the primary defensive functions and excessive tissue damage actions.

86 ns, contributes to the prediction of protein functions and facilitates protein-protein docking calcul

87 gnificant role in maintaining the structure, functions and integrity of the aquatic ecosystem.

88 cose, insulin, insulin resistance, beta-cell function, and adiponectin at age 11.5 years.

89 d neurotransmitter control of nervous system function, and fundamental changes in behaviors such as l

90 iew starts with a description of the ER, its function, and its role in cancer progression and treatme

91 g MI limits cardiac damage, improves cardiac function, and mitigates remodeling to a larger extent th

92 mortality, hospital mortality, and physical function- and mental health-related quality of life at 2

93 ry domain impair NHE6 activity and endosomal function are poorly understood.

94 Emerging methods to infer cellular functions are beginning to shed new light on the interpl

95 In somatic cells, these functions are both mediated by Scc1-cohesin, which in mi

96 Many lysosome functions are determined by a lumenal pH of ~5.0, includ

97 its major branches; however, their specific functions are not well-understood.

98 g, how this relates to HCV entry, and CD81's function as a molecular scaffold; these insights are rel

99 the setting of tumour-derived antigens, cDC1 function as an autonomous platform capable of antigen pr

100 arum (PfA-M17) and Plasmodium vivax (Pv-M17) function as catalytically active hexamers to generate fr

101 nd 3' boundaries of this mammalian gene that function as enhancers and insulators.

102 ctivity are a set of protein assemblies that function as molecular motors to couple the energy of nuc

103 uses deep learning to learn a cell embedding function as well as a set of landmarks in the cell embed

104 ich will provide important insights into its function as well.

105 her, AGO1 controls cell and tissue growth by functioning as a direct transcriptional repressor of the

106 central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-depend

107 together, these findings suggest that TRIM32 functions as a regulator of PKCzeta that controls the di

108 that have aided in correlating ontogeny with function, as well as how these findings can be translate

109 s challenges our understanding of organismal functioning, as the link among electron transfer, metabo

110 recapitulating effects observed in tethered function assays.

111 Y) 7 (Y7) and Y15 examinations, with cardiac function assessed at Y30 after adjustment for key covari

112 asers, and readers, the breadth of chromatin functions associated with ubiquitin signaling is emergin

113 p cohort study included 263 KTRs with grafts functioning at least 1 year after transplantation.

114 ics in the context of biodiversity-ecosystem functioning (BEF) research.

115 lls and behaviour along with their cognitive functions beyond navigation.

116 complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking, includin

117 Exploring the correlations between immune function, body mass and moult, showed that an increase i

118 he respective LRR-RK leads to strong gain-of-function brassinosteroid, floral abscission, and stomata

119 stability (C253) and (4) those with no known function (C28 and C75).

120 atterns in different environments, a circuit function called "remapping." We tested remapping in amyl

121 Review, we summarize how adult reproductive function can be shaped by childhood events.

122 heart, and abnormalities in its structure or function cause sick sinus syndrome, the most common reas

123 Because of its immunomodulatory function, CD40L has been used to enhance immune response

124 hroughput discovery and subsequent structure-function characterization, we present simple peptides th

125 hanges, inference is highly sensitive to the function choice.

126 h2K/+/Rom1+/- mice had improved rod and cone function compared with Prph2K/+ as well as amelioration

127 t older adult mice, causes defects in muscle function, consistent with a prolonged postnatal role for

128 Proteinuria is associated with renal function decline and cardiovascular mortality.

129 uding RPS27L, were associated with pulmonary function deficits in obese children with asthma.Conclusi

130 ive of an inflammatory response and cellular function deficits.

131 Hypertension often occurs before renal function deteriorates in autosomal dominant polycystic k

132 gical changes that cause alterations in lung function, diminished pulmonary remodeling and regenerati

133 e identified a significant excess of loss-of-function DNMs in genes highly expressed in craniofacial

134 ems can affect whole-organism physiology and function due to off-target effects.

135 Moreover, Med19 loss of function experiments in vivo or in cellulo indicate that

136 ivity suggest nearly invariant structure and function for aluminosilicate zeolite MFI two-dimensional

137 Here, we describe a function for NEK10 in the regulation of p53 transcriptio

138 To deconvolve the different functions for KHARON, we have identified two partner pro

139 al to migrate is one of the most fundamental functions for various epithelial, mesenchymal, and immun

140 Emerging evidence indicates dynamic functions for various MAPs in activity-dependent synapti

141 es directly translate to distinct biological functions: free IgE initiated allergic inflammation thro

142 process that is essential for many cellular functions, from cell division to lysosome degradation an

143 and pushes our understanding of human brain function further along the spectrum from strict modulari

144 t implications for understanding tetraspanin function generally.

145 nsion pores determine organelle dynamics and functions, giving rise to physical observables during th

146 In this study, Fc-mediated effector functions have been quantified in vivo relative to the c

147 and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been

148 Finally, we demonstrated robust function in biomedically and industrially relevant bacte

149 ia are important for neuronal maturation and function in cells of the SC and dLGN.

150 s vital for accurately understanding protein function in cellular processes.

151 ave revolutionized our understanding of gene function in complex biological settings, including T cel

152 g recurrent cancer mutations exhibit loss of function in modulating the Hippo pathway, inducing CIP,

153 ure to measures of proximal and distal motor function in patients after hemispherotomy.

154 the HOTAIR regulatory element and that both function in regulating glioma cell sensitivity to TMZ.

155 rotein deubiquitinase USP4 and, in turn, its function in the cell.

156 's effect on intercalated and principal cell function in the cortical collecting duct (CCD).

157 modulation of olfactory sensory neuron (OSN) function in the Drosophila larva.

158 rdial energetics and measures of contractile function in the mouse heart.

159 ach for preparing islets that enhances islet function in vitro and reduces immunogenicity.

160 signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored.

161 external rhizospheric and internal hormonal functions in flowering plants.

162 however, how degradation events regulate BCR functions in GCs is unclear.

163 d by appropriate breeding, implying distinct functions in karyokinesis and cytokinesis.

164 d with HSF1 in a stress-inducible manner and functions in repression of specific HSF1 target genes.

165 that disruptions in flexible decision-making functions in substance-dependent individuals are a conse

166 deficiencies to show that Sox10 has multiple functions in the developing mammary gland.

167 Here, we demonstrate that Parkin has functions in the nucleus and that Parkinson's disease-as

168 argely by paracrine activation of angiogenic functions in the peri-ischemic vasculature.

169 CHC22 functions in transport from the ERGIC, as demonstrated b

170 nd unbiased interrogation of USP22-regulated functions in vitro demonstrated critical roles for USP22

171 EVs) are known to influence their biological function, in terms of, e.g., cellular adhesion, endo/exo

172 PVAT's contributions to vascular function include more than production of vasoactive subs

173 genes RPL4A and RPL4D, and that RPL4 loss-of-function increases osmotic stress tolerance and decrease

174 CCC1 functions independently of PM depolarization and negativ

175 n tolerance, implying that CsrA controls key functions involved in the transmission of A. baumannii i

176 Cellular regulation of protein functions involves differential gene expressions, post-t

177 ms governing how tissue specificity of their function is achieved are poorly understood.

178 mplicated in heterochromatin regulation, its function is inconsistent across different systems; ortho

179 ogical analyses, we found that mitochondrial function is maintained in the presence of H(2)S in sulfi

180 nscriptome related to ciliogenesis and cilia function is significantly impaired during differentiatio

181 however, its impact on pancreatic beta-cell function is unknown.

182 nderstanding why a hypomorphic loss of BCCIP functions is more relevant to tumorigenesis.

183 reveal that a gain-of-function JAK1 genetic variant results in a mutant protei

184 Inpp5e(rdg) function largely depended on the presence of cilia and o

185 the zmnlp5 mutant plants, loss of the ZmNLP5 function led to changes in expression for a significant

186 utations are demonstrated to exert a gain-of-function mechanism, augmenting transforming growth facto

187 dition to providing evidence that complement function modulates SARS-CoV-2 infection outcome, the dat

188 o the rgi1/2/3/4/5 quintuple mutant, loss-of-function mutants of MPK3 and MPK6, MKK4 and MKK5, or YDA

189 identification and the discovery of loss-of-function mutations associated with human disease.

190 Gain-of-function mutations in KCNT1, the gene encoding Slack (K(

191 ioinformatics, we identified Glt(Ph) gain-of-function mutations in the flexible helical hairpin domai

192 Recently, gain-of-function mutations in the mechanosensitive ion channel P

193 sus macaque CD200R, as well as the potential function of a secreted form of vCD200.

194 Previous studies demonstrated that loss of function of ANK or ENPP1 (reducing PP(i)) resulted in in

195 lement of ion channels and to understand the function of biological circuits.

196 These data shed light on the function of C9orf72 in normal physiology, and in amyotro

197 thers, indicating a conditional pro-survival function of caspase-8 in cancer.

198 of Klk1b21, suggesting that the cooperative function of EBE and TIE is essential for mediating AF-1-

199 modelled CCF50 as a time-series random walk function of educational attainment and contraceptive met

200 ging because P varies within landscapes as a function of geology, topography and climate.

201 However, the function of GPR139 and its signaling mechanisms are poor

202 ease progression, but the precise biological function of HtrA1 in the eye and its contribution to dis

203 Here we identify a novel and critical function of IKK2 and its co-factor NEMO in the activatio

204 s a better understanding of the assembly and function of metalloclusters in diverse application areas

205 for future investigations of the biological function of metaphosphates in many organisms.

206 The true ecological function of most SMs remains obscure, but understanding

207 protein lipoylation, the best characterized function of mtFAS, as mutants lacking lipoylation have a

208 However, the function of NE in expression of aversively-conditioned r

209 s in recent years have uncovered the crucial function of neuroimmune interactions in maintaining tiss

210 nts that alter the structure, expression, or function of protein-coding regions of cancer-biology rel

211 Thus, both the molecular function of STEAP1 and its role in cancer progression re

212 n this study we characterized the biological function of the ACKR2-V41A receptor compared to the wild

213 multiple structural features or a nullified function of the chimeric construct.

214 sive techniques to investigate mitochondrial function of the CNS in vivo.

215 in the adult pancreas and highlight a novel function of the Delta/Notch pathway in beta-cell insulin

216 We hypothesize that one function of the P and L rings is to seal the outer membr

217 n of silent gene clusters and the ecological function of the produced compounds is of importance to r

218 variants are predicted to result in loss-of-function of the protein.

219 he mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 is

220 s activation, and may aid future work on the function of this effector during Legionella pathogenesis

221 Here, we explored the function of this kinase in macrophages with studies of i

222 e been previously detected, the location and function of this mark within the infectious cycle is unk

223 ring animal infection, implying an important function of this protein in bacterial infection.

224 s in a transcription factor critical for the function of thymus-derived regulatory T (Treg) cells (ie

225 anges in the community structure as a smooth function of time.

226 by agonistic Abs enhances the expansion and function of tumor-infiltrating lymphocytes (TILs) for tr

227 of organismal tolerances on the assembly and functioning of reef fish communities are largely unknown

228 We further validated the functions of 3 new adipose IR genes by overexpression-ba

229 al in protective, metabolic, and physiologic functions of human health.

230 to act by cysteine modification to alter the functions of immune-relevant proteins; however, our unde

231 The functions of importin-alpha/importin-beta and importin-1

232 Recent studies have demonstrated new functions of individual members of the FABP family.

233 -responsive materials that mimic the complex functions of living systems.

234 le tag does not interfere with the essential functions of RanBP9.

235 ed to repression of gene expression, but the functions of repressive histone methylation dynamics dur

236 ture investigation of the diverse biological functions of SA1 and SA2.

237 We investigated the functions of the antiapoptotic protein MCL1, another mem

238 ctric output is strongly related to the work functions of the materials.

239 has somewhat different surfaceomes, but the functions of these proteins are harmonized by common bio

240 hape perception is one of the most important functions of vision.

241 lated degenerative disorders, and the normal functions of Vn, especially those related to bone resorp

242 CoREST) enables a chromatin enzyme (LSD1) to function on a nucleosome and not just histones, we have

243 ng that anthrose may serve an antiphagocytic function on the spore surface.

244 -designed protein, conferring entirely novel functions on the peptide scaffolds.

245 rporating indexing into frameworks of memory function opens new avenues of study and even therapies f

246 s iron and copper are essential for cellular functions, others such as cadmium and arsenic are inhere

247 traditional ARDSnet settings to improve lung function, oxygenation and ventilation/perfusion matching

248 onal ubiquitin chains in neural development, function, plasticity, and related pathologies.

249 nt administration of a neutralizing/effector function-positive bNAb via the airway and systemic route

250 drug repurposing, disease modeling and gene function prediction.

251 antibodies as tools to interrogate structure-function relationships of assembly line PKSs.

252 des a further understanding of the structure-function relationships of large viruses and should aid i

253 SERCA function remains constant in CH but decreases (tau for S

254 equired nor sufficient for cohesion, and its function remains unknown.

255 n vivo, for transducing light stimuli to non-functioning retinas.

256 e association with physical domain (physical functioning, role limitations caused by physical health

257 However, its cellular function(s) and whether it plays a role in maintenance o

258 Cell surface-based loss-of-function screens reveal that ATP7A, a copper-exporter up

259 es in functional descriptions and biological functions shared among genes.

260 Through this polar DprA targeting function, sigma(X) mediates the timely shut-off of the p

261 h domain protein, regulates various cellular functions, such as vesicle trafficking, activity of the

262 played an essential role in heterochromatin function, suggesting an ancestral role of this mark in t

263 ous adverse events related to abnormal liver function tests (OR 11.19, 95% CI: 2.09-60.02) or pneumon

264 s genetic models of mouse DC development and function that have aided in correlating ontogeny with fu

265 hogens, antibodies mediate additional immune functions that may have both protective and pathological

266 eukocytes have non-traditional immunological functions that regulate organismal metabolism by control

267 ass concentrations using probability density functions that represent environmental microplastic.

268 isease-associated genetic mutations that may function through regulation of m7G methylation.

269 ganized structures of host immune cells that function to contain the bacteria.

270 nsights into how FOXA1 mutations perturb its function to dictate cancer progression and therapeutic r

271 However, the contribution of this function to tumor suppression is poorly understood.

272 Together, our findings suggest that m6A functions to enhance translation of key morphogenetic re

273 ew classes of small molecules that endow new functions to enzymes via proximity-mediated effect are e

274 these SCFAs directly impact B cell intrinsic functions to moderately enhance class-switch DNA recombi

275 ings demonstrate that BRCA2 tumor suppressor function tolerates substantial reduction in full-length

276 Vascular K(ATP) channel function (topical glibenclamide superfused onto hindlimb

277 In the absence of DXO1 function, transcripts displaying a high proportion of NA

278 ncreased cytokinin signaling in ARR1 gain-of-function transgenic lines is associated with increased r

279 Molecules regulating interneuron function under redox control include NMDA receptor subun

280 y HIOs generated in this way to measure CFTR function using cystic fibrosis patient-derived iPSC line

281 Bi-allelic loss-of-function variants in genes that encode subunits of the a

282 VPS4A function was also required for normal endosomal morpholo

283 and moult, showed that an increase in immune function was associated with a decrease in body mass and

284 Normal diastolic function was found in 23 (11%) patients, dysfunction gra

285 Contractile function was similarly impaired (ejection fraction, day

286 A partial loss of BCCIP function was sufficient to trigger genomic instability a

287 ing recruited cells to elicit their effector function, was, at least in part, dependent on formation

288 understand how these compounds alter T cell function, we assessed their therapeutic activity in a mo

289 To determine if structure informs function, we generated mice with zG-specific expression

290 Color contrast response functions were measured in two experiments with differen

291 Throughout, we correlate structure with function whenever possible.

292 ion adversely impacts niche activity and HSC function which is reversible upon suppression of inflamm

293 in cardiac hypertrophy and impaired systolic function, which could severely limit the therapeutic pot

294 fferentiate effector binding from biological function, which has ramifications for riboswitch charact

295 nced T-cell activation, differentiation, and function, which translates in vivo to an improved abilit

296 -selective multibit programming, and erasing functions, which allow in-pixel image pre-processing.

297 and identified a membrane protein of unknown function with low sequence homology but high structural

298 ally active, which suggests mammalian lipins function with the same domain architecture as Tt Pah2.

299 tor (GAF), a Drosophila pioneer-like factor, functions with both SWI/SNF and ISWI family chromatin re

300 cer of Shh signaling, indicating that Inpp5e functions within the cilium to regulate the pathway.