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1 d hypertension, and has been demonstrated to function as a beta-arrestin-biased ligand for the beta(2
2 ral Networks (DNN) to predict toehold switch function as a canonical riboswitch model in synthetic bi
4 ne expression, and demonstrates that NMD can function as a cell intrinsic restriction mechanism actin
5 P1 on actin dynamics puts a spotlight on its function as a central signaling molecule that regulates
6 (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response
7 the results together indicate that HAI-2 can function as a cognate inhibitor for TMPRSS2 in human pro
8 thod with sufficient scale to simultaneously function as a companion diagnostic, therapeutic personal
12 esults suggest that slow blink sequences may function as a form of positive emotional communication b
16 results indicate that water solubility could function as a limiting factor for bioaccessibility of in
17 independently through time and space and may function as a molecular marker to follow any further spr
18 molecules contribute to the OM's ability to function as a molecular permeability barrier that protec
19 g, how this relates to HCV entry, and CD81's function as a molecular scaffold; these insights are rel
20 ggest that CREB, within CeA Crh neurons, may function as a molecular switch that regulates expression
22 heric, hydrologic and geomorphological realm function as a nonlinear filter that fundamentally alters
23 new essential epigenetic regulator that may function as a nuclear effector of MILI to silence TEs by
25 shows that the WT1 protein affecting ZF4 can function as a protestis factor in an XX chromosomal cont
26 with a transmembrane protein kinase that may function as a receptor for the egg elicitor and other ge
27 at, like TEMs, OsRAV9/OsTEM1 has a conserved function as a repressor of photoperiodic flowering upstr
29 port a model in which SNAP23 plays a crucial function as a scaffold for ATG16L1 necessary for the sup
30 uclear roles are unknown, but it is known to function as a scaffolding or adaptor protein at cell-cel
31 on of corresponding NHC-Ir molecules and can function as a solid molecular recyclable catalyst for de
32 erstanding of male germ cell biology and TLR function as a starting point to explore the mechanistic
37 TC-PTP), encoded by Ptpn2, has been shown to function as a tumor suppressor during skin carcinogenesi
39 ein receptor-related protein-1 (LRP1), which functioned as a cell-signaling receptor system in lipid
41 A single acetylation mark lysine258 on ACO2 functioned as a regulatory motif, and the acetylation-de
42 r laboratory indicated that V. cholerae OmpR functioned as a virulence regulator through repression o
43 the first example of an RNA-binding protein functioning as a central regulator of cancer metabolism
44 her, AGO1 controls cell and tissue growth by functioning as a direct transcriptional repressor of the
45 t sites with a degenerate motif, while still functioning as a gene-specific transcriptional regulator
46 d limited support for alteration in HPA axis functioning as a general mechanism for the health conseq
47 l physiology and stress-responsive behavior, functioning as a global regulator of organismal response
48 nonreductive amination, while simultaneously functioning as a matrix in MALDI-MS glycan analysis.
49 table metal-free photosensitizer (aPS), also functioning as a pre-photosensitizer as it is converted
50 rate that Protrudin promotes regeneration by functioning as a scaffold to link axonal organelles, mot
54 ption factor aryl hydrocarbon receptor (AHR) functions as a biosensor in intestinal neural circuits,
55 the Cdk1-counteracting phosphatase PP2A-B55 functions as a bistable switch, even when the bistabilit
57 In contrast to previous claims that PbgA functions as a cardiolipin transporter(6-9), our structu
60 in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and
63 wn that the conjugated polyelectrolyte CPE-K functions as a conductive matrix to electronically conne
64 our results suggest that the IRAK2 Myddosome functions as a critical link between inflammation and me
65 or that opsonizes bacteria for clearance and functions as a damage-associated molecular pattern to ac
67 These results suggest that striatal Gadd45b functions as a dopamine-induced gene that is necessary f
68 ministic in DSB repair pathway choice, 53BP1 functions as a DSB escort that guards against illegitima
70 wly identified subunit of the TIM23 complex, functions as a gatekeeper of presequence translocase and
71 9, a Neurospora crassa DEAD-box protein that functions as a general chaperone for mitochondrial group
74 er with weakly coordinating anion nodes that functions as a high-performing single-ion conducting ele
79 is creating conditions within which Sesarma functions as a keystone species that is driving dynamic,
81 te profile of AldC suggests that this enzyme functions as a long-chain aliphatic aldehyde dehydrogena
83 y primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally div
86 eloid translocation gene family protein that functions as a master transcriptional corepressor in hem
88 ant childhood brain tumor, but whether DDX3X functions as a medulloblastoma oncogene or tumor suppres
91 coregulator analysis, we show that bilirubin functions as a molecular switch for the nuclear receptor
92 central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-depend
93 is localized at the plasma membrane where it functions as a molecular switch, coupling extracellular
94 gmental nucleus (LDTg) expresses GLP-1Rs and functions as a neuroanatomical hub connecting the nucleu
97 her, these studies strongly suggest that BTK functions as a physiologic inhibitor of NLRP3 inflammaso
98 Mechanistic experiments revealed that IFITM3 functions as a PIP3 scaffold and central amplifier of PI
101 Together these studies indicate that SOX3 functions as a pro-commitment factor in spermatogonial s
103 rating that its phosphorylation at serine-70 functions as a redox sensor to prevent drug-induced oxid
105 for development and viability in Drosophila, functions as a regulator of autophagic flux in multiple
106 together, these findings suggest that TRIM32 functions as a regulator of PKCzeta that controls the di
108 Because this peripheral heterochromatin functions as a repressive phase, mechanisms that relocat
109 t the dual regulation of GR by PI3K and PTEN functions as a rheostat that can be exploited for the tr
110 of neutrophils where cell-membrane potential functions as a rheostat to modulate the SOCE response.
112 uter membrane (OM) of Gram-negative bacteria functions as a selective permeability barrier to the env
118 MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an alp
123 form of PKM2 has alternative, nonglycolysis functions as a transcriptional coactivator to enhance th
126 rine/threonine Protein Phosphatase 2A (PP2A) functions as a tumor suppressor by negatively regulating
130 of evidence supporting the notion that ICP22 functions as a virally encoded cochaperone (J-protein/Hs
131 ption factor family, that we recently showed functions as a virulence factor alternating the host's i
132 llustrate that although HIV-1 RNA serves two functions, as a translation template and as a viral geno
135 as emerged as a satellite organelle that can function as an acentrosomal microtubule-organizing cente
137 the setting of tumour-derived antigens, cDC1 function as an autonomous platform capable of antigen pr
139 findings underscore the importance of their function as an evolutionary advantage and that of the H2
140 monstrate that tumor-targeting EDV nanocells function as an immunotherapeutic by delivering a cytotox
141 ncluding human cells, I/LnJ CD300LF does not function as an MNV entry factor in macrophage-like cells
143 role for STK19 in melanoma progression via a function as an NRAS kinase, suggested by Yin et al. (201
144 and BRD4, for degradation, whereas it might function as an oncoprotein in kidney cancer, for example
146 ligands can serve a Lewis base or Lewis acid function, as an aromatization/dearomatization shuttle, o
149 se of a boron-chalcogen mixture, where boron functions as an "oxygen sponge" to remove oxygen from an
150 Collectively, we reveal self-association functions as an additional mode of Gle1 regulation to en
151 ate that by inactivating gliomedin, Bmp1/TLD functions as an additional regulatory mechanism to ensur
156 g a synthetic polymer nanoparticle (NP) that functions as an effective, broad-spectrum metalloprotein
158 instead suggest that protonated aminomethyl functions as an electron-withdrawing group to reduce the
159 Further examination indicated that circDYM functions as an endogenous microRNA-9 (miR-9) sponge to
161 protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic activator of AR transcription
162 he hypothesis that LeuRS-F, but not LeuRS-I, functions as an essential tRNA synthetase that accuratel
163 r, our data indicate that NF-YB21-FUS3-NCED3 functions as an important avenue in auxin-regulated popl
165 ction mechanism in autophagy and that UBQLN2 functions as an important regulator of the expression an
166 nd activated by DNA double-strand breaks and functions as an important sensor of reactive oxygen spec
167 d lysine of protein kinases (Lys111 of PDK1) functions as an integrator node to coordinate allosteric
168 the N-terminal extracellular domain of PC-1 functions as an intrinsic agonist that is necessary and
169 In contrast to the C57BL/6J allele, which functions as an MNV entry factor in all tested cell type
173 ative plants introduced to Great Britain may function as analogues of novel anthropogenic habitats fo
174 r responses while retaining their ability to function as antigen-presenting cells and by actively sup
176 vessels, resulting in improved microvascular function, as assessed by laser Doppler imaging and ionto
177 intermediate filaments assembled by keratins function as asymmetrically inherited fate determinants i
178 at isolated bovine antibody knob domains can function as autonomous entities by binding antigen outsi
179 s transmitted by cell-surface receptors that function as biological switches controlling mainly immun
182 on yeast, the inverted repeats IR-L and IR-R function as boundary elements at the edges of a 20-kb si
184 udding yeast (Saccharomyces cerevisiae), EVs function as carriers to transport cargo proteins into th
185 arum (PfA-M17) and Plasmodium vivax (Pv-M17) function as catalytically active hexamers to generate fr
188 ovides evidence that eukaryotic RND proteins function as cholesterol transport systems in the Hedgeho
189 tochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase
191 ts support a stronger role for nuclear CELF1 functions as compared to cytoplasmic CELF1 functions in
192 suggested that Lmo2 exerts these effects by functioning as component of a multi-subunit transcriptio
193 but that its intense and varying hues could function as concealment [2] rather than signaling seems
194 are prototypical dual function proteins that function as coupled glutamate/Na(+)/H(+)/K(+) transporte
196 regression model exhibited enhanced effector functions as defined by in vitro cytotoxicity assays.
198 uring the transition, whereas epilepsy genes function as downstream effectors in the same processes,
199 eria is typically conferred by proteins that function as efflux pumps or enzymes that modify either t
203 es, we show here that two uL18-type proteins function as factors necessary for the splicing of certai
206 rally diverse lipids that also share a known function as glycosylphosphatidylinositol (GPI) anchors i
209 conia endodontic posts (n = 23) were used to function as implants that were inserted into the center
210 romoted renal scarring and compromised renal function, as indicated by elevated serum creatinine, BUN
212 ne-rich repeat (LRR) receptor (NLR) proteins function as intracellular immune receptors that perceive
213 e is evidence suggesting that astrocytes may function as intracranial baroreceptors that play an impo
214 eases in cerebral perfusion pressure and may function as intracranial baroreceptors, tuned to monitor
216 e an update of the current knowledge of RGS2 function as it relates to molecular mechanisms of regula
218 protein (Fzr) and its mammalian homolog Cdh1 function as key regulators of endoreplication entrance b
219 olymers when produced by pathogenic bacteria function as major virulence factors, whereas when they a
220 ydrangea, Rosa, Spiraea, Syringa, Viburnum), functioned as major pollen sources, but the majority of
221 lts demonstrate that EBV latent antigens can function as master regulators of this multisubunit repre
224 h blood and saliva was a predictor of visual function as measured by HVF diameter, rod amplitude, fli
226 nd first studies provide insights into their functions as mediators or antagonists of vascular diseas
227 uberculosis cytosolic translocation but also function as modulators of host immune responses by modul
230 ctivity are a set of protein assemblies that function as molecular motors to couple the energy of nuc
232 could be used to predict the timing of gene function, as mRNA abundance was found to correlate with
233 s fundamental idea is to use multiple energy functions as multi-objectives in an effort to correct th
235 CAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macromolecules s
236 s CTP to 3'-deoxy-3',4'-didehydro-CTP, which functions as novel chain-terminating antiviral nucleotid
237 se of the insulin receptor super-family that functions as oncogenic driver in a range of human cancer
238 d the mechanistic validation highlight Golgi function as one of the key cellular features altered dur
239 nucleases, are 'guns for hire' that can also function as parts of defence mechanisms and are often sh
240 ide evidence that the BADC and BCCP subunits function as pH sensors required for light-dependent swit
241 ic helix-loop-helix factors, HECATEs (HECs), function as positive regulators of photomorphogenesis by
243 cations in imaging and biosensing, but their functions as precise regulators in living systems are st
245 protegens Pf-5 as a model to elucidate PelX function as Pseudomonas aeruginosa lacks a pelX homologu
248 a response to perturbation of mitochondrial function, as reflected in decreased membrane potential a
249 is a cytokine that exerts immunosuppressive functions, as reflected by its ability to induce regulat
250 stly attributed to the ability of lncRNAs to function as regulatory noncoding transcripts, there is g
251 with more stringent activation requirements function as repressors by blocking promoter access of SH
253 rfaces, the resulting fibrous chemiresistors function as sensitive and selective sensors for gaseous
254 ndings reveal a novel mechanism in which ROS function as signaling messengers necessary for melanin p
255 peptidoglycan fragments (muropeptides) that function as signaling molecules for spore germination or
256 , we show that reactive oxygen species (ROS) function as signaling molecules that regulate autophagy
263 g enhancer and suggesting an SLC30A8 gain of function as the cause for the increased risk for the dis
264 xysomes are bacterial microcompartments that function as the centerpiece of the bacterial CO(2)-conce
265 col-derived, oligomeric ethers were found to function as the formylating agent, with 1,4-dioxane affo
267 ichment analysis revealed immune-stimulatory function as the most significant enriched biological pro
269 s challenges our understanding of organismal functioning, as the link among electron transfer, metabo
270 ancreatic ER kinase (PERK) branch of the UPR functions as the master regulator of protein translation
271 walking combined with blue-light irradiation functions as the mechanistic switch from coordination in
272 cal chromatin interactions, implying that it functions as the organizer for the local three-dimension
273 ), which is a calcium-permeable ion channel, functions as the primary molecular sensor of cold and me
275 mmaR engagement and subsequent ADCC effector function, as they contain a decrease in afucosylated bis
276 equently, identified binders were tested for function as third generation Chimeric Antigen Receptors
277 icularly effective for impacting hippocampal function, as this stimulation rhythm should resonate wit
278 be classified as "epigenetic ribozymes" that function as transcriptional switches during stress.
279 Here, we show AR and its corepressor, REST, function as transcriptional-repressors of SPINK1, and AR
280 on studies using cloned eRNAs to study their function as transcripts, revealing roles for eRNAs in en
281 ed that both VASH1- and VASH2-SVBP complexes function as tubulin carboxypeptidases in cardiomyocytes,
283 This is followed by a phase with elevated function as viral replication is controlled to a set-poi
285 uses deep learning to learn a cell embedding function as well as a set of landmarks in the cell embed
286 letion of IDO show an improvement of cardiac function as well as cardiomyocyte contractility and redu
287 encompassing measures of brain structure and function as well as genetic and cell-specific transcript
288 nt brain circuits to understand their normal function as well as how they respond to drugs and contri
289 velopment of both healthy behavior and brain function as well as risk for poor mental and physical ou
290 paid to the influence of preoperative kidney function as well as the impact of the radiological follo
291 The composition of EVs determines their function as well as their interactions with cells, which
292 n of BTNL2, which was able to inhibit T cell function as well, exhibits distinctive structural featur
294 rotransmission, neurodevelopment, and immune function, as well as differential miRNA expression (e.g.
295 that have aided in correlating ontogeny with function, as well as how these findings can be translate
297 naling, skin barrier function, and mast cell function, as well as pathways that have not yet been elu
299 it, basic asthma examinations including lung function, as well as questionnaires for health-related q
300 re patient's physical, mental, and cognitive functioning, as well as their quality of life before ICU