ライフサイエンスコーパス: functional

1 plittings are computed using the benchmarked functionals.

2 Of the 86 patients, 46 had CMD (28 functional, 18 structural), and 40 patients formed the r

3 Antibody- or shRNA-mediated functional ABCB5 blockade inhibited proliferation and su

4 Functional abdominal pain disorders are common disorders

5 Functional activity, characterised by the measurement of

6 However, the temporal nature and drivers of functional adaptation remain undefined.

7 ri of stem tetrapods share a unique suite of functional adaptations, but do not conform to their own

8 ssociate and dissociate may confer on them a functional advantage with respect to nondissociating pro

9 ve immunity is achieved by the assembly of a functional AgR gene on one allele, with subsequent feedb

10 c proteins, the gut microbiome also produces functional amyloids.

11 Together, these findings unveil functional analogies and differences in the organizing p

12 In this study, functional analyses of CpRbp1 were performed by construc

13 Expression and functional analyses of PunPgp-2 and PunPgp-9 in Saccharo

14 Functional analysis of ALG6 variants identified a cataly

15 Functional analysis of VirChR1 shows that it is a highly

16 The most enriched DEGs in GO functional analysis were mainly associated with cell adh

17 development of methods for isoform-centered functional analysis.

18 ian randomization, polygenic risk score, and functional analysis.

19 The development of novel data-driven functional analytic tools has enabled the derivation of

20 The study evaluates both functional and anatomical outcomes of retinal detachment

21 Remarkably, despite these functional and behavioral distinctions, all ~15 individu

22 high-resolution structures in the context of functional and biochemical data, we attempt to summarize

23 nic mouse models to evaluate the structural, functional and biochemical effects of eliminating one al

24 fects in Xinbeta knock-out mice-indicating a functional and genetic interaction between Xinbeta and Y

25 ieu and systemic regulation that resulted in functional and histological recovery after 24 h of normo

26 many major PTMs have been studied, while the functional and mechanical characterization of major PTMs

27 f TET1-targeted neuronal genes, offering new functional and mechanistic understanding of NONO in stem

28 These functional and morphologic changes indicate the developm

29 A non-functional and non-genetically evolving viral reservoir

30 sing and data analysis and interpretation in functional and structural MRI research.

31 ur laboratory has shown that FR PBM improves functional and structural outcomes in animal models of r

32 le the adult electric organ (EO) was not yet functional, and the electrocytes lacked papillae.

33 Interestingly, the functional annotations of this core set center around re

34 ed representatives, and 40% of the UHGP lack functional annotations.

35 In conclusion, development of functional antibodies follows survival of acute EVD.

36 entific and industrial communities for multi-functional applications.

37 And, aromatic and functional aspects of sour cherry vinegar were revealed

38 patients' CSF antibodies or SSM5, we used a functional assay based on cytosolic Ca(2+) imaging.

39 r analyses of the genome, transcriptome, and functional assays advance general understanding of the A

40 How functional assembly of presynaptic active zones is contr

41 a 12% absolute difference between groups in Functional Assessment of Cancer Therapy-Bone Marrow Tran

42 s model facilitates imaging and quantitative functional assessment.

43 Strikingly, mice and flies lacking functional autophagy develop early onset progressive neu

44 e that the DFD regimen favors persistence of functional B cells after the third dose.

45 ronal relays across lesions that can provide functional benefit.

46 with thoughts on novel strategies to protect functional beta-cell mass.

47 ealing the enhanced ability to produce these functional biomolecules.

48 een locomotor ability, brain microstructure, functional brain activity, and alpha-syn pathology by lo

49 How these structural and functional brain changes may relate to the cognitive and

50 ow that contemporary statistical methods for functional brain imaging-including univariate contrast,

51 We performed repeated structural and functional brain MRI in 108 Barcelona participants.

52 te that the cysteines in OGG1 fall into four functional categories: those that are necessary for (1)

53 he newly introduced Thr residue explains the functional change.

54 ardial infarction (MI) causes structural and functional changes in the heart leading to heart failure

55 osomes leads to differential biophysical and functional changes including, adhesion and migration in

56 the effect of hypoxia on their proteome and functional characteristics that might reproduce pASCs wo

57 h-quality reference genomes are required for functional characterization and taxonomic assignment of

58 immunoprecipitation with deep sequencing and functional characterization conducted in human induced p

59 Their anatomical-functional characterization has been impeded by the inab

60 Functional characterization of OFF-RGC terminals in tect

61 ectious disease agents may be debatable, the functional characterization of such antibodies represent

62 vided useful resources and tools for further functional characterization of the niche in the future.

63 Functional characterization showed that MTCH2 and MTCH2x

64 oup interactions for subgroups based on NYHA functional class and race.

65 e.g. metalloenzyme name, ligand identifier, functional class, bioinorganic class, metal ion and meta

66 lure to disabling New York Heart Association functional classes III/IV (5.2%/year); 67% have survived

67 Functional CMD is characterized by elevated resting flow

68 e presence of a previously unknown degree of functional compensation in the ageing mouse cochlea.

69 cally separated, compound heterozygosity for functional complementary mutations may protect individua

70 confirm that KHARON assembles into distinct functional complexes and that the subpellicular complex

71 As LSTs are a primary functional component of homologous recombination deficie

72 The functional component was calculated with a linear model

73 ilateral projections of CSNs, which can form functional connections with spinal neurons.

74 uations across the brain are interpreted as "functional connections" for maps and neurological diagno

75 Group differences in global efficiency and functional connectivity among 12 regions comprising a pr

76 discussing the potential advantages of fMRI functional connectivity methods for improving our unders

77 Functional connectivity was found both between similar (

78 Resting-state functional connectivity was largely unaltered in childre

79 n networks and identified gene clusters with functional connectivity.

80 ion was predominantly associated with higher functional connectivity.

81 lities and disordered prefrontal-hippocampal functional connectivity.

82 The functional consequence of CK1alpha mutation remains unkn

83 However, the functional consequence of LEC priming of CD8(+) T cells

84 of mutational recurrence or approximate the functional consequences of nonsynonymous mutations by us

85 inct 3' UTR isoforms are more likely to have functional consequences.

86 affect non-hotspot residues, whose potential functional contributions to disease are unstudied.

87 s data set also led to our identification of functional convergence in expression between distantly r

88 The molecular mechanism underlying the functional conversion of EZH2 from a gene repressor to a

89 consistency, candidate causes, and potential functional corollaries of sex-biased brain anatomy in hu

90 Pronounced functional crosstalk was observed between the two recept

91 response seems to be key for the spontaneous functional cure.

92 This study hypothesizes that the functional decline is faster at the edge of the dense sc

93 y persisting viral Ags exhibit both discrete functional deficits and a notable surplus.

94 dently associated with a 23% reduced risk of functional dependence at 3 months after onset (RR per ye

95 1) complementation with TgSPY-MYC(3), 2) its functional dependence on amino acids critical for OGT ac

96 e often violated due to both redundancies in functional descriptions and biological functions shared

97 Biochemical and functional details of the Myo1c-14-3-3beta interaction h

98 Here, to shed light on their functional determinants, we seek to exploit the evolutio

99 The phenotypic and functional dichotomy between IRF8(+) type 1 and IRF4(+)

100 ap chimeras also revealed previously unknown functional differences in the GTPase and stalk domains.

101 we understand little about how taxonomic and functional diversity contributes to the symbiotic lifest

102 The origin of vertebral functional diversity does not correlate with the evoluti

103 of conformational heterogeneity and related functional diversity emphasize the necessity of developi

104 nvestigated epicardial heterogeneity and the functional diversity of discrete epicardial subpopulatio

105 to 132, covering much of the structural and functional diversity of endonucleases throughout the bio

106 BC transporters, allowing all four consensus functional domains to be linked.

107 of the astrocytes can extend across neuronal functional domains.

108 oscopy, SMOLM exposes the organizational and functional dynamics of lipid-lipid, lipid-protein, and l

109 mplete understanding of its pathophysiology, functional dyspepsia is difficult to treat and, in most

110 s and single-cell patch-clamp to analyze the functional effect of the four stillbirth mutants on TRPM

111 Proteomics data further reveal functional effects of somatic mutations and copy number

112 rovide mechanistic insight into the opposing functional effects produced by mu-opioids within the OFC

113 To formulate a functional electrolyte system that can stabilize the lit

114 riptomic data commonly ignore non-coding but functional elements e.g. small RNAs, long antisense RNAs

115 at the putative T. gondii CGL gene encodes a functional enzyme.

116 n, synthesis, and chemical study of a set of functional epidithiodiketopiperazines (ETPs) and evaluat

117 Functional expression of endothelial ICAM-1 and VCAM-1 w

118 advantage for their possible application as functional food ingredients with anti-diabetic propertie

119 however, how this pathway was evolved to be functional from its origin is still largely unknown.

120 retention at the cell surface in the form of functional gap junctions indicating that Abeta(25-35) ca

121 We review methods for assaying putatively functional genetic variants and regions, emphasizing MPR

122 Previously published comparative functional genomic data sets from primates using frozen

123 In this review, we provide an overview of functional genomic resources and methods that can be use

124 ted RNAi approach is a tool for studying bee functional genomics and potentially for safeguarding bee

125 nitzschia multistriata Here, we describe how functional genomics and reverse genetics have contribute

126 RISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates.

127 ing RNA has potential applications for plant functional genomics, crop improvement and crop protectio

128 dy period; of these, 39 patients still had a functional graft at last follow up and 9 (18.8%) pancrea

129 lementary ion pairs leading to more complete functional group characterization compared to CAD.

130 Such a sulfonyl group dance (functional group swap) results from a cascade of S(N)Ar

131 The broad generality and functional group tolerance of this method is extensively

132 od features a broad substrate scope and good functional group tolerance, and the in situ-generated HC

133 thereby demonstrating its broad utility and functional group tolerance.

134 ity structure and productivity of a critical functional group, independent of live coral loss.

135 exhibiting a single double bond as the only functional group, such as alpha-pinene, beta-pinene and

136 The reaction shows outstanding functional-group tolerance with respect to both the alph

137 nopores), architecture (branched vs linear), functional groups (coordinating or ionic), specific prop

138 m mechanisms in humans can be broken down by functional groups and translated to model organisms.

139 trate that phosphine oxides are highly polar functional groups leading to high solubility and metabol

140 :1 interactions of crown ethers with various functional groups to be characterized in solution and th

141 Compatibility with common organic functional groups was observed with the reduced cobalt(0

142 riety of arylacetonitriles bearing different functional groups were converted into the corresponding

143 different ketones bearing a wide variety of functional groups with an average yield of 60+/-16 %.

144 ves the selective modification of particular functional groups, inserting nuclei to act as reporters

145 aliphatic substituents and a broad range of functional groups, providing a variety of N-H pyrroles i

146 of substrates with reactive, acid-sensitive functional groups.

147 n previously reported ordered gradients in C functional groups.

148 Emerging data point to functional heterogeneity of fibroblasts.

149 The discovery of D1-mGlu5 functional heteromers mediating maladaptive molecular an

150 on site and induced a remarkable increase of functional immune responses against GBS compared to the

151 d for association of variants with predicted functional impact in ~ 1300 additional Utah suicides unr

152 We sought to elucidate the functional impact of L6CT projections from the primary v

153 These functional impacts of Kv2.1 depend on its level of expre

154 nd allelic deletion in human cancer, but the functional implications of such alterations are not know

155 expression by CD8(+)T(M) serves as a unique functional imprint of prior antigenic experience; induce

156 A transferable 'all-in-one' vector was functional in Escherichia coli, Pseudomonas syringae and

157 he identification of eQTLs, which may not be functional in the corresponding tissue, due to linkage d

158 es, the challenge to characterize genes with functional information is even more important.

159 Kenaf also showed versatile utility as a functional ingredient in food, folk medicine, and animal

160 t could be potentially used in the future as functional ingredient.

161 ants could be an excellent source of natural functional ingredients.

162 racterized by decreased static resting-state functional integration and dynamic stability within the

163 nterregional integration to characterize the functional interaction between basal ganglia and thalamu

164 ent of ISG15 conjugation and relies on ISG15 functional interaction with the DNA helicase RECQ1, whic

165 emory performance depends on the strength of functional interactions between the frontoparietal and d

166 roduced compounds is of importance to reveal functional interactions in microbiomes.

167 Functional intermediate- and small-conductance K(+) (IK

168 t overlapping GO terms hindering informative functional interpretations.

169 rful system for discovery, live imaging, and functional investigation of cell states throughout melan

170 These studies pave the way for the design of functional ion pairs that have the potential to particip

171 owed that neurons in the adult nAc expressed functional KI GlyRs that were rather insensitive to etha

172 ve deficits in communication skills, similar functional language, more social motivation challenges i

173 Conclusion The functional liver imaging score derived from gadoxetic ac

174 n high-throughput screening used to identify functional lncRNAs.

175 mulated shopping market as well as follow up functional magnetic resonance imaging (fMRI) in the more

176 Functional magnetic resonance imaging (fMRI) revealed tw

177 rocessing of own- and other-race faces using functional Magnetic Resonance Imaging (fMRI).

178 Resting-state functional magnetic resonance imaging scans were acquire

179 Here we use behavioural modelling and functional magnetic resonance imaging to describe how hu

180 In this study, we combined functional magnetic resonance imaging with semantic cont

181 d heartbeat perception during and outside of functional magnetic resonance imaging.

182 ate that Smad4-mediated signaling drives the functional maturation and connectivity of basal VSNs.

183 s the failure of these cells to achieve full functional maturity.

184 le hypothalamic nuclei and elucidate a novel functional mechanism for the preoptic DA neurons in the

185 The functional mechanisms that lead to their clearance of ha

186 ) had pure AR, and 167 (14%) had AR + MR (9% functional mitral regurgitation [FMR] [84% nonischemic]

187 eous Therapy for Heart Failure Patients With Functional Mitral Regurgitation), treatment of heart fai

188 ants for 41 genes belonging to the different functional modules of the network revealed that 76% of t

189 ient number of polymorphic, informative, and functional molecular markers are essential for studying

190 -synthesized gold nanoparticles (AuNPs), and functional monomer.

191 Recent resting-state functional MRI (fMRI) studies have revealed that the glo

192 Here, we show using functional MRI (fMRI) that at least three hypothalamic s

193 netic resonance imaging (MRI), resting-state functional MRI (fMRI), and sensory-evoked fMRI on 20 mic

194 n models based on single visit resting-state functional MRI (rs-fMRI) data that assess observed longi

195 We investigated this issue using a functional MRI adaptation paradigm in awake male macaque

196 In this study, we used dynamic resting state functional MRI analyses to increase temporal resolution

197 To address this question, we conducted two functional MRI experiments in which we dissociated the p

198 synthetic materials that rival their highly functional, natural counterparts.

199 roles in driving formation of structural and functional network connectivity during early development

200 y methods for improving our understanding of functional neuroanatomy and disruptions in psychiatric d

201 neurocognitive, structural neuroimaging, and functional neuroimaging outcomes associated with cannabi

202 Functional neurological disorder is a common and phenome

203 We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic he

204 NAs, covering 16 isoacceptor classes, and 23 functional orthogonal tRNA-cognate aaRS pairs.

205 y was 30% (95% CI 25% to 30%) and favourable functional outcome was 45% (95% CI 40% to 50%) and after

206 Favourable functional outcome was defined as a modified Rankin Scal

207 two PA2G4 isoforms translate into different functional outcomes.

208 Our work demonstrates that although functional p53 status negatively affects identification

209 veal significant differences in taxonomic or functional pathway alpha-diversity between CTX-T and CTX

210 cific CD8 T-cell responses showed beneficial functional patterns and significantly lower frequencies

211 However, the tunable functional performance of such systems is still largely

212 Thus, TLQP21 can modulate the functional phenotype of microglia, which may have an imp

213 f demographic-dependent selection in shaping functional phenotypic variation.

214 umed as fresh fruits, processed foods and as functional plants.

215 be of interest due to their nutritional and functional potential.

216 rs, develop crops and production, and design functional products rich in flavonols and carotenoids wi

217 A combination of molecular and functional profiling of bone marrow and peritoneal cells

218 Its functional properties are regulated in a tissue-specific

219 Here, we characterize the functional properties of CysLTR2-L129Q.

220 Functional properties of infrared heat-moisture treated

221 communication by analyzing the structure and functional properties of the SERCA mutant E340A.

222 g oxygen supply, restoring optimal diaphragm functional properties.

223 In conclusion, MOCS1 produces two functional proteins, MOCS1A and MOCS1B, which follow dif

224 ely, our data demonstrate application of the functional proteome strategy along with the shotgun lipi

225 l score on the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R; range, 0 to 4

226 hese findings, along with the structural and functional rationale for epitope conservation, provide i

227 ial role of extrapyramidal plasticity during functional recovery after SCI.

228 Primary outcome was time to functional recovery and length of hospital stay.

229 oaches promote significant axonal growth and functional recovery in vivo in a spinal cord injury mode

230 subdomains of the plant TGN and suggest that functional redundancy can be achieved through paralleliz

231 of each TRPC in each pathology, considering functional redundancy.

232 ir roles and a quantitative measure of their functional redundancy.

233 The main cause of explantation was functional refractive failure followed by spontaneous ex

234 tanding of distinct subpopulations and their functional relevance in human satellite cells is lacking

235 ndent cohort of HCs, and recapitulated their functional relevance with a post hoc meta-analysis on ta

236 to overt psychosis may stem from an aberrant functional reorganization of the brain during adolescenc

237 els and rod outer segment structure, but not functional rescue in rods or cones.

238 , our analysis demonstrates that through its functional resemblance to an ear horn (aka ear trumpet),

239 tients with HLHS, which may portend impaired functional reserve of the single-ventricle circulation.

240 AD3C, the protein product of which lacks key functional residues.

241 We advocate further comparisons of functional responses to understand the invasiveness and

242 problem can be circumvented by assembling a functional ribozyme by the templated ligation of short o

243 Taken together, our data indicate functional roles for RhoA and Rho-kinase in mediating de

244 mmunity hub species with core structural and functional roles for their use in restoration.

245 The functional roles of the lipid asymmetry of biomembranes

246 Functional roles of the prioritized candidate SNPs were

247 loid folds, however, also display a range of functional roles particularly in the microbial world.

248 y relevance and integrate them into a single functional score.

249 ethyl cellulase activity was isolated during functional screening of a human gut metagenomic library

250 gation of the changes in gene expression and functional screening using an in vitro mouse oocyte deve

251 binding under shear stress mechanosignals a functional shift in iMo toward an inflammatory phenotype

252 uture opportunities to better understand the functional significance of genetic variants and to utili

253 The regulatory dynamics and functional significance of putative aging-related hetero

254 In order to address the functional significance of the 'off' component of the pr

255 The functional significance of these components in ETI was c

256 However, the functional similarities and differences among these prot

257 an optimal local protein environment for the functional site.

258 To prioritize functional sites, we used machine learning to identify 5

259 ch, for example, the design of novel dynamic functional soft materials for future use in flexible dev

260 ated the adverse impact of housing damage on functional status, suggesting a buffering mechanism.

261 rix and metallic nanoparticles can merge the functional, structural, and mechanical properties of the

262 Functional studies suggest that the loss of dAKAP1-RNA i

263 Our structural and functional study establishes the extracellular loops as

264 glia-matrix communication for structural and functional support of the nervous system.

265 d with systematic mutational analysis of the functional surfaces to directly measure Syt1-membrane in

266 expressed Ca(v)3.1 and Ca(v)3.2 and produced functional T-type VGCC currents when patch clamped.

267 demonstrate that DarT(Mtb) -DarG(Mtb) form a functional TA pair and essentiality of darG(Mtb) is depe

268 Spin-polarized periodic density functional theory (DFT) and nonperiodic DFT calculations

269 Density functional theory (DFT) calculations indicate that, in a

270 Supported by density functional theory (DFT) calculations, redox disproportio

271 h operando infrared spectroscopy and density functional theory (DFT) modeling, targeting methanol for

272 Density functional theory (DFT) showed water has minor effects o

273 Density functional theory (DFT) simulations unveil the crucial r

274 Where possible, we have employed density functional theory (DFT) to develop a more complete under

275 predictive model was developed using density functional theory (DFT) to potentially predict the titan

276 Quantum mechanical time-dependent density functional theory (TDDFT) calculations indicate that the

277 Density functional theory calculations and symmetry analysis of

278 Static density functional theory calculations of the benzene-to-phenyl

279 Density functional theory calculations showed that (*)OH oxidize

280 clear magnetic resonance studies and density functional theory calculations were carried out on the s

281 magnetic resonance spectroscopy, and density functional theory calculations.

282 supported by detailed computational density functional theory studies, which fully address multi-spi

283 solved scanning probe microscopy and density functional theory to reveal how the generation of S-vaca

284 Density functional theory was used to predict structural changes

285 Using density functional theory, we assign the two states to two diffe

286 mplexes inside intact and photosynthetically functional thylakoid membranes to be able to understand

287 ing or ion conduction activities of the dual-functional TMEM16F.

288 ssess independent prognostic implications of functional TR.

289 ng reported measurements, we developed grass functional trait values (physiological, structural, bioc

290 ralism, we measured host growth benefits and functional traits.

291 role in the AML-EV-induced phenotypical and functional transition of monocytes.

292 te genes required for iron acquisition and a functional type 9 secretion system.

293 zation of PM proteins via the recognition of functional Tyr motifs also operates in plants.

294 a behavioral task, as well as structural and functional underpinnings of waiting impulsivity and tics

295 However, a functional understanding of the putative PC-1/PC-2 polyc

296 The proteins MCU and EMRE form the minimal functional unit of the mitochondrial calcium uniporter c

297 sponses and consistently enables and extends functional use.

298 or epigenetics in T1D pathogenesis; however, functional validation is warranted.

299 2 high-LD variants, we identify 39 candidate functional variants from 14 loci displaying allelic tran

300 We also describe the expression of a functional vitamin D receptor in IDEC.