ライフサイエンスコーパス: functional activity

1 s associated with a considerable increase in functional activity.

2 ined three-dimensional structures to acquire functional activity.

3 soluble intracellular receptor fragment with functional activity.

4 eins that require ubiquitin binding for full functional activity.

5 e RNA-binding protein motif that retains its functional activity.

6 directly to protein synthesis and downstream functional activity.

7 ly correlated with an impairment in MBL-MASP functional activity.

8 with heterogeneity to predict areas of true functional activity.

9 ther increased in patients with lower C1-INH functional activity.

10 whole blood, sera from immunized mice showed functional activity.

11 found between regional diffusion metrics and functional activity.

12 individuals and controls in conflict-related functional activity.

13 mice and to characterize their phenotype and functional activity.

14 close to residue 24 were also important for functional activity.

15 ydrolyze protein, peptide separation and its functional activity.

16 ghest affinities were investigated for their functional activity.

17 was model-derived steady-state trough C1-INH functional activity.

18 dendrimers can enhance binding affinity and functional activity.

19 lls that display enhanced antibody-dependent functional activity.

20 , we examined the role of NBS1 in macrophage functional activity.

21 r cognitive control and increased prefrontal functional activity.

22 ly cleaved protein with no ligand binding or functional activity.

23 tle is known about their receptors and their functional activity.

24 s ion channel yields only very low levels of functional activity.

25 cture-activity relationships for binding and functional activity.

26 time points in infection tend to have higher functional activity.

27 and evaluated based on binding affinity and functional activity.

28 displayed significantly different levels of functional activity.

29 of Treg cells, but also for regulating their functional activity.

30 ssion, cellular mislocalization, and reduced functional activity.

31 nformational change in the RRE and increased functional activity.

32 on through a precise genetic dissociation of functional activity.

33 sfected cells, we noted disparities in their functional activities.

34 hich are important for substrate binding and functional activities.

35 STAT1 might affect NK cell proliferation and functional activities.

36 fractions and evaluate their biological and functional activities.

37 reported to exhibit bio-functional or techno-functional activities.

38 g expression, activation, proliferation, and functional activities.

39 T cell activation to better understand their functional activities.

40 rs or older who were evaluated monthly in 13 functional activities (1998-2012).

41 ence of blockade does not predict absence of functional activity; 2) neutralizing mAbs bind spatially

42 c and sensitive enough to reveal directional functional activity across layers.

43 While some CARs showed varying functional activity across these assays, 1 CAR based on

44 hat mGluR5 coordinates a reduction in mGluR1 functional activity after cocaine treatment.

45 tration in humans; however, its clinical and functional activity after longer-term administration has

46 all three CD4-based CARs displayed specific functional activities against HIV-1 Env-expressing targe

47 tivity and binding inhibition and opsonizing functional activities against IE using two CSA-binding l

48 In conclusion, mAb 2C7 showed functional activity against all gonococcal HepI LOS stru

49 esidents in malaria endemic areas have shown functional activity against blood-stage parasites as jud

50 affinity, and the reduction in differential functional activity against the sensitive and Pgp overex

51 Functional activity analyses indicated that mutant LRP5

52 ing their distribution, morphology, density, functional activities and inflammatory phenotype.

53 induced antibodies with opsonophagocytic and functional activities and provided consistent protection

54 nse to several cytokines, we studied NK cell functional activities and STAT1 signaling in 8 patients

55 bs against different epitopes have different functional activities and that the binding of one MAb ca

56 during post-baseline plasma levels of C1-INH functional activity and C1-INH antigen concentration, st

57 fMRI states exhibit contrasting patterns of functional activity and coupled infraslow network dynami

58 gineering to enhance specificity, stability, functional activity and delivery.

59 e effect of enhancer variation upon enhancer functional activity and downstream phenotypes has barely

60 tistical threshold in order to maximize true functional activity and eliminate false positives.

61 neuronal wiring and to integrate these with functional activity and gene expression.

62 IFNalpha protein correlated well with functional activity and IFN-stimulated gene expression.

63 on therapy (CCRT) would modify resting brain functional activity and improve cognitive function in pa

64 Dopamine-induced lateralization of functional activity and networks during speaking is not

65 pe of catalytic micro-compartment with multi-functional activity and provide a step towards the devel

66 omeprazole in fundic organoids and indicated functional activity and regulation of parietal cells.

67 pe differences in medial temporal lobe (MTL) functional activity and structure at mid-age might contr

68 ease patients have an impairment in MBL-MASP functional activity and that this defect is associated w

69 y: compared to wild type, one (R175P) had no functional activity and the other (C192F) had decreased

70 Education, rehabilitation within functional activity and the use of taught self-managemen

71 st format because it had overall the highest functional activity and was very stable in vitro in both

72 relation between M1 PAM binding affinity and functional activity, and that [(3)H]PT-1284 can serve as

73 ranslational modifications are essential for functional activity, and the ability to identify them wi

74 he nature and location of DCLRE1C mutations, functional activity, and the clinical phenotype has been

75 may allow for determination of areas of true functional activity, and thus eliminate clinician bias.

76 Substantial effector functional activities (antibody-dependent cell-mediated

77 Although P450 functional activities are known to be affected by lipids

78 ders, central dopaminergic and overall brain functional activity are altered to different degrees, ca

79 Differences in RRE functional activity are attributable to specific changes

80 mpair both mitochondrial energetics and BSEP functional activity are more sensitive to more severe ma

81 These shifts in functional activity are often accompanied by negligible

82 vities, localized the epitopes, and measured functional activities as potency in inhibition of hemagg

83 r organs and long-term preservation of miRNA functional activity, as assessed by monitoring the expre

84 that such a kinetic trap retains native-like functional activity, as shown by the preserved ability t

85 The in vitro functional activity assays, performed by using cyclic AM

86 4, and 21 days, with mRNA/protein levels and functional activity assessed by: 1) real-time polymerase

87 omatic units and evaluated their binding and functional activities at the D3 and D2 receptors.

88 antagonists in order to achieve the intended functional activity at a GPCR of therapeutic interest.

89 ds as high affinity ligands with conflicting functional activity at the alpha2-adrenoceptor, a G-prot

90 As to the functional activity at the CB2R, compounds able to act e

91 re no differences in peanut IgG(4) levels or functional activity at the end of the study.

92 exhibits good potency but not the preferred functional activity at the GPCR of choice.

93 We identified 9 which retained functional activity at the target M1 mAChR and D2R and d

94 ivity against ROCK and strong differences of functional activity between parent compounds and expecte

95 ing region of an antibody), yet it maintains functional activity, binding to p40 and p19 specific rea

96 rovements in solubility while retaining good functional activity but displayed new liabilities associ

97 asigin interaction in vitro is predictive of functional activity, but absence of blockade does not pr

98 ons between gene expression in the brain and functional activity by comparing fractional amplitude of

99 the O:4-specific antibodies provided in vivo functional activity by decreasing the bacterial load in

100 Immune sera were also tested for functional activity by in vitro opsonophagocytic-killing

101 C1-INH concentration and functional activity (C1-INHc+f ), C1(q,r,s), C3, C4, C3a

102 The mean trough plasma levels of C1-INH functional activity, C1-INH and C4 antigen levels during

103 Network, demonstrating that the location of functional activity can be affected by local sulcal patt

104 Following spinal transection, functional activity can be regained, to a degree, follow

105 Identifying key miRNAs, defined by their functional activities, can provide a deeper understandin

106 ve identified subsets of ILCs with differing functional activities, capacities to produce cytokines a

107 ges to improve biological target affinity or functional activity, change physical properties, enhance

108 ystem such that structural and resting-state functional activity changes occur in the brain by four w

109 Functional activity, characterised by the measurement of

110 perior recognition of tumor cells and higher functional activity compared with TCRs from humans.

111 or only slightly reduced ligand binding and functional activity compared with the most common polymo

112 ed ligands leading to major changes in their functional activity, converting agonists into antagonist

113 ough HSCs numerically expand with age, their functional activity declines over time, resulting in deg

114 r = 0.4, P = 0.01) but not of NF54 isolates; functional activities did not correlate in plasma from p

115 surface-expressed epitopes involved in each functional activity differ among P. falciparum strains.

116 for pollen development, and defines distinct functional activities during early and late pollen devel

117 ic diseases, the progressive loss of certain functional activities during Trypanosoma cruzi infection

118 ed for multiple comparisons) as well as with functional activity during a sexual cue-reactivity parad

119 stical parametric maps tested differences in functional activity during the AX-CPT, and vertexwise ma

120 nal connectivity patterns to measurements of functional activity during two independent tasks.

121 -derived glycans represent the most abundant functional activities encoded by genes unique to the hum

122 To assess functional activity, fluorescent avidin-based degranulat

123 A10 and C-terminal-specific 2AF4 mAbs showed functional activity for epitope recognition suggesting t

124 and did not show any significant decrease in functional activity for six months.

125 istinct pathologic patterns in overall brain functional activity for various parkinsonian disorders.

126 ted (HbR) hemoglobin, holds promise to study functional activity from motor, visual, and memory corti

127 From the database, we identified functional activity groups of burster (isolated neuron)

128 f IL-2 to expand T cells with maintenance of functional activity has been translated into the first r

129 moderate to severe pain that interfered with functional activity; however, emotional distress to pain

130 rent understanding of key microbial taxa and functional activities in both natural and restored ecosy

131 ralogues specify distinct biochemical and/or functional activities in vertebrate cells.

132 SSC demonstrated functional activity in 100% of cancer patients and healt

133 The emergent compounds were assessed for functional activity in a battery of assays, including bi

134 We report studies that show 16 has functional activity in cellular assays by modulation of

135 annose-associated serine protease (MBL-MASP) functional activity in Crohn's disease patients.

136 picomolar enzymatic Ki values and nanomolar functional activity in human Raji cells.

137 ane analogues, namely 1 and 2, showed potent functional activity in in vitro and in vivo models.

138 Herein, we report the measurement of MRP1 functional activity in individual cancer cells using sca

139 memory reactivation are supported by altered functional activity in key cognitive and motor networks,

140 iciency leads to increased TF expression and functional activity in macrophages after challenge with

141 The results showed higher functional activity in the RFIC to own versus other infa

142 rring muscarinic agonist xanomeline on brain functional activity in the rodent brain.

143 romatin state, indicative of their selective functional activity in the transcriptional regulatory ne

144 by the assay and are demonstrated to support functional activity in vitro and in plants.

145 ort a novel BK channel-targeted peptide with functional activity in vitro and in vivo.

146 ype-switched IgGs in mice and pigs, yielding functional activity in vitro and protection against a le

147 ntagonist (>1000x over Kv1.1) with picomolar functional activity in whole blood and a pharmacokinetic

148 Equally cross-reactive Fc receptor-mediated functional activities, including ADCC and antibody-depen

149 adapt to the underlying surface, while MRP1 functional activity increases once the dimensions of the

150 y overlooked property of antibodies is their functional activity inside cells.

151 sociations with individual variations in DMN functional activity, intelligence, sociability, and ment

152 Furthermore, we found that their functional activity is controlled by the presence of the

153 ectious diseases, but dysregulation of their functional activity leads to the development of inflamma

154 However, the cross-reactive MAbs had functional activities limited to strains expressing colo

155 Functional activity maps at the cellular level in specif

156 onditions and disease.SIGNIFICANCE STATEMENT Functional activity maps identify brain circuits respond

157 ase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep.

158 Enhancing the induction of these functional activities may be a strategy to improve the p

159 TTP regulation provides a clue as to how its functional activity may be used in a physiologic pathway

160 This suggests that functional activity may represent a powerful indicator o

161 nnose-binding lectin, mannose-binding lectin functional activity, MBL2 and NOD2 polymorphisms, anti-S

162 their origin and processes for development, functional activity, migratory pattern, and activation s

163 he extent of editing correlates with 5-HT2CR functional activity: more highly edited isoforms exhibit

164 tRNA increases LARP4 levels and reveals its functional activity, net lengthening of the PATs of hete

165 ears to dominate the low levels of intrinsic functional activity observed when the channel is express

166 er assay (lentiMPRA) to directly compare the functional activities of 2236 candidate liver enhancers

167 The present study set out to define the functional activities of bovine granzyme B and determine

168 Therefore, understanding the functional activities of each genomic aberration to be t

169 The functional activities of ectonucleotidases such as CD39

170 These new functional activities of HDAC6i involved regulation of t

171 ets and suggest that strategies to influence functional activities of inflammatory cells may benefit

172 cs can provide invaluable information on the functional activities of intestinal microbiota and on ho

173 The functional activities of key miRNAs were further demonst

174 BDL mice show altered functional activities of Kupffer cells compared with sha

175 us have on the early summer CyanoHAB and the functional activities of Nostoc- and Anabaena-dominated

176 e the regulation and diverse biochemical and functional activities of peptidoglycan hydrolases, and h

177 s aimed at enhancing the recruitment and the functional activities of polymorphonuclear leukocytes du

178 Gene regulatory networks controlling functional activities of spatially and temporally distin

179 Here we have investigated functional activities of the AS-SRO, the element necessa

180 We evaluated the functional activities of the compounds at all three mono

181 We analyzed the functional activities of the hemagglutinin-neuraminidase

182 S17), or CS1, suggesting that the breadth of functional activities of the MAbs was more restricted th

183 tory cells with or without modulation of the functional activities of the MIF/CD74 complex.

184 The functional activities of the tumor suppressor promyelocy

185 ss the effect that the human body has on the functional activities of VRC01 as measured by several in

186 l modifications that are likely to alter the functional activity of a GPCR ligand may be of use to re

187 We validated the functional activity of a PCRM associated with joint-rela

188 herapeutic strategies aimed at mimicking the functional activity of BCL-3 may be effective in the tre

189 lycosylated dimeric protein that retains the functional activity of both cytokine moieties.

190 A cell proliferation assay revealed potent functional activity of both FGF2 and IGF1, suggesting th

191 cells as a secreted protein that retains the functional activity of both the antigen binding domain a

192 The functional activity of brain areas (network nodes) were

193 etween JNK and PP2A pathways determining the functional activity of c-Jun/AP-1 in tumour cells.

194 The residual functional activity of C5 can be screened using a 50% he

195 We assessed the functional activity of CAIX in two colorectal tumor mode

196 luorescent marker techniques to evaluate the functional activity of cardiac cells.

197 ified F4/80+/CD11b+ mdx macrophages revealed functional activity of Cx43, which was inhibited by admi

198 al role of the Hsp90 chaperone in regulating functional activity of diverse protein clients is essent

199 ce package Basset to apply CNNs to learn the functional activity of DNA sequences from genomics data.

200 We hypothesize instead that changes in the functional activity of E-cadherin expressed on tumor cel

201 We also assessed the existence and functional activity of ecto-ATPase for extracellular ATP

202 Thus, IL-7R signaling on Treg supports the functional activity of effector Treg by increasing their

203 ariants, suggesting that CFH variants affect functional activity of FH rather than serum levels.

204 erative stress, leading to a decrease in the functional activity of HSCs.

205 ive also in mammals, where it stimulates the functional activity of innate immune cells, of mesenchym

206 lucosylation gene from C. bombicola, and the functional activity of its gene product.

207 ere used to determine the expression and the functional activity of LRRC8-mediated channels.

208 Interestingly, SUMOylation regulates the functional activity of many of the transcription factors

209 emature ovarian failure (POF) diminishes the functional activity of MCM8.

210 Expression and functional activity of MRP1 were determined using flow c

211 compound myoVin-1 inhibits the enzymatic and functional activity of myosin-5B in vitro Partial inhibi

212 ned the impact of Tks4 gene silencing on the functional activity of primary human umbilical vein endo

213 k between FPR1 and CCR1 was dependent on the functional activity of protein kinase Cbeta.

214 ates for single-molecule (sm) studies of the functional activity of protein-DNA complexes.

215 The abundance and functional activity of proteins involved in the formatio

216 However, how the functional activity of PrP(C) is subverted to deliver ne

217 auto-inhibitory mechanism that regulates the functional activity of PrP(C).

218 ments in an enhancer reporter assay indicate functional activity of several of de novo H3K4me1-marked

219 This work further highlights the functional activity of short open reading frame-encoded

220 fter-hyperpolarization and a decrease in the functional activity of SK channels.

221 Functional activity of soluble PfTopoII from the transla

222 ) can influence tumor immunogenicity and the functional activity of specific immune cells.

223 erging roles in modulating the metabolic and functional activity of T cells.

224 microanatomy of the intact tongue mucosa and functional activity of taste cells in response to topica

225 ng basic molecular mechanisms underlying the functional activity of the AhR.

226 which antibodies that can interfere with the functional activity of the antigen are more likely to co

227 We assessed functional activity of the cerebellum associated with mo

228 tantly, both drugs rescue DAT maturation and functional activity of the DTDS-associated mutations A31

229 action with the Trp residues involved in the functional activity of the enzyme as demonstrated by adv

230 several BCRP probe substrates confirmed the functional activity of the human transporter in these mi

231 may help to explain the generally increased functional activity of the immunoproteasome.

232 Disruption to the functional activity of the intestinal microbiome may res

233 ctrophysiology measurements demonstrated the functional activity of the microsomes harboring KcsA sho

234 We tested the hypothesis that high functional activity of the mineralocorticoid endocrine p

235 ht into the synthesis reaction and potential functional activity of the product.

236 NA recognition and therefore may control the functional activity of the protein-DNA complex.

237 h hampers progress toward enhancing yield or functional activity of the target protein.

238 cell identity and (ii) interfering with the functional activity of the transcription factor Blimp1.

239 cogenic methyltransferase that represses the functional activity of the tumor suppressor proteins p53

240 ed after a spinal cord lesion by re-engaging functional activity of the upper limbs?

241 rough physico-chemical characterization, the functional activity of these novel agents was establishe

242 We confirmed the functional activity of this channel in the mouse brain u

243 MRP1) is prevalent in many cancer types, the functional activity of this efflux pump is more difficul

244 rain areas quantified at rest relates to the functional activity of those areas during task.

245 We investigated the functional activity of truncated TSLP using a PBMC-based

246 Posttranslational modifications control the functional activity of TSLP in humans and overproduction

247 that the latter dominates the low intrinsic functional activity of TWIK-1.

248 We previously described the functional activity of two RREs found in circulating vir

249 y illustrating a molecular mechanism linking functional activity of VGSCs to transcriptional activati

250 clear phagocytes and exerts immunoregulatory functional activities on lymphocytic and nonlymphocytic

251 using noradrenaline (NorA) as a modulator of functional activity on a cellular and subcellular levels

252 able alternative to proteins with respect to functional activity on membranes.

253 ignored is the processing demands of making functional activity out of the many degrees of freedom o

254 with validation studies (e.g., signaling and functional activities) provides opportunities for the di

255 or the ICU, Katz activities of daily living, Functional Activities Questionnaire (measuring instrumen

256 ons (for Katz activities of daily living and Functional Activities Questionnaire scores) or via gener

257 (activities of daily living scales, Pfeffer Functional Activities Questionnaire, and Katz Activities

258 principle-components analysis); nonimaging (functional activities questionnaire, apolipoprotein E, a

259 Among the predictor variables age, sex, Functional Activities Questionnaire, Mini-Mental State E

260 re, the reasons underlying its low levels of functional activity remain unclear.

261 sporter (DAT) availability and overall brain functional activity, respectively.

262 l magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of in

263 lso evaluated the alteration of myeloid cell functional activity.RESULTSWe provide evidence that pati

264 For the resting brain functional activity, significant group x time interactio

265 erence of CD23 binding, the data underline a functional activity similar to omalizumab.

266 or occupancy assay corresponds with in vitro functional activity, suggesting a direct correlation.

267 em cell-derived astrocytes have demonstrated functional activities that are equivalent to those obser

268 erapies and that Axl and Mertk have distinct functional activities that impair host antitumor respons

269 nd provide a more direct measure of regional functional activity that is less dependent on nonlineari

270 Both peptides exhibit similarities in their functional activities: They provoke contraction in Nemat

271 ning options for multidimensional control of functional activities through combinations of orthogonal

272 integrating structural network topology and functional activity to predict the influence of stimulat

273 e CTL clones also severely compromised their functional activities toward autologous tumor cells.

274 nthesized and examined for their binding and functional activities toward melanocortin receptor subty

275 to maintain high affinity, selectivity, and functional activity toward the mu-opioid receptor.

276 n paxillin (Pxn) in downstream signaling and functional activities triggered through alphaE/CD103 cha

277 and displayed cytochrome P450 activities and functional activities typical of mature primary hepatocy

278 inal homing/retention by Tregs nor a lack of functional activities typically associated with CD103(+)

279 broadly shared as well as cell type-specific functional activities unique to the trophoblast lineage.

280 omewhat lower for appraisal of overall brain functional activity using (123)I-FP-CIT and (18)F-FDG im

281 th R and/or R-induced alterations in Ikaros' functional activities via cellular signaling pathways.

282 losteric regulation triggering the protein's functional activity via conformational changes is an int

283 sion/injection serum VRC01 retained expected functional activity (virus neutralization, antibody-depe

284 C1-INH functional activity was assessed by EIA.

285 Functional activity was assessed using allergen-induced

286 d CD200L was measured by flow cytometry, and functional activity was assessed using blocking antibodi

287 ng and secretion, endothelial signaling, and functional activity was assessed.

288 the basal ganglia, whereas the overall brain functional activity was examined using VOIs across the b

289 An increase in RRE functional activity was observed over time, and a key mu

290 Antibody functional activity was quantified by Opsonophagocytic K

291 Affinities and functional activities were determined at recombinant hHx

292 erozoites, IE surface antigens, and antibody functional activities were quantified.

293 y, size, concentration, cargo components and functional activity were compared.

294 Both expression and functional activity were investigated.

295 sis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma.

296 Biomolecules and functional activity were measured in milk obtained twice

297 -weighted structural MRI scans and drive its functional activity with a dual phase-encoded stimulus.

298 that discriminated between E and NE areas of functional activity, with a cross-validation AUC and suc

299 erential regulation of interlinked predicted functional activities within the intestinal environment

300 t human NK cells are able to terminate their functional activity without the aid of other immune cell