ライフサイエンスコーパス: functional gene

1 nt HGT events and further fuse them into one functional gene.

2 current DNA sequence data available for each functional gene.

3 n be mapped to two biologically relevant and functional genes.

4 ceus with high expression levels of keystone functional genes.

5 insulin and downregulation of many beta cell functional genes.

6 ty, and the upstream sites had more distinct functional genes.

7 ans and Europeans, and thus are likely to be functional genes.

8 ctly assessed by measuring the expression of functional genes.

9 he investigation of the interactions between functional genes.

10 identified 2,335 genes, including 565 within functional genes.

11 o promote positive interactions of important functional genes.

12 surements of the abundance and expression of functional genes.

13 ucing protein Tipalpha) and hitherto unknown functional genes.

14 in the relative abundances of representative functional genes.

15 is central to Ag binding and consists of 48 functional genes.

16 ts by inversions and permutations to produce functional genes.

17 cterial and archaeal amplicons and community functional genes.

18 nerated, heterochromatic chromosome with few functional genes.

19 idual genome contains the full complement of functional genes.

20 of recombination, and ancient Ys contain few functional genes.

21 ly inert heterochromatic DNA but contain few functional genes.

22 of existing DNA primers for denitrification functional genes.

23 omatin information to improve annotations of functional genes.

24 n cells versus wild-type cells) m6A-mediated functional genes.

25 findings suggest that bacterial species and functional genes absent in the gut microbiome of individ

26 gnificant correlations were observed between functional gene abundance and vascular plant primary pro

27 Incorporating microbial functional gene abundance data into a microbially-enable

28 decreased, while the community structure and functional gene abundance did not exhibit any significan

29 Hence, functional gene abundance is a valuable index that integ

30 anges in microbial community composition and functional gene abundance may imply actual changes in su

31 n via 16S rRNA gene amplicon sequencing, and functional gene abundance using qPCR.

32 2O production were accounted for by archaeal functional gene abundance.

33 d shifts in many microbial, phylogenetic and functional gene abundances and pathways.

34 Etheneotroph and methanotroph functional gene abundances ranged from 10(2) to 10(9) ge

35 sition by shifting community composition and functional gene abundances toward those that tolerate st

36 Based on path analysis, functional gene abundances were the most important varia

37 Thus, although the resulting Y-linked functional gene acquisition rate (0.25 new genes per mil

38 We assessed abundance of functional genes affiliated with nitrification (bacteria

39 topsoil (0-15 cm) microbial communities and functional genes along a permafrost thaw sequence (1, 10

40 The tropical isolates have several functional genes also present in known fluorescent Pseud

41 metabolism, as well as most of the detected functional genes also showed clear backwater and riverin

42 Functional gene analyses were performed using modular re

43 Functional gene analysis indicated that genes involved i

44 ains have remained unchanged for decades and functional gene analysis of Agrobacterium has been hampe

45 anscriptional profiling, bioinformatics, and functional gene analysis, we identify a new axis of mosq

46 hin sample diversity analysis, enterotyping, functional gene and metagenomic species analysis have be

47 varies significantly in the multiplicity of functional genes and in the substrate specificity of its

48 retensis is undergoing decay through loss of functional genes and insertion sequence expansion, often

49 ., Limnohabitans), and a higher abundance of functional genes and KEGG orthology (KO) groups involved

50 The human microbiome contributes functional genes and metabolites which affect human phys

51 nly a limited number of available reports on functional genes and microbes that take part in the degr

52 vealed distinct presence/absence profiles of functional genes and pseudogenes (e.g., virulence genes)

53 processes are mediated by the expression of functional genes and their translation into enzymes that

54 etheneotroph and anaerobic VC-dechlorinator functional genes and transcripts than those with bulk VC

55 The putative functional genes and variants identified could help impr

56 sociation studies have struggled to identify functional genes and variants underlying complex phenoty

57 impact of thaw on microbial phylogenetic and functional genes, and relate these data to measurements

58 Functional gene annotation analysis indicated predominan

59 as well as gain-of-function mutagenesis for functional gene annotation in vertebrate models, includi

60 lizing SARG and a previously proposed hybrid functional gene annotation pipeline, we developed an onl

61 In addition, ANISEED provides full functional gene annotation, anatomical ontologies and so

62 genome assembly and gene model set, refined functional gene annotation, and anatomical ontologies, a

63 ted gene functions is a powerful approach of functional gene annotation.

64 signment, and (ii) can assign structural and functional gene annotations with varying degrees of spec

65 Large-scale expression data, functional gene annotations, experimental protein-protei

66 The available data consist of structural and functional gene annotations, homologous gene families, m

67 ging from building phylogenies to predicting functional gene annotations.

68 The remaining functional genes are ubiquitously expressed, functionall

69 and seven monitor wells were analysed with a functional gene array (GeoChip 3.0), and functional mole

70 Functional gene array (GeoChip 5.0) analysis showed the

71 Here, 16S rRNA Illumina sequencing and functional gene array (GeoChip 5.0) were used to assess

72 In this study, a functional gene array (i.e., geochip 4.2) was used to an

73 Functional gene array (i.e., GeoChip) analysis of Arctic

74 NA sequencing, qPCR of mcrA transcripts, and functional gene array-based analysis of arsM expression,

75 atasets of 12-day time-series generated by a functional gene array-GeoChip 4.2.

76 ) experimental sites using a high-throughput functional gene array.

77 Functional gene arrays (FGAs) are a special type of micr

78 Functional gene arrays (FGAs) have been considered as a

79 Comprehensive functional gene arrays covering a wide range of ecologic

80 ng a metagenomic approach with GeoChip-based functional gene arrays to establish metabolic capabiliti

81 gies, such as high throughout sequencing and functional gene arrays, provide revolutionary tools for

82 ; however, a plasmid knockout identified the functional gene as being present on the chromosome.

83 Second, the usefulness of functional genes as indicators of stress response was ex

84 The relative abundance of functional genes associated with assimilatory sulfate re

85 re decreased the relative abundances of most functional genes associated with C degradation and N cyc

86 The relative abundance of functional genes associated with denitrification was not

87 trogen metabolism, the relative abundance of functional genes associated with dissimilatory pathways

88 e sequence data using PICRUSt and identified functional genes associated with nitrogen and sulfur met

89 ssing challenge is how to effectively detect functional genes associated with or causing phenotypic o

90 yrosequencing to identify microorganisms and functional genes associated with PCE degradation to ethe

91 potential) analysis identifies a core set of functional genes associated with root colonization in bo

92 et the transcriptome changes, we constructed functional gene association networks of differentially e

93 estries may facilitate the identification of functional genes at associated loci.

94 Here, we present a functional gene-based framework for describing microbial

95 from engineered and natural environments, a functional gene-based microarray, termed StressChip, has

96 transcription factors for the expression of functional genes being differentially expressed.

97 decreased by 25% and 5%, while the community functional gene beta-diversity increased by 34% and 45%,

98 measurements of pmoA, which is a widely used functional gene biomarker for methanotrophs.

99 two smaller chromosomes are devoid of known functional genes but nonetheless contain diagnostic mito

100 , at 95.25% coverage, representing all broad functional gene categories in the genome.

101 clear receptors and distinct enrichments for functional gene categories.

102 f TCRalpha and TCRbeta genes, and amplifying functional genes characteristic of different T cell subs

103 Thus, the Solanum functional gene cluster evolved by duplication and diver

104 esis, nonparalogous genes were arranged to a functional gene cluster with shared regulatory elements.

105 and clustering method that perform best for functional gene clustering using annotation sets of vary

106 ession profiles revealed temporally distinct functional gene clusters for apoptosis, chemotaxis, and

107 First, we identified functional gene clusters from these data.

108 Functional gene clusters, containing two or more genes e

109 ction and glucose uptake, many of which form functional gene clusters.

110 e how the similarities of both taxonomic and functional genes co-vary over geographic distance within

111 he differences in coral-associated microbial functional gene composition and metabolic potential amon

112 n some permafrost soils and a rapid shift in functional gene composition during short-term thaw exper

113 es have recently revealed the identities and functional gene composition of microorganisms in some pe

114 We investigated phylogenetic turnover and functional gene composition of saprotrophic fungi along

115 r-year field experiment, we investigated the functional gene composition of three types of soils (Pha

116 eviously unappreciated level of variation in functional gene content between humans.

117 s of diversity both in terms of sequence and functional gene content.

118 on event was followed by several losses of a functional gene copy attributable to gene loss or pseudo

119 A new functional gene database, FOAM (Functional Ontology Assi

120 The expression profiles of twelve functional genes detected via RNA-Seq were corroborated

121 he topsoil microbial community structure and functional genes differed from the control.

122 e genome assemblies will provide a basis for functional gene discovery and breeding to deliver the ne

123 , an important vertebrate model organism for functional gene discovery.

124 nities was significantly correlated with the functional gene dissimilarity, and the upstream sites ha

125 Here, we characterized the taxonomic and functional gene diversity (16S rRNA gene amplicon and me

126 diversity of bacteria and of biota overall, functional gene diversity of algae, bacteria, fungi and

127 However, the observed decrease in functional gene diversity was more attributable to a los

128 onomic diversity, but were found to decrease functional gene diversity.

129 rary sequences and archetype analysis from a functional gene DNA microarray, detected broad phylogene

130 by combining inverse modeling and microbial functional genes during decomposition with a metagenomic

131 nal potential and are integral components of functional gene dynamics in aquatic bacterial metacommun

132 Mice without a functional gene encoding MGAT2 (Mogat2(-/-)) are protect

133 egulated so that only one allele assembles a functional gene, ensuring that nearly every T and B cell

134 Etheneotroph functional genes (etnC and etnE) and VC reductive dehalo

135 e evolution, linking chromosome evolution to functional gene evolution.

136 ize an evolutionary model according to which functional genes evolve de novo through transitory proto

137 In conclusion, ECM could rescue the functional genes expression after cell detached from cul

138 Our findings demonstrate that -2 PRF is a functional gene-expression mechanism in eukaryotes and a

139 Thus, GSDMB is a functional gene for both asthma susceptibility and sever

140 The genome contains numerous functional genes for iron and sulphur metabolism, nitrog

141 d with the increase in relative abundance of functional genes for stable C degradation.

142 or single-copy genomic targets or introduce functional genes, foreshadowing potential applications t

143 al underpinnings of horizontal transfer of a functional gene from prokaryotes to vertebrates.

144 We evaluated FunFrame on functional genes from four PCR-amplified clones with seq

145 The loss of functional genes from non-recombining sex-specific chrom

146 Functional genes from the three major VC-degrading bacte

147 rs, with EGFR-SEPT14 being the most frequent functional gene fusion in human glioblastoma.

148 Though functional gene fusions encoding oncogenic proteins are

149 three loci identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functio

150 cts meta-analyses by genotype and predefined functional gene group (thrombophilic, vasoactive, metabo

151 r mutations occurring in the same pathway or functional gene group across a cohort of cancer samples.

152 extract meaningful patterns corresponding to functional gene groups and patient clusters from the gen

153 s suggest that NPCs regulate the activity of functional gene groups by acting as scaffolds that promo

154 eased relative abundance of bacteria and key functional gene groups for C degradation were related to

155 n of a literature network, we extracted 3444 functional gene groups that represented biological pathw

156 Among these genes, several functional gene groups were present, including transcrip

157 eparation of expression profiles among major functional gene groups, with carbohydrate, lipid, and xe

158 ncing and categorized the disease genes into functional gene groups.

159 ain JNA for subsequent genome sequencing and functional gene identification.

160 his approach may potentially miss some truly functional genes if both its low and high modes have ass

161 bacteria to humans, including some important functional genes, illustrates the significance of viral

162 suggested multiple changes in structural and functional genes important for placental health and func

163 modules arising from an uninterrupted, fully functional gene in the entomopathogenic bacterium Photor

164 d ANGPTL3 and HLC ASE gene ACAA2 to be lipid-functional genes in mouse models.

165 titative polymerase chain reaction (qPCR) of functional genes in the denitrification pathway.

166 Despite the high number of functional genes in the mouse Cyp2c cluster and the repo

167 oles in the regulation of expression of many functional genes in the prenatal and postnatal hearts.

168 izes and shifts in the importance of several functional genes, including those associated with cyanob

169 ed by expression quantitative trait loci, or functional genes indicates that most cancer susceptibili

170 Depth horizons with functional genes indicative of methane-cycling and sulfa

171 However, its genomic and functional gene information remain unknown due to extrem

172 from Arabidopsis thaliana seeds to compute a functional gene interaction network, termed Seed Co-Pred

173 og this heterogeneity and use it to identify functional gene interactions and genotype-dependent liab

174 stance of purposeful integration of multiple functional genes into a clostridial chromosome--here, th

175 Fungal functional genes involved in hydrolysis of organic matte

176 Abundances of functional genes involved in labile C degradation decrea

177 Correspondently, key functional genes involved in metal homeostasis (e.g., ch

178 First, 46 functional genes involved in microbial responses to envi

179 Fungal beta-diversity and composition of functional genes involved in plant litter decay were unr

180 s facilitating lactate utilization, and that functional genes involved in plant polysaccharide metabo

181 that the unique ORFX in the WIV1 strain is a functional gene involving modulation of the host immune

182 Efficient integration of functional genes is an essential prerequisite for succes

183 ys that restore population modification with functional genes, is needed for long-term success.

184 The increase of the functional genes led to an increase in both soil respira

185 ersity and composition at both taxonomic and functional gene levels, and microbial association networ

186 The impact of functional gene loss was predicted based upon position w

187 flect a balance between gene acquisition and functional gene loss.

188 nce of key components and informing targeted functional gene manipulation studies.

189 dy found 157 associated genes (124 new), and functional gene mapping analysis linked 146 additional g

190 on lookups, gene-based association analysis, functional gene mapping, and genetic correlation estimat

191 ed with TSWV resistance made it possible for functional gene mapping, map-based cloning, and marker-a

192 Detection of phylogenetic and functional gene markers related to those of Ca.

193 suggest that variations in transcription of functional genes may supplement sOUR based assays as ear

194 genes were identified using high-throughput functional gene microarray (GeoChip 3.0), and functional

195 sequencing of 16S rRNA gene amplicons and a functional gene microarray.

196 Methanotroph functional genes (mmoX and pmoA) were not related to VC

197 n of conjugated siRNA described here enables functional gene modulation in vivo in several extra-hepa

198 h AD neuropathology, and pinpoint a specific functional gene module underlying selective vulnerabilit

199 g potential for detecting condition-specific functional gene modules (i.e. biclusters).

200 cient dropouts-saving expansion strategy for functional gene modules optimization using information d

201 tworks induced different numbers of putative functional gene modules, and each similarity measure ind

202 ks, provides a powerful approach to identify functional gene modules.

203 ditional autoregressive prior to integrate a functional gene network and to share information between

204 Here, we present BaiHui, a brain-specific functional gene network built by probabilistically integ

205 Here, we present an updated co-functional gene network for A. thaliana, AraNet v2, whic

206 ly published a description of a genome-scale functional gene network for A. thaliana, AraNet, which w

207 Both affected a functional gene network related to cell death and surviv

208 rks of jointly dysregulated genes within the functional gene network which capture three distinct bio

209 We previously developed a human functional gene network, HumanNet, by integrating divers

210 1 week and yielded over 60% of cells with a functional gene network.

211 Functional gene networks and crucial molecules associate

212 vered by the API include 144 tissue-specific functional gene networks in human, global functional net

213 pression and promote selective deployment of functional gene networks in response to complex profiles

214 omatin bound transcription factors regulates functional gene networks in response to GPCR activation

215 h was constructed by integrating multiple co-functional gene networks inferred from diverse data type

216 ese findings implicate that dysregulation of functional gene networks may be involved in the emergenc

217 ntation donor organ samples, but most of the functional gene networks overlapped.

218 THC altered functional gene networks related to cell morphogenesis,

219 Bioinformatics analysis identified functional gene networks, including members of the compl

220 Functional gene networks, representing how likely two ge

221 nvolved in both mutation-specific and shared functional gene networks.

222 the dorsal flap tissue thereby bringing new functional gene networks; these presumably enabled the T

223 to survey the diversity of a denitrification functional gene, nirS (encoding cytchrome-cd1 nitrite re

224 on of heterocyst regulatory, structural, and functional genes occurred over the 24 h required to form

225 because it identifies the abundances of the functional genes of the organisms present in the origina

226 Our findings mechanistically link the two functional gene ontologies that have been implicated in

227 could be potentially treated by supplying a functional gene or changing the expression levels of spe

228 important information for screening the key functional genes or molecular markers of estrus expressi

229 The functional genes or single nucleotide polymorphisms (SNP

230 Functional gene parts for the synthesis of DNA- and RNA-

231 t, in addition, the chimpanzee has a seventh functional gene, Patr-AL, which is not polymorphic but c

232 rmal vent sites and symbiont evolution using functional gene phylogenies.

233 inimally thawed site, the number of detected functional gene probes across the 15-65 cm depth profile

234 ed genes that cannot be transcribed into any functional gene products.

235 es recently described algorithms to de-noise functional gene pyrosequences and performs ecological an

236 Normal liver stiffness maintained functional gene regulation by hepatocyte nuclear factor

237 However, identifying functional gene regulatory elements has been challenging

238 NA gene sequences, the relative abundance of functional genes related to assimilatory nitrate reducti

239 undated areas, and the relative abundance of functional genes related to dissimilatory nitrate reduct

240 Functional genes related to key biogeochemical cycles in

241 decrease in both the abundance and number of functional genes related to methanogenesis.

242 ale haplotype blocks and may be close to the functional genes related to SHB development.

243 sis of the metagenomes showed that microbial functional genes relating to energy production and conve

244 This process of functional gene relocation, now rare in eukaryotes, cont

245 ons and the identification of the implicated functional genes remain largely undefined.

246 ced differences in bacterial assemblages and functional gene repertoires were noted between US reside

247 Based on functional gene representation, transcriptome samples cl

248 We uncover an endogenous strategy of functional gene rescue that safeguards neuronal RNA sign

249 orious polychlorinated biphenyls (PCBs), and functional genes responsible for PCB detoxification rema

250 % and 45%, respectively, revealing decreased functional gene richness but increased community heterog

251 ection of more resistant AOB and NOB sharing functional gene sequences close to those of, respectivel

252 notyping techniques such as phylogenetic and functional gene sequencing, can provide more insights in

253 Microarray and functional gene set enrichment analysis revealed a strik

254 ical relevance of our approach, we performed functional gene set enrichment and survival analyses.

255 In sum, our results define the first functional gene set for habituation learning in a verteb

256 troduced an adjustable "soft threshold" to a functional gene-set algorithm and found that two differe

257 thway is an R/Python wrapper for pathway (or functional gene-set) analysis of genomic loci, adapted f

258 Identifying functional gene sets and their regulatory networks that

259 xisting data collections to directly extract functional gene sets from big data.

260 ved in microarray data analysis and discover functional gene sets linked to patient survival.

261 sponse target gene set with GO Slim and KEGG functional gene sets, and also by inspecting association

262 annotation, gene expression data, and known functional gene sets, we showed that the functionality o

263 spread resting enrichment of proinflammatory functional gene sets, while upstream regulator analysis

264 biology-to-clinic" framework to uncover core functional gene-sets signatures.

265 d studies of N(2) O fluxes and relevant soil functional genes (SFGs, that is, archaeal amoA, bacteria

266 gatively with T cell histone methylation and functional gene signatures.

267 perform gene set analysis using data-defined functional gene signatures.

268 These conjugated siRNAs enable functional gene silencing in lung, muscle, fat, heart an

269 injection to the intracellular setting where functional gene silencing occurs.

270 LPS by both APC and thrombin was analyzed by functional, gene silencing, and signaling assays.

271 We sought to dissect functional genes/SNPs for asthma by combining expression

272 human bronchial epithelial cells to dissect functional genes/SNPs for asthma severity in the Severe

273 ared genes (87.2%) but had different overall functional gene structures as revealed by two datasets o

274 and DO were shown to be effective in shaping functional gene structures of the systems by statistical

275 vation (CRISPRa) approaches hold promise for functional gene studies and genome-wide screens in human

276 erived Cre recombinase is widely applied for functional gene studies in mice.

277 Furthermore, we identified Sparc as a novel functional gene target of Etv1 by luciferase assays, and

278 erformed kinase inhibitor screens to predict functional gene targets in primary specimens from patien

279 community composition, biodiversity and two functional genes tested.

280 Here we revealed that the unique ORFX is a functional gene that is involved in the modulation of th

281 casional transcripts from several apparently functional genes that carry aberrant recombination signa

282 are ecotype-specific signals of selection in functional genes that correspond to cultural foraging be

283 However, the Xi is a reservoir of >1,000 functional genes that could be potentially tapped to tre

284 Pseudogenes are defined as fragments of once-functional genes that have been silenced by one or more

285 genomes affords the opportunity to mine for functional genes that may lead to new generation drugs r

286 re fueled by early reports of delivering new functional genes to dystrophic muscle in mouse models us

287 icrobial nitrogen (N) cycling and associated functional genes to elevated temperature at the global s

288 enomes already showed a similar diversity of functional genes to the developed soils, with a similar

289 By contrast, we found no evidence for functional gene transfer to the nucleus or loss of mitoc

290 ion studies (GWASs), the characterization of functional genes underlying complex traits, and the sequ

291 uencing identified other risk alleles but no functional gene variants.

292 ericans and examined the role of whole-exome functional gene variations in the patients' antidepressa

293 d suggest that alternative splicing provides functional gene versatility that is essential for distin

294 Results showed that the distribution of functional genes was mainly associated with glacier area

295 ion profiles revealed that the most affected functional genes were related to angiogenesis, inflammat

296 ferentiation, some heterocyst structural and functional genes were upregulated, while the heterocyst

297 able C decomposition by modulating microbial functional genes, which could reinforce a warmer climate

298 N subtypes maintain the characteristics of a functional gene while ifs becomes a pseudogene.

299 f previously unidentified bacterial taxa and functional genes with high biomedical importance.

300 observed in humans, identifying TM6SF2 as a functional gene within a locus previously known as NCAN-