ライフサイエンスコーパス: functional impairment

1 ts who develop intolerable neuropathy and/or functional impairment.

2 more likely to have preexisting cognitive or functional impairment.

3 ollowed by progressive cognitive decline and functional impairment.

4 resence of cholesterol in surfactant without functional impairment.

5 t and who continue to experience distress or functional impairment.

6 nsuccessful, accompanied by CTL deletion and functional impairment.

7 e mild cognitive decline and no, or limited, functional impairment.

8 oid bursitis, muscle or joint stiffness, and functional impairment.

9 ry (TBI) and a major driver of mortality and functional impairment.

10 low-risk procedure if the outcome was severe functional impairment.

11 etes and if overlooked may result in chronic functional impairment.

12 UR1 are retained in the ER and have variable functional impairment.

13 responsiveness to IL-2, contributes to Treg functional impairment.

14 fect translates into reductions in hind limb functional impairment.

15 eas the other groups demonstrated persistent functional impairment.

16 e with PAD are associated with the degree of functional impairment.

17 on are at risk for developing depression and functional impairment.

18 on, generalised anxiety, alcohol misuse, and functional impairment.

19 monitored and correlated with physiological functional impairment.

20 conditions are transient and do not lead to functional impairment.

21 ciation with other psychiatric disorders and functional impairment.

22 ent-reported measures of quality of life and functional impairment.

23 ent-reported measures of quality of life and functional impairment.

24 s) along with depressive symptoms and severe functional impairment.

25 tion in peripheral blood NK cells and marked functional impairment.

26 is associated with greater lesion burden and functional impairment.

27 of predominantly short-term memory loss and functional impairment.

28 Similar patterns were observed for PTSD and functional impairment.

29 th schizophrenia with greatest cognitive and functional impairment.

30 experience nursing home admission or severe functional impairment.

31 rate skeletal muscle wasting with associated functional impairment.

32 n intratumoral T cells that displayed marked functional impairment.

33 ecessary to determine the mechanisms of this functional impairment.

34 icipants continued to exhibit high levels of functional impairment.

35 annabis that causes significant clinical and functional impairment.

36 index, muscle and fat indices, and acquired functional impairment.

37 19 [11.9%] of 159 for violent offence), and functional impairment.

38 d 42 [6.6%] of 640 for violent offence), and functional impairment.

39 etal muscle mass associated with significant functional impairment.

40 VC-related thrombosis), however, neither had functional impairment.

41 , often resulting in neuronal cell death and functional impairment.

42 related positively with disease duration and functional impairment.

43 leaf water potential Psi(leaf) thresholds of functional impairment.

44 's TM domains resulted in varying degrees of functional impairment.

45 These changes were accompanied by neuronal functional impairment.

46 ients older than 60 years of age with severe functional impairment.

47 e endoplasmic reticulum (ER), leading to its functional impairment.

48 he accuracy of predictability in post-stroke functional impairment.

49 thin complex III, causing its structural and functional impairment.

50 ners with serious mental health problems and functional impairment.

51 years with CFS and severe fatigue leading to functional impairment.

52 to neuronal death, thus causing irreversible functional impairments.

53 s for all critically ill children at risk of functional impairments.

54 l nitric oxide synthase (nNOSmu), leading to functional impairments.

55 in the artery wall that results in selective functional impairments.

56 ry stress, apoptosis, and structural but not functional impairments.

57 k factor for a large number of disorders and functional impairments.

58 5) for PTS, -0.42 (95% CI: -0.58, -0.27) for functional impairment, -0.48 (95% CI: -0.61, -0.34) for

59 gh levels of both psychological distress and functional impairment according to the 12-item General H

60 ent report of poor general or mental health, functional impairment, activity limitation, or cancer-re

61 ent report of poor general or mental health, functional impairment, activity limitation, or cancer-re

62 ared for quantification of tissue injury and functional impairment after MI using murine models with

63 higher dose of NP001 had significantly less functional impairment after the treatment period compare

64 stress (AMD, -5.86; 95% CI, -8.53 to -3.19), functional impairment (AMD, -4.17; 95% CI, -5.84 to -2.5

65 dysfunction is independently associated with functional impairment among acute lung injury survivors

66 mptoms and produced a smaller improvement in functional impairment among OVC having experienced high

67 unctional impairment on which 0 indicates no functional impairment and 24 indicates maximum impairmen

68 vaccinated with ATIV were older and had more functional impairment and comorbidities.

69 Functional impairment and decline are common in middle a

70 mine the epidemiology and clinical course of functional impairment and decline in middle age.

71 nic hepatitis B virus (HBV) infection is the functional impairment and depletion of antiviral T cells

72 is particularly debilitating due to combined functional impairment and disfigurement.

73 d on the basis of animal experiments showing functional impairment and electrophysiologic disturbance

74 rsistent exposure to cognate Ag leads to the functional impairment and exhaustion of HIV-specific CD8

75 Functional impairment and functional decline are common

76 The prevalence and extent of functional impairment and functional decline in PAD may

77 We examined functional impairment and impairment in activities of da

78 Functional impairment and loss of dental enamel, caused

79 ders affect 13% of females and contribute to functional impairment and mortality, but few studies hav

80 en to the individual and to society, causing functional impairment and physical disability, risk for

81 among young people, leading to cognitive and functional impairment and raised mortality, particularly

82 between individualized lesion location, and functional impairment and recovery in reaching/grasping,

83 Aging is characterized by functional impairment and reduced capacity to respond ap

84 natural process characterized by progressive functional impairment and reduced capacity to respond ap

85 logy and tooth loss are associated with both functional impairment and reduced quality of life.

86 essive therapy which places them at risk for functional impairment and scoliosis, these patients are

87 dr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well a

88 e can produce vastly different magnitudes of functional impairment and subsequent recovery.

89 ldren and adolescents and is associated with functional impairment and suicide.

90 varied as a function of both the severity of functional impairment and the temporal distance from str

91 obe the neurobiological mechanism underlying functional impairment and to longitudinally monitor prog

92 te in lung TCD8 characterized by progressive functional impairment and upregulation of numerous inhib

93 ic delivery of recombinant protein, reversed functional impairments and restored genomic integrity in

94 risk model for older patients who considered functional impairments and was suitable for use before h

95 women had a higher prevalence of age-related functional impairments and, among the STEMI subgroup, a

96 y of a benign tumor (nonmalignant tumor with functional impairment), and those with a history of mali

97 f benefit with regards to quality of life or functional impairment, and (3) the abundant evidence of

98 nxiety, 75% and 37% for PTS, 67% and 22% for functional impairment, and 71% and 32% for aggression.

99 onset, symptom duration, weight at baseline, functional impairment, and estimated rate of functional

100 s associated with prior HF hospitalizations, functional impairment, and higher N-terminal pro-B-type

101 sions were associated with disease activity, functional impairment, and patient global assessment in

102 e, PTSD, other psychopathology, risk events, functional impairment, and service use.

103 ocial interactions with other ethnic groups, functional impairment, and subjective wellbeing.

104 ic characteristics, psychiatric comorbidity, functional impairment, and treatment seeking.

105 in presentation characteristics, treatments, functional impairments, and in-hospital complications in

106 Reduced neurocognitive performance, functional impairments, and nonpositive attenuated sympt

107 g unfavourable health behaviours, health and functional impairments, and social risk factors) and 4.3

108 of depression and PTS (primary outcomes) and functional impairment, anxiety symptoms, aggression, and

109 nality disorder, whereas negative affect and functional impairment are more stable features of the di

110 Schwann cells, suggesting that the observed functional impairments are directly linked with choleste

111 paralysis and sensory disturbances, but such functional impairments are often short lived because of

112 locomotor muscle from the potentially severe functional impairment as a consequence of severe intramu

113 atients with ALS correlated with severity of functional impairment, as measured by total score on the

114 failure and to compare the time course with functional impairment assessed by cardiac MRI.

115 uestioned due to the absence of evidence for functional impairment associated with drug-induced devel

116 Carbonylation of MyBPC showed significant functional impairment associated with its actin binding

117 nces, including demonstrable symptomatic and functional impairment associated with persistent subclin

118 , the biological basis underlying visuomotor functional impairments associated with these clinical co

119 adial pulsation or occlusion, local pain, or functional impairment at 30 days.

120 adults aged 50 to 56 years who did not have functional impairment at enrollment.

121 pants with childhood ADHD, ADHD symptoms and functional impairment at follow-up were significantly co

122 y play a role in the persistence of acquired functional impairment at hospital discharge.

123 Age-associated functional impairments at baseline were more common in w

124 gher scores indicating worse symptoms]), and functional impairment (average score across 20 tasks [ra

125 09.98=2.66 [95% CI, 0.17-1.18]; P=.009), and functional impairment (B [SE], 0.24 [0.08]; t111.40=3.01

126 in which symptoms of dementia, cognitive and functional impairment become observable.

127 ion-induced exacerbation of brain injury and functional impairment caused by cerebral ischemia.

128 Alterations and functional impairment caused by jaundice increase the ri

129 and with a portion of these cells exhibiting functional impairment, checkpoint molecule immunotherapi

130 ive perceptions are associated with reported functional impairment, chest pain and anxiety, but not i

131 st 5% developed clinical characteristics and functional impairment comparable to previously described

132 s and the insulin-secreting beta cells whose functional impairment contributes to diabetes mellitus.

133 This functional impairment corresponded to increased lung inf

134 eome of diet-induced obese rats, even before functional impairment could be detected in vivo by echoc

135 Such functional impairment could be related to 1) the observe

136 7% in 2010, whereas the prevalence of severe functional impairment declined by 47.1% (P < 0.001), fro

137 ese results indicate that PD-1 mediates TCD8 functional impairment during acute viral infection and m

138 ontributes to pulmonary CD8(+) T cell (TCD8) functional impairment during acute viral LRI, but the ro

139 Functional impairment during successful antiretroviral t

140 ups reported similar severity of fatigue and functional impairments during the study, but duration wa

141 d factors before (e.g., frailty, preexisting functional impairments), during (e.g., duration of delir

142 g may be most beneficial among patients with functional impairment, elevated inflammatory markers, or

143 icated grief causes substantial distress and functional impairment even years after a loss, yet knowi

144 peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increa

145 ion of the NF-kappaB pathway showed complete functional impairment for null mutations, whereas partia

146 Apathy has profound consequences, such as functional impairment, higher service utilization, highe

147 es hippocampal hyperactivity as a very early functional impairment in AD transgenic mice and provides

148 ctivation, and immunosenescence markers with functional impairment in aging human immunodeficiency vi

149 trans form, contributes to tau pathology and functional impairment in an animal model of severe TBI.

150 l sensitivity and their value to reflect the functional impairment in chronic CSC.

151 of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.

152 el mice, that such defects may contribute to functional impairment in DS, and that these phenotypes,

153 de useful information in determining risk of functional impairment in glaucoma.

154 This caused a functional impairment in MSC hematopoietic supportive ca

155 e propose that this might be the result of a functional impairment in noradrenergic circuits associat

156 ent to which they share common features with functional impairment in older adults.

157 Functional impairment in people with serious mental illn

158 ial cognition is an important determinant of functional impairment in schizophrenia, but its relation

159 tivation and anhedonia, are a major cause of functional impairment in schizophrenia.

160 Axonal degeneration, which contributes to functional impairment in several disorders of the nervou

161 (VSM) and in genetic human syndromes causes functional impairment in some regional circulations, the

162 ng information on the risk of development of functional impairment in the disease.

163 common pathological hallmark associated with functional impairment in the elderly which has been mode

164 eral inflammation, giving rise to associated functional impairment in the form of reduced spatial mem

165 o determine if FoxO inhibition resulted in a functional impairment in vascular relaxation, we culture

166 similar format in reducing OCD symptoms and functional impairment in young children (5-8 years of ag

167 h increased risk for psychiatric illness and functional impairment in youth.

168 Functional impairments in children with TBI were more pr

169 dition to numerical decline, sepsis leads to functional impairments in DCs, diminishing their capacit

170 of cranial nerve VIII tumors correlates with functional impairments in hearing and balance, as measur

171 that can aggravate neuronal degeneration and functional impairments in many neurological conditions,

172 ate and severe TBI were rated as having more functional impairments in multiple domains than those wi

173 At least some of these morphological and functional impairments in p73 null cells can be rescued

174 pment that contributes to the persistence of functional impairments in self-regulation in BN.

175 estations are associated with structural and functional impairments in skeletal muscle, emphasizing a

176 results indicate significant structural and functional impairments in the barrel cortex of the Bird

177 s, uninjured mutant mice have anatomical and functional impairments in the peripheral nervous system.

178 icipants underwent in-hospital assessment of functional impairments including cognition, vision, hear

179 This patient population generally had severe functional impairment, including 1192 (24%) patients wit

180 omorbidities, and had a higher prevalence of functional impairments, including activities of daily li

181 l infarction (AMI) have higher prevalence of functional impairments, including deficits in cognition,

182 Mice expressing KIM-1Deltamucin had greater functional impairment, inflammatory responses, and morta

183 Functional impairment is persistent in the year followin

184 hosphate, and reduced NAD phosphate, whereas functional impairment is reflected in reduced neutrophil

185 56 weeks after RD surgery but structural and functional impairment is still present.

186 re adaptations to ageing-induced atrophy and functional impairment is still unsettled.

187 ch patients have mild neuropsychological and functional impairments, lack characteristic bvFTD brain

188 -based differences in clinical presentation, functional impairments, management, and in-hospital comp

189 These alleles leading to subtle functional impairment may contribute to complex, polygen

190 Aging-related functional impairments may inform risk prediction but ar

191 s examined with parent-reported symptoms and functional impairment measures using a categorical (DSM-

192 Biomarkers of functional impairment, neuronal loss, and protein deposi

193 onstrates that the CD4 T cell exhaustion and functional impairment observed in CVID patients is assoc

194 y related to the progressive, structural and functional impairments observed in AD.

195 the neurosteroid allopregnanolone mitigated functional impairments observed in preCGG neurons in a r

196 We demonstrate that structural and functional impairments occur in glutamatergic synapses i

197 ation, partial loss of oligodendrocytes, and functional impairment, occurred in the adult mice lackin

198 dy-mediated rejection that has progressed to functional impairment of a renal transplant have been de

199 This suggests that functional impairment of A1/C1 CA neurons resulting from

200 ponses in heart and kidneys, associated with functional impairment of both organs.

201 One reason for functional impairment of BSEP is systemic administration

202 We show that the functional impairment of CD4 T cells, including the redu

203 ls of prebeta-1 HDL may serve as an index of functional impairment of cholesterol efflux or esterific

204 ts a 50% change in CTD protein sequence, and functional impairment of exon 7 exclusion activity in a

205 aret gene led to ultrastructural changes and functional impairment of flight muscles, and transcripts

206 Ablation or functional impairment of Foxp3(+) Tregs in vivo at the s

207 uced GABA(A) receptor clustering, suggesting functional impairment of GABA signaling.

208 The reduced expression levels and functional impairment of global miRNAs are related to va

209 pe glutamate receptors, along with prominent functional impairment of glutamatergic synapses in the h

210 The functional impairment of HSV-2-exposed DCs could be part

211 everity showed a direct correlation with the functional impairment of MeCP2.

212 They also demonstrated functional impairment of medial temporal lobe (MTL) stru

213 te attenuator (BTLA) plays a similar role in functional impairment of MiHA-specific T cells after all

214 These processes led to a functional impairment of mitochondria, culminating in ce

215 accumulation leads to crystal formation and functional impairment of multiple organs.

216 cluding T-cell exhaustion, viral escape, and functional impairment of naive-like HCV-specific CD8(+)

217 Functional impairment of oxidative phosphorylation was t

218 Loss or functional impairment of p53 occurs in many human cancer

219 Persistent viruses often cause depletion or functional impairment of pDCs, but the role of pDCs in t

220 ain, may thus underlie the vulnerability and functional impairment of pivotal inhibitory circuits in

221 d to aberrant intracellular localization and functional impairment of promyelocytic leukemia zinc-fin

222 In conclusion, functional impairment of renal sodium and BP homeostasis

223 ge-related muscle decline is associated with functional impairment of satellite cells (SCs).

224 tive was to evaluate chronic pain states and functional impairment of septic and nonseptic patients 6

225 ion of the proline substitution in the helix functional impairment of Sgs1 function varied, gradually

226 Functional impairment of stress granules has been implic

227 rogrammed death-1 (PD-1) are involved in the functional impairment of T cells during infection.

228 In vivo, functional impairment of T(RM) cells in mice with double

229 d affinity leads not to stabilization but to functional impairment of the glomerular filtration barri

230 lucose uptake and insulin resistance (IR) to functional impairment of the heart.

231 in N- and 6-O-sulfated domains demonstrating functional impairment of the HS2ST1.

232 mol/L glucose or dapagliflozin, indicating a functional impairment of the islets of these donors to g

233 state of mPFC disinhibition resulting from a functional impairment of the local prefrontal GABAergic

234 regulation by HCV core protein coupled with functional impairment of the membrane attack complex und

235 nia, and cognitive aging may result from the functional impairment of the motivational salience signa

236 Atrial fibrillation ablation results in functional impairment of the UGI system, including the e

237 ulsation loss or occlusion and local pain or functional impairment of the upper extremity.

238 bundant CYP enzyme in the human liver, and a functional impairment of this enzyme leads to unanticipa

239 onal start sites; and 12 involving potential functional impairment of transcriptional regulators.

240 These data show a functional impairment of Tregs in a proportion of patien

241 nflammatory environment, that exacerbate the functional impairment of Tregs, which are reduced in num

242 ing that this inflammatory milieu is key for functional impairment of Tregs.

243 We hypothesized that functional impairment of tumor-specific T cell responses

244 blockage of the bladder outflow tract or by functional impairment of urinary voiding.

245 eptor specifically in T reg cells results in functional impairment of virus-specific CD8(+) and CD4(+

246 der precise lesion location and the specific functional impairments of each subject since these varia

247 ms that underlie the disparate cognitive and functional impairments of schizophrenia.

248 These results suggest that functional impairments of the prefrontal striatonigral c

249 orthopaedic trauma, that results in chronic functional impairments of the soft tissue.

250 ire commonly used to measure LBP and related functional impairment on which 0 indicates no functional

251 g-standing symptoms were not associated with functional impairment or a particular strain of B. burgd

252 Functional impairment or complete loss of type VII colla

253 Functional impairments or trafficking defects of inhibit

254 dize patency and lead to recurrent symptoms, functional impairment, or a threatened limb.

255 The risk of nursing home admission, severe functional impairment, or death was low (16%) for patien

256 analysis in cells showed that the degree of functional impairment paralleled changes in receptor-cor

257 latively mild early TBI experience long-term functional impairments, particularly in the context of l

258 disorder (OCD), and is associated with worse functional impairment, poorer quality of life, and poore

259 tal health (PR, 1.66; 95% CI, 1.52 to 1.80), functional impairment (PR, 4.53; 95% CI, 3.91 to 5.24),

260 nd 58 (92%) expected the patient to have new functional impairments preventing independent living.

261 Its functional impairment promotes autoimmunity and atherosc

262 1 values the best correlation with the later functional impairment (R(2) =0.94).

263 s coordinated by a case manager who assessed functional impairments relating to mood symptoms.

264 ailure with preserved ejection fraction have functional impairment resulting in reduced quality of li

265 Here we have characterized the functional impairments resulting from conditional knocko

266 sruption of the ELM, and significant macular functional impairment (RS decrease) vs SND-.

267 s, individuals with persistent ADHD had more functional impairment (school/work: OR, 3.30 [95% CI, 2.

268 Patients with more severe functional impairment showed lower mean dMT network conn

269 of conditions that lead to neuronal loss and functional impairment.SIGNIFICANCE STATEMENT We show tha

270 Adding functional impairments significantly improved model perf

271 exhibited inhibitory receptor expression and functional impairment similar to those of mice experienc

272 8 induced long-term neuroprotection, reduced functional impairment, stabilized blood-brain barrier th

273 ood or anxiety state is related to even more functional impairment, suggesting that prolonged fatigue

274 nter the peripheral repertoire in a state of functional impairment, termed anergy.

275 indicated that HcrtR antagonists cause less-functional impairment than BzRAs.

276 ilure by oligodendrocytes contributes to the functional impairment that characterizes the demyelinati

277 ls specific for subdominant epitopes undergo functional impairment that is associated with the expres

278 ompared with wild-type animals, resulting in functional impairments that affect in particular the sen

279 Traumatic brain injury causes monocyte functional impairments that may affect the host's suscep

280 s ex vivo; virus-specific CD8(+) T cells had functional impairments that were temporally restricted t

281 er patients at high risk for death or severe functional impairment the option of pursuing care focuse

282 ess Disorder Reaction Index (range, 0-4) and functional impairment using a locally developed measure

283 Functional mobility was the only functional impairment variable retained but was the stro

284 pulmonary CD8+ cytotoxic T lymphocyte (TCD8) functional impairment via programmed death-1/programmed

285 walpindi), age (<6 years or >/=6 years), and functional impairment (Vineland Adaptive Behaviour Scale

286 Functional impairment was a composite of poor academic p

287 This in vivo functional impairment was accompanied by dampened expres

288 Functional impairment was attributed to over 100-fold lo

289 Acquired functional impairment was defined as increase greater th

290 Physical and mental health status and functional impairment was measured by the Medical Outcom

291 es in tumor-related pain, disfigurement, and functional impairment was observed.

292 o identify the mechanisms underlying NK cell functional impairment, we characterized the distribution

293 ut in nearly all patients, both symptoms and functional impairment were mild and had resolved by 4 mo

294 ge, 11.1-11.8 years]), the combined rates of functional impairment were not significantly different b

295 Functional impairments were assessed during hospitalizat

296 Comorbidities with functional impairments were common.

297 These functional impairments were driven by rare Nef polymorph

298 omplications, such as worsening symptoms and functional impairment when a medication dose wears off (

299 Rather, PTCy induced alloreactive T-cell functional impairment which was supported by highly acti

300 umatic Stress Disorder Checklist for DSM-5), functional impairment (WHODAS 2.0), progress on problems