ライフサイエンスコーパス: functional importance

1 species than the other parts, implying their functional importance.

2 al organization of chromosomal elements with functional importance.

3 interpreted in terms of the vague concept of functional importance.

4 evolutionarily conserved exons, a proxy for functional importance.

5 ome pols achieve medium or low fidelity with functional importance.

6 our understanding of bacterial shape and its functional importance.

7 stabilizing selection, suggesting potential functional importance.

8 fluenced by its expression level rather than functional importance.

9 d, raising the question of the extent of its functional importance.

10 ation, inhibition, or ablation to test their functional importance.

11 l intermediates or hidden states that are of functional importance.

12 nts would uncover deeper insights into their functional importance.

13 nserved across disparate species, indicating functional importance.

14 in human cells, underscoring their conserved functional importance.

15 ly-onset neurodegeneration, underscoring its functional importance.

16 e during the course of NTN, indicating their functional importance.

17 tuberculosis is unusual in its composition, functional importance and activation mechanism.

18 These data underscore the functional importance and cell type specificity of many

19 This strongly indicates that isomiRs are of functional importance and have contributed to the evolut

20 However, the functional importance and mechanisms of action for human

21 of AGO proteins with profound structural and functional importance and provide the first hints at str

22 N variability and provides evidence both for functional importance and redundancy of G-CSF receptor-m

23 ion, it is therefore important to assess the functional importance and regulation of GRB10 under thes

24 ed us to identify those residues of critical functional importance and revealed a unique sequence sig

25 preservation of this feature highlights its functional importance and suggests that this highly cons

26 several surface-exposed regions of potential functional importance and test their importance using mu

27 main TMs, identified pore-lining residues of functional importance, and provided evidence of an emerg

28 l warmth, its transcriptional mechanisms and functional importance are unknown.

29 ventral surface of the disc lamellae implies functional importance associated with the adhesive mecha

30 Their functional importance at a clinical level, however, rema

31 To better understand functional importance, bioinformatic analysis predicted

32 tered in our structure, and we confirmed its functional importance by mutagenesis.

33 Due to its functional importance, DBP is considered a prime vaccine

34 experimental tools to map detour circuits of functional importance, directing circuit rewiring to pro

35 Of functional importance, disruption of CDCP1 reduces nucle

36 nidentified, and despite their frequency and functional importance, distribution and abundance patter

37 mechanistic studies that demonstrated their functional importance during inflammation, autoimmune di

38 under tight control by arginase 1 and is of functional importance during ischemia-reperfusion.

39 However, their functional importance during the priming phase of an org

40 se different annotations into one measure of functional importance (Eigen) that, unlike most existing

41 est that composition of weight loss may have functional importance for energy balance regulation, wit

42 the Hoxa9-ES9S interaction demonstrates the functional importance for such selective mRNA-rRNA bindi

43 the perspective on allostery and implicates functional importance for the directionality of alloster

44 Overall, we uncover the functional importance for the restricted transmission of

45 the TMD of IFNAR1 is low, suggesting limited functional importance for this region.

46 l biological roles, but their prevalence and functional importance has remained elusive because they

47 Despite the functional importance, how DRG neurons function at a pop

48 f neuron subtype-specific isoform usage with functional importance, identifies potential drug targets

49 to rafts in the plasma membrane, which is of functional importance in a wide range of cellular proces

50 To address their functional importance in angiogenic processes, several e

51 traints reveal hitherto unseen structures of functional importance in apparently disordered proteins.

52 utations in cancer cells, underscoring their functional importance in cellular regulation.

53 y for testing these secondary structures for functional importance in CHIKV replication and pathogene

54 that mechanically gated ion channels are of functional importance in chondrocyte mechanotransduction

55 the dynamic nature of RNA structures and its functional importance in gene regulation.

56 ive immune responses; however, their in vivo functional importance in hepatic ischemia/reperfusion (I

57 as an acetyl-lysine-binding module, but its functional importance in human cancer remains unknown.

58 le challenge for now-we cannot establish its functional importance in human health, disease and new t

59 To address this issue, we established its functional importance in mammary tumor progression in mi

60 lesions in multiple sclerosis (MS), but its functional importance in pathogenesis is unclear.

61 expression of these genes, supporting their functional importance in promoting proliferation.

62 onal modifications in eukaryotic cells, with functional importance in protein degradation, subcellula

63 e discussion of the potential structural and functional importance in proteins of the related anion-a

64 sly expressed transcriptional regulator with functional importance in the central nervous system.

65 The functional importance in the disease was corroborated by

66 n define a novel cluster of amino acids with functional importance in the regulation of type I interf

67 emains unknown and we aimed to determine its functional importance in these tissues.

68 Despite its functional importance in various fundamental bioprocesse

69 Despite its functional importance in various fundamental bioprocesse

70 Despite its functional importance in various physiological events, t

71 hepatic vasculature, suggesting constitutive functional importance in vivo.

72 mouse mast cell responses in vitro and their functional importance in vivo.

73 selection on specific codons, supporting its functional importance in widow venom.

74 he regions of conformational flexibility and functional importance, indicating that the cavities faci

75 This functional importance is because of three novel cellular

76 , but the consistent decline of invertebrate functional importance is indicative of a human-induced s

77 f the water pathway in the protein nor their functional importance is known.

78 accompany numerous brain diseases, but their functional importance is not understood.

79 viruses, R-loop investigation is limited and functional importance is poorly understood.

80 To identify regions of functional importance, M proteins from a variety of VHSV

81 Yet, despite their presumed functional importance, M. mulatta Ab receptors are large

82 Despite their functional importance, mechanistic details for cluster s

83 Uniformity is of both practical and functional importance, necessary to increase structural

84 Despite this functional importance, no large-scale neuroimaging genet

85 This work reveals the functional importance of 30S shoulder rotation for produ

86 To explore the functional importance of 5hmU, we develop a method for t

87 lation, but we currently only understand the functional importance of a few of these PTMs.

88 ular studies define the structural basis and functional importance of a form of LIMP-2 for lipid traf

89 e data represent a rare determination of the functional importance of a genome-wide disease associati

90 lorubrum extorquens AM1, we investigated the functional importance of a proposed lanthanide-coordinat

91 ic algorithm to estimate the topological and functional importance of a protein from the global netwo

92 port current models of regions of particular functional importance of AGO proteins.

93 mine the AGO1-mediated EC transcriptome, the functional importance of AGO1-regulated endothelial func

94 tine-induced antiallodynia, highlighting the functional importance of alpha6beta4 in pain.

95 The functional importance of amblyopia at an individual leve

96 Altogether, our observations describe the functional importance of amino acid 375H in CRF01_AE env

97 nt studies, however, question the extent and functional importance of apoA-I Tyr(166) nitration based

98 The functional importance of approximately 50% of the ORF2p

99 y breaking perfect six-fold symmetry implies functional importance of asymmetric association of p97 s

100 equirements for p29 and p48 cleavage and the functional importance of autoproteolysis in the context

101 O and abolished by diclofenac indicating the functional importance of B2R-induced activation of endot

102 In view of the functional importance of bacterial communities in the ph

103 In this study, the functional importance of beta1 integrin in lung epitheli

104 pecies does not necessarily translate to the functional importance of biodiversity measured in whole

105 However, the functional importance of blocking caspase-8-mediated cle

106 These findings highlight the functional importance of cancer cell O-glycans and relat

107 eavage, recent studies have demonstrated the functional importance of carboxyl terminal fragments of

108 Exchanging exonic regions revealed the functional importance of CCK1R exon 3, extending from th

109 In this study, we investigated the functional importance of CD82 expression in melanoma-med

110 ng RNA-mediated depletion, demonstrating the functional importance of cellular proteins in the biolog

111 derivatives, very little is known about the functional importance of chemical modifications on other

112 nuate hepatic glucose output, suggesting the functional importance of circulating FABP4.

113 Overall, our results show the structural and functional importance of conserved extracellular cystein

114 We investigated the nature and functional importance of contact-dependent communication

115 Our work offers a proof of the functional importance of CSCs in breast cancer, and it e

116 ort a new model of CUB and indicate that the functional importance of CUB, as well as synonymous site

117 One relates to the functional importance of dehydroascorbate reductases (DH

118 rk of lung mesenchymal niches and reveal the functional importance of developmental pathways in promo

119 , rich resources and novel hypotheses on the functional importance of diploidy.

120 The functional importance of dual- (or multi-) transmitter n

121 Finally, we tested the functional importance of dynamic MyoVa:melanosome intera

122 gulates the IKS channel, thus confirming the functional importance of E3-ligase autoinhibition.

123 in human cells, approaches to determine the functional importance of each phosphosite are lacking.

124 ip residues in cardiomyocytes shows that the functional importance of each skip residue is associated

125 omal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood.

126 ecular tools will be poised to elucidate the functional importance of endophytes in natural plant pat

127 ons of craniofacial shape, demonstrating the functional importance of enhancers in defining face and

128 appaBalphaSR transgenic mice to evaluate the functional importance of epithelial NF-kappaB in respons

129 These studies confirm the functional importance of ER mutations in endocrine resis

130 etrial cancer cells, and here we explore the functional importance of ETV4.

131 at may lead to a deeper understanding of the functional importance of facilitation.

132 hanisms of Wnt signalling activation and the functional importance of FZD subtypes, and the use of Wn

133 The functional importance of gene enhancers in regulated gen

134 nsights into molecular underpinnings and the functional importance of genetic pathways governing vari

135 incorporating epigenome data to estimate the functional importance of genetic variation on gene expre

136 n increased survival, and we demonstrate the functional importance of GRIN2A mutations in melanoma an

137 Together, these data demonstrate the functional importance of H3K9me3 in hypoxia, and they pr

138 proteins under ambient conditions belies the functional importance of higher-energy conformational st

139 lin function, also shedding new light on the functional importance of hormone's B-chain C-terminus fo

140 Together, our findings highlight the functional importance of IKBKE in pancreatic cancer, sup

141 In this study, we have examined the functional importance of IL-27 receptor (IL-27R) signali

142 While early studies identified the functional importance of individual EDC genes, the recog

143 negative selection can be used to infer the functional importance of individual protein domains of i

144 However, the functional importance of individual species does not nec

145 re locations, time spans, and functions, the functional importance of individual species is becoming

146 While the functional importance of inflammasomes in blood-derived

147 pathophysiology of CRSwNP demonstrating the functional importance of innate lymphoid cells in Th2-me

148 r proteins in Drosophila and demonstrate the functional importance of insulators to partition transcr

149 To demonstrate the functional importance of integrin beta3 in promoting end

150 Despite the functional importance of its homopolymers, no structural

151 The functional importance of KCa3.1 channels in the regulati

152 basal layer of Krt5-null mice to assess the functional importance of keratin IF self-organization in

153 in mice provides insights into the specific functional importance of laminin polymerisation during d

154 To test the functional importance of Lp-PLA2, we generated chimeric

155 n spatial learning and memory, revealing the functional importance of LSD1n in neuronal activity-regu

156 this approach, we provide an overview of the functional importance of many Hippo pathway components a

157 The functional importance of many non-coding RNAs (ncRNAs) g

158 th WT and CRF(2)(-/-) BMMCs demonstrated the functional importance of MC CRF(2) in modulating stress-

159 provide new insight into the development and functional importance of medullary microenvironments dur

160 E2 domain, but unresolved is the nature and functional importance of metal ion binding to APLP1 and

161 er cell migration and invasion, suggesting a functional importance of mitochondria in breast cancer m

162 Thus, our study reveals the functional importance of mitophagy during the dynamic re

163 The functional importance of mRNA localization to centrosome

164 ted N-glycans and strongly suggest potential functional importance of N-glycan sulfation of influenza

165 Emerging evidence has highlighted the functional importance of non-coding RNAs, particularly m

166 To explore the functional importance of nonhematopoietic BMDCs to pregn

167 and the repair of the DSB, demonstrating the functional importance of nucleosome disruption in DSB re

168 These findings provide insights into the functional importance of O-GlcNAcylation in the dopamine

169 However, the functional importance of O-mannosylation in these tissue

170 Altogether, these results converge to the functional importance of OGRE/G4 elements in DNA replica

171 red regions of the genome, and confirmed the functional importance of one structure using mutagenesis

172 To assess the functional importance of OPN and CLU, peripheral nerve r

173 Other experiments have tested the functional importance of oscillations and their coupling

174 In support of the functional importance of our findings, oral administrati

175 seeding in the lungs, which demonstrates the functional importance of oxidative phosphorylation in me

176 The functional importance of palmitoylation results in part

177 ommunity by providing detailed clues for the functional importance of particular mutations, as well a

178 ial for seed and pollen development, but the functional importance of PDAT in vegetative tissues rema

179 by increased PDLIM5 levels, underscoring the functional importance of PDLIM5 for proper kAE1 membrane

180 To determine the functional importance of phosphatases that control the P

181 This study strongly suggests the functional importance of piwil2 in PGCs survival.

182 g miRNAs can arise infrequently and that the functional importance of polyomaviral miRNAs is context

183 Despite the greater functional importance of protein levels, our knowledge o

184 To investigate the functional importance of Proton Gradient Regulation5-Lik

185 odeling guided electrophysiology reveals the functional importance of radial tuning of the S6 segment

186 Our results demonstrate the functional importance of radial tuning of the sodium cha

187 Our results provided new insights into the functional importance of RBPs in coordinating the expres

188 However, firm evidence for the existence and functional importance of resident microbiomes in larval

189 KEY POINTS: The functional importance of residues in loop G of the GABAA

190 But how this occurs, and the functional importance of S-nitrosation sites across the

191 In summary, our study illustrates the functional importance of SID-1 ECD as a dsRNA binding do

192 While much is known about the functional importance of signaling centers, relatively l

193 These findings underscore the functional importance of simultaneous interactions and p

194 To reliably predict the functional importance of single isolated UMCs across the

195 Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-me

196 therefore provide valuable insights into the functional importance of SNX14 with distinct opportuniti

197 To further explore the functional importance of specific AREG domains, we stabl

198 the 3-dimensional structure of chromatin and functional importance of specific genomic regions can be

199 In addition, the functional importance of specific MPK features could be

200 sitivity alpha2beta2 nAChR and validated the functional importance of specific residues in alpha2 and

201 This regulation shows the functional importance of splicing-regulated miRNA and su

202 The functional importance of such correlations in vivo was c

203 methylation levels in vivo, illustrating the functional importance of such sites.

204 organization is consistent with the emerging functional importance of synaptically and extrasynaptica

205 (reg) progenitor populations and discuss the functional importance of T(reg) cells generated via eith

206 In vitro kinase assays revealed the functional importance of T207 and Y210, but not T198, in

207 Our results demonstrate the functional importance of TADs for orchestrating gene exp

208 cal PI(3)P binding domain, demonstrating the functional importance of targeting PTEN to endosomal mem

209 ested in the intron, indicating the possible functional importance of the bindin intron variability.

210 bi-allelic TRAPPC11 variants highlights the functional importance of the carboxy-terminal portion of

211 To determine the structural-functional importance of the conserved cysteines and the

212 ecting basal transcription, highlighting the functional importance of the Crl-beta'CT interaction.

213 mised the formation of dimer, indicating the functional importance of the dimer.

214 The results suggest functional importance of the dimerization interfaces in

215 d lipogenesis in COS-7 cells, indicating the functional importance of the dimerization.

216 Collectively, our study demonstrates the functional importance of the FTO-dependent cardiac m6A m

217 the upper arm, likely reflecting the special functional importance of the hand.

218 As further evidence for the functional importance of the HR complex, RAD51C mutants

219 ll cultures and mouse models to validate the functional importance of the identified molecular pathwa

220 The functional importance of the identified site was validat

221 of the 90-kDa palladin isoform revealed the functional importance of the interaction with MT1-MMP in

222 of each other on FLC chromatin, showing the functional importance of the interaction.

223 growth, but we also provide evidence for the functional importance of the local PIF-induced response.

224 Collectively, our study demonstrates the functional importance of the m(6)A methylation and the c

225 Together, these studies establish the functional importance of the MAML1 region from residues

226 the pen2 mutant phenotype, corroborating the functional importance of the mitochondrial PEN2 protein

227 Information on the functional importance of the most centrally located heli

228 ses fusion and viral entry, highlighting the functional importance of the MPER/TM-FL interaction in E

229 Finally, to confirm the functional importance of the NAc-S to VP-m pathway we us

230 can trigger distinct signaling cascades, the functional importance of the PAR(2)-biased agonism is un

231 f post-Paleozoic crinoids suggests a general functional importance of the pigments, contributing to t

232 signature' and provides new insight into the functional importance of the plasticity of RNA.

233 The findings highlight the special functional importance of the right frontoinsular cortex-

234 his shape change are now well described, the functional importance of the spherical mitotic cell for

235 yme catalysis and regulation, indicating the functional importance of the tetramer.

236 However, the structural and functional importance of the TM-helix is unclear because

237 c mode of UCPH-101 inhibition underlines the functional importance of the trimerization domain of the

238 Using mutagenesis, we extrapolate the functional importance of the vestibule binding site to t

239 X proteins through their direct binding, the functional importance of their interaction in leukemogen

240 -based mutations of these factors reveal the functional importance of their interactions for ribosome

241 ippo signalling components and establish the functional importance of their localization to Warts act

242 The functional importance of these bridges remains largely u

243 t roles in normal and disease cells, but the functional importance of these clustered enhancer elemen

244 ious studies in arid zones have demonstrated functional importance of these communities in reducing s

245 both candidate genes revealed evidence for a functional importance of these genes by influencing diff

246 amine (DA) receptors ex vivo; the nature and functional importance of these interactions in vivo rema

247 mediated through multi-SIM modules, and the functional importance of these interactions is demonstra

248 However, the functional importance of these intricate inter-connectio

249 uture experiments aimed at understanding the functional importance of these kinetoplastid-specific ri

250 ng evolutionary constraint, highlighting the functional importance of these regions.

251 -forming segments of NALCN, highlighting the functional importance of these segments.

252 methylator phenotype (G-CIMP), although the functional importance of this altered epigenetic state r

253 Characterization of the functional importance of this conserved aspartate, relat

254 We provide evidence for the functional importance of this conserved intragenic eleme

255 ith good surface complementarity, suggesting functional importance of this crystallographic dimer.

256 h reduced IL-2 production, demonstrating the functional importance of this early metabolic program.

257 e actin-remodeling protein gelsolin, but the functional importance of this gelsolin modification has

258 ance (MCM) plays a role, but the details and functional importance of this interaction have not been

259 Here we demonstrate the functional importance of this interaction through the an

260 defective APP processing, demonstrating the functional importance of this interaction.

261 Finally, we show the functional importance of this latter phenomenon, demonst

262 cNAc during T cell activation to address the functional importance of this modification and to identi

263 A new study highlights the functional importance of this neurophysiological phenome

264 The functional importance of this NLRP1-binding motif was fu

265 To test the functional importance of this observation, LNK was eithe

266 ling and recruitment in vivo demonstrate the functional importance of this pathway.

267 ffect T cell cytotoxicity, demonstrating the functional importance of this pathway.

268 We also suggest that the functional importance of this region is significantly di

269 1's first hydrophilic loop suggests critical functional importance of this region.

270 And yet quantification of the functional importance of this response heterogeneity rem

271 ligands and the studies that underscore the functional importance of this signaling pathway in physi

272 Here, we identified the functional importance of TLR2 signaling in this process.

273 srupting conditions allows us to analyze the functional importance of TNTs in an ex vivo model.

274 tion during HIV-1 assembly and establish the functional importance of trimeric MA for Env incorporati

275 teract with the Cys-rich domain revealed the functional importance of VWF residues Ile1642, Trp1644,

276 Our results highlight the functional importance of weak interactions, typically a

277 To understand the functional importance of Wnt signalling in oocytes, we d

278 in cell-based NER assays, demonstrating the functional importance of XPA DBD-RPA70AB interaction.

279 el acetyllysine-binding module; however, the functional importance of YEATS domain-containing protein

280 were undertaken to define the regulation and functional importance of zinc-dependent histone deacetyl

281 Despite its functional importance, our present understanding of this

282 strate negatively correlated fluctuations in functional importance (r = -0.23 in healthy control subj

283 However, its extent and functional importance remain a subject of intense invest

284 ns (UTRs) of human messenger RNAs, but their functional importance remains unclear.

285 Despite their functional importance, several questions remain about ho

286 Genes with high expression and functional importance, such as the kai genes, are usuall

287 significance to identify candidate genes of functional importance that would otherwise be overlooked

288 However, despite their functional importance, the mechanisms controlling digit

289 Despite their functional importance, the molecular mechanisms of funct

290 his region is relatively conserved, implying functional importance, the origins of which are not well

291 However, despite its prevalence and functional importance, the pathophysiology of post-traum

292 Despite their functional importance, the thermodynamic properties of t

293 rovide compelling evidence that MUC1-C is of functional importance to induction of DNMT1 and DNMT3b a

294 Here, we demonstrate such a complex and its functional importance to modulate signaling.

295 common loci and investigated their potential functional importance using magnetic resonance imaging d

296 The functional importance was tested in an ex vivo model of

297 d contacts mRNA via conserved residues whose functional importance was unknown.

298 To uncover its functional importance, we developed a MALAT1 knockout mo

299 s a 20-nucleotide region, long known for its functional importance, where structural flexibility help

300 Condel were used to predict each mutation's functional importance, whereas the actual effect was mea