ライフサイエンスコーパス: functional interaction

1 d multiple proteasome subunits, suggesting a functional interaction.

2 double heterozygotes, genetically confirming functional interaction.

3 concurrently overexpressed, confirming their functional interaction.

4 TRPV1 contributes to the complexity of their functional interaction.

5 es and this allows MDM4 to promote p53/HIPK2 functional interaction.

6 ptin localization and function, suggesting a functional interaction.

7 and gH/gL exhibit an essential type-specific functional interaction.

8 Drosophila GATA TF Pannier (Pnr), suggesting functional interaction.

9 h the nucleus through physical proximity and functional interaction.

10 e food intake and body weight via reciprocal functional interactions.

11 s, consistent with targeted strengthening of functional interactions.

12 ule relations combine mutual exclusivity and functional interactions.

13 ein interactions as well as suggesting novel functional interactions.

14 providing a molecular explanation for their functional interactions.

15 ical interactions contribute to the observed functional interactions.

16 ged as the predominant motif associated with functional interactions.

17 , limiting our knowledge of the archaellum's functional interactions.

18 e whole protein, and thus interfere with its functional interactions.

19 rbital prefrontal cortical regions and their functional interactions.

20 may account for distinct or similar types of functional interactions.

21 proteins participating protein complexes and functional interactions.

22 uding direct (physical) as well as indirect (functional) interactions.

23 72 EBV-human protein pairs, we obtain 51,485 functional interactions (7.94%), 869 stringent physical

24 Patterns of functional interactions across distributed brain regions

25 hods: from activities of individual genes to functional interactions across genes.

26 ions are associated with highly coherent and functional interactions across several millimeters of th

27 ational modelling to characterize changes in functional interactions across widespread neural network

28 uses, providing new insights into gp120-gp41 functional interactions affecting Env refolding during H

29 reatment decisions may also be influenced by functional interactions among different MDRO species, wi

30 n OFC and MFC.SIGNIFICANCE STATEMENT Altered functional interactions among orbital frontal cortex (OF

31 umented in several previous studies, but the functional interactions among PLPE, gut microbiota, and

32 Here, we review evidence of key functional interactions among PM regions and their relat

33 everal recent studies have helped define the functional interactions among the different cellular sub

34 heir diversification is likely shaped by the functional interactions among these biotic stresses.

35 yelinated axons and in myelinating glia, but functional interactions among these proteins have not be

36 nance of glucose homeostasis is achieved via functional interactions among various organs: liver, ske

37 To identify functional interactions among yeast chronological ageing

38 2DS4 with that of HLA-C*05:01, indicative of functional interaction and balancing selection.

39 growth upon co-manipulation suggest complex functional interaction and cross-regulation between thes

40 ing analysis can accelerate the discovery of functional interactions and 3D structures involving RNA.

41 s complementarity must be optimized both for functional interactions and against mis-interactions, an

42 senting sequence data to predict structural, functional, interaction and expression of proteins, DNAs

43 n of microRNA landscapes, the study of their functional interaction, and the possibility of using suc

44 -driven genes and associated networks, whose functional interactions are likely to be actively modula

45 physical) interactions, as well as indirect (functional) interactions, as long as both are specific a

46 lar loop (ECL2) with radioligand binding and functional interaction assays to quantify effects on all

47 tastasis, and provides new insights into the functional interaction between a lncRNA and tumor microe

48 mic AMPAR plasticity, our results identify a functional interaction between acidotoxicity and excitot

49 rtially attenuates FRAP recovery, indicating functional interaction between actin subunit turnover at

50 n vitro and murine data that suggest a close functional interaction between ADAMTS3 and CCBE1 in trig

51 e with PRC2, we observed minimal overlap and functional interaction between BAP1 and PRC2 in embryoni

52 nterregional integration to characterize the functional interaction between basal ganglia and thalamu

53 Here we characterize a functional interaction between BBS4 and the secreted pro

54 Here we interrogate functional interaction between BRCA1 and COBRA1 during m

55 phospho-NKCC2 in SORLA-deficient mice, and a functional interaction between calcineurin Abeta and SOR

56 of focal adhesion tension and suggests that functional interaction between Cav1 Y14 phosphorylation

57 Our studies unravel a new paradigm of functional interaction between CCN1 and YAP and undersco

58 RT1 proteins were misregulated, indicating a functional interaction between CURT1B and PSI-LHCII comp

59 ders, it is possible that alterations in the functional interaction between DAT and Kv2.1 affect dopa

60 Here, we describe a novel physical and functional interaction between DAT and the voltage-gated

61 This review focuses on functional interaction between DNA polymerases and DNA l

62 tive gene elimination, we identified a novel functional interaction between E2f Transcription Factor

63 Here, we describe a physical and functional interaction between EBOV VP40 (eVP40) and WWP

64 displaced [(3)H]SR141716A, but there was no functional interaction between either of these ligands a

65 FGF19 increases functional interaction between endogenous SHP and SREBP-

66 Although previous studies have suggested functional interaction between FAO and the ETC, their ph

67 We have identified a functional interaction between FcepsilonRI and CD13 in m

68 These data are indicative of a functional interaction between FcepsilonRI and CD13 on M

69 rat model of PD, partial elimination of the functional interaction between FKBP12 and calcineurin, w

70 The functional interaction between FLCN and Rab7A appears co

71 Disruption of the switch abrogates the functional interaction between FZDs and the phosphoprote

72 Our data disclose a previously unidentified functional interaction between IQGAP1 and AMPK and sugge

73 We explored the functional interaction between Kv1.3 and NavBeta1 throug

74 le of LUBAC in TLR3 signaling and discover a functional interaction between LUBAC components and TLR3

75 In this study, we report a functional interaction between macroautophagy and Cortic

76 We further demonstrate that functional interaction between MCT4 and CAII requires di

77 objects across sensory modalities relied on functional interaction between multiple cortical regions

78 Together, the data reveal a functional interaction between neprilysin 1 and amyloid

79 Interestingly, we observed a functional interaction between normal and polyglutamine-

80 entirely ineffective, indicating an obligate functional interaction between NPC2 and LBPA in choleste

81 re, these data indicate for the first time a functional interaction between Orai1, TRPC1, and CaV1.2

82 The present study explored the functional interaction between p38 MAPK-mediated NET reg

83 Double-mutant analyses support a specific functional interaction between PAPS1 and components of t

84 lectively, our data suggest a biological and functional interaction between PD-L1 and chemoresistance

85 with Abcc4 deficiency, illustrated a crucial functional interaction between phosphodiesterases and AB

86 Arp2/3 complex and confirmed a physical and functional interaction between Plk4 and Arp2 in mediatin

87 cell-like ionic conditions, consistent with functional interaction between RNAP and the 30S subunit.

88 with photoreceptor ciliary rootlets and the functional interaction between rootletin and Nesprin1 in

89 Here, we report a functional interaction between Rx1 and NbGlk1, a Golden2

90 Consistent with a functional interaction between SHCA and LPP, TGFbeta-ind

91 Snx14-associated ER-LD contacts and define a functional interaction between Snx14 and Delta-9 FA desa

92 ced by oenocytes in spin mutants allude to a functional interaction between Spin and Lpp, underscorin

93 However, nothing is known about a potential functional interaction between STEP and PSD-95.

94 rtment compared with WT cells, pointing to a functional interaction between TET and DNMT proteins and

95 The functional interaction between the brain's two hemispher

96 eview clinical evidence in light of this new functional interaction between the cerebellum and basal

97 The functional interaction between the coupled pairs correla

98 this work, we have investigated the possible functional interaction between the enzyme that produces

99 Collectively, these results implicate a functional interaction between the Fanconi anemia DNA re

100 These data demonstrate a functional interaction between the N-terminal and linker

101 veal that ATP hydrolysis by UPF1 modulates a functional interaction between the NMD machinery and ter

102 Previously, we identified a functional interaction between the NMD machinery and ter

103 We elucidated a genetic and functional interaction between the respective KS-associa

104 ation generator (SEG)." We have examined the functional interaction between the SEG neurons and the h

105 monstrated that PB selectively increases the functional interaction between the steroid receptor coac

106 al cytoplasmic segment are necessary for the functional interaction between the STT3A and Sec61 compl

107 This suggests that a negative functional interaction between the TIR and NB domains ho

108 in triggering IB formation, demonstrating a functional interaction between the two proteins.

109 ypothesized these glands were the sites of a functional interaction between these 2 hormones.

110 that this physical association underlies the functional interaction between these molecules.

111 nase (DNA-PK), and we demonstrate a biphasic functional interaction between these proteins, wherein D

112 A functional interaction between these regions during acti

113 Furthermore, we demonstrate a functional interaction between these two determinants in

114 A direct functional interaction between TLR4 and TRPV1 is shown i

115 The functional interaction between topoisomerase I and RNA p

116 ese data suggest a novel mechanism whereby a functional interaction between TRPV4 and Rac1 leads to c

117 In this study, we investigate the functional interaction between various colonization patt

118 This study initially shows both physical and functional interaction between VCL and cardiac sodium ch

119 Genetic studies revealed functional interactions between Abl kinases and microtub

120 Furthermore, affect modulated functional interactions between affective and perceptual

121 a critical role in regulating structural and functional interactions between astrocytes and neurons a

122 Functional interactions between brain regions were inves

123 es in network science to analyze patterns of functional interactions between brain regions.

124 y these results identify strong physical and functional interactions between C9orf72 and SMCR8 and su

125 It can also be used to predict new functional interactions between cancer driving genes and

126 We use hot-wired endocytosis to describe the functional interactions between clathrin and AP2.

127 d implications for understanding the complex functional interactions between diet, gut microbiota, an

128 uenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut m

129 directed to understanding the complexity of functional interactions between different brain regions

130 Taken together, functional interactions between ELS, methamphetamine SA,

131 sease (PD), it is important to determine the functional interactions between factors linked to the di

132 sent a mathematical model, based on inferred functional interactions between fish, which accurately d

133 PTSD psychotherapy adaptively attenuates functional interactions between frontoparietal and limbi

134 tween co-occurrence, mutual exclusivity, and functional interactions between genes will further impro

135 e, we summarize our current understanding of functional interactions between ILCs and the adaptive im

136 We assessed functional interactions between key frontal and subcorti

137 Taken together, our data suggest that functional interactions between KIR and HLA modify risks

138 -catenin transcription is determined through functional interactions between lineage-specific Sox TFs

139 We further demonstrated functional interactions between LRG1 and PPARbeta/delta

140 Our understanding of the physical and functional interactions between meiotic proteins is also

141 mented in the brain, less is known about the functional interactions between neurons that maintain ga

142 Functional interactions between neurons, vasculature, an

143 computational analyses, we show physical and functional interactions between NF-kappaB and the E2 Fac

144 The emergence of functional interactions between nucleic acids and polype

145 The functional interactions between Pax9 and Dkk1 are shown

146 In the current study, we review the known functional interactions between PDZ domain-containing pr

147 umber of DCX(+)PCNA(+) cells correlates with functional interactions between presynaptic SNARE protei

148 Functional interactions between proteins result in coevo

149 mutagenesis demonstrate that ET-MIp predicts functional interactions between residue pairs, particula

150 se findings characterize, in space and time, functional interactions between scene- and object-proces

151 pportunities for gaining novel insights into functional interactions between sexual and clonal reprod

152 Functional interactions between some PD genes, like PINK

153 We identify physical and functional interactions between specific domains of DLX3

154 r work highlights the critical importance of functional interactions between stage and lineage-restri

155 Facilitatory and inhibitory functional interactions between striatal A2AR and CB1R h

156 To assess the functional interactions between sulfatide and gangliosid

157 cocaine seeking has been shown to depend on functional interactions between the basolateral amygdala

158 Complex formation requires functional interactions between the C- and N-terminal do

159 There is increasing evidence of functional interactions between the chemosensory and nut

160 However, the functional interactions between the corresponding protei

161 mbrane synthesis may not require physical or functional interactions between the divisome and phospho

162 There are also known functional interactions between the eCB and serotonin sy

163 ur knowledge-the existence and mechanisms of functional interactions between the endogenous mammalian

164 a suppressor of the p53 response, suggested functional interactions between the exocyst and the DDR.

165 cellular function requires knowledge of all functional interactions between the expressed proteins.

166 emory performance depends on the strength of functional interactions between the frontoparietal and d

167 are able to independently modulate discrete functional interactions between the motor and microtubul

168 Closure is accompanied by functional interactions between the N-domain beta5-beta6

169 sk for COVID19 neuroinfection based on known functional interactions between the nicotinic receptor a

170 Evidence for functional interactions between the placenta and brain i

171 ceptors and ligands were predicted to affect functional interactions between the placenta and brain.

172 ence that BLA noradrenergic activity enables functional interactions between the PrL and the aIC and

173 nists with AT(1)R blockers, and suggest that functional interactions between the three receptors on m

174 during fMRI provides a detailed view of the functional interactions between the two visual processin

175 Here, we propose that functional interactions between these higher-order and l

176 However, functional interactions between these proteins during as

177 Investigations of putative functional interactions between these regions are compli

178 Furthermore, functional interactions between this network and hippoca

179 To elucidate the complex structural and functional interactions between those genomic loci, netw

180 treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathwa

181 Our studies reveal unexpected genetic and functional interactions between two seemingly unrelated

182 The functional interactions between VDAC and alpha-syn, reve

183 accharomyces cerevisiae to investigate novel functional interactions between viral proteins and eukar

184 ces cerevisiae as a system to identify novel functional interactions between viral proteins and eukar

185 ng EBV carcinogenesis remain elusive and the functional interactions between virus and host cells are

186 al pathogenesis, continuing to elucidate the functional interactions between viruses and the cellular

187 Physical and functional interactions between VP40 and host proteins s

188 d that the actin cytoskeleton regulates this functional interaction by influencing the organization o

189 affords sufficient binding affinity for the functional interactions, commonly mediated by short IDR

190 we develop a model describing the effect of functional interaction (cross talk) between ryanodine re

191 rization framework to integrate physical and functional interaction data of genomic segments.

192 he exact mode of action and the relevance of functional interactions differ, pointing to a surprising

193 al mechanism of genome folding that mediates functional interactions during interphase and compacts c

194 g that catecholamines reduce the strength of functional interactions during rest.

195 olutionary couplings help identify important functional interactions-e.g., at switch points in ribosw

196 Proteins and their functional interactions form the backbone of the cellula

197 ultiplexed affinity assay system to identify functional interactions from transcriptome-wide RNA stru

198 Further blending of prior knowledge from functional interactions has the potential to enrich for

199 ved in various neurological disorders, their functional interactions have not yet been studied.

200 r in contact with each other, many exhibited functional interactions, implying at-a-distance coupling

201 tion and excitation is well described, their functional interaction in signal processing remains elus

202 vin, indicating pathway cross-regulation and functional interaction in vitro.

203 expression and complex, but largely unknown, functional interactions in a sub-population of primary s

204 for mechanisms of cancer processes and their functional interactions in an intuitive unbiased manner.

205 roduced compounds is of importance to reveal functional interactions in microbiomes.

206 ween global and regional properties of brain functional interactions in supporting conscious cognitio

207 ata provide strong evidence that large-scale functional interactions in the brain dynamically reconfi

208 be involved in interactions by incorporating functional interaction information from the Integrative

209 of this critical cytokine and we reveal its functional interaction interface with high-affinity liga

210 erresolution microscopy, we show SMURF2-EGFR functional interaction is important for EGFR stability a

211 lls in experimental osteoarthritis and their functional interaction is promoted by the CXCL10/CXCR3 a

212 somal docking, and the way in which this key functional interaction is regulated following translatio

213 ed in vivo, but the structural basis of this functional interaction is still a matter of debate.

214 sequences of transmembrane domains and their functional interactions is in most cases unknown.

215 it different brain networks, compared to the functional interactions it entertains during perception

216 utionarily conserved in M proteins to enable functional interactions necessary for pathogenesis.

217 oscape based on the highly reliable Reactome functional interaction network algorithm.

218 Functional interaction network analysis suggested enrich

219 the GWAS results onto the amygdala-specific functional interaction network.

220 ng genetic studies using the tissue-specific functional interaction network.

221 nia and autism genes within a brain-specific functional interaction network.

222 -based dual-luciferase reporter gene assays, functional interaction occurred between miR-18a-5p and t

223 These studies identify a novel functional interaction of Aurora kinase A with both PAX3

224 uggesting that this site is critical for the functional interaction of bile acids with the channel.

225 ymal phenotypes and enhancing expression and functional interaction of CD151 and alpha3beta1-integrin

226 tional significance of DmMGenes by assessing functional interaction of DmMGenes with their signaling

227 -mediated degradation, without affecting the functional interaction of IgE-tp with important receptor

228 s in vitro, as a system to monitor cell-cell functional interaction of PDECs and pancreatic islets, c

229 RBPJ Inhibitor-1 (RIN1) also blocked the functional interaction of RBPJ with SHARP, a scaffold pr

230 Functional interaction of TCAF1/TRPM8 also leads to a re

231 cambium and wood, but how the expression and functional interaction of these genes determine the uniq

232 tion, we provide evidence for anatomical and functional interaction of this freezing pathway with lon

233 erase complementation assay, we identified a functional interaction of two RRs of the OmpR/PhoB subfa

234 Here we describe a functional interaction of VE-cadherin with the cell pola

235 The functional interaction of visual cortical neurons and hi

236 The keynote lecture on functional interactions of bacteria and viruses in the g

237 netoclax treatment, combined with dissecting functional interactions of Bcl-2 family members, in an i

238 To assess the functional interactions of beta-cells with vagal sensory

239 Visualizing the functional interactions of biomolecules such as proteins

240 in developing approaches to investigate the functional interactions of bitopic membrane proteins emb

241 tion of the actin cytoskeleton in regulating functional interactions of FcepsilonRI.

242 d a novel role of FRbeta: that is, we report functional interactions of FRbeta with receptors mediati

243 irpin binding, which may be advantageous for functional interactions of LysRS with a variety of diffe

244 ably, these alterations arise from disrupted functional interactions of mGluR5 with estrogen receptor

245 Our findings provide novel insight into the functional interactions of soil bacteria active in proce

246 euronal cells are crucial in determining the functional interactions of specific neuronal subpopulati

247 Second, dynamic functional interactions of the SN were among the most sp

248 r outpaces the research on the structure and functional interactions of these RNA gene sequences.

249 e have focused this study on identifying the functional interactions of three Nipah virus proteins du

250 dium channels, to examine the structural and functional interactions of VPA.

251 findings offer new insights into the latent functional interactions, or lack thereof, between compon

252 modomain-independent manner, revealing a new functional interaction partner for BRD4 that can direct

253 rome X-linked (ATRX) as a novel physical and functional interaction partner of FANCD2.

254 Here we identify Nipbl as a functional interaction partner of the neural transcripti

255 ntify when laminar activity and interlaminar functional interactions showed surround suppression, the

256 thought to bind substrate proteins, but its functional/interaction sites and the structural alterati

257 In functional interaction studies, we revealed that the miR

258 es the analysis of gene networks and reveals functional interactions that are inaccessible to individ

259 raphs, we identify the presence of groups of functional interactions that fluctuate coherently in str

260 ve holoenzyme conformations reveal important functional interactions that maintain PCNA orientation d

261 Here, we detail the functional interactions that make microRNA 155 (miR-155)

262 he recipient organism may acquire genes with functional interaction through two different HGT events

263 tergic and endocannabinoid systems exhibit a functional interaction to modulate several neural proces

264 Several novel interaction hubs and functional interactions were discovered.

265 behaviors and induces specific new brainwide functional interactions, which predict the degree of anh

266 wall composition is further supported by its functional interaction with BasA (sphingolipid biosynthe

267 , polarized them ex vivo, and examined their functional interaction with breast cancer cells in cultu

268 ogether with fine-localization of d-LDH, the functional interaction with CYTc in vivo strongly sugges

269 evidence that Tim establishes a physical and functional interaction with DDX11, a super-family 2 iron

270 an upstream site in the Rnf43 gene, enabling functional interaction with distant TCF4/beta-catenin-bi

271 sponse to hindlimb ischemia, potentially via functional interaction with eNOS.

272 f TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9A(-/-

273 itin ligases, and the resultant physical and functional interaction with eVP40 facilitates VLP and vi

274 PTHrP and Col10a1, through its physical and functional interaction with Gli2.

275 ts to ask whether RNA may be a factor in the functional interaction with HIV-1 Vif.

276 protein sequence, phylogenetic history, and functional interaction with progressively increasing acc

277 ents with Meier-Gorlin syndrome disrupts the functional interaction with Rad53 in yeast.

278 d a stable Rca hexamer ring and analyzed its functional interaction with Rubisco.

279 pressor in highly metastatic PCSCs by direct functional interaction with the 3'-untranslated regions

280 tabolism and cholesterol trafficking through functional interaction with the cholesterol efflux regul

281 ent of ISG15 conjugation and relies on ISG15 functional interaction with the DNA helicase RECQ1, whic

282 While each domain showed a close functional interaction with the respective histone mark

283 gy, these brain regions exhibited changes in functional interactions with brain regions engaged in sw

284 g of how the IDP nature of p27 underpins its functional interactions with Cdk2/Cyclin A provides insi

285 ch deposits H2A.Z, we uncovered evidence for functional interactions with components of the spliceoso

286 ne escape of HIV-infected cells required for functional interactions with downstream binding partners

287 gyrase subunits appear to prevent efficient functional interactions with heterologous subunits.

288 he properties of membrane proteins and their functional interactions with lipid molecules.

289 ature Drp1 self-assembly in solution impairs functional interactions with membrane-anchored Mff.

290 work on the HTT protein and for studying its functional interactions with other biomolecules.

291 rmational dynamics of the FAT domain and its functional interactions with other parts of the molecule

292 terminal arms to expand outwards encouraging functional interactions with partner proteins.

293 n transcription factors are proposed to form functional interactions with RNA to facilitate proper re

294 the identity and location of the object via functional interactions with the aIC and dHPC, respectiv

295 erpinned successful performance and involved functional interactions with the amygdala and hippocampu

296 fects of the mutated proteins are due to non-functional interactions with the wild-type protein or PH

297 oxygen sensing are increasingly dependent on functional interaction within this microenvironment.

298 regions, thalamic circuits shift and sustain functional interactions within and across cortical areas

299 l variation is a potent strategy for probing functional interactions within gene regulatory networks.

300 o understand these rapid effects, we studied functional interactions within the affective amygdala ci