ライフサイエンスコーパス: functional protein

1 retained in the endoplasmic reticulum as non-functional protein.

2 eparation-of-function-mutation in this multi-functional protein.

3 e because the mutated gene still expresses a functional protein.

4 and plants is often limited by low titers of functional protein.

5 in cells expressing the fluorescently tagged functional protein.

6 , led to an internally deleted but partially functional protein.

7 rol inspection and export of the mutant, yet functional protein.

8 codon in intron 1 and a much truncated, non-functional protein.

9 e GroEL/ES to prevent misfolding and produce functional protein.

10 ms from the inability of obtaining purified, functional protein.

11 (HSP90) significantly increased the yield of functional protein.

12 balances adenine nucleotide pool, is a multi-functional protein.

13 ut we showed that this would not result in a functional protein.

14 ystrophin gene that result in the absence of functional protein.

15 site that restore splicing and production of functional protein.

16 rtion of transcribed DNA does not code for a functional protein.

17 nd cytoplasm until its final deployment as a functional protein.

18 f a length that may be suitable for coding a functional protein.

19 l SMA patients, which produces low levels of functional protein.

20 nce of in-frame mutations that still produce functional protein.

21 , leading to the production of a full length functional protein.

22 n of a truncated non-functional or partially functional protein.

23 reassemble, without covalent linkage, into a functional protein.

24 o its coding region is unlikely to produce a functional protein.

25 its in-frame skipping leads to a potentially functional protein.

26 d amino acids, indicates that matR encodes a functional protein.

27 an retrovirus, HERV-K, can encode individual functional proteins.

28 e AIS with high enrichment of structural and functional proteins.

29 rnavirus-derived elements (EBL) might encode functional proteins.

30 tations by preventing the expression of semi-functional proteins.

31 tionary time to be incorporated into stable, functional proteins.

32 to TRAIL-induced apoptosis by inhibiting key functional proteins.

33 obodies that bind conformational epitopes of functional proteins.

34 ions and partially restore the expression of functional proteins.

35 ity, indicating that both NCED4 genes encode functional proteins.

36 e ribosome is essential for the synthesis of functional proteins.

37 H bending motions enables rational design of functional proteins.

38 y convert stable off-pathway conformers into functional proteins.

39 ions and partially restore the expression of functional proteins.

40 gen presentation than the turnover of mature functional proteins.

41 this approach has for the rational design of functional proteins.

42 and Asn-19 followed by genetic screening for functional proteins.

43 tides can be generated from fully folded and functional proteins.

44 onserved regions within HIV's structural and functional proteins.

45 ters (yaps), nine of which appear to produce functional proteins.

46 ypes) suggest that all 39 predictions encode functional proteins.

47 CERV1 and -2 proviruses are known to encode functional proteins.

48 cessing the viral precursor polyprotein into functional proteins.

49 es, including epitopes normally derived from functional proteins.

50 mall percentage become new genes that encode functional proteins.

51 structurally, it is more difficult to design functional proteins.

52 caffolding, can produce mg ml(-1) amounts of functional proteins.

53 volved in the assembly of these domains into functional proteins.

54 ability and usefulness in terms of designing functional proteins.

55 enerate bespoke supramolecular assemblies of functional proteins.

56 iciency and quality of mRNA translation into functional proteins.

57 that needs to be searched through to obtain functional proteins.

58 ing are crucial maturation steps to generate functional proteins.

59 cial to avoid producing misfolded and/or non-functional proteins.

60 synonymous codon usage on the production of functional proteins.

61 ular biological components including diverse functional proteins.

62 polymers, polypeptides, polysaccharides, and functional proteins.

63 s in some or all genes that are expressed as functional proteins.

64 an in-frame mRNA and a truncated, but still functional, protein.

65 ificially express pseudogenes into novel and functional proteins?

66 l of transported mRNAs to be translated into functional proteins after transport.

67 This study reveals that HADHA (tri-functional protein alpha), a monolysocardiolipin acyltra

68 trait analysis) indicate that the genotyped functional protein-altering variation yields a heritabil

69 ity of lipid-related proteins, and revealing functional protein and genetic variants that are predict

70 P2C is the most likely duplicate to encode a functional protein and is among the most fixed human-spe

71 er EmrE in vitro from a denatured state to a functional protein and monitored the influence of lipids

72 ctron transport via the p-n junction between functional proteins and abiotic materials remains a chal

73 that the nitrogen assimilation genes encode functional proteins and are expressed in the ocean.

74 C-terminus result in truncated but partially functional proteins and are often associated with leaky

75 rs are often deleterious to the synthesis of functional proteins and could therefore be promoted ther

76 le released from MSCs, were thought to carry functional proteins and RNAs to recipient cells and play

77 idence has indicated that EVs, which contain functional proteins and small RNAs, facilitate intercell

78 biology, amyloids are key structures in both functional proteins and the end product of pathologic pr

79 ide 19) *2 and *3 alleles leads to a loss of functional protein, and carriers of these loss-of-functi

80 oEP) platform for delivery of nucleic acids, functional protein, and Cas9 single-guide RNA ribonucleo

81 substitution results in poor secretion of a functional protein, and the domain-specific defect in fo

82 nclear, because LAT is not known to encode a functional protein, and the LAT transcript is found larg

83 A) nanostructures to control the assembly of functional proteins, and facilitates further investigati

84 however, these mRNA are not translated into functional proteins, and these iPSC lines do not induce

85 ynthetic and chemically modified versions of functional proteins, and, therefore, constitutes a promi

86 number of experimental studies dominate the functional protein annotations collected in databases.

87 tructurally compact, units from which larger functional proteins are assembled; however, almost 4% of

88 Many functional proteins are at least partially disordered pr

89 cripts contain open reading frames for known functional proteins as well as numerous alternative read

90 orrection of BTK mRNA restored expression of functional protein, as shown both by enhanced lymphocyte

91 in homozygosity in public databases encoded functional proteins, as did all other variants with an a

92 lar architectures, we measured the levels of functional proteins associated with EGF receptor (EGFR)

93 gical membrane coating consisting of diverse functional proteins associated with human platelets.

94 F), also known as mitosin, are large, multi-functional proteins associated with the outer kinetochor

95 Functional protein association networks, gene annotation

96 However, quantitatively profiling of functional proteins at single CTC resolution has not yet

97 In vivo, functional protein-based condensates are often referred

98 et decoding is crucial for the expression of functional protein because deviations either into the -1

99 ctions between individual interfaces used in functional protein binding and thereby contains the deta

100 The large number of these functional protein binding correlations point to a dynam

101 otein, is important for bacterial growth and functional protein biosynthesis under certain conditions

102 (3) is likely to be important for optimizing functional protein biosynthesis.

103 this trajectory comprise sequence-duplicated functional proteins built from 10 amino acid types, with

104 n produced a mutant mRNA that could encode a functional protein but was degraded by nonsense-mediated

105 genes are transcribed--and some may produce functional proteins--but are dispensable for infection o

106 that are subsequently used to produce fully functional protein by an in vitro refolding process.

107 system offers a novel approach to create new functional proteins by replacing a specific amino acid i

108 t undergo rearrangement and joining before a functional protein can be expressed.

109 uire nucleosomal DNA to be unwrapped so that functional proteins can access their target sites, which

110 e demonstrated that, alongside drug loading, functional proteins can be tethered to the surface utili

111 n which splice together in cellula to form a functional protein capable of site-specific DNA cleavage

112 cal modifications, especially structural and functional protein changes.

113 Two gradients reflecting the abundance of functional protein classes along the longitudinal root a

114 1505 to 4082 amiRNAs, each targeting defined functional protein classes.

115 edicted to contain 137, 150, and 155 unique, functional protein-coding genes, respectively, of which

116 resent at levels that suggest that these are functional protein-coding genes.

117 ts specified their degradation pathways, and functional protein-coding transcripts could be produced

118 Rare and low-frequency functional protein-coding variants (minor allele frequen

119 We here demonstrate the assembly of a novel functional protein complex at the TGN and its key member

120 l allosteric binding mechanism and that this functional protein complex mediated transport of the cor

121 These data suggest that MyRIP only forms a functional protein complex with BR-MyoVa on SGs when cAM

122 We have shown that gK forms a functional protein complex with UL20p, which is required

123 al formation and dissociation of hundreds of functional protein complexes and the dynamics of host-ho

124 a novel mechanism in which the formation of functional protein complexes drives mitochondrial protei

125 ChaC may also be applicable to dissect other functional protein complexes in the context of phenotypi

126 iving cells achieve sufficient abundances of functional protein complexes while minimizing promiscuou

127 ate the physiology of the cell by generating functional protein complexes.

128 roteins to favor their correct assembly into functional protein complexes.

129 c separation as a promising route to deliver functional protein concentrates as novel food formulatio

130 der long-term selective pressure to encode a functional protein; consequently, we hypothesized that t

131 Finally, we generated a functional protein consisting of an SpoVE-SpoVD fusion a

132 TRPM7 is an unusual bi-functional protein containing an ion channel covalently

133 ilapia burtoni, only one of which produces a functional protein containing the signature tachykinin m

134 protein transfection materials composed of a functional protein core chemically modified with a dense

135 Using glucose oxidase as a functional protein core, we show activity-based, amplifi

136 highly programmable nucleic acid shell or a functional protein core.

137 ifically collagen IV networks, contribute to functional protein damage in diabetes.

138 examined the role of glucose autoxidation in functional protein damage using lysozyme and RGD-alpha3N

139 onstrate that these lipids are effective for functional protein delivery into mouse brain for gene re

140 e (TTQ) to yield the mature protein with the functional protein-derived TTQ cofactor.

141 eline should become a useful online tool for functional protein design and drug discovery studies.

142 dence is emerging on peptides derived from a functional protein, directly translated from small open

143 y utilized in recruiting genetically encoded functional proteins, display of small molecules using CR

144 anisms by which these proteins assemble into functional protein-DNA complexes are not fully understoo

145 eated motifs, which can display a variety of functional protein domains (cargo) at defined positions

146 rresponding receptors and for fingerprinting functional protein domains in living cells.

147 ciated into their constituent structural and functional protein domains.

148 ng CRISPR-Cas9 mutagenesis to exons encoding functional protein domains.

149 exclusively in patients were found in likely functional protein domains.

150 trinsic structural price to be paid for some functional protein domains.

151 a transcription factor, WTX lacks conserved functional protein domains.

152 evel promises to impact our understanding of functional protein dynamics and energy landscapes.

153 t several case studies of complex changes in functional protein dynamics caused by temperature, genet

154 n regulatory protein C (NtrC), by connecting functional protein dynamics of phosphorylation-dependent

155 The ability of DNA to produce a functional protein even after transfer to a foreign host

156 se biological functions by means of inducing functional protein expression in a dose-dependent and ti

157 In particular, IDRs of multi-functional proteins feature more sticky amino acids than

158 lations, and discuss how comparisons between functional protein filaments and structures that are ass

159 o bypass mutations and generate modified but functional proteins for an array of genetic disorders.

160 vdMs may enable design of functional proteins for applications in sensing, medicin

161 r corneal cells, we selected 9 structural or functional proteins for which 3D patterns were specific

162 teins (IDPs) are a newly recognized class of functional proteins for which a lack of stable tertiary

163 undation for engineering a new generation of functional proteins free from natural evolution.

164 tes with the cognate Hsp70 system to recover functional protein from aggregates.

165 ctive Hsp104 variant impairs the recovery of functional protein from aggregates.

166 significant hurdle is the extraction of the functional protein from its natural lipid membrane.

167 be due to persistent low-level expression of functional protein from their mutant allele.

168 in vitro selection and directed evolution of functional proteins from libraries of more than 10(12) d

169 hat facilitates quantification of a panel of functional proteins from statistical numbers of single c

170 ins; it should now be possible to design new functional proteins from the ground up to tackle current

171 to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained,

172 Four functional protein groups involved in autophagosome form

173 In this work, we compiled the basic functional protein groups of the three main routes for h

174 c lesions in RIBA1 and FLU encoding the dual-functional protein GTP cyclohydrolase II/3,4-dihydroxy-2

175 n mRNA and allow production of a full-length functional protein hold great therapeutic potential for

176 romatin domains, and reflect the assembly of functional protein hubs and DNA processing during the ra

177 Functional protein immobilization on the surface was con

178 es integration into a microarray format with functional protein immunoassays, all of which are incorp

179 ant DNA molecules can produce a biologically functional protein in a foreign host.

180 t TRAP1 mutation leading to complete loss of functional protein in a patient with late onset Parkinso

181 d from a proximal promoter and that produces functional protein in neurons.

182 er that is thought to result from absence of functional protein in the brain.

183 rogenase 11 (RDH11) gene, resulting in a non-functional protein, in all affected children.

184 RM CD200R, while vCD200-Sec represents a non-functional protein incapable of affecting CD200R signali

185 cting increased expression of structural and functional proteins, including filaggrin and filaggrin-2

186 nables discovery and efficient validation of functional protein interaction networks on long RNAs in

187 plement a minimal model for the evolution of functional protein-interaction networks using a sequence

188 The transition from soluble, functional protein into insoluble amyloid fibril occurs

189 The abnormal folding and aggregation of functional proteins into amyloid is a typical feature of

190 nstration of a nonviral-mediated delivery of functional proteins into the spinal cord establishes the

191 mation, by converting precursors into mature functional proteins involved in forming the extracellula

192 quiring A-to-I editing to encode full-length functional proteins is AMD1 that encodes a protein with

193 Translation of the genome into functional proteins is critical for cellular life.

194 The design of stable, functional proteins is difficult.

195 The timely production of functional proteins is of critical importance for the bi

196 TR, the only mechanism capable of generating functional proteins is the read-through, but the outcome

197 possibility that RE splicing might generate functional protein isoforms.

198 as a structural component, and its role as a functional protein key for organizing membrane domains f

199 Our results support the role of TIO as a functional protein kinase that interacts with Kinesin-12

200 carrying an inducible antibody that causes a functional protein "knock-down" and allows temporal cont

201 Taken together with data showing that functional protein knockout shifts splicing toward the f

202 LC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due

203 Mutations in TBX3 that result in reduced functional protein lead to ulnar-mammary syndrome, a dev

204 ne expression profiles of tumor cells at the functional/protein level than conventional mRNA microarr

205 The intimate relationship between functional protein levels and cellular architectures exp

206 -150 nm in diameter, which can transfer RNA, functional proteins, lipids, and metabolites to recipien

207 showed that salt-stress-responsive GR3 is a functional protein localized in chloroplasts and mitocho

208 ls to combine the most important tenets of a functional protein microarray such as covalent attachmen

209 methods will be useful for a wide variety of functional protein microarray users.

210 Here we demonstrate that functional protein microarrays are particularly well-sui

211 Fully functional protein microarrays, with monolayer arrangeme

212 In conclusion, MOCS1 produces two functional proteins, MOCS1A and MOCS1B, which follow dif

213 Structural and functional protein modeling indicate a biochemical effec

214 pathway and image analyses, define multiple functional protein modules enriched in a conformation-sp

215 Proteome-based networks distinguish functional protein modules for breast tumor groups, with

216 Effects on diffusion of functional protein modules in both lipid--anchored and T

217 terizing simulation data, particularly since functional protein motions and transitions are often rar

218 sible suggest a route to the construction of functional protein nanomaterials tailored to specific ap

219 To identify functional protein networks and potential inhibitors, we

220 ted proteins in both tissues were members of functional protein networks associated brain changes in

221 The proteins and functional protein networks of the tight junction remain

222 During polyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited ont

223 n-regulation of caveolin-1, a structural and functional protein of caveolae that function as signalin

224 3% higher in ASM (P < 0.001), structural and functional proteins of ECs were much better preserved in

225 d glycoproteins, gB, gH and gL, are the core functional proteins of the herpesvirus fusion complex.

226 nts with unique properties to design new and functional proteins, offering both a possible pathway of

227 g permitted highly specific visualization of functional protein on the cell surface and its subsequen

228 costs of protein misfolding, such as loss of functional protein or attenuation of growth-limiting pro

229 c AS events are likely to be translated into functional proteins or simply reflect noisy splicing, th

230 MN2 is present, which produces low levels of functional protein owing to an alternative splicing even

231 cient for CSR and identified PA1 as its main functional protein partner.

232 bitors of mammalian DNA ligases and/or their functional protein partners that potentiate the effects

233 ture termination codons (PTCs) and restoring functional protein production from genes disrupted by no

234 Ataluren was developed to restore functional protein production in genetic disorders cause

235 may yield mature transcripts that encode non-functional protein products, an important predictor of M

236 uORFs (namely, in SLC35A4 and MIEF1) encode functional protein products.

237 raction of truncating mutations can generate functional protein products.

238 e-relevant sequences can be rescued to yield functional protein products.

239 h-bond behavior in biologically relevant and functional protein-protein bonds.

240 ensitivity of SA11-tsC and shed new light on functional protein-protein interaction sites of VP1.

241 log knowledge transfer method to reconstruct functional protein-protein interactions (PPI) networks b

242 Phage display screening allows the study of functional protein-protein interactions at the cell surf

243 In living cells, functional protein-protein interactions compete with a m

244 ptides as therapeutics for the disruption of functional protein-protein interactions in membranes.

245 e conclude that FHL2 has both structural and functional protein-protein interactions with beta-cateni

246 lated through mechanisms of gene regulation, functional protein-protein interactions, transcription f

247 We infer that these lysine residues impede functional protein-protein interactions.

248 ons for possible overlapping and distinctive functional protein-protein or protein-ligand interaction

249 The rugged folding landscapes of functional proteins puts them at risk of misfolding and

250 for the constructs we have analyzed, mature functional proteins, rather than defective ribosomal pro

251 red fluorescent protein (mRFP1) to produce a functional protein (RecA-RFP) that is suitable for in vi

252 Individual functional proteins recognize a set of multiple overlapp

253 MNDelta7 transgene to encode a modestly more functional protein referred to as SMN read-through (SMN(

254 rovides a fine-grained view of an organism's functional protein repertoire, proteins, more commonly f

255 tes sequence and network structure to create functional protein representations, embedding proteins f

256 Hsp104 is an active ATPase, the recovery of functional protein requires the species-specific coopera

257 Production of functional proteins requires multiple steps, including g

258 e probability that frameshifts result in non-functional proteins, revealing that these species may ev

259 /or disordered regions, suggesting that many functional protein-RNA contacts remain unexplored.

260 munoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites.

261 ecific gp78/AMFR genetic ablation results in functional protein stabilization of several hepatic P450

262 Importantly, a majority of the functional protein studied responds to CFTR modulators l

263 on of astroglial processes and expression of functional proteins, such as GLT1, is significantly decr

264 ed morphology and the induction of important functional proteins, such as glutamate transporter GLT1.

265 hat provides a mechanism for optimization of functional protein synthesis.

266 trol protein function and tune production of functional protein systems.

267 onsive PBD-lipid produced 5- to 35-fold more functional protein than control DLNPs formulated with tr

268 binding of GDP to eIF2 and is therefore a bi-functional protein that acts as a GDP dissociation inhib

269 Iron regulatory protein 1 (IRP1) is a bi-functional protein that can act either as a post-transcr

270 beta-catenin is a multi-functional protein that has an important role in the mat

271 regulatory protein ICP27 is a multifunction functional protein that interacts with many cellular pro

272 on of NR1 splice variants may serve as a key functional protein that maintains hypersensitivity follo

273 PPS encoded in the A. thaliana genome 10 are functional proteins that can synthesize GGPP.

274 transcribed and translated and could encode functional proteins that contain important targets of an

275 h may offer general benefits for engineering functional proteins that have risky folding landscapes,

276 ple cleavage of long polyprotein chains into functional proteins that include the viral protease itse

277 Intrinsically disordered proteins (IDPs) are functional proteins that lack a well-defined three-dimen

278 Arrestins are multi-functional proteins that regulate signaling and traffick

279 ibraries of novel sequences and selected for functional proteins that rescue Escherichia coli cells i

280 BAG-1 is a multi-functional protein, the expression of which is up-regula

281 he method can be generalized to design other functional proteins through backbone grafting.

282 GST protein anchor can be used to immobilize functional protein to PEGDA microspheres and the protein

283 The delivery of fully functional proteins to infected cells upon virion envelo

284 The scarcity of effective means to deliver functional proteins to living cells is a central problem

285 Delivery strategies that can transport functional proteins to reach intracellular targets are n

286 The ability to direct functional proteins to specific DNA sequences is a long-

287 in most studies, the contribution of mature functional proteins to the class I peptide pool has not

288 nt conjugation, which allows the delivery of functional proteins to the hMSC membrane.

289 E-BP1 and S6K, which led to induction of the functional protein translational machinery.

290 ism to swiftly translate synaptic mRNAs into functional protein upon synaptic signaling using stalled

291 Functional protein uS3m is encoded by three complementar

292 idence of transgene expression even when the functional protein was not visualized in skeletal muscle

293 ments in neurons are supplied with necessary functional proteins, we studied mechanisms of dendritic

294 patens expresses two UVR8 genes that encode functional proteins, whereas the single M. polymorpha UV

295 Parkinson's disease when mutated, is a multi-functional protein with anti-oxidant and transcription r

296 with AGXT2L1 and AGXT2L2) forming bi- or tri-functional proteins with a putative kinase belonging to

297 i with a temperature-sensitive AK identified functional proteins with novel architectures, suggesting

298 sing evidence shows that cadherins are multi-functional proteins with novel, adhesion-independent sig

299 These vectors can produce functional proteins within defined regions of biomateria

300 In contrast, natural systems selected functional proteins without any design a priori.