ライフサイエンスコーパス: functional redundancy

1 ir roles and a quantitative measure of their functional redundancy.

2 ome cases, be at the basis of their apparent functional redundancy.

3 of the polymers with a remarkable degree of functional redundancy.

4 curately predict current densities and chart functional redundancy.

5 compensatory mechanism and suggests partial functional redundancy.

6 ore, our results challenge the generality of functional redundancy.

7 ifferent developmental stages, indicative of functional redundancy.

8 onnections, and an apparently high degree of functional redundancy.

9 1(-/-) and Tll1(-/-) lethality and issues of functional redundancy.

10 tion (i.e., Aegyptin, apyrase, D7) represent functional redundancy.

11 wn whether this diversity reflects extensive functional redundancy.

12 statistical power) raise the possibility of functional redundancy.

13 exhibited synergistic phenotypes, indicating functional redundancy.

14 sSPTa promoter, indicating ssSPTa and ssSPTb functional redundancy.

15 l through the same proteins, and can exhibit functional redundancy.

16 defects, presumably due to their significant functional redundancy.

17 ith key topological features that favor high functional redundancy.

18 roteins whose structural similarity suggests functional redundancy.

19 jor impact on pancreas formation, indicating functional redundancy.

20 utM share several overlapping activities and functional redundancy.

21 of each TRPC in each pathology, considering functional redundancy.

22 d - implying an ecological property known as functional redundancy.

23 y overlapping manner, indicating a degree of functional redundancy.

24 en there are over 70 MRPs and suggest little functional redundancy.

25 malian actin isoforms that appear to exhibit functional redundancy.

26 ing due to overlapping tissue expression and functional redundancy.

27 s and uncovers phenotypes normally masked by functional redundancy.

28 its transfection into HEK293 cells suggests functional redundancy.

29 required for reactivation, indicating little functional redundancy.

30 ression of either RPN5a or RPN5b, indicating functional redundancy.

31 uld substitute for each other, indicative of functional redundancy.

32 nce identity as a means to identify possible functional redundancy.

33 xpress Nkx6.1, suggesting the possibility of functional redundancy.

34 is-regulatory network seems to exhibit great functional redundancy.

35 it converging signaling pathways, leading to functional redundancy.

36 d abundance evenness, leading to declines in functional redundancy.

37 several topological features that favor high functional redundancy.

38 transcription factor paralogs with apparent functional redundancy.

39 f secreted effector proteins comprising high functional redundancy.

40 ex required for mitosis, demonstrating their functional redundancy.

41 ct with the same set of GPCRs, which implies functional redundancy.

42 al expression largely supports the notion of functional redundancy.

43 for postnatal glucose homeostasis, with some functional redundancy.

44 be maintained in sponge microbiomes through functional redundancy.

45 king EHDs 1, 2, and 4 confirms this apparent functional redundancy.

46 hat the low levels of other isoforms provide functional redundancy.

47 ed by a combination of embryonic defects and functional redundancy.

48 oviding a molecular basis for their observed functional redundancy.

49 hese roles have been masked by unanticipated functional redundancies.

50 dered to increase genetic robustness through functional redundancy, accelerating the evolution of nov

51 loor, and determined to what extent there is functional redundancy across ants, other invertebrate an

52 Functionally, GeoChip analyses showed a functional redundancy across the toposequence, with gene

53 This functional redundancy allows limited fatty acid biosynth

54 We conclude that there is significant functional redundancy among activators and that the spec

55 While there is likely to be some functional redundancy among C. elegans tubulin genes, ou

56 s and 53BP1 at DSBs, suggesting considerable functional redundancy among cellular DUBs that restrict

57 gR3 as CSPG receptors, suggest that there is functional redundancy among CSPG receptors, and provide

58 XE receptors indicates that there is limited functional redundancy among Dictyostelium P2X receptors.

59 This discrepancy is possibly due to the functional redundancy among different Wnts.

60 Functional redundancy among factors and pathways underli

61 ontinental scales indicates a high degree of functional redundancy among fungal communities in global

62 The lack of functional redundancy among GmRIN4a and GmRIN4b and thei

63 ypic variation that was previously hidden by functional redundancy among homoeologs.

64 These findings identify functional redundancy among Kit-dependent hematopoietic

65 However, functional redundancy among localization elements has ma

66 results indicate that although there is some functional redundancy among mitophagy receptors, efficie

67 hile the complexity of glycosylation and the functional redundancy among sialyltransferases provide o

68 mains incompletely defined, and the level of functional redundancy among subsets of these proteins re

69 We also acquired evidence for functional redundancy among tetraspanins in both C. eleg

70 Until now, functional redundancy among the actin-bundling proteins

71 static stability and that there is a lack of functional redundancy among the different KChIPs in hipp

72 infection model, suggesting at least partial functional redundancy among the homologues.

73 nts in these neurons, that there may be some functional redundancy among the kinesin-1 isoforms with

74 Functional redundancy among the three mtACPs was indicat

75 time frame for hepatopancreas specification, functional redundancy among Wnt ligands, and pleiotropic

76 Such changes are expected to decrease the functional redundancy and complementarity of pollinator

77 The newfound multiplicity, functional redundancy and conservation of cis-acting con

78 d TAGL1 genes and to better understand their functional redundancy and diversification, we characteri

79 These cells lack significant PARP-1 functional redundancy and efficiently support the posten

80 rare biosphere has the potential to increase functional redundancy and enhance the ability of soil co

81 The importance of these genes in confirming functional redundancy and enhancing the value of single

82 across different co-existing taxa supported functional redundancy and imparted process stability to

83 uggest that UPEC iron receptors provide both functional redundancy and niche specificity for this pat

84 d LPS synthesis in a wbpW mutant, indicating functional redundancy and overlapping roles for these tw

85 The functional redundancy and overlapping target specificiti

86 Functional redundancy and phase variation might explain

87 To investigate functional redundancy and plasticity in S. oneidensis MR

88 sly marginal species can achieve a degree of functional redundancy, and that their compensatory herbi

89 Since c-Myc and N-myc share substantial functional redundancy, another factor that could influen

90 ies with the greatest mutualist richness and functional redundancy are nearly two times more likely t

91 osely related proteins exhibited substantial functional redundancy, as ectopic expression of either p

92 GO4/6/9, based on their sequence similarity, functional redundancy, as well as species and features o

93 cteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift.

94 Several levels of functional redundancy at different scales of the bacteri

95 These results underscore functional redundancy at the TopIB-DNA interface.

96 tion is advised in drawing conclusions about functional redundancy based on a single environmental si

97 e have no obvious phenotype, possibly due to functional redundancy, because Sdr16c5 and Sdr16c6 exhib

98 modulation of stress-induced anxiety and the functional redundancy between AEA and 2-AG signaling in

99 High functional redundancy between APP and APLP2 suggests tha

100 a in the mesenchymal component and a limited functional redundancy between BmprIa and BmprIb in a tis

101 ng sequences) to further study the extent of functional redundancy between both genes regarding two p

102 In this study, we tested the functional redundancy between different SAMPs and how th

103 n give rise to stronger phenotypes, implying functional redundancy between distinct residues on histo

104 In the nucleus, there is significant functional redundancy between DNA ligase IIIalpha and DN

105 ishment and plant growth, suggesting partial functional redundancy between DRP3A and DRP3B.

106 We propose that functional redundancy between duplicated paralogous gene

107 These results demonstrate functional redundancy between Gata4 and Gata5 during car

108 Functional redundancy between gene family members is one

109 Taken together, our findings reveal a functional redundancy between GL2 and HDG11, two homeodo

110 Functional redundancy between H3K27 demethylase activiti

111 on epistasis model to estimate the degree of functional redundancy between homeoallelic loci and a st

112 Partial functional redundancy between homeologous genes should r

113 Our results demonstrate a functional redundancy between human SHOX and mouse Shox2

114 Finally, we demonstrate functional redundancy between Ldb1 and Ldb2.

115 This may be due, in part, to functional redundancy between miRNAs.

116 NMDA receptor-mediated currents, suggesting functional redundancy between NLs and LRRTMs during earl

117 UVR8-mediated responses in plants, although functional redundancy between proteins could influence t

118 onferred H(2)O(2)-sensitivity, demonstrating functional redundancy between Rad18 and non-homologous e

119 These results support a model in which the functional redundancy between roX1 and roX2 RNAs is base

120 e SLK genes and to investigate the degree of functional redundancy between SEU and SLK genes, we char

121 n this study, we set to investigate possible functional redundancy between SHOX and SHOX2 in vitro an

122 richness of early diverging lineages and the functional redundancy between species increased multifun

123 These data reveal functional redundancy between specific assembly factors

124 tudies for Stx1 have been elusive due to the functional redundancy between Stx1 isoforms Stx1A and St

125 In this work, we seek to determine the functional redundancy between the kinase domains of the

126 uld control HIF timing and we probed for the functional redundancy between the three main PHD protein

127 These findings show that there is a level of functional redundancy between the two ATG4s, and that AT

128 perties tested here, indicating considerable functional redundancy between the two proteins.

129 Moreover, we show that there is functional redundancy between the two type II receptors

130 Our findings support the existence of functional redundancy between the Y chromosome genes and

131 expression and extinction but that there is functional redundancy between them.

132 A previously suggested general functional redundancy between these and other lipoprotei

133 t physiological roles, a pharmacological and functional redundancy between these canonical eCB signal

134 promote Type 2 responses, but the extent of functional redundancy between these cytokines is unclear

135 nd vertebrates were excluded, indicating low functional redundancy between these groups.

136 Although this similarity suggests some functional redundancy between these proteins, an increas

137 ap in their endodermal expression domains, a functional redundancy between these signals might mask a

138 ole-plant phenotype, suggesting considerable functional redundancy between these two genes.

139 strong ern1-1 ern2-1 phenotype demonstrates functional redundancy between these two transcriptional

140 This is the first evidence of functional redundancy between Wnt ligands in posterior p

141 al of WOX2, providing an explanation for the functional redundancy between WOX2 and STPL.

142 We also provide new information on functional redundancy between WRN and BLM.

143 This study demonstrates functional redundancy between YidC orthologs in gram-neg

144 d physiological assays revealed that despite functional redundancy, BIN2 plays a dominant role among

145 ctive Zn-SodCII and while CopA and GolT show functional redundancy, both require CueP to activate Sod

146 volve neutrally after duplication because of functional redundancy but a fraction of these genes were

147 LC and dermal DC subsets often show functional redundancy, but LCs are required for specific

148 scued by both RPT2a and RPT2b, indicative of functional redundancy, but not by RPT2a mutants altered

149 the purine pathway unexpectedly bypasses its functional redundancy by exploiting both the nature of p

150 subdomains of the plant TGN and suggest that functional redundancy can be achieved through paralleliz

151 This result suggests that functional redundancy can further decrease when spatial

152 ection of posttranslational modifications or functional redundancy conferred by protein families, whi

153 eory suggests that high species richness and functional redundancy could promote mutualism persistenc

154 nclear why three proteins with such apparent functional redundancy exist in mammals.

155 ary tumor model highlights the importance of functional redundancies existing between the Apc protein

156 null mutants, suggest that a high degree of functional redundancy exists among CLE gene family membe

157 rvations suggest that although some level of functional redundancy exists between Pak1 and Pak6 in pr

158 However, no such functional redundancy exists for the 3'-phosphatase acti

159 t in any phenotypic changes, suggesting that functional redundancy exists in proteins containing simi

160 their physiological roles and the extent of functional redundancy following embryo implantation.

161 In addition, the absence of functional redundancy for Drpr in Drosophila may help el

162 s, previous studies identify a high level of functional redundancy for PKD1 and PKD2 in various cellu

163 We also uncover functional redundancy for somatic embryogenesis among ot

164 n loss of mycobacterial LM/LAM, indicating a functional redundancy for this enzyme in mycobacteria.

165 four SOD alleles within the genome provides functional redundancy for this key enzyme.

166 This two-tier functional redundancy for translation quality control br

167 t are incompletely described possibly due to functional redundancy, gene family proliferation, and/or

168 N/Eph system concerns their large number and functional redundancy given the promiscuous cross-activa

169 raits in polyploid wheat; we also argue that functional redundancy has 'locked up' a wide range of ph

170 Such functional redundancy has been hypothesized to underlie

171 In contrast, extreme functional redundancy has evolved among expanded gene fa

172 ty of the species-rich biota to display high functional redundancy: i.e., a high number of species pe

173 the pocket protein family provides for some functional redundancy, important differences have been o

174 Maps of genetic interactions can dissect functional redundancies in cellular networks.

175 out strong phenotypes, presumably because of functional redundancies in this gene family.

176 skin, where H3K27me3 is abolished, revealing functional redundancy in EZH1/2 proteins.

177 stem to examine the capabilities afforded by functional redundancy in fatty acid synthesis.

178 Additionally, there appears to be functional redundancy in genera of CCRA providing cues t

179 with multiple members in each class suggests functional redundancy in growth inhibition.

180 Shapes suggesting functional redundancy in one environment can change, sug

181 This functional redundancy in RasGEFs during negative selecti

182 mutational analysis has shown the absence of functional redundancy in resistance to SCN.

183 in unrestored networks, indicating a higher functional redundancy in restored communities.

184 n and assembly in vivo reveal structural and functional redundancy in Spc42 assembly.

185 th the notion that there is a high degree of functional redundancy in target gene regulation by ETS-d

186 distinct BBSome components, show unexpected functional redundancy in the context of cilia in C. eleg

187 Our data clearly establish a functional redundancy in the essential C(26)-monooxygena

188 mutant provided some evidence for a lack of functional redundancy in the gene family.

189 e explored the hypothesis that an underlying functional redundancy in the homologous elements hs3a an

190 lutionary processes that create and maintain functional redundancy in the human microbiome and contri

191 Here, we investigate the basis for functional redundancy in the human microbiome by analyzi

192 are more stringently required, likely due to functional redundancy in the latter.

193 etion of either isoform alone, demonstrating functional redundancy in the maintenance of sensory neur

194 Second, there may be high functional redundancy in the methanogens with regard to

195 at determine life support functions, but the functional redundancy in the microbiota of most soils ha

196 entified, nor has the mechanism behind their functional redundancy in the thymus.

197 omic turnover continues unabated, suggesting functional redundancy in the traits examined.

198 d not show any altered phenotype, indicating functional redundancy in these genes.

199 pathogenic Pseudomonas syringae, indicating functional redundancy in this large gene family.

200 Whether these predictions reflect actual functional redundancies is unclear.

201 We found that the highest functional redundancy is located in the Central Indo-Pac

202 any developing organs but whether they share functional redundancy is not known.

203 The origin of functional redundancy is still elusive.

204 t TFI gene expression cannot be explained by functional redundancy, is supported by active transcript

205 ecombination in normal cells, but because of functional redundancy, it is absolutely required for thi

206 While duplicate genes may retain some functional redundancy, it is clear that to survive selec

207 nces of type-III effectors, as well as their functional redundancy, make studying type-III effectors

208 n in this organism, the absence of extensive functional redundancy makes C. elegans an ideal model fo

209 dly, given the multigenic nature and partial functional redundancy observed in the PYR/PYL family, th

210 comes intrinsic drug resistance ensuing from functional redundancy of Bcl-2 proteins, but also abroga

211 t display any cognitive phenotype supporting functional redundancy of both factors.

212 ct pathways may share factors to enhance the functional redundancy of both.

213 ts closely related homolog bt1, indicating a functional redundancy of BT1 and BT2 for NUE.

214 Such functional redundancy of class IA PI3K isoforms upon sus

215 s of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes.

216 results provide the basis to understand the functional redundancy of CPPs and CAPs.

217 ed in the mir-58.1 single mutant, indicating functional redundancy of distinct members of this miRNA

218 ts in DVL1-mediated Robinow syndrome and the functional redundancy of DVL1, DVL2, and DVL3, we electe

219 These AlaXps are thought to provide functional redundancy of editing.

220 This dissociation between the functional redundancy of either the mouse or the fly tra

221 dependence on PRC2 activity and the partial functional redundancy of enhancer of zeste homolog 1 (Ez

222 us work from our laboratory suggested either functional redundancy of ERK isoforms or a predominant r

223 verexpression in RWPE cells, emphasizing the functional redundancy of ETS rearrangements.

224 imal models frequently is complicated by the functional redundancy of homologous genes.

225 of IL-36alpha in the lung, demonstrates the functional redundancy of IL-36alpha with other agonist c

226 Although we have not observed a functional redundancy of kif3b and kif17, kif17 is able

227 e priming step and further insights into the functional redundancy of lipoteichoic acid biosynthesis

228 eting cancer drugs is thought to result from functional redundancy of mitotic kinesins.

229 Reverse genetics showed functional redundancy of NHX1 and NHX2 genes.

230 ot affect fruit development, which suggested functional redundancy of PIN proteins, but did lead to a

231 The results demonstrate the functional redundancy of Sia and Twn and their essential

232 atial dynamics of communities as well as the functional redundancy of taxonomic groups.

233 its target, but also the innate or adaptive functional redundancy of that target and its attendant p

234 These findings indicate functional redundancy of the B. pseudomallei phospholipa

235 However, functional identity and functional redundancy of the community as a whole remain

236 similarity, close location and the potential functional redundancy of the gene family members.

237 ration is controversial, probably due to the functional redundancy of the PARP family in mammalian ce

238 Functional redundancy of the Pf-5 Fpvs was also apparent

239 ota transplantation (FMT), finding that high functional redundancy of the recipient's pre-FMT microbi

240 expressed under 35S promoter, indicating the functional redundancy of the RWA proteins.

241 This yields insights on the functional redundancy of the system as well as its behav

242 the absence of any single ZDHHC, suggesting functional redundancy of these enzymes in the IFITM3-med

243 To address the potential for functional redundancy of these genes, homozygous double

244 in neurons to investigate the specificity or functional redundancy of these HDACs in learning and syn

245 As a result of the functional redundancy of these three cytokines on eosino

246 e than in Fli1(+/-) mice, indicating partial functional redundancy of these transcription factors dur

247 hyte, but not vice versa, indicating partial functional redundancy of these two closely related isofo

248 despite the strong structural similarity and functional redundancy of these two enzymes, the mechanis

249 Corresponding to this apparent functional redundancy of TLR signaling pathways, HRS imm

250 port that there is a previously unrecognized functional redundancy of Trx f1 and NTRC in regulating p

251 The functional redundancy of Wnt genes and the many forms of

252 or morphology, indicating either a degree of functional redundancy or a function in an alternative st

253 However, the functional redundancy or differentiation of PACT and TRB

254 ecies and changes in species' relative local functional redundancy or distinctness.

255 L receptors, but little is known about their functional redundancy, or if their mutation can be physi

256 However, due to functional redundancy, other PSD-MAGUKs can presumably c

257 Given the functional redundancies present in human tumors and esca

258 The resulting genetic and functional redundancy prevents the analysis of their spe

259 We propose that this functional redundancy provides one explanation for the a

260 unities, despite their extreme diversity and functional redundancy, respond to disturbances like many

261 Because of functional redundancies, single gene mutations in the pl

262 man colon is very high with apparently large functional redundancy such that within each bacterial fu

263 This functional redundancy suggests that therapeutic targetin

264 Together, these data emphasize the functional redundancy that leads to robustness in the ca

265 relaxed evolutionary constraint, with enough functional redundancy that variation in, or even loss of

266 However, due to functional redundancy, their contribution to osmotic str

267 The need for functional redundancy through biological diversity in wa

268 be indicative of unappreciated evolutionary functional redundancy to facilitate angiogenesis and ens

269 dual cells while also being flexible through functional redundancy to guarantee high fidelity of the

270 However, due to functional redundancy, typically the contribution of ind

271 icient for cell specificity, indicating that functional redundancy underlies this key aspect of C(4)

272 s overlapping subsets of tubulin genes whose functional redundancy varies between cell types and in v

273 Thus, in addition to revealing TLS and HR functional redundancy, we establish that UV-induced reco

274 erns throughout development, indicating high functional redundancy, which might be necessary for safe

275 ablished network of signalling cascades with functional redundancy, which provides them with robust c

276 rt, but consistent with a widespread loss of functional redundancy, while adaptive radiations of gene

277 omal signal joins or coding joins because of functional redundancy with ataxia telangiectasia mutated

278 issue-specific requirement of BmprIa and its functional redundancy with BmprIb during the development

279 we investigate the role of Chk in platelets, functional redundancy with Csk, and the physiological co

280 In the nucleus, LigIII has functional redundancy with DNA ligase I whereas LigIII i

281 Here, we show that XLF has dramatic functional redundancy with DNA-PKcs in the V(D)J SJ join

282 to interact with OsPIP5K1 and shares partial functional redundancy with DWT1 in controlling rice unif

283 cause an overt phenotype, likely because of functional redundancy with Ezh1.

284 ing domains, but to what extent they provide functional redundancy with FMRP is unclear.

285 We postulated that functional redundancy with its closely related family me

286 critical for embryogenesis and shows partial functional redundancy with its homolog PCAF.

287 or enhancer H3K4me1/2 methyltransferase with functional redundancy with MLL3 (KMT2C).

288 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C).

289 ono- and di-methyltransferase with a partial functional redundancy with MLL3 (KMT2C).

290 To address potential functional redundancy with murin Dcx, we targeted one of

291 nt effect on meiotic cross-overs, suggesting functional redundancy with other RECQ family members.

292 e responsible for pilus assembly and exhibit functional redundancy with respect to backbone assembly

293 Based on functional redundancy with similar motifs derived from h

294 (-/-) homozygotes, apparently as a result of functional redundancy with the paralogous Alx4 gene.

295 There is extensive functional redundancy within and between these protease

296 robiota illustrates niche specialization and functional redundancy within members of its major bacter

297 ors on vertebrate cardiogenesis is masked by functional redundancy within multiple lineages.

298 ficantly affected due to potential bacterial functional redundancy within the compost samples.

299 median eminence suggested that rather than a functional redundancy within the TIDA population, the do

300 at these interactions also contribute to the functional redundancy within this gene family.