ライフサイエンスコーパス: functional similarity

1 modules and interact tightly based on their functional similarity.

2 inR can complement a luxN mutant, suggesting functional similarity.

3 ation typically uses structural, sequence or functional similarity.

4 e study, causing an underestimation in their functional similarity.

5 on structural characteristics rather than on functional similarity.

6 g functions of unknown proteins based on the functional similarity.

7 I) reduction and OmcB expression, suggesting functional similarity.

8 ation to aid interpretation of structure and functional similarity.

9 ed p40 subunit, this does not translate into functional similarity.

10 rol of acpA and acpB, two genes with partial functional similarity.

11 ance is how structural similarity relates to functional similarity.

12 w extensive sequence homology, indicative of functional similarity.

13 charge distribution, which may explain their functional similarity.

14 toxicity, enzyme sharing, and coarse-grained functional similarity.

15 ng closely related species by means of their functional similarity.

16 nts and animals as the cause of sequence and functional similarity.

17 deed have genetic alterations of significant functional similarity.

18 ns and protein-protein interactions based on functional similarity.

19 origins of replication, predicting important functional similarities.

20 I together with TFIIB highlights significant functional similarities.

21 ale gene expression dataset and predict gene functional similarities.

22 inding proteins with striking structural and functional similarities.

23 hen run on gene sets with varying degrees of functional similarities.

24 ture strongly suggests that the enzymes have functional similarities.

25 ished six groups of potential structural and functional similarities.

26 family of proteins that share structural and functional similarities.

27 e another according to different measures of functional similarity, after which belief propagation is

28 utational methods for automated inference of functional similarities among genes and their products.

29 f the most ancient of cellular processes and functional similarities among its molecular machinery ar

30 However, because many functional similarities among these organisms have arise

31 their unique expansion and to probe putative functional similarities among these systems, here we com

32 inner ear, these experiments suggest a deep functional similarity among primary somatosensory neuron

33 e no reliable means to predict the extent of functional similarity among proteins.

34 ubstrate space provide a distance measure of functional similarity among the MMPs.

35 tructures, implying structural, and possibly functional, similarity among existing RNAs.

36 We also uncovered functional similarities and differences among BRD2, BRD4

37 However, the functional similarities and differences among these prot

38 s of human EB1 family proteins and to reveal functional similarities and differences among these prot

39 t a physical-chemical basis for the observed functional similarities and differences between these tw

40 We review the phenotypic and functional similarities and differences of ILCs between

41 CYP1A1 possesses functional similarities and differences with human CYP1A

42 oring scheme which measures enzyme-to-enzyme functional similarity and a fast algorithm which efficie

43 d duplicates still maintain a high degree of functional similarity and are synthetically lethal or si

44 visualization, retrieval, and computation of functional similarity and associations of GO terms and g

45 eloped NaviGO, which visualizes and analyses functional similarity and associations of GO terms and g

46 ic data to accurately evaluate the extent of functional similarity and divergence between paralogs on

47 The relationships between the gene functional similarity and gene expression profile, and b

48 oach, we quantified the relationship between functional similarity and high-throughput data, and code

49 omical bias by grouping voxels based only on functional similarity and ignoring anatomical proximity.

50 isms show that: (i) the relationship between functional similarity and network proximity is captured

51 Despite functional similarity and structural homology, they exhi

52 ork similarity measure, sequence similarity, functional similarity and structural similarity.

53 similarity of capistruin and MccJ25 reflects functional similarity and suggest that the functional ta

54 nd evaluation of evolutionary divergence and functional similarity, and discuss future applications o

55 t rely on genetic homology or structural and functional similarity, and it significantly outperforms

56 urrent theories of rodent/primate prefrontal functional similarity, and provide insight into the role

57 oposed metric should not be interpreted as a functional similarity, and therefore cannot be used to s

58 human PTIP DNA damage response factors, but functional similarities appear limited.

59 ng similarities of gene expression maps, the functional similarities are increased too.

60 These functional similarities are reflected at the anatomical,

61 ed with PIWI and TDRD5/7 revealed that these functional similarities are reflected in remarkable stru

62 underlying neuronal mechanisms allowing the functional similarity are incompletely understood.

63 ting measures and (ii) network proximity and functional similarity are significantly more correlated

64 nd XIAP demonstrate no obvious structural or functional similarity, are not coordinately regulated wi

65 in nonlymphoid tissues share phenotypic and functional similarities, as well as a unique shared deve

66 To test whether the contact metric detects functional similarity, as defined by Gene Ontology (GO)

67 e H2B deubiquitination complexes show strong functional similarity, as do suppressors in the silencin

68 Moreover, the results from functional similarity-based network alignment display li

69 the concanavalin A-type lectins, highlights functional similarities between agrin and laminin G doma

70 nto TFIIIB complexes, reveals structural and functional similarities between Bdp1 and Pol II factors

71 . cerevisiae CTD kinase and provide striking functional similarities between Bur1 and metazoan P-TEFb

72 The remarkable functional similarities between CFIm and SR proteins sug

73 The functional similarities between COVID-19 and COVID-2 in

74 The biochemical and functional similarities between DAR1 and other animal se

75 These data provide evidence of further functional similarities between DCs and H/RS cells.

76 ght several developmental, morphological and functional similarities between Drosophila and vertebrat

77 of maps: chroGPS(factors), which visualizes functional similarities between epigenetic factors, and

78 -catenin signaling pathway and highlight the functional similarities between gal-3 and beta-catenin.

79 The model predicts the functional similarities between genes to a certain degre

80 Thus, our results indicate functional similarities between immune T cells residing

81 These studies highlight the structural and functional similarities between kindlins and the talin h

82 sponding M. marinum mutants, emphasizing the functional similarities between M. tuberculosis and M. m

83 ion about miRNAs and diseases, including the functional similarities between miRNAs, the similarities

84 es and vertebrates have revealed a number of functional similarities between motion-processing pathwa

85 re prediction of the MUN domain and suggests functional similarities between MUN domain-containing pr

86 es have highlighted extensive phenotypic and functional similarities between normal stem cells and ca

87 Our results also indicate significant functional similarities between POT1 and Cdc13 from budd

88 stigations of individual subunits, including functional similarities between Ppc89 and the budding ye

89 Structural and functional similarities between RbfA, NusA, and other ba

90 The sequence and functional similarities between RTA and IRFs suggest tha

91 the Mediator complex and further extend the functional similarities between Saccharomyces cerevisiae

92 In light of the functional similarities between SPC proteins, we develop

93 tage of the repair process and extending the functional similarities between TCR in bacteria and euka

94 lators, TF co-occurrence, open chromatin and functional similarities between TFs and genes are better

95 I highlight functional similarities between the activation mechanism

96 een the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 doma

97 In more general terms, we suggest functional similarities between the HIRAN, the OB, the H

98 Here, we demonstrate functional similarities between the replication and chec

99 of the small intestine, suggesting there are functional similarities between these classes of ICC.

100 is only 18%, these results suggest that the functional similarities between these proteins containin

101 Despite the structural and functional similarities between these receptors, their c

102 The anatomical overlap and functional similarities between these two neurotransmitt

103 scussed in light of the known structural and functional similarities between troponin I and the gamma

104 rminants for oligomer assembly and to assess functional similarities between Yta10 and Yta12.

105 ed to influence feeding owing in part to the functional similarity between acetylcholine and nicotine

106 nge edges is best explained by the degree of functional similarity between current and novel competit

107 er, there is a high degree of structural and functional similarity between each nitrogenase.

108 e been recently proposed for quantifying the functional similarity between gene products according to

109 To explore possible functional similarity between HTT and Atg11, we investig

110 Here we show that GO-based functional similarity between human and mouse orthologs,

111 To evaluate functional similarity between identified sequences and t

112 We apply similarity measures to assess the functional similarity between interacting proteins.

113 y to each gene utilizing a known property of functional similarity between neighboring genes in bacte

114 first postnatal week greatly diminished the functional similarity between sister neurons, suggesting

115 Given the sequence and functional similarity between spastin and katanin, we hy

116 eIF4G and eIFiso4G were distinct despite the functional similarity between the eIF4G proteins.

117 The structural and functional similarity between the ligand-binding region

118 The functional similarity between the NS2B/NS3 proteases fro

119 These observations reveal a functional similarity between the tryptophan-based endoc

120 mf1 and emf2 mutants was consistent with the functional similarity between the two genes.

121 f the WT enzyme, suggesting a structural and functional similarity between the two positively charged

122 etabolism and proliferation, thus suggesting functional similarity between this immunoreceptor and tu

123 sefelness by using its indexing mode to find functional similarity between yeast and human PPI networ

124 recent paper has proposed a metric for the "functional similarity" between two genes that uses only

125 sed in a number of contexts, including gene "functional similarity" clustering and the related proble

126 rganization of dynamical correlations, where functional similarity decouples from physical connectivi

127 information including miRNA sequences, miRNA functional similarity, disease semantic similarity, and

128 arning methodology to predict pair-wise gene functional similarity from multiplex gene expression map

129 arning methodology to predict pair-wise gene functional similarity from multiplex gene expression map

130 ared several methods for detecting gene-gene functional similarity from phenotypic knock-down profile

131 Structural and functional similarities, genomic context in operons cont

132 PelA(h), respectively) share structural and functional similarities given their ability to degrade G

133 This expectation of functional similarity has not been tested experimentally

134 New measures of functional similarity have been integrated, including fo

135 ocations of these two genes as well as their functional similarity have hindered efforts to define wh

136 les of these proteins and exposing potential functional similarities hidden by their rapid evolution,

137 that share very little sequence or seemingly functional similarities; however, their translocations i

138 Despite high overall structural and functional similarity, human (h) and murine (m) MD-2 exh

139 not only on sequence similarity, but also on functional similarity, i.e. sequences in each family mus

140 -43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA

141 In this review, we describe functional similarities in eyes and gaze stabilization r

142 roseate terns by characterizing genetic and functional similarities in species aryl hydrocarbon rece

143 Despite the structural and in vivo functional similarities in the compounds, only (R)-18 wa

144 megalovirus proteins IE1 and pp71 share some functional similarities in their abilities to counteract

145 al attributes across entity groups to assess functional similarity in a statistically meaningful and

146 Our results indicate functional similarity in carbon, nitrogen, and sulfur as

147 results indicate that ABF1 and RAP1 achieve functional similarity in part via mechanistically distin

148 Results show high functional similarity in resulting gene sets, increasing

149 ight several metabolic pathways that exhibit functional similarity in these coral and sponge microbio

150 ever, genes associated with each trait share functional similarities, including genes involved in apo

151 gions collectively share many anatomical and functional similarities, it has become increasingly clea

152 Based on sequence and functional similarity, it was believed that their three-

153 Despite high sequence and functional similarities, KorB (pSB24.2) was found to exi

154 We propose a statistically motivated functional similarity measure that takes into account fu

155 carry out network alignment using a protein functional similarity measure.

156 formally compare it with other quantitative functional similarity measures (such as, shortest path w

157 Despite these functional similarities, MERS-CoV nsp1 used a strikingly

158 each other; and further the region by region functional similarity network and genetic similarity net

159 network, by means of combining a fused gene functional similarity network, gene-disease associations

160 cing clusters of genes with great amounts of functional similarity, new data-mining algorithms are re

161 despite their high degree of structural and functional similarities, normal levels of both p300 and

162 e structurally related pseudoknot pairs have functional similarities not previously known: one pair i

163 this study was to elucidate the mechanism of functional similarities observed in the two pathways.

164 larities of Gene Ontology (GO) terms and the functional similarities of gene products, and for furthe

165 s still no effective method to determine the functional similarities of genes based on gene annotatio

166 esults of using our algorithm to measure the functional similarities of genes in pathways retrieved f

167 GO annotations result in biased estimates of functional similarities of genes, but it is still unclea

168 Therefore, functional similarities of GO terms that are not explici

169 The structural and functional similarities of gp10, gp11, and gp12 and thei

170 e this model to test the hypothesis that the functional similarities of muscle actions are embedded i

171 The sequence and functional similarities of P4H1 to animal HIFalpha-type

172 om expression maps and the labels denote the functional similarities of pairs of genes.

173 ventral stream and a dorsal stream, and the functional similarities of the areas in humans and macaq

174 Given structural and functional similarities of the GP1 receptor binding site

175 ntified in this study closely paralleled the functional similarities of the mutant gene products, the

176 n those already described and to investigate functional similarities of the regulators.

177 The structural and functional similarities of the Ustilago replication-coup

178 tively, our data provide strong evidence for functional similarities of Type 1 CRYs across insect spe

179 hich the genes act, explaining why a greater functional similarity of (within-species) paralogs than

180 We present biochemical evidence for the functional similarity of Escherichia coli RecO protein a

181 One class of such methods measures the functional similarity of genes based on their distance i

182 , we designed a new algorithm to measure the functional similarity of genes.

183 It instead proposed that the functional similarity of homologous genes is primarily d

184 The strong functional similarity of human ADAR2 and Drosophila Adar

185 To examine the functional similarity of mammalian homologs of SID-1 (SI

186 Furthermore, we demonstrate that the functional similarity of proteins within known regulator

187 is that weak binding sites contribute to the functional similarity of sequences.

188 This indicates functional similarity of the human isoforms in yeast and

189 The functional similarity of the MARCH family and the K3 fam

190 The homology, expression profile, and functional similarity of the receptors in the dog, ferre

191 into four families based on the sequence and functional similarity of their Galpha subunits: G(s), G(

192 To test the functional similarity of their respective intracellular

193 the HCV E2 ectodomain shares structural and functional similarities only with domain III of class II

194 s of ancient origin, and examine some of the functional similarities polydnaviruses share with phage-

195 Plant parasites share functional similarities regarding feeding, but many simi

196 ation in global properties between networks, functional similarity remains high.

197 However, despite these functional similarities, Sca2 is structurally unrelated

198 First, it computes our novel protein functional similarity scores by fusing information from

199 heir ability to produce good topological vs. functional similarity scores, whereas SANA usually outsc

200 results by analyzing the correlation between functional similarity, sequence similarity, expression s

201 RdRps have no sequence homology, they share functional similarities such as copying messenger RNA te

202 Nevertheless, these proteins show several functional similarities, such as their ability to bind t

203 fusion proteins share several structural or functional similarities, suggesting that they may impart

204 Despite their structural and functional similarities, superantigens display subtle di

205 Depending on structural and functional similarities, the six members of PAK family a

206 The method integrated the miRNA functional similarity, the disease similarity, and the m

207 cationic and share this particular aspect of functional similarity, their protein sequence identity i

208 s in these two tissues show a high degree of functional similarity, there are important differences i

209 Based on sequence and functional similarities, this novel IL-17 receptor homol

210 K7 bears sequence and functional similarities to A52, which interacts with int

211 Both genes encode enzymes that have functional similarities to AtGA2ox7 and AtGA2ox8, which

212 g and annealing activities and displays some functional similarities to bacterial RecG and RecQ helic

213 yte-like cells, which display structural and functional similarities to bile duct cells in normal liv

214 ural similarities to the lung collectins and functional similarities to C1q.

215 e early Cambrian of China and Greenland with functional similarities to certain modern crustaceans an

216 show that ABH2 and ABH3 have structural and functional similarities to E.coli AlkB.

217 , alias Krox20) protein shows structural and functional similarities to Egr-1, these two related earl

218 -proline-rich (H/P) domain with sequence and functional similarities to HKa-D5.

219 -B*06:03 variant has striking structural and functional similarities to HLA-B*57, the human allotype

220 DmBlm has functional similarities to human BLM (hBLM) as mutants d

221 obulin domains, but show strong sequence and functional similarities to human LILR.

222 Here, we show that DlEPV exhibits functional similarities to known parasitoid viral elemen

223 ial heme peroxidase with high structural and functional similarities to LPO was described.

224 ch individual subject, three regions showing functional similarities to macaque core, belt, and parab

225 ubtype that shows striking morphological and functional similarities to mammalian astrocytes.

226 Taste receptor cells harbor functional similarities to neurons but, like epithelial

227 e T cells with distinct Ag specificities but functional similarities to NKT cells.

228 Despite the substantial structural and functional similarities to p53, accumulating evidence su

229 les were induced by expressing 1a, which has functional similarities to retrovirus virion protein Gag

230 in the lymph gland, a signaling center, with functional similarities to stromal signaling in mammalia

231 plants possess an NAE-signaling pathway with functional similarities to the "endocannabinoid" pathway

232 ve origin of mitochondria, and examine their functional similarities to the lambda bacteriophage (lam

233 ion regulation on cellular stress and reveal functional similarities to the mammalian system.

234 x)-deficient PLB-985 cells, indicating close functional similarities to the phagocyte oxidase (phox).

235 la nephrocyte has molecular, structural, and functional similarities to the renal proximal tubule cel

236 Structural and functional similarities to the Tet repressor and the Bmr

237 ely 80-residue N-domain shows structural and functional similarity to 106-residue Escherichia coli Cl

238 allows position specific plots of potential functional similarity to be compared in a simple compact

239 to insulin(+) cells with close molecular and functional similarity to beta cells.

240 CRK4-regulated phosphoproteins with greatest functional similarity to CDK2 substrates, particularly p

241 expansion of an atypical NK cell subset with functional similarity to cells referred as IFN-producing

242 sion of inclusions and shares structural and functional similarity to eukaryotic SNAREs.

243 Because of functional similarity to Fen1, and because Exo1 is invol

244 We show that using functional similarity to map proteins across species imp

245 hares a high degree of sequence homology and functional similarity to mNAT, we named it mNAT2.

246 PV+ neurons showed functional similarity to neighboring neuronal population

247 ibitors is complicated by its structural and functional similarity to other protein prenyltransferase

248 dothelial-like cells that have molecular and functional similarity to primary cells.

249 and adherence, Als1p has both structural and functional similarity to S. cerevisiae Flo11p.

250 This 5'-nuclease has strong structural and functional similarity to the FEN1 nuclease family.

251 yte has remarkable anatomical, molecular and functional similarity to the glomerular podocyte, a cell

252 These data reveal EpiSC/hESC functional similarity to the glycolytic phenotype in can

253 PTBA exhibits structural and functional similarity to the histone deacetylase (HDAC)

254 to members of the actin-fold family and the functional similarity to the nitrogenase Fe- protein.

255 of xisC showed that the XisC recombinase has functional similarity to the phage integrase family.

256 ation of TgVP1 in enriched fractions shows a functional similarity to the respective plant enzyme.

257 sophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and

258 d type II enzymes show marked structural and functional similarities, topoisomerase V represents a di

259 The notion that sequence homology implies functional similarity underlies much of computational bi

260 Functional similarity was observed in regulation by huma

261 eta (Poleta), with which Poliota shares many functional similarities, we believe that this modificati

262 In contrast to their structural and functional similarity, we observe a remarkable differenc

263 ression was restricted to the heart of mice, functional similarities were clearly observed between th

264 ionally critical amino acids and may suggest functional similarity when geometrically matched to othe

265 The key structural and functional similarities, which we found between Rho-depe

266 Moreover, the structural and functional similarities with Basonuclin1 suggest that Ba

267 Because HPPL cysts display structural and functional similarities with bile ducts, the 3D culture

268 Transcriptional targets of Cn Sp1 shared functional similarities with Crz1 factors, such as cell

269 Platelets share structural and functional similarities with granulocytes known to parti

270 These proteins have some functional similarities with herpes simplex virus 1 (HSV

271 Although HDAC3 shares some structural and functional similarities with other class I HDACs, it exi

272 mily of transporters and shares sequence and functional similarities with P-glycoprotein of cancer ce

273 exchangeable apolipoprotein that shares many functional similarities with related apolipoproteins suc

274 We conclude that AAF shares structural and functional similarities with RPA-32 and regulates DNA re

275 However, based on its structural and functional similarities with soluble collectins, we hypo

276 CXCR5(+) CD4(+) T cells share phenotypic and functional similarities with T follicular helper cells.

277 dendritic process sharing organizational and functional similarities with the AIS.

278 e shares substantial amino acid sequence and functional similarities with the bacteriophage T7 primas

279 terium nucleatum, which share structural and functional similarities with the chlamydial major outer

280 e domain receptor that shares structural and functional similarities with the family of atypical chem

281 Despite striking structural and functional similarities with the lymphatic vascular syst

282 coded factor Mc, which shares structural and functional similarities with the male sex-determining fa

283 n vivo, and shares intriguing structural and functional similarities with the mammalian telomeric pro

284 ve these configurations, and they share some functional similarities with the plasminogen disulfides.

285 -sensing signal, AgrD, shares structural and functional similarities with the PSM family of toxins.

286 inal center formation, these results suggest functional similarities with the unrelated Bcl-6 oncopro

287 Cdc5 and Plo1, respectively) bear remarkable functional similarities with those in metazoan organisms

288 an invertebrate IgCAM, shares structural and functional similarities with vertebrate NCAM and therefo

289 effectiveness of this approach in detecting functional similarity with an average F-score: 0.85.

290 GTPases and shares significant sequence and functional similarity with Cdc42.

291 amily GTPase that shares strong sequence and functional similarity with Cdc42.

292 ed late in plant evolution and exhibits more functional similarity with eIF4G than with eIFiso4G1 dur

293 hese data suggest that the Map53 shares some functional similarity with human p53 as well as with oth

294 ein, shares significant sequence homolog and functional similarity with p53.

295 and shares the highest sequence identity and functional similarity with PEPM.

296 MLN shares structural and functional similarity with phospholamban (PLN) and sarco

297 LmACR2 displays sequence and functional similarity with the arsenate reductase ScACR2

298 Wrch-1 shares significant sequence and functional similarity with the Cdc42 small GTPase.

299 ons expressing CaMKIIalpha displayed no such functional similarity with the neighboring population.

300 , members of this class share structural and functional similarities, with conserved features of the