ライフサイエンスコーパス: functionalization

1 ction of different kinds of amines and their functionalization.

2 zation cascade for divergent elaboration and functionalization.

3 the prospering field of non-covalent surface functionalization.

4 r sequential hydrocarbon activation and N(2) functionalization.

5 ubstrates through multilayer network surface functionalization.

6 ereoselective transition-metal-catalyzed C-H functionalization.

7 vity, and switchable chemical reactivity for functionalization.

8 ing, as well as knowledge regarding possible functionalization.

9 0.4)I(3) perovskite stabilized via interface functionalization.

10 hetic applications toward site-selective C-H functionalization.

11 e, providing an unprecedented high degree of functionalization.

12 ed here are modular, allowing for their post-functionalization.

13 ributed to the hydroxylated alkyl side-chain functionalization.

14 genation also provides opportunities for C-H functionalization.

15 approaches to alkylamine synthesis and their functionalization.

16 reactivity toward sigma-bond activation and functionalization.

17 tocks to tertiary alkylamines via C(sp(3))-H functionalization.

18 activity for such a demanding process as C-H functionalization.

19 ing end could undergo further regioselective functionalization.

20 lity under wet conditions without additional functionalization.

21 h functionalization to regions with no prior functionalization.

22 e BNNTs in PDMS while avoiding sonication or functionalization.

23 anoboron intermediates amendable for further functionalization.

24 icability, even in the context of late-stage functionalization.

25 s, C-H and X-H (X = N, O, S, Se, Si, Sn, Ge) functionalizations.

26 ts of biomedical m-bots: design/fabrication, functionalization, actuation, and localization.

27 ate evolutionary change through sub- and neo-functionalization among paralogous gene pairs.

28 of a carbon-based outer layer (for antibody functionalization), an intermediate Ni layer (for magnet

29 in a one-pot manner through selective C(7)-H functionalization and concomitant cyclization.

30 Transition metal-catalysed C-H functionalization and decarboxylative coupling are two o

31 he potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity

32 PS), confirmed the occurrence of both sulfur functionalization and GO reduction.

33 The versatility of functionalization and high tumour selectivity of the qua

34 overview on the state of the art in POM post-functionalization and highlights the key design and stru

35 Multi-functionalization and isomer-purity of fullerenes are cr

36 of carbon with a planar surface amenable to functionalization and nanoscale dimensions that confer p

37 hypervalent iodine electrocatalysis for C-H functionalization and provides mechanistic insight that

38 SANS results confirmed nanoparticles' functionalization and revealed the interfaces between na

39 This C-H bond functionalization and spirocyclization showed wide subst

40 ation method and biosurfactant was used as a functionalization and stability providing moiety.

41 ent main approaches-tether-directed covalent functionalization and supramolecular masks-the control o

42 it relates to N(2) activation and potential functionalization and the effect of polarizing the bridg

43 quantifiable size depended on the degree of functionalization and the surface available for labeling

44 study of the relationship between the linker functionalization and the thermodynamic stability of met

45 n, (b) transition-metal catalyzed C(sp(3))-H functionalization, and (c) transition-metal catalyzed vi

46 ccess to its redox sites, even without PEDOT functionalization, and outperformed the PEDOT composite

47 s in information storage/encryption, surface functionalization, and printable three-dimensional const

48 s rooted in hidden symmetry recognition, C-H functionalization, and radical retrosynthesis played key

49 (~500 Da), the water solubility, the ease of functionalization, and the selectivity profile, are prom

50 wever, polystyrene surfaces are inert toward functionalization, and this makes the uniform conjugatio

51 C-C bond formation via an uninterrupted C-H functionalization/annulation/decarboxylative aroylation

52 to prepare iodinated polyesters using a pre-functionalization approach.

53 Asymmetric, radical C-H functionalizations are rare but powerful tools for solvi

54 emical cyclization, glycosylation, and final functionalization at position 6 through cross-couplings

55 Methods for RNA functionalization at specific sites are in high demand b

56 sts have a greater tendency for inducing C-H functionalization at tertiary C-H bonds versus their tri

57 roduce high yields of heteroarylsilanes from functionalization at the most sterically accessible C-H

58 Here, we overcome those functionalization barriers through composition of stable

59 expensive reactants extensively explored for functionalization, but never considered for radical hydr

60 S have greatly increased the rate of variant functionalization, but the development of comprehensive

61 lysis of the product films revealed that C-H functionalization by [B(12)X(11)](-) occurred in the pre

62 optical transparency, porosity, and hydrogel functionalization by a well-controlled reactive group ca

63 e of controlling the site selectivity of C-H functionalization by means of C-H insertion with donor/a

64 to that obtained with other methods of arene functionalization can be achieved.

65 aluable for both the (beta/gamma)-C(sp(3))-H functionalization catalytic cycles.

66 nderlines the development of C(sp(3))-H bond functionalization chemistry that should find wide applic

67 e begin with a historical discussion of N(2) functionalization chemistry that traverses a timeline of

68 fficient and reproducible (CV = 9%) anti-CRP functionalization, controlled stopped-flow operations as

69 data show that GNPs with or without aptamer functionalization could form a nanoparticle-assembled po

70 core-shell structure and subsequent carboxyl functionalizations (CSD-PLNPs) were rationally fabricate

71 antibacterial activity, indicating that DBO functionalization did not impair penetration.

72 pecies have been implicated in catalytic C-H functionalization, discrete activation of C-H bonds at N

73 first focuses on the significance of defects/functionalization, discussion of different allotropes, a

74 resents a key challenge for non-directed C-H functionalization, even when the C-H bond is intrinsical

75 , encapsulation of biomolecules, and surface functionalization for drug delivery.

76 i-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation

77 rhodium catalysis is more selective for meta-functionalization for monosubstituted arenes and that th

78 enlists click chemistry for flexible protein functionalization; (ii) in principle can be applied to a

79 Despite efforts for beta-C-H functionalization in carbon-carbon and carbon-heteroatom

80 Moreover, these steroid derivatives undergo functionalization in the form of a highly regio- and ste

81 ability to catalyze C-H bond activation and functionalization, in many cases, the C-F bond cleavage

82 These post-functionalizations include a selective base- or rutheniu

83 rocedures and can be utilized in "any-stage" functionalization, including late-stage azetidinylation

84 4-ABA functionalization induces separation of the RGO layers,

85 directing groups for selective C-H-activated functionalization instead of deprotecting and/or throwin

86 structural characterization of authentic C-H functionalization intermediates, and not kinetically sta

87 onalized piperazinones by utilizing post-Ugi functionalization is described.

88 The synthetic utility of this double C-H functionalization is illustrated by conversion of alipha

89 ility in organic solvents whereas phosphorus functionalization is shown to facilitate decarboxylation

90 but a detailed understanding of the surface functionalization is still lacking.

91 nal materials without the need for a seed or functionalization layer; however, this also leads to sig

92 as reticular materials, surfactants, surface functionalization, light harvesting materials, non-linea

93 The late stage functionalization (LSF) of complex biorelevant compounds

94 tion of E.Coli using a faster and innovative functionalization method that exploit Protein-A/antibody

95 ility of PLA substrates and demonstrated the functionalization method to be stable over a time period

96 This late-stage functionalization method tolerates a remarkably wide ran

97 rated excellent performance of our universal functionalization method, showing limits of detection an

98 Here we report an advance in C-H bond functionalization methodology that enables the introduct

99 ion of the stereogenic axis by efficient C-H functionalization methods is extremely rare and challeng

100 We first briefly introduce different functionalization methods of MOFs with aptamers, which p

101 s) requires specialized fragmentation and/or functionalization methods.

102 he practical application of C(sp(3) )-H bond functionalization methods.

103 (PS) particle models with controlled surface functionalization mimicking the nanoplastics formed duri

104 pecially when they are combined with aptamer functionalization, MOFs can be utilized to construct hig

105 The functionalization occurs at C3 and C2 carbon atoms, resp

106 favorable free energy pathway of late-stage functionalization of (R)-muscone paves the path to desig

107 ald-Hartwig cross-coupling reaction, for the functionalization of 1,2,4,5-tetrazines is presented.

108 Rhodium-catalyzed directed C-H functionalization of 2-arylindazoles with N-sulfonylform

109 sible light-photoinduced protocol for direct functionalization of 2-methylquinolines has been develop

110 eport on the characterization and biological functionalization of 2D MoS(2) flakes, epitaxially grown

111 Acid functionalization of a carbon support allows to enhance

112 six fluoroalkyl analogues through late-stage functionalization of a natural product-derived FDA-appro

113 '-bi-2-naphthol-derived substituents via the functionalization of a readily accessible enantiopure li

114 in synthesis was showcased in the late-stage functionalization of a variety of pharmaceutical compoun

115 ample of Pd(II) -catalyzed gamma-C(sp(3) )-H functionalization of aliphatic and benzoheteroaryl aldeh

116 Herein, we report a direct decarboxylative functionalization of aliphatic carboxylic acids using N-

117 e scope of electrochemistry to the reductive functionalization of alkenes.

118 stereoselective distal allylic/benzylic C-H functionalization of allyl and benzyl silyl ethers was a

119 For these reasons, deaminative functionalization of amines has emerged as an important

120 Here we report a controllable alpha-functionalization of amines in which regioselectivity ca

121 Photocatalytic alpha-functionalization of amines provides a mild and atom-eco

122 n both CO(2) hydrosilylation and reductive N-functionalization of amines using CO(2) as the C(1) sour

123 Key steps in the functionalization of an unactivated arene often involve

124 Direct C-H functionalization of aromatic compounds is a powerful to

125 One manifold for the functionalization of aromatic molecules utilizes diazo c

126 The functionalization of azulenes via reaction with cationic

127 A room-temperature C-H bond functionalization of benzamides has been developed by me

128 ed here is a photocatalytic protocol for the functionalization of benzylic C-H bonds with a wide rang

129 ond-forming step in the copper-catalyzed C-H functionalization of benzylic substrates R-H with alkyne

130 Ir-OTf also competently catalyzed late-stage functionalization of bioactive and drug molecules such a

131 s under environmentally friendly conditions, functionalization of biomacromolecules, and preparation

132 This double-unsymmetrical functionalization of both o,o'-C-H bonds of arene moiety

133 the -OH-containing aryl part and followed by functionalization of bromine through a palladium-catalyz

134 Z isomers, indicating that the covalent bis-functionalization of C(60) can be controlled by light.

135 This approach to direct site-selective functionalization of C(sp(3))-H bonds provides the basis

136 The selective functionalization of C-H bonds is one of the Grails of s

137 ontrol in transition-metal catalysis for the functionalization of C-H bonds under mild conditions.

138 Site-selective functionalization of C-H bonds will ultimately afford ch

139 ng from isomerizations to the stereospecific functionalization of C-H bonds, are employed to generate

140 ion of allylic radical intermediates in beta-functionalization of carbonyls will highlight the common

141 esents the first example of the simultaneous functionalization of CH(4) and CO(2) mediated by single

142 ance, and can be employed for the late-stage functionalization of complex druglike molecules.

143 The functionalization of coordinated dinitrogen to form nitr

144 other methods for the C-C bond cleavage and functionalization of cyclopropanols, including base-medi

145 bornene-mediated Pd-catalyzed meta-C(aryl)-H functionalization of diarylmethylamines.

146 This double functionalization of diazo compounds proceeds via select

147 ther carboxylic acids and its utility in the functionalization of DNA is presented, notably using vis

148 on method that is compatible with late-stage functionalization of drug scaffolds and natural products

149 ue opportunities to achieve smooth and clean functionalization of drugs by unlocking site-specific re

150 an efficient and selective catalyst for the functionalization of ethane in oleum at low temperatures

151 hly regioselective electrophotocatalytic C-H functionalization of ethers is described.

152 ccess to such materials through the C-H bond functionalization of feedstock alicyclic amines, the sim

153 the Pd-catalyzed enantioselective C(sp(3))-H functionalization of free aliphatic amines (cyclopropylm

154 investigation of different reagents for the functionalization of gold nanorod materials are reported

155 Dearomative functionalization of heteroaromatics, a readily availabl

156 alizing separate-sided different single-atom functionalization of hollow graphene.

157 ntific curiosity to an important tool in the functionalization of hydrocarbons.

158 tion of imidazoheterocycles led to the first functionalization of imidazo[1,2-a]pyrimidine cores on t

159 The method is also applicable to the functionalization of important compound classes, such as

160 Methods for direct C3-functionalization of indazoles are relatively rare, comp

161 A new strategy for the C(7)-H functionalization of indoline derivatives using first-ro

162 range of oxidation reactions, including the functionalization of inert C-H bonds, which is a major c

163 Functionalization of iron oxide nanoworms (NWs) and meta

164 The oxidative alpha-functionalization of ketones by external nucleophiles co

165 oxide/DMSO-catalyzed (E)-stereoselective C-H functionalization of ketones with acetylenes followed by

166 hodium carbenes led to highly site-selective functionalization of less activated allylic and benzylic

167 Inhibitor design entailed the functionalization of lithocholic acid at C(3) and at the

168 The PDA functionalization of microcarriers surface not only prov

169 omplexes that can catalyse the reduction and functionalization of molecular dinitrogen, including the

170 The functionalization of molecules by cleaving inert carbon-

171 Functionalization of nanotubes with donor and acceptor p

172 Examples are demonstrated of the late-stage functionalization of natural products and drug molecules

173 tected NHCs, synthetic challenges hinder the functionalization of NHC surfaces with protic functional

174 This research demonstrates the functionalization of opto-electrochemically active ruthe

175 ss of methods for selective modification and functionalization of organic molecules.

176 ite phosphorus (P(4)), the metal-free direct functionalization of P(4) has remained rare.

177 ectron-deficient alkynes allowing for facile functionalization of payload molecules.

178 ein we report a Cu-catalyzed, site-selective functionalization of peptides that employs an aspartic a

179 A strategy involving functionalization of perylene core with several polyhedr

180 In addition, the late-stage functionalization of pharmaceuticals is also presented.

181 n be used for the preparation and late-stage functionalization of pharmaceuticals, as highlighted by

182 A new method for cobalt-catalyzed C(sp(2))-H functionalization of phenylglycinol derivatives with ter

183 However, the undirected functionalization of primary C-H bonds without competing

184 te how the degree of polymerization (DP) and functionalization of PVA impact its IRI.

185 unprecedented, high-yielding dearomative C-4 functionalization of quinolines with organometallics wit

186 n, then it would give rise to deracemizative functionalization of racemic tertiary C-H bonds for ster

187 and ionization energy of GO, supporting the functionalization of Ru(II).

188 bstrates, including synthesis and late-stage functionalization of scaffolds relevant to medicinal che

189 ation of primary C-H bonds without competing functionalization of secondary C-H bonds is rare.

190 ethod for rapid, chemoselective, and modular functionalization of serine residues in native polypepti

191 ethod is demonstrated through the late-stage functionalization of several drug analogues.

192 The selective functionalization of strong, typically inert carbon-hydr

193 This protocol enabled the C-H functionalization of substituted 2-methylquinolines with

194 The results demonstrate that this functionalization of superelastic NiTi is an enabling te

195 thesis of alpha-branched amines by reductive functionalization of tertiary carboxamides and lactams i

196 The development of methods for functionalization of the alpha-methylene C-H bonds of th

197 -aminoalkylboronates is exemplified with the functionalization of the amino group, stereospecific oxi

198 Functionalization of the beta-C-H bonds of aliphatic aci

199 yl sulfone-containing compounds by selective functionalization of the C(sp(3))-H bond adjacent to the

200 as well as the selective post-synthetic C-H functionalization of the core HCTD scaffold at position

201 Through the functionalization of the Janus particles with an antibod

202 of the metal centers, including changing the functionalization of the linkers (replacing oxido donors

203 es, with the specificity provided by aptamer functionalization of the microelectrode surface.

204 of tris- and tetra-adducts formed upon Prato functionalization of the most pyramidalized regions of t

205 nd to be not very sensitive to the degree of functionalization of the nanotube.

206 Functionalization of the oxidized products via cross-cou

207 Functionalization of the oxygen atom is found to stabili

208 ituted phosphoarenes, and in situ downstream functionalization of the products is described.

209 en method for both the synthesis and in-situ functionalization of the QDs.

210 shown that the prerotaxanes allow late-stage functionalization of the ring fragment introducing furth

211 Functionalization of the SCPs with different types of li

212 ith a structural design that presents remote functionalization of the stator with respect to the fluo

213 Functionalization of the surfaces of the QDs with isonic

214 ithout any Raman enhancer), and the flexible functionalization of this material holds great promise f

215 n of amides, occurs by means of a triple C-H functionalization of three unreactive piperidine sp(3) c

216 The organic functionalization of two-dimensional MOLs can generate t

217 high-pressure approach to facile late-stage functionalization of unclosed cryptands (UCs) (11 exampl

218 field, methods for the direct alpha-C-H bond functionalization of unprotected alicyclic amines remain

219 A double functionalization of vicinal sp(3) C-H bonds has been de

220 of a metal soap (Zn-oleate) and the surface-functionalization of ZnO nanoparticles (NPs), which were

221 Instead, the C-O functionalizations of aryl sulfonates will not be covere

222 Site-selective functionalizations of C-H bonds are often achieved with

223 omprehensive picture of the enantioselective functionalizations of C-H bonds by chiral iridium comple

224 transition-metal catalyzed enantioselective functionalizations of carbon-hydrogen (C-H) bonds repres

225 catalysis for the beta- and gamma-C(sp(3))-H functionalizations of ketones are investigated with dens

226 will focus on the recent updates on the C-O functionalizations of less-activated phenol derivatives,

227 c challenge is how to achieve the direct C-O functionalizations of relatively less-activated phenol d

228 Typical functionalizations of the 5,10-diheterotruxene core have

229 , is demonstrated through various downstream functionalizations of the alkyl boron compounds.

230 Towards this end, noncovalent functionalization offers a route to reversibly modify an

231 reparation, and the consequences of chemical functionalization on biodegradability.

232 proach was used to rationalize the effect of functionalization on the free energies of nitrone reacti

233 lectivity of graphene can be enhanced by its functionalization or combination with other materials.

234 mized apparatus, controlled environments, or functionalization or covalent modification of reagents.

235 This modular and versatile biomaterial functionalization platform can provide new opportunities

236 y addressable applications including surface functionalization, polymer conjugation and cross-linking

237 ngs, addition reactions, cycloadditions, C-H functionalizations, polymerizations, hydrogenations, and

238 on the combination of two advanced patterned-functionalization principles, namely, laser-writing and

239 Diastereoselective functionalization processes have also been explored to d

240 This late-stage functionalization protocol generates molecules as comple

241 o-step N1 dealkylation and regioselective N3 functionalization protocol, including computational rati

242 However, different surface functionalization protocols are required, depending on t

243 alyst system to promote a para-selective C-H functionalization reaction from benzylic electrophiles.

244 t area) is controlled by the duration of the functionalization reaction.

245 investigated for this DG-mediated late-stage functionalization reactions along with the crystal struc

246 Expanding the toolbox of C-H functionalization reactions applicable to the late-stage

247 es has inspired the development of novel C-H functionalization reactions as well as mechanistic studi

248 bene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl](2)

249 As such, enantioselective C(sp(3))-H functionalization reactions directed by innate functiona

250 tunity to develop general para-selective C-H functionalization reactions from benzylic electrophiles

251 Transition metal-catalysed allylic functionalization reactions have been established as a c

252 Transition metal-catalysed allylic functionalization reactions involving radicals are compa

253 ation approach for regioselective remote C-H functionalization reactions may lead to the ultimate rea

254 ieving highly regio- and stereoselective C-H functionalization reactions using a newly developed Rh(2

255 products were amenable to various downstream functionalization reactions, including reactions that we

256 oposed mechanisms of Pd-catalyzed C(sp(3))-H functionalization reactions, though few examples of Pd(I

257 reasingly common ligands in Pd-catalyzed C-H functionalization reactions.

258 eir large potential in the field of C-H bond functionalization reactions.

259 ichiometric C-H activation and catalytic C-H functionalization reactions.

260 undation for understanding its rapid methane functionalization reactivity.

261 gration of well-designed m-bots with surface functionalization, remote actuation systems, and imaging

262 The spatial distribution of MOF functionalization reveals that postsynthetic modificatio

263 extensive framework for the analysis of NGS functionalization screens available as an R package call

264 Although synthetic protein functionalization strategies allow mimicry of PTMs(3,4),

265 , environmentally friendly, and customizable functionalization strategy for producing a toolbox of LA

266 conductivity, degree of exfoliation, surface functionalization, strong photoluminescence, strong opti

267 fold enables facile and selective late-stage functionalizations that cannot be accomplished with carb

268 epends on the type of material, the chemical functionalization, the aqueous dispersibility and the re

269 ional and structural tunability, and ease of functionalization, the family of gel materials opens exc

270 h and its ability to provide high degrees of functionalization, the prerequisite of 2D patterning of

271 a "chain-walking" event, to allow for remote functionalization through various termination processes.

272 ctions and sigmatropic rearrangements to C-H functionalizations, thus allowing the rapid construction

273 CF(2)Br intermediates was showcased through functionalization to a variety of enantioenriched alpha,

274 has the significance in terms of late-stage functionalization to access new molecular entities which

275 he synthetic value of these DHIQs by further functionalization to either reduced tetrahydroisoquinoli

276 m phosphine carboxylic acid (PH(2) COOH) and functionalization to form esters is shown to increase th

277 migrate several microns from regions of high functionalization to regions with no prior functionaliza

278 with complementary methods, such as chemical functionalization, to provide tools with unique and usef

279 oprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-b

280 Quinolines undergo catalyst-free double CH-functionalization upon treatment with secondary phosphin

281 raditional cross-coupling reactions with C-H functionalization using the same precatalyst.

282 ls have long been known to enable remote C-H functionalization via 1,5-hydrogen atom abstraction.

283 of this transformation is an unusual remote functionalization via chain walking to the most sterical

284 groups serve as chemical handles for further functionalization via direct cross-coupling, iodination,

285 Further functionalization via gold(I) coordination was demonstra

286 Decarboxylative functionalization via hydrogen atom transfer offers an a

287 presence of epoxy groups allows for further functionalization via nucleophilic substitution reaction

288 The LRP-1-targeted functionalization was essential for delivery of carnosin

289 Alternately, mono-functionalization was regioselectively carried out with

290 In the context of Ni-catalyzed C(sp(3))-O functionalization, we have developed a unique strategy e

291 ility of this new methodology for late-stage functionalization, we have directly derivatized a broad

292 nking strategy that could be used in further functionalization while retaining the excellent photophy

293 QD functionalization with beta-cyclodextrin molecular baske

294 This work describes ETT's functionalization with curcumin photosensitizer, as well

295 long-wavelength variants and enables facile functionalization with different chemical groups.

296 end-capped polymers is illustrated here via functionalization with dyes to yield colored, hydrocarbo

297 mulation techniques that incorporate surface functionalization with peptides for better anticancer ef

298 mical impedance spectroscopy after electrode functionalization with specific anti-PARK7/DJ-1 antibodi

299 of such a biosensor is the simple and direct functionalization with suitable antibodies to ensure the

300 iency in positive-/negative-ion mode and the functionalization yield compared to the previously intro