ライフサイエンスコーパス: functionally

1 rity of these domains have not been analyzed functionally.

2 were then isolated, phenotyped, and assessed functionally.

3 xogenous administration of miR-127, which is functionally activated in target cells, inhibits growth

4 ly prevents cGAS from oligomerizing into the functionally active 2:2 cGAS-dsDNA state.

5 gens in mice to demonstrate the induction of functionally active polyclonal antibody responses as mea

6 s confirmed that the majority of the REs are functionally active, and CREs are more active than TREs

7 We demonstrate this by functionally altering memory CD8 T cells using CRISPR/Ca

8 d potentials and single neuron activity in a functionally and anatomically interconnecting somatosens

9 prosthesis in combination with an IOL having functionally and cosmetically exceptional reconstruction

10 fore, we characterized the human ERICH3 gene functionally and identified ERICH3 mRNA transcripts and

11 mal protein S25 (eS25), which is required by functionally and structurally diverse IRESs, impacts bot

12 ding a whole new level of customization both functionally and visually.

13 ongly support the hypothesis of molecularly, functionally, and spatially distinct subdomains of the p

14 n yeast (Saccharomyces cerevisiae) system to functionally annotate maize (Zea mays) auxin signaling c

15 Assphage failed to detect related phages, or functionally annotate most of the genes, subsequent rean

16 TCF sites and provides a simple approach for functionally annotating the regulatory consequences of C

17 tors that influence substrate selectivity on functionally antagonistic sites in PERIOD that directly

18 We sought to determine whether LTD(4) functionally antagonizes LTC(4) signaling at CysLT(2)R.

19 Functionally, antibody depletion assays demonstrate that

20 naling dynamics patterns are translated into functionally appropriate gene regulation programs.

21 icroscopy (cryo-EM) structure of the channel functionally arrested by tarantula toxin.

22 ctance being large enough for EAAT5 to serve functionally as an "inhibitory" glutamate receptor.

23 ological sensors may be used to identify and functionally assay axo-axonic synapses.

24 we use an intersectional genetic approach to functionally assess the contribution that eight classes

25 ght temporoparietal junction (rTPJ) has been functionally associated with both social behavior and wi

26 atal development, we identified markers that functionally capture the establishment of the mesenchyma

27 s to force trajectories by syringeal muscles functionally changes over vocal development in zebra fin

28 Here, we functionally characterize a binding site for the 3' vRNA

29 Here, we functionally characterize a large cluster of microRNAs (

30 sed Caenorhabditis elegans to systematically functionally characterize ASD-associated genes in vivo.

31 ncestral gene giving rise to a new toxin and functionally characterize both genes in the same species

32 ol designed to bolster efforts to map and to functionally characterize neural circuits.

33 on pairs, thus opening up avenues to further functionally characterize these human genes in a simplif

34 We have functionally characterized 12 TBC (Tre-2/Bub2/Cdc16) dom

35 The CsTPSs described and functionally characterized here include 13 that had not

36 Here, we functionally characterized human TMEM165 by heterologous

37 The few functionally characterized members share a catalytic mec

38 We functionally characterized MM-specific active distant en

39 In this study, we identified and functionally characterized prototypical ANO/SCN/TRPM ion

40 The functionally characterized SmFucTs can also be applied t

41 We functionally characterized that MBIP mediates activation

42 yellow mosaic virus (ZYMV), was employed to functionally characterized the AtSRBP1-4 (AtGRP7/2/4/8)

43 Using a variety of biological resources, we functionally characterized the identified genomic loci.

44 Campylobacter jejuni; however, few have been functionally characterized to date.

45 d in a subset of S. aureus genomes, has been functionally characterized.

46 d mushroom bodies, are both structurally and functionally comparable.

47 In various altricial rodents, OHCs become functionally competent from around postnatal day 7 (P7),

48 Since the discovery of functionally competent, energy-consuming brown adipose t

49 need to be present in the same cell and can functionally complement across cells, maintaining genome

50 in a genetically susceptible host, which was functionally confirmed by bacterial isolation and commen

51 us reductions in OL numbers and myelination, functionally confirming OL transcriptional signatures.

52 rebrovascular lesions in stroke) to identify functionally connected brain networks.

53 is thought to spread across anatomically and functionally connected brain regions.

54 , we determined the network of brain regions functionally connected to each Alzheimer's disease patie

55 ed nigrostriatal pathway is structurally and functionally connected with core regions of the SMN, whe

56 eocortex were at least twice as likely to be functionally connected with the EL_INST compared to the

57 and VASH1-mediated angiogenesis pathways are functionally connected.

58 ing finding that human JPX and mouse Jpx are functionally conserved although they have low similarity

59 clocks in fungi and animals are driven by a functionally conserved transcription-translation feedbac

60 , it remains unclear which of these features functionally contribute to enhancer activity.

61 ese data suggest that miR-149 downregulation functionally contributes to breast tumor progression by

62 Finally, these functionally convergent ASD gene modules predicted share

63 specific target sites impacts expression of functionally coordinated sets of mRNAs and involves comb

64 inhibitor-resistance screen, and identified functionally correlated mutations.

65 dhesion G Protein-Coupled Receptors (aGPCRs) functionally couple to heterotrimeric G proteins has bee

66 hypothesized that ClC-5 and H(+)-ATPase are functionally coupled during H(+)-ATPase-mediated endosom

67 Here we exploit the response dynamics of two functionally coupled Purkinje cell types in the vestibul

68 Functionally, CRC factors contribute significantly to ce

69 To test for a functionally critical C-terminal conformation, calcium i

70 biophysical properties of droplets, RNA is a functionally critical constituent that defines the ident

71 ore, IL6/STAT3 and ER oncogenic pathways are functionally decoupled, highlighting the potential of IL

72 We identified a distinct, anatomically and functionally defined serotonergic subpopulation in the D

73 Functionally, deletion of Bbeta2 and maintained Drp1 Ser

74 roversial, and whether glucose metabolism is functionally different during fully oxidative glycolysis

75 ics assays indicate that B. fragilis UroS is functionally different from canonical bacterial UroS pro

76 ilar in sequence, some of the plant JDPs are functionally different.

77 ole of active STAT5 as a survival factor for functionally differentiated epithelial cells by expressi

78 pontaneous activity pulses may help preserve functionally disconnected sub-circuits.

79 the adaptive immune system is determined by functionally discrete subsets of CD4(+) T cells, but it

80 Here we functionally dissect the Erv46 subunit and define an app

81 identical neurons that serve specialized and functionally dissociable functions.

82 at ventral CA1 (vCA1) projection neurons are functionally dissociable, the basic principles of how th

83 are highly heterogeneous because of multiple functionally distinct alleles for many genes, the presen

84 ring on the same chromosome, each encoding a functionally distinct AOX enzyme.

85 pectroscopy (MRS) may cover anatomically and functionally distinct areas, such as p32 and p24 of the

86 prefrontal networks through connections with functionally distinct areas.

87 hat the C1 cells and the pFRG may constitute functionally distinct but interacting populations for co

88 is broadly defined, and whether it comprises functionally distinct cell subsets is not known.

89 sion are thus controlled by anatomically and functionally distinct circuits, highlighting the diversi

90 ers and co-organize the axis together with 2 functionally distinct cohesin complexes (REC-8 and COH-3

91 ering a shift in population ensembles toward functionally distinct conformational or dynamic states.

92 p of mossy fiber terminals, originating from functionally distinct cortical areas, within crus I, par

93 of the cell surface protein CD26 to identify functionally distinct fibroblast subpopulations in human

94 tions make differential connections with the functionally distinct first-order and higher-order thala

95 reveal that aerobic glycolysis is a process functionally distinct from conventional glucose metaboli

96 hat ancient large-herbivore assemblages were functionally distinct from those that exist today.

97 be new heterogeneity, enabling separation of functionally distinct human satellite cell subpopulation

98 otection from the external environment using functionally distinct layers, cell types and extracellul

99 CPSF contains two functionally distinct modules: a cleavage factor (mCF) a

100 afish are distinct behaviors mediated by two functionally distinct motoneuron (Mn) types.

101 y engrams in the mouse dentate gyrus contain functionally distinct neuronal ensembles, genetically de

102 fication of multiple new enhancers to target functionally distinct neuronal subtypes.

103 re catalyzed by terminase assembled into two functionally distinct nucleoprotein complexes; the matur

104 auditory stimuli suggesting the presence of functionally distinct parallel subnetworks.

105 s support the idea that MCs and TCs comprise functionally distinct pathways for odor information proc

106 y dynamic Wnt-secreting niches that regulate functionally distinct phases of airway regeneration and

107 e, we present the crystal structures of four functionally distinct plant AAAD paralogs.

108 Several topologically and functionally distinct polyubiquitin chains can be assemb

109 s, insulin secretory granules (SGs) exist in functionally distinct pools, displaying variations in mo

110 ained by diffuse release of Ca(2+) through a functionally distinct process.

111 axonomy of the fibrotic milieu characterises functionally distinct stromal cell types and states, inc

112 each region could be further subdivided into functionally distinct subcomponents.

113 ere enriched using this device and these two functionally distinct subpopulations were tested for dif

114 Functionally distinct synapses exhibit diverse and compl

115 ked to the transition from two ancestral and functionally distinct TIM complexes, found in most eukar

116 tep transformation into two structurally and functionally distinct types of macrocyclic derivatives:

117 eg cells in the colon are phenotypically and functionally distinct, but their origins and relationshi

118 Modified DNA bases functionally distinguish the taxonomic forms of life-5-m

119 spite sharing structural homology, they have functionally diverged to suit their distinct cellular ro

120 istinguishes two classes of paralogs: a more functionally divergent subset and another that retained

121 s from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs.

122 tions in eukaryotes, and it does so across a functionally diverse and morphologically disparate range

123 This ensemble of chemically and functionally diverse biomolecules is termed the 'matrixo

124 nse from this regimen was highly durable and functionally diverse for the duration of the study (25 w

125 Plastids are morphologically and functionally diverse organelles that are dependent on nu

126 Several structurally and functionally diverse proteins have been implicated in th

127 of transcription factors and are composed of functionally diverse subsets correlating to their origin

128 : they are genomically, phylogenetically and functionally diverse yet a distinct group of environment

129 Many are functionally dominated by macroalgae, but this community

130 However, they are largely dormant functionally, due to IFN-I-induced negative regulators.

131 Here, we show that SWELL1 (Lrrc8a) functionally encodes a swell-activated anion channel tha

132 sue engineering, shear-induced gelation, and functionally engineered rheology crucially depend on mic

133 [(225)Ac]hu11B6-IgG(3) was a functionally enhanced alternative to [(225)Ac]hu11B6-IgG

134 Functionally, enhanced ROS in Angpt2-silenced tumor cell

135 tissue-specific functions, and marked genes functionally enriched for tissue-specific processes.

136 GF-beta, whether all sources of TGF-beta are functionally equivalent is unknown.

137 his result indicates that the Hv2OGO gene is functionally equivalent to its Arabidopsis counterpart a

138 MARCKS binds with its functionally essential effector domain (ED) to polysiali

139 ultidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based o

140 Functionally, exosomes with the Nogo-66 domain on their

141 whole tissues, but CD38 did not appear to be functionally expressed by SMCs or ICC.

142 Functionally, genetic-inducible endothelial deletion of

143 lows a simple one-step route for fabricating functionally graded materials by controlling the stress

144 t defense, but whether MP CD4(+) T cells are functionally heterogeneous and, if so, what signals spec

145 ed fibroblasts (CAFs) are phenotypically and functionally heterogeneous.

146 Functionally, high expression of SDCBP is positively rel

147 n that hyperactivity is present throughout a functionally homogeneous CA3 network.

148 nance versus a newly established barrier and functionally identify differential ceramide synthase 4 p

149 LF proteins made the mutant C57BL/6J CD300LF functionally impaired and the corresponding mutant of I/

150 SP on regulatory T cells (Tregs), which are functionally impaired in DED, remains unclear.

151 2 mutants that are implicated in disease are functionally impaired to a degree that correlates with t

152 somal Sm site but the engineered U7 snRNP is functionally impaired.

153 Functionally important AGP glycans are synthesized in th

154 ility, including four previously identified, functionally important CHIKV RNA structures.

155 sets are often incomplete and may be missing functionally important content and strain variation.

156 These results show that the DPR is a functionally important core promoter element that is wid

157 This approach allowed us to identify functionally important eQTLs and show mechanisms that ex

158 ggest that the MUN-bound template complex is functionally important for SNARE assembly and neurotrans

159 These methods help to identify functionally important genes because they test for assoc

160 red flexible linkers (DFLs) are abundant and functionally important intrinsically disordered regions

161 world and are known to be rich resources of functionally important microorganisms.

162 This revealed a functionally important patch of residues that forms amin

163 Functionally important regions, including the NTD beta-h

164 ed by natural selection from genes and other functionally important regions.

165 Capturing the folding dynamics of large, functionally important RNAs has relied primarily on glob

166 self-reported Native Hawaiians (N = 3693) a functionally important, Polynesian-specific variant in t

167 deficits in submucosal neurons are reflected functionally in delayed gastric emptying, slowed colonic

168 a (17-37 days) following CA who recovered to functionally independent behavioral levels.

169 , 39 (15%) were dependent, and 32 (12%) were functionally independent.

170 amma is active, though both gamma and delta' functionally influence an adjacent gamma subunit.

171 s the entire pri-miR-17-92 cluster and hence functionally inhibits all six miRNAs emanating from it.

172 t tumor/brain-interface often exist behind a functionally intact blood-brain barrier (BBB), and so ar

173 vided somewhat limited insight into how they functionally integrate during the assembly process.

174 trated that regenerating corticospinal axons functionally integrate into spinal circuits.

175 se is a minimal enzyme, and its subunits can functionally interact with subunits from other bacteria.

176 We show that Sox17 functionally interacts with the canonical Wnt pathway to

177 Here, we show that NUCKS1 physically and functionally interacts with the DNA motor protein RAD54.

178 that although HflX and the RRF/EF-G pair are functionally interchangeable, HflX is expressed at low l

179 ostructural organization was mirrored in its functionally interconnected circuits with the anterior c

180 idine and return of consciousness (ROC) in a functionally interconnecting somatosensory and ventral p

181 In particular, ASOs are frequently used to functionally interrogate long noncoding RNAs (lncRNAs) a

182 er, our studies illustrate the importance of functionally interrogating diverse tumour phenotypes dri

183 espondingly high-throughput assay exists for functionally interrogating individual isoforms.

184 Functionally, knockout of SNORD42A reduced colony format

185 Functionally, lack of SerpinB2 in aged knockout mice had

186 Functionally, leaf growth was decoupled from photosynthe

187 Functionally, leukocyte adhesion and integrin activation

188 With these tools, GO can be exploited to functionally link BE events at endogenous genomic loci t

189 Shotgun metagenomic analysis functionally linked 26 metabolic pathways to the diurnal

190 Here we show that FERONIA controls several functionally linked conditions to prevent the penetratio

191 on human GC B cells and identified multiple functionally linked subpopulations, including the distin

192 We functionally localized modifiers of cAMP signaling, the

193 Moreover, functionally localized, body-selective visual cortex res

194 lectrophysiology in Xenopus laevisoocytes to functionally map the determinants of S4 helix motion dur

195 icate that preferential connectivity between functionally matched patches is a prominent organization

196 ng development before becoming quiescent and functionally mature.

197 uggest that the antibody/Fc-receptor complex functionally mimics viral receptor in mediating viral en

198 The 35 kDa OCP is structurally and functionally modular, consisting of an N-terminal effect

199 ulation, are enriched dorsolaterally and are functionally modulated by ethanol.

200 Functionally, MOF is found in two distinct complexes: NS

201 ies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange.

202 colon were associated with structurally and functionally more diverse and variable microbial communi

203 or further investigation of the role of this functionally multifaceted transcription factor in enhanc

204 Functionally, naive B cells expressing moderate levels o

205 rge majority (89%) of missense variants were functionally neutral, perhaps unexpectedly in light of i

206 Deletion of this N terminus leads to functionally non-inactivating channels and structures of

207 Furthermore, FGF9-FGFR3 signaling functionally opposed FGF10-FGFR2b signaling, and FGFR3 p

208 mates, the pulvinar is a topographically and functionally organized thalamic nucleus that is largely

209 parallelization of molecularly distinct but functionally overlapping pathways.

210 strates via docking motifs, but the range of functionally permissible motif sequences is often poorly

211 d or more genes may confer risk for ASD when functionally perturbed, however, only around 100 genes c

212 ognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally disti

213 Functionally, platelets were hyperactivated in COVID-19

214 Functionally, rapid spontaneous transitions between sele

215 Functionally, re-expression of PINCH-1, but not that of

216 as purified from Torpedo electric tissue and functionally reconstituted in lipids optimal for cryo-el

217 t coupling ligand-based redox chemistry with functionally redox-inactive Ni centers enables oxidative

218 ing genome packaging; furthermore, there are functionally redundant binding sites in viral RNA.

219 ted pattern of Fgf8 expression suggests that functionally redundant FGF ligands may contribute to ves

220 ignalling molecules RSPO1 and RSPO3 act in a functionally redundant manner to permit WNT/beta-catenin

221 h we designate here PgnE, that appears to be functionally redundant to pelX In line with this, a Delt

222 ssay, we found that C2 and C10 are partially functionally redundant, and some but not all disease-cau

223 logs have similar activities and are largely functionally redundant.

224 Stem cell treatments are thought to functionally regenerate the urethral sphincter in patien

225 Furthermore, LIMK1/2 functionally regulated cell invasiveness, in part, by di

226 B*44 alleles which form the B44 supertype of functionally related alleles (0.29, 95% CI, .14-.60).

227 entify a role of Ppargamma as regulator of a functionally related class of AF-miRNAs.

228 bstantially with other modules projecting to functionally related cortical regions.

229 the mutation frequencies of these and other functionally related genes are largely unknown, particul

230 ng statistical-learning, we demonstrate that functionally related genes cluster by morphotypic simila

231 rain, involving networks of co-expressed and functionally related genes.

232 experiments in the dataset in the context of functionally related metabolic reaction modules identifi

233 We report widespread, recurrent, and functionally relevant 3'-UTR alterations associated with

234 eceptor ligands were able to induce distinct functionally relevant conformational changes of arrestin

235 e findings demonstrate the capacity to image functionally relevant conformational processes in biolog

236 enable megafaunal populations to recover to functionally relevant densities.

237 curred later than those of LOC, supporting a functionally relevant feedback modulation from LOC to EV

238 hysiology subsequently revealed that 21a had functionally relevant interactions with both the C-termi

239 ies (TWAS) show increased power in detecting functionally relevant loci by leveraging expression quan

240 plored potential crosstalk between these two functionally relevant pathways to coordinate their growt

241 rotein kinase (TYK2) inhibitor which shows a functionally relevant potency shift between human and pr

242 parable to those in measurements of weak but functionally relevant self-generated fields and to those

243 Renal resident cells were the most functionally relevant source of AREG.

244 fluence of outdated D1-SPN plasticity within functionally relevant striatal territories to reshape vo

245 try and ion mobility spectrometry, revealing functionally relevant structural attributes.

246 This was functionally relevant, as deletion of RUNX1 in ccRCC cel

247 iation of HAT1 with nascent chromatin may be functionally relevant, as HAT1 loss decreased replicatio

248 an effective combinatory strategy to promote functionally-relevant axon regeneration of adult neurons

249 reby a single ion channel mediates distinct, functionally-relevant ionic signatures on demand.

250 disease (PD) models, whether and how grafts functionally repair damaged neural circuitry in the adul

251 The M. smegmatis Tam functionally replaced Escherichia coli BioC both in vivo

252 The selected mutations define a functionally reproducible evolutionary trajectory.

253 situ, but only N-cadherin was activated and functionally required during metastasis.

254 anges after injury of the adult spinal cord, functionally resembling the immature active-stem cell ni

255 athic pain, however, the cell types that are functionally responsible for mediating this protective e

256 Thus, we show that myeloid-derived IL-33 functionally restrains colitic disease, whereas intestin

257 upstream attenuator hairpin activity is also functionally retained in both viruses, despite differenc

258 and has important implications for design of functionally selective GPCR-targeted drugs.

259 o-dimensioned electrodes to achieve improved functionally selective recording.

260 mically sensitive in the inundated areas and functionally sensitive in the emerged areas.

261 These results demonstrate that a functionally significant neural entrainment can occur at

262 Cancer Cell, it is shown that, when EZH2 is functionally silenced, HR+, CARM1-high, high-grade serou

263 convergent evolution of phylogenetically or functionally similar associations in diverse lineages (p

264 were common to both mouse lines, indicating functionally similar effects on the transcriptome and be

265 s represent different conformations of these functionally similar metazoan channels.

266 Benchmarking CIPR against existing functionally similar software revealed that our algorith

267 d trophoblast stem cells are molecularly and functionally similar to trophoblast stem cells derived f

268 nt in terms of taxonomic composition, may be functionally similar with respect to the enzymatic trans

269 n general principles of self-organisation in functionally specialised dendrites.

270 ensifies pollen limitation, ecologically and functionally specialized plants are at risk of pollen li

271 notypes induced by P. gingivalis, indicating functionally specialized roles for bacteria in oncogenic

272 ion of principal cells, we find evidence for functionally specialized subpopulations of stromal cells

273 ne expression programs that produce multiple functionally specialized T helper (Th) subsets.

274 inates from a linear combination of diverse, functionally specialized, lamina-specific, and topograph

275 In conclusion, we reveal a functionally specific role of PFN2 as a stable interacto

276 markers, increased PGC1alpha expression, and functionally suppressed invasion within PGC1alpha-silenc

277 the need for improved tools to identify and functionally test transcriptional components to define t

278 Functionally the latter underlines the idea of a primari

279 Because macrophages are functionally the most important cells in obesity-induced

280 Functionally, the apoptotic metabolite secretome induced

281 Functionally, the HMGB2-TOP1cc-cGAS axis determines the

282 Functionally, the mutation increases JAK1 activity and t

283 Functionally these cells initiate stem cell cultures and

284 Functionally, TICAM2 deficient mice were protected from

285 IM-BP) connects release sites physically and functionally to the ELKS family Bruchpilot (BRP)-based s

286 Functionally, UBR5 suppressed MYC-mediated apoptosis in

287 dentified the PDI family member P4HB and the functionally uncharacterized protein NT5DC2, a member of

288 rferes with EL targeting of mitochondria and functionally uncouples BAX clustering from cytochrome c

289 viruses encode smaller, unessential, and/or functionally undefined in-frame versions of A/A*-like pr

290 Here, we identify and functionally validate a CRC 'trio' constituted by three

291 To functionally validate these findings, we utilized an ex

292 lele was created to generate this model, and functionally validated by in vitro, ex vivo and in vivo

293 s of cell-specific alternative splicing of a functionally validated exon in normal and disease states

294 Finally, we refined and functionally validated the sorting strategy for the HSCs

295 NA synthesis increased mRNA at paired genes, functionally validating enhancer-gene predictions.

296 Functionally, we demonstrate that ACh contributes to sus

297 Functionally, we establish that the NEIL3 GRF domain inh

298 ropy as a surrogate for differentiated state functionally, we identified increased CD44 as a characte

299 r a direct measurement of neural activity in functionally well-characterized brain networks, we prese

300 ith diverse genes during growth and overlaps functionally with the other heat-shock protease-encoding