ライフサイエンスコーパス: functionally distinct

1 The four cell classes were functionally distinct.

2 nterventions, are both pharmacologically and functionally distinct.

3 properties suggesting that these states are functionally distinct.

4 rsus those fusing in response to stimuli are functionally distinct.

5 arization states, or phenotypes, that may be functionally distinct.

6 best explained by either G, G + E or GxE are functionally distinct.

7 Cells assemble and maintain functionally distinct actin cytoskeleton networks with v

8 clin D1 (Ccnd1) mRNA was associated with two functionally distinct AGO-miR complexes.

9 are highly heterogeneous because of multiple functionally distinct alleles for many genes, the presen

10 These data support a model whereby these two functionally distinct allosteric networks cooperate to t

11 Four functionally distinct alphabeta heterodimers are assembl

12 These tendons are functionally distinct and are also among the most common

13 of gamma-tubulin that are biochemically and functionally distinct and differentially regulated.

14 each skeletal MyBP-C isoform's N terminus is functionally distinct and has modulatory capacities that

15 variate analyses revealed the recruitment of functionally distinct AnG subregions during the retrieva

16 n entorhinal cortex (ERC) is subdivided into functionally distinct anterolateral (alERC) and posterom

17 ring on the same chromosome, each encoding a functionally distinct AOX enzyme.

18 molecular features that make these proteins functionally distinct are poorly defined.

19 n about the factors guiding the emergence of functionally distinct areas in the brain.

20 eys of both sexes, we investigated how these functionally distinct areas may interact through pregenu

21 neurons (Glut4 neurons) in anatomically and functionally distinct areas of the CNS.

22 somatosensory cortex (S1), two adjacent but functionally distinct areas, display striking difference

23 pectroscopy (MRS) may cover anatomically and functionally distinct areas, such as p32 and p24 of the

24 prefrontal networks through connections with functionally distinct areas.

25 Taxonomically, metabolically and functionally distinct bacterial communities developed be

26 neurons that operate within anatomically and functionally distinct brain regions.

27 hat the C1 cells and the pFRG may constitute functionally distinct but interacting populations for co

28 These data demonstrate functionally distinct, but cooperative, roles for each k

29 multiple alphabeta T cell lineages that are functionally distinct, but mechanisms that control this

30 eg cells in the colon are phenotypically and functionally distinct, but their origins and relationshi

31 (IP(3)) and ryanodine may be located in two functionally distinct Ca(2+) stores.

32 dentified, suggests that animals can produce functionally distinct calls that are built in a way supe

33 rodent astroglia subtypes are regionally and functionally distinct, can regulate local neuronal dendr

34 Moreover, miR-128, miR-9, and let-7 are functionally distinct; capable of specifying neurons for

35 ral killer (NK) cells have been divided into functionally distinct CD3(-) CD56(bright) CD16(-) and CD

36 Here, we show that four functionally distinct cell classes can be robustly ident

37 nstrate that ES and LS neurons represent two functionally distinct cell classes in the CeL and intera

38 LC projection mapping revealed functionally distinct cell modules with specific anatomi

39 nism relies on cell interactions between two functionally distinct cell populations, and we present e

40 is broadly defined, and whether it comprises functionally distinct cell subsets is not known.

41 at miRNA profiles differ dramatically across functionally distinct cell types of the mouse jejunal in

42 both robustly and variably expressed across functionally distinct cell types of the murine jejunal e

43 ur experiments provide new insights into the functionally distinct cell types present at the maternal

44 o computing spatial information, composed of functionally distinct cell types such as place and grid

45 work has not accounted for the diversity of functionally distinct cell types that make up the immune

46 ed the decomposition of complex tissues into functionally distinct cell types.

47 Due to functionally distinct cell-mediated immunity, newborns a

48 in our body share largely identical DNA, yet functionally distinct cells are generated to give rise t

49 ion of SPT activity differentially regulates functionally distinct ceramide synthase activities as pa

50 ry cell walls, a requirement for two or more functionally distinct CESA isoforms for secondary cell w

51 cent polypeptide dictates the recruitment of functionally distinct chaperones.

52 vent this difficulty and show that a pair of functionally distinct chestnut-crowned babbler (Pomatost

53 ults demonstrate new mechanistic insights of functionally distinct CHK1 activities and highlight a po

54 demonstrate that H3K9me2 and H3K9me3 define functionally distinct chromatin states and uncover a mec

55 igenome analyses highlight the importance of functionally distinct chromatin states for accurate cell

56 sion are thus controlled by anatomically and functionally distinct circuits, highlighting the diversi

57 ntify multiple classes of epigenetically and functionally distinct cis-regulatory elements (CREs).

58 recovery kinetics to synaptic volume in two functionally distinct classes of cells: primary and seco

59 ons of the flip/flop cassette generating two functionally distinct classes of partially and fully TAR

60 verse HCV strains, assigning the NAbs to two functionally distinct clusters.

61 In metazoans this enzyme is found in two functionally distinct coactivator complexes, SAGA (Spt A

62 speech perception, as in other domains, two functionally distinct coding schemes have been proposed

63 We present evidence that two functionally distinct cognitive abilities, general and s

64 ers and co-organize the axis together with 2 functionally distinct cohesin complexes (REC-8 and COH-3

65 Here, we show two populations of functionally distinct cohesin on chromosomal arms using

66 n microhabitats within each host would shape functionally distinct communities.

67 mTOR kinase acts in two functionally distinct complexes, mTOR complex 1 (mTORC1)

68 g, which is mediated by two structurally and functionally distinct complexes, mTORC1 and mTORC2, has

69 hat drives the dynamic assembly of these two functionally distinct complexes.

70 tein operates as part of two molecularly and functionally distinct complexes.

71 sts of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular

72 that the same underlying circuit implements functionally distinct computations.

73 ering a shift in population ensembles toward functionally distinct conformational or dynamic states.

74 not able to predict the presence of the two functionally distinct conformations just from the knowle

75 ed whether Abeta can assume structurally and functionally distinct conformations within the brain.

76 ther these spatial relationships vary across functionally distinct cortical areas are not known.

77 p of mossy fiber terminals, originating from functionally distinct cortical areas, within crus I, par

78 ns that are also reciprocally connected with functionally distinct cortical regions, differentially i

79 ed connectivity and synaptic signaling among functionally distinct corticospinal populations in Fisch

80 testinal tumors can contain dynamic pools of functionally distinct CSC populations, which seem to int

81 ions between different m(6)A sites and three functionally distinct cytoplasmic YTHDF m(6)A-binding pr

82 alpha- and gamma-proteobacteria requires two functionally distinct dehydratases, FabA and FabZ.

83 cluster cells to distinct groups and reveal functionally distinct differences.

84 as a switch that regulates the expression of functionally distinct DmNmnat variants.

85 Spatially and functionally distinct domains of heterochromatin and euc

86 cording to this model, GPIHBP1 comprises two functionally distinct domains: (1) an intrinsically diso

87 cceptor interactions with three structurally/functionally-distinct donor classes including organic dy

88 Thus, there are functionally distinct dopamine populations in the VTA fo

89 ptic inputs, and project to anatomically and functionally distinct downstream targets, including the

90 rated that the E6AP/UBE3A ligase harbors two functionally distinct E2 approximately ubiquitin-binding

91 o velocity, requiring ordered binding at two functionally distinct E2 approximately ubiquitin-binding

92 SNPs have revealed two functionally distinct ecotypes overlapping in the Centra

93 tion of MICU1 and MICU2, two paralogous, but functionally distinct, EF-hand Ca(2+)-binding proteins.

94 ns of innate-like T cells differentiate into functionally distinct effector subsets during their deve

95 suggesting that RELMalpha and RELMbeta have functionally distinct effects on immunity and inflammati

96 enable the derivation of cardiomyocytes and functionally distinct endothelial cell (EC) subtypes fro

97 Notably, we detected a novel class of functionally distinct enhancers enriched in H2BK20ac but

98 d connectivity of spatially intermingled but functionally distinct ensembles.

99 When we do so, does our brain split into functionally distinct entities?

100 Separation of the functionally distinct ESCRT-0 and SNX-1/RME-8 microdomai

101 ganized into hierarchical classifications of functionally distinct families and sub-families.

102 tinguishes these two closely related, though functionally distinct, families.

103 of the cell surface protein CD26 to identify functionally distinct fibroblast subpopulations in human

104 r findings describing anatomically discrete, functionally distinct fibroblast subsets with non-overla

105 tions make differential connections with the functionally distinct first-order and higher-order thala

106 Up to 53% of each mapped, functionally distinct forest presents an opportunity for

107 The two functionally distinct forms of gH/gL present in HCMV mak

108 Melanoma cells can adopt two functionally distinct forms, amoeboid and mesenchymal, w

109 ctors Nfil3 and T-bet but phenotypically and functionally distinct from adipose mature natural killer

110 oth muscle actin and are morphologically and functionally distinct from adjacent precapillary smooth

111 evidence suggests that neonatal immunity is functionally distinct from adults.

112 Like Bqt4, MtgA has meiotic roles but is functionally distinct from Bqt4 as MtgA is not required

113 CD133(+) cells were functionally distinct from CD133(-) cells and showed inc

114 racterized by a high expression of CD163 and functionally distinct from classical bone marrow-derived

115 The ipRGCs are structurally and functionally distinct from classical rod/cone photorecep

116 ses of GM-CSF dendritic cells (DCs) that are functionally distinct from conventional DCs (cDCs) and d

117 reveal that aerobic glycolysis is a process functionally distinct from conventional glucose metaboli

118 rocompartment and demonstrate that CsoS2B is functionally distinct from CsoS2A in the assembly of alp

119 bdomains, which are structurally similar but functionally distinct from each other.

120 collected from Crohn's disease patients are functionally distinct from gut microbiota collected from

121 15, Hxt16 and Hxt17 are phylogenetically and functionally distinct from known polyol transporters.

122 assayed conditions, suggesting that m6Am is functionally distinct from m6A.

123 T cells (recent thymic emigrants [RTEs]) are functionally distinct from naive T cells that have compl

124 embryonic piwi-1+ cells are molecularly and functionally distinct from neoblasts: they express uniqu

125 ll population but were transcriptionally and functionally distinct from other secondary effector memo

126 g S-phase itself, respectively, and hence is functionally distinct from previously identified MGS-ass

127 LRCs are molecularly and functionally distinct from reporter-marked reserve ISCs.

128 e data indicate that human ex-Th17 cells are functionally distinct from Th1 and Th17 cells, and sugge

129 ialized vasculature that is structurally and functionally distinct from that of the periphery.

130 MP3 indirectly targets MICB with a mechanism functionally distinct from that of ULBP2.

131 eposited in a form which is structurally and functionally distinct from the ECM-constituting fibrilla

132 work identifies a fibroblast subtype that is functionally distinct from the pro-fibrotic alphaSMA-exp

133 Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts.

134 sue-resident memory (Trm) CD8(+) T cells are functionally distinct from their circulating counterpart

135 RTEs are functionally distinct from their more mature but still n

136 lls (BRM cells) that were phenotypically and functionally distinct from their systemic counterparts.

137 hat ancient large-herbivore assemblages were functionally distinct from those that exist today.

138 Thus, BMAT is functionally distinct from WAT and BAT.

139 These electrodes were intermixed with, yet functionally distinct from, sites that encoded different

140 FtsZ2-1, a close paralog of FtsZ2-2, and the functionally distinct FtsZ1-1, indicating more relaxed c

141 aterians, the Shaker family consists of four functionally distinct gene families (Shaker, Shab, Shal,

142 cells and increases the effective number of functionally distinct gene products.

143 SNPs to compare the genetic contributions of functionally distinct genomic regions for five agronomic

144 ration of variable ligand-dependence amongst functionally-distinct GHSR(1a) populations is used to ge

145 Finally, we show that functionally distinct glioblastoma stem cells can be sep

146 rks but also divides these states into three functionally distinct groups, of which only one specific

147 We identified two functionally distinct groups, one overlapping with the c

148 nd plasticity measures form structurally and functionally distinct groups.

149 Multiple mechanisms allow functionally distinct guide RNAs for transposition: a co

150 tudy suggests that although often considered functionally distinct, H3K9me3 and H3K27me3 may share a

151 We show that H3K9me2 defines a functionally distinct heterochromatin state that is suff

152 , leading to the production of at least four functionally distinct heterodimers from only five subuni

153 ceptors to mimic the ligand specificities of functionally distinct homologs.

154 be new heterogeneity, enabling separation of functionally distinct human satellite cell subpopulation

155 that are both geographically restricted and functionally distinct, i.e. supporting rare traits and f

156 We propose the existence of two functionally distinct IMD networks, one in insects and a

157 ents indicate that BnMS5(a) and BnMS5(c) are functionally distinct in B. napus and that BnMS5(d) can

158 o colony morphologies were taxonomically and functionally distinct in the North Atlantic and North Pa

159 ive expansion of only the histologically and functionally distinct inner cortex.

160 asses of HSP proteins, previously considered functionally distinct, into a unifying pathway for axona

161 3)- and Ry-receptors are associated with two functionally distinct intracellular Ca(2+) stores, respe

162 gression, alternative mRNA splicing produces functionally distinct isoforms of Mena, an actin regulat

163 tem, alternative pre-mRNA splicing generates functionally distinct isoforms that play key roles in no

164 herbivore community structure and identified functionally distinct landscape-scale herbivory regimes

165 otection from the external environment using functionally distinct layers, cell types and extracellul

166 ates, Endothelin signaling involves multiple functionally distinct ligands (Edns) and receptors (Ednr

167 GluMIs and type 2 OFF bipolar cells possess functionally distinct light-driven responses and may the

168 dometrial epithelial lineages, including the functionally distinct luminal and glandular epithelia, t

169 ling a hierarchy of monocyte contribution to functionally distinct macrophage subsets.

170 AcrVA4 and AcrVA5) block Cas12a activity via functionally distinct mechanisms, including a previously

171 that hair cells express two molecularly and functionally distinct mechanotransduction channels with

172 We have identified two functionally distinct membrane-binding regions in ATG16L

173 The temporally separated and functionally distinct modifications are manifested by ad

174 ucting pore of TMEM16A is constituted of two functionally distinct modules: a Ca(2+)-binding module f

175 CPSF contains two functionally distinct modules: a cleavage factor (mCF) a

176 criptional network can be divided into three functionally distinct modules: Polycomb, Core, and Myc.

177 We also identify a related but functionally distinct motif in XLF, WRN, MRI and PAXX, w

178 afish are distinct behaviors mediated by two functionally distinct motoneuron (Mn) types.

179 ytic subunit in two structurally related but functionally distinct multi-component kinase complexes,

180 mTOR forms two functionally distinct multiprotein complexes, mTOR Compl

181 terization of a phylogenetically related yet functionally distinct N-methyltransferase (NMT) from opi

182 q) and RNA sequencing, respectively, in four functionally distinct neural cell types: induced pluripo

183 tory receptors integrate into segregated and functionally distinct neural pathways.

184 he vertebrate spinal cord comprises multiple functionally distinct neuronal cell types arranged in ch

185 Synapses are functionally distinct neuronal compartments that are cri

186 y engrams in the mouse dentate gyrus contain functionally distinct neuronal ensembles, genetically de

187 We characterize these functionally distinct neuronal populations by comparing

188 ng is dynamically regulated between the many functionally distinct neuronal populations of the brain.

189 fication of multiple new enhancers to target functionally distinct neuronal subtypes.

190 r time to sequentially produce six layers of functionally distinct neurons.

191 lived and are divided into two spatially and functionally distinct niches in the retina.

192 of this study was to investigate the role of functionally distinct NK cell subsets in alloimmunity wi

193 ificity of NPY release is conferred by three functionally distinct NPY+ cell types, with differences

194 re catalyzed by terminase assembled into two functionally distinct nucleoprotein complexes; the matur

195 It is the most structurally and functionally distinct P2X subtype, containing a unique c

196 rimary visual cortex (V1) are organized into functionally distinct parallel processing streams.

197 auditory stimuli suggesting the presence of functionally distinct parallel subnetworks.

198 nd structural modeling of ABHD5 and ABHD4, a functionally distinct paralog that diverged from ABHD5 5

199 s support the idea that MCs and TCs comprise functionally distinct pathways for odor information proc

200 -specific interventions in the GPe to target functionally distinct pathways, with the potential to in

201 These effects involved functionally distinct pathways.

202 at primate visual cortex is divided into two functionally distinct pathways.

203 y dynamic Wnt-secreting niches that regulate functionally distinct phases of airway regeneration and

204 hus, the consolidation of LTM depends on two functionally distinct phases of protein synthesis: an ea

205 e, we present the crystal structures of four functionally distinct plant AAAD paralogs.

206 Several topologically and functionally distinct polyubiquitin chains can be assemb

207 binding proteins as a mechanism to establish functionally distinct pools of a single transcript speci

208 s, insulin secretory granules (SGs) exist in functionally distinct pools, displaying variations in mo

209 synaptic vesicles which are segregated into functionally distinct pools.

210 synaptic vesicles which are segregated into functionally distinct pools.

211 find that dynein can be in biochemically and functionally distinct pools: either tracking dynamic mic

212 ly be more informative to focus attention on functionally distinct portions of genes.

213 at junctions, contractile pericytes within a functionally distinct postarteriole transitional region

214 itivity utilizes kinetically, regulatory and functionally distinct pressure transducers to inform the

215 , using 98-channel microelectrode arrays, in functionally distinct primary somatosensory areas 3b and

216 ained by diffuse release of Ca(2+) through a functionally distinct process.

217 entrainment in delta and theta bands reflect functionally distinct processes.

218 ve of the current study was to determine how functionally distinct proinflammatory and anti-inflammat

219 , in DA neurons enhanced cocaine seeking via functionally distinct projections to forebrain limbic re

220 mitotic subunits endow septin complexes with functionally distinct properties.

221 uggest that the phenotypic specialization of functionally distinct proprioceptor subtypes depends, in

222 ernative splicing event to generate multiple functionally-distinct proteins.

223 One gene can give rise to many functionally distinct proteoforms, each of which has a c

224 t subnuclei of this region are populated two functionally distinct PV-IN networks.

225 eir regulatory activity is associated with a functionally distinct Qa-1(b)-dependent population coexp

226 YUC8 uncovered functionally exchangeable and functionally distinct regions in both proteins, which is

227 MB communities in the colon and jejunum, two functionally distinct regions of the gastrointestinal tr

228 interacting with the lncRNA Firre and three functionally distinct regions of the lncRNA Xist.

229 Thus, two structurally and functionally distinct regions underlie the majority of s

230 The LHb contains two anatomically and functionally distinct regions: lateral (LHbl) and medial

231 and STAT5B, and the extent to which they are functionally distinct, remain uncertain.

232 Here we examine 2 functionally distinct replicons in the same cells to dis

233 These anatomically and functionally distinct responses may contribute to the ho

234 Our results reveal functionally distinct roles of different regions of Tim1

235 Our results provide further ground for the functionally distinct roles played by various types of n

236 and distinct subregions of the same ICN have functionally distinct roles with other ICNs at 2 frequen

237 or eRpL22 function, and that paralogues have functionally distinct roles, not yet defined.

238 e-selective activity suggests that, although functionally distinct, scene and object processing pathw

239 Object size is represented by functionally distinct sectors along the ventral visual p

240 We show that the ATF2 TAD is controlled by functionally distinct signaling pathways (JNK and p38) t

241 In this study, we generated two functionally distinct sorafenib-resistant human Huh-7 HC

242 Our results identify four functionally distinct spike-waveform-based cell classes

243 ation and diversification of synapses across functionally distinct spinal regions and advance our gen

244 sh that P-SSCs are a long-term repopulating, functionally distinct SSC subset responsible for lifelon

245 lls progressed through transcriptionally and functionally distinct stages and provided differential s

246 V2 cytochrome oxidase stripes participate in functionally distinct streams of visual information proc

247 axonomy of the fibrotic milieu characterises functionally distinct stromal cell types and states, inc

248 The mammalian brain is composed of numerous functionally distinct structures that vary in size withi

249 ing, we found that blood is detected by four functionally distinct stylet neuron classes, each tuned

250 During thymus organogenesis, these functionally distinct sub-lineages are thought to arise

251 Our analysis revealed two functionally distinct subclasses of release sites differ

252 dendrites likewise contain structurally and functionally distinct subcompartments.

253 each region could be further subdivided into functionally distinct subcomponents.

254 c remodeling of relative excitatory drive to functionally distinct subcortical neuronal output popula

255 ngs reveal anatomically, physiologically and functionally distinct subdivisions of the SPB tract that

256 e hippocampus itself contains several small, functionally distinct subfields, examining the role of t

257 We define functionally distinct subnetworks of the structural conn

258 revealed that each network consists of three functionally distinct subnetworks: (i) a core, consistin

259 al CR-expressing cells comprise at least two functionally distinct subpopulations based on their resp

260 er SNc dopaminergic neurons in mice comprise functionally distinct subpopulations distinguished by th

261 Identification of functionally distinct subpopulations in this disease is

262 ere enriched using this device and these two functionally distinct subpopulations were tested for dif

263 t the noradrenergic system contains multiple functionally distinct subpopulations.

264 T(reg) cells consist of at least three functionally distinct subpopulations.

265 ated, providing support for the existence of functionally distinct subregions along the parahippocamp

266 iate fMRI analyses, we provide evidence that functionally distinct subregions of angular gyrus (AnG)

267 ated 256 thalamocortical cells spread across functionally distinct subregions of the visual thalamus.

268 Adherent-invasive Escherichia coli (AIEC), a functionally distinct subset of resident intestinal E. c

269 could be subdivided into phenotypically and functionally distinct subsets based on CD5, CD163, and C

270 ls can be classified into phenotypically and functionally distinct subsets based on levels of CD56 re

271 varied across stimulus dimensions and across functionally distinct subsets of boutons.

272 gh differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T hel

273 ctions transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in p

274 onse evolves during MeV clearance to produce functionally distinct subsets of MeV-specific CD4(+) and

275 These posttranslational modifications create functionally distinct subsets of microtubule networks in

276 erent modes of MTOR-sensitive translation of functionally distinct subsets of mRNAs, which may explai

277 rives dynamic dendritic and spine changes in functionally distinct subsets of neurons, resulting in f

278 ctors that control intrinsic excitability in functionally distinct subsets of peripheral neurons.

279 Phenotypically and functionally distinct subsets of Tregs have been identif

280 ls represent a heterogeneous population with functionally distinct subsets, and the balance among sub

281 nd PTMs that divide the MT cytoskeleton into functionally distinct subsets.

282 ersity and lineage relationship of these two functionally distinct subsets.

283 Macrophages polarize into functionally distinct subtypes while responding to micro

284 such cells could be further stratified into functionally distinct subtypes.

285 e we present X-ray crystal structures of two functionally distinct SusCD complexes purified from Bact

286 Functionally distinct synapses exhibit diverse and compl

287 e recycling and coordinated recruitment from functionally distinct synaptic vesicle (SV) pools.

288 The metabolic programs of functionally distinct T cell subsets are tailored to the

289 to the recruitment of brain areas across two functionally distinct tasks (visual and semantic).

290 ent of PPC in humans suggest the addition of functionally distinct territories.

291 ked to the transition from two ancestral and functionally distinct TIM complexes, found in most eukar

292 are known, but the requirement for multiple, functionally distinct transcription factors needs clarif

293 dies provide additional markers to delineate functionally distinct Treg subsets that may help direct

294 We describe cell type-specific, functionally distinct TTFLs in neurons and astrocytes of

295 tep transformation into two structurally and functionally distinct types of macrocyclic derivatives:

296 Second, CCKergic TCs drive GCs through two functionally distinct types of monosynaptic connections:

297 e are widespread and comprise at least three functionally distinct types.

298 processes via attachment of structurally and functionally distinct ubiquitin (Ub) chains.

299 behavioral modulation in rats is mediated by functionally distinct units of neurons (neural ensembles

300 neurophysiological correlates and are likely functionally distinct, which has important implications