ライフサイエンスコーパス: fundamental

1 en is a well-established technology, whereas fundamental advances in CO(2) electrolysis are still nee

2 pothesis', which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) t

3 Since then, a number of fundamental and applied aspects have been studied in thi

4 ugates will find utility in a broad range of fundamental and applied clinical studies, including glyc

5 control structures.SIGNIFICANCE STATEMENT A fundamental and defining feature of human behavior is th

6 chanisms and cellular bases underlying these fundamental and important biological processes responsib

7 Despite the fundamental and physiological importance of FFAs, an ove

8 ded to fully realize the promise of OoCs for fundamental and translational applications.

9 Medicinal chemistry plays a fundamental and underlying role in chemical biology, pha

10 Here, recent progress in fundamentals and applications of cold spraying is review

11 We introduce the fundamentals and typical model architectures of DL.

12 dels at the cell and tissue scales to expose fundamental arrhythmia vulnerability mechanisms and comp

13 of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly

14 A cycle, suggesting that they can re-program fundamental aspects of their host's central carbon metab

15 Oxygen octahedral rotation forms a fundamental atomic distortion in perovskite oxides, but

16 sting patterned polymer film to study SLED's fundamental behavior in a bilayer geometry.

17 he genetic basis of this disorder highlights fundamental beta-cell mechanisms.

18 derstanding of animal social networks within fundamental biological contexts.

19 encode small proteins or micropeptides with fundamental biological importance.

20 The fundamental biological process of electron transfer (ET)

21 thods are particularly valuable for studying fundamental biological processes and gene interactions i

22 embrane channels and pores have key roles in fundamental biological processes(1) and in biotechnologi

23 ns at the molecular level is a major goal of fundamental biology and therapeutic drug development.

24 enabled by these structures for elucidating fundamental biology as well as developing improved diagn

25 model of sufficient complexity to encompass fundamental biomolecular structure-function relationship

26 s based on the combination of many different fundamental building blocks may be able to constructivel

27 This work provides a proof of concept for fundamental catalytic action of the hollow nanoreactors.

28 adequately recognized structural racism as a fundamental cause of poor health and disparities in card

29 trix (ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading, gro

30 in kinases central to the regulation of many fundamental cellular processes.

31 Thus, PGCC formation might represent a fundamental cellular response to Aurora kinase inhibitor

32 A fundamental challenge in developing treatments for autis

33 To address this fundamental challenge in psychiatry, a number of methods

34 the rules of their connectivity represents a fundamental challenge to the neurosciences.

35 A fundamental challenge, however, has been the fact that p

36 tter control of nervous system function, and fundamental changes in behaviors such as learning, memor

37 esponse to the breakout of COVID-19 required fundamental changes in individual behavior, such as isol

38 erence, including more choice switches after fundamental changes versus stochastic fluctuations in re

39 Advances in our understanding of the fundamental chemistry underlying the materials used in b

40 ctroscopy is a powerful tool for probing the fundamental chiroptical features of optically emissive c

41 the electronic and nuclear dynamics of this fundamental class of reactions.

42 Categorical perception is a fundamental cognitive function enabling animals to flexi

43 Although the SC is a fundamental component of the visual pathways in mice, it

44 nities can access a comprehensive summary of fundamental concepts regarding lipid peroxidation, exper

45 apply this framework and explain underlying fundamental concepts through experimental examples with

46 ited in precision measurements of forces and fundamental constants.

47 All these fundamental constraints preclude the continual reduction

48 ut also with a more ambitious goal: to study fundamental cross-scale biological phenomena.

49 Objects constitute the fundamental currency of our consciousness: they are the

50 ies could serve as a textbook standard and a fundamental database for scientific research, practical

51 e irradiation environments and understanding fundamental defect dynamics in layered oxides.

52 xists to derive city size distributions from fundamental demographic choices while also explaining co

53 s to peripheral neuropathy and emphasize the fundamental dependence of neuropathy on the systemic int

54 ticipants' avoidance of WM usage showcases a fundamental dependence on external information during ec

55 This work addresses a fundamental design principle for constructing molecular

56 eptors facing presynaptic release sites is a fundamental determinant of their coactivation and of syn

57 This article aims to assess fundamental determinants of use of biologic medicines in

58 Knowledge of fundamental differences between breast cancer subtypes h

59 strikingly diverse binding modes, suggesting fundamental differences in gammadelta T cell recognition

60 Our findings, along with the fundamental differences in the life histories between Fl

61 However, fundamental discoveries and technological translations o

62 How cohesin executes these fundamental DNA transactions is not understood.

63 Our work provides evidence of fundamental, domain-general learning differences in para

64 ical and aphasiological battery, to identify fundamental domains of post-stroke aphasia.

65 Sea surface temperature (SST) is a fundamental driver of tropical weather systems such as m

66 ties of apex predators may indirectly affect fundamental ecosystem processes, such as decomposition,

67 y, as insulin action is preserved to protect fundamental energetic processes in the muscle.

68 he biogeography of diverse marine species to fundamental energetic requirements that are shared acros

69 Temperature is one of the fundamental environmental variables that determine the c

70 e, we further demonstrate that more than ten fundamental equations, including that of classical mecha

71 Lateral inhibition is a fundamental feature of circuits that process sensory inf

72 spheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives sympto

73 Using a rat model recapitulating fundamental features of the human menopausal transition,

74 ght affects living systems through these six fundamental features, and the associated health risks of

75 e role of opioid signaling within the OFC is fundamental for a mechanistic understanding of the seque

76 racellular matrices, and mineral deposits is fundamental for an improved understanding of mineralizat

77 Conservation of our cultural heritage is fundamental for conveying to future generations our cult

78 nt ensembles of identical quantum systems is fundamental for many studies in quantum metrology(1), si

79 he biomolecules AMP, ATP, and CoA, which are fundamental for numerous biochemical processes in every

80 Cell and tissue polarization is fundamental for plant growth and morphogenesis.

81 Detection of NaCl by the gustatory system is fundamental for salt intake and tissue homeostasis.

82 This knowledge is fundamental for studying the relevance of cuticular stra

83 Adequate energy intake and homeostasis are fundamental for the appropriate growth and maintenance o

84 e main source of chondroitin sulfate and are fundamental for the constitution of the cone-specific gl

85 Indeed, herein we demonstrate that I(h) is fundamental for the recruitment of pigment dispersing fa

86 on of protein-protein interactions (PPIs) is fundamental for the understanding of cellular machinerie

87 ght structure and input/output statistics is fundamental for understanding the computational capabili

88 hitecture, which we call DynaMoE, provides a fundamental framework for how the prefrontal cortex may

89 elucidate the next steps needed to develop a fundamental framework needed for a deeper understanding

90 eech and music evoke a strong pitch at their fundamental frequency (F0), especially when they contain

91 is primarily characterized by speakers' mean fundamental frequency (F0), related to glottal pulse rat

92 r to understand a pulsed Nd:YAG laser at the fundamental frequency (lambda = 1,064 nm) to ablate Ag a

93 a series of multicycle tonal pulses, but the fundamental frequency and first several harmonics are mi

94 anged from approximately 200 Hz to 25 kHz in fundamental frequency and from 0.03 s to 2.07 s in durat

95 Self-regeneration is a fundamental function of all living systems.

96 The potential to migrate is one of the most fundamental functions for various epithelial, mesenchyma

97 Its fundamental idea is to use multiple energy functions as

98 that both contribute to and result from the fundamental immunological process of clonal expansion, h

99 Continued advances in fundamental immunology, genetic engineering, gene editin

100 DNA molecules is a long-standing problem of fundamental importance across disciplines(1,2).

101 states with magnetic or electric order is of fundamental importance for basic research and device tec

102 ation in connective tissue, highlighting the fundamental importance of non-collagenous matrix and sug

103 he processes governing ligand dynamics is of fundamental importance.

104 Isomerization reactions are fundamental in biology.

105 evolutionary modification of development was fundamental in generating extant plant diversity.

106 Blood transfusion is fundamental in managing hematologic malignancies.

107 mal, reversible phase transitions, which are fundamental in physics and can be easily induced, have n

108 sorders, there is a critical need to collect fundamental information about basic properties of the do

109 that this method is able to capture the most fundamental information contained in multivariate climat

110 ing antibody-based inhibitors is the lack of fundamental information relating sequences of antibodies

111 se studies reveal a striking divergence in a fundamental innate immune response pathway in AMs and es

112 l loading in functional materials, providing fundamental insight into the deformation process of the

113 Fundamental insights into structure-property relationshi

114 These results provide fundamental insights into the molecular mechanism that e

115 zation in this preclinical setting establish fundamental insights, laying the framework for optimizat

116 diction in a complex network is a problem of fundamental interest in network science and has attracte

117 Of fundamental interest is whether the chirality of the ban

118 ; therefore, evolution of this process is of fundamental interest.

119 nimal models and patient cells support their fundamental involvement in ALS/FTD.

120 Power dissipation is a fundamental issue for future chip-based electronics.

121 earch interest, uncertainties remain on some fundamental issues, such as the contributions of differe

122 Thus, understanding the fundamental kinetics of MOF-based molecular catalysis of

123 ability of these Xe-Fe oxides, which advance fundamental knowledge for understanding xenon chemistry

124 iew concludes with a perspective on how this fundamental knowledge might inform future clinical devel

125 These findings expand our fundamental knowledge of microbial reductive dehalogenat

126 time-bandwidth product (TBP) exceeding the 'fundamental' limit of ordinary resonant systems by a fac

127 ns in moving images to speed, specifying the fundamental limits imposed by natural stimuli.

128 istic quantum communication channels imposes fundamental limits on the communication rates of various

129 al perspectives regarding future research in fundamental materials aspects of high efficiency photoca

130 e on this porous composite to understand its fundamental mechanics.

131 nimal movement among disparate habitats is a fundamental mechanism by which energy, nutrients, and bi

132 st dynamics in flavodoxin and elucidates the fundamental mechanism of nonequilibrium ET dynamics, whi

133 volution, suggest that admixture serves as a fundamental mechanism that drives rapid adaptive evoluti

134 h4-mediated immune tolerance subversion as a fundamental mechanism that licenses tissue inflammation

135 these areas will yield new insights into the fundamental mechanisms and a broader utility for PARP-ta

136 Together, our results reveal the fundamental mechanisms and constraints with which conver

137 To understand fundamental mechanisms associated with post-flight ortho

138 ls but also highlight the need for exploring fundamental mechanisms behind interaction of electromagn

139 with nonaqueous electrolytes and reveals the fundamental mechanisms behind this improved stability.

140 ed granular materials, shedding light on the fundamental mechanisms controlling wave velocities, disp

141 al observations and provide insight into the fundamental mechanisms underlying film evolution at pres

142 However, the fundamental mechanisms underpinning cilia biogenesis and

143 lization is often understood in terms of the fundamental microstructural elements of the crystallite

144 ult of historical developments rather than a fundamental necessity.

145 (i.e., supramolecular) interactions are two fundamental nongenetic attributes of life.

146 spite enormous progress in understanding the fundamentals of bacterial gene regulation, our knowledge

147 Studying genome and epigenome led to the fundamentals of development and progression of human dis

148 two membranes (Gram-negative or diderm) is a fundamental open question in the evolution of Bacteria.

149 This review focuses on the fundamental operational principles of the main single-mo

150 The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal

151 A deeper understanding of fundamental organometallic reactivity of gold(III) has r

152 mylation have been isolated and evaluated in fundamental organometallic transformations relevant to a

153 characterised by the frequency of the star's fundamental oscillation mode (f-mode).

154 ransmission and exciton migration; these key fundamental pai functions are unique to sp(2) carbon-con

155 analysis of the reduced density gradient, a fundamental parameter at the core of Density Functional

156 ch in these areas is grounded in a number of fundamental perspectives within cognitive, emotional, mo

157 m plays an important role in a wide range of fundamental phenomena.

158 ment at the molecular scale, we describe the fundamental photochemical and redox processes that can e

159 is placing new emphasis on understanding the fundamental physicochemical forces driving their formati

160 which are required for precision studies of fundamental physics(6).

161 nities for sensing applications and tests of fundamental physics.

162 This tool is expected to help elucidate fundamental physiological and pathological processes rel

163 ted within the hypothalamus control the most fundamental physiological needs in vertebrates(1,2).

164 icant progress in prediction algorithms, the fundamental predictability of structures remains unclear

165 ted scientific scrutiny which challenged the fundamental premise that muscle anoxia was requisite for

166 Structure-function relationships are a fundamental principle of many naturally occurring system

167 A biomathematical framework based on fundamental principles of evolution and radiobiology for

168 Here, the fundamental principles of MRI contrast agents are discus

169 A fundamental problem for the evolution of pregnancy, the

170 The fundamental problem in axon growth and guidance is to un

171 e genetic regulation of organ structure is a fundamental problem in developmental biology.

172 Transcription of DNA is a fundamental process in all cellular organisms.

173 Pre-mRNA splicing is a fundamental process in mammalian gene expression, and al

174 ntinuities and restore tissue integrity is a fundamental process in normal development and repair of

175 Speciation is a fundamental process shaping biodiversity.

176 fate of new mutations within species is the fundamental process underlying evolution.

177 Ion transport and regulation are fundamental processes for various devices and applicatio

178 al learning and probabilistic prediction are fundamental processes in auditory cognition.

179 Porphyrinoids, well-known cofactors in fundamental processes of life, have stimulated interest

180 Understanding the fundamental processes of light-harvesting is crucial to

181 siveness, but it also provides insights into fundamental processes such as dispersal and adaptation.

182 ribution of metabolically active bacteria in fundamental processes triggering environmental and publi

183 ganism's ability to disperse influences many fundamental processes, from speciation and geographical

184 However, tangible progress in probing their fundamental properties and/or their integration into opt

185 ng to address this question by investigating fundamental properties of lncRNA genes, revealing new in

186 nd to unanticipated increases in volume is a fundamental property of cells, essential for cellular in

187 Spontaneous neurotransmitter release is a fundamental property of synapses in which neurotransmitt

188 Tunneling is a fundamental quantum process with no classical equivalent

189 ransformed into long-term memories remains a fundamental question for neuroscience research.

190 rom damage in a fluctuating environment is a fundamental question in biology.

191 ecific systemic response, highlighting a new fundamental question in plant biology: are plants capabl

192 We addressed this fundamental question of causality using longitudinal ana

193 One fundamental question that remains to be directly address

194 This is related to another fundamental question: Starting from many copies of noisy

195 own few of the desired health gains, raising fundamental questions about current approaches.

196 e data in this Matters Arising article raise fundamental questions about the recently proposed role f

197 uniquely obtained by in situ TEM to address fundamental questions and practical issues regarding pha

198 ory of cells is key to answering diverse and fundamental questions in biology.

199 Promotion of C-C bonds is one of the key fundamental questions in the field of CO(2) electroreduc

200 genomic loci imaging approaches can address fundamental questions on chromatin dynamics in a range o

201 These striking results raise fundamental questions regarding tumor innervation, how i

202 We have probed these fundamental questions using the fission yeast Schizosacc

203 n to early and lower vertebrates and ask two fundamental questions.

204 is time period has often come in the form of fundamental, rather than applied, advances.

205 rol, and protein degradation have emerged as fundamental regulators of proteome complexity that regul

206 Allostery is a fundamental regulatory mechanism of protein function.

207 Together, these data indicate a fundamental regulatory role of the VDR in the regulation

208 The core nucleosome performs a fundamental regulatory role, apart from the histone "tai

209 ease pathophysiology remain ambiguous as the fundamental relationship between glutamate dynamics and

210 As one of the fundamental requirements for cell growth and proliferati

211 where radar, navigation, communications, and fundamental research rely on less stable microwave sourc

212 Despite the fundamental role biodiversity plays in forest regenerati

213 common than currently known, and may play a fundamental role in age-dependent changes in reproductiv

214 nthalpies (BDEs) of organic molecules play a fundamental role in determining chemical reactivity and

215 Snow plays a fundamental role in global water resources, climate, and

216 Theory of mind plays a fundamental role in human social interactions.

217 otective barrier, temporarily, which plays a fundamental role in maintaining a homeostatic environmen

218 Lymphatic contractions play a fundamental role in maintaining tissue and organ homeost

219 Circadian (~24 hour) clocks have a fundamental role in regulating daily physiology.

220 , we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and t

221 Crucially, calcium plays a fundamental role in stabilizing cbEGF domains.

222 Knots play a fundamental role in the dynamics of biological and physi

223 Radiology departments play a fundamental role in the management of COVID-19, both in

224 Our results demonstrate the fundamental role of choroidal MC involvement in GA disea

225 It is argued here that a fundamental role of inter-hemispheric inhibition is to s

226 ype 1 receptor (CB1R) signaling based on the fundamental role of the endocannabinoid system in synapt

227 plaque morphology in the cerebellum and the fundamental role of the surrounding tissue in driving th

228 tic changes in gene expression profiles play fundamental roles in multistep process of tumorigenesis,

229 f Li ions (Li(+)) and Na ions (Na(+)) is the fundamental root cause for the poor stability, reversibi

230 w our findings may lead to technological and fundamental science applications of dynamic self-assembl

231 es to advance therapeutics, diagnostics, and fundamental science.

232 ernal chains of bonded nitrogen atoms, is of fundamental scientific interest in chemical structure an

233 Ca(2+) is a fundamental second messenger in all cell types and is re

234 ed a drive for a deeper understanding of the fundamental signaling mechanisms of opioid receptors.

235 s coronary artery disease-associated gene in fundamental SMC processes and indicating the importance

236 Despite this fundamental split, our current knowledge of cellular and

237 and treatment of diseases as a necessary and fundamental step towards precision medicine, which will

238 Cellular differentiation is a fundamental strategy used by cells to generate specializ

239 motif, a lack of sequence identity and some fundamental structural differences currently designates

240 review article provides a reflection on how fundamental studies have facilitated the discovery, opti

241 ations to quantum information processing and fundamental studies of many-body dynamics.

242 or proof-of-concept demonstrations(6-16) and fundamental studies(17-30)-is clearly not scalable for p

243 ociated architectural proteins are part of a fundamental support system for cellular DNA-dependent pr

244 chemical compositions around nanovoids is a fundamental task for research and development of various

245 monodisperse nanomaterials is among the most fundamental tasks in inorganic synthesis and materials s

246 echanosensory cellular apparatus, regulating fundamental tendon cell functions relevant to exercise-i

247 expect that future quantum technologies and fundamental tests of nature in higher dimensions will be

248 The fundamental thermodynamic and kinetic parameters obtaine

249 Here, a fundamental thermodynamic description is developed, and

250 y important changes in our environment it is fundamental to detect deviations from regularities of se

251 Several auto-Ags are fundamental to disease development, suggesting T1D etiol

252 Further, we observe that this G4 is fundamental to ensuring delivery of Task3 mRNA to distal

253 finity and kinetics of target engagement are fundamental to establishing structure-activity relations

254 or-biased genes, engaging molecular pathways fundamental to foraging behavior.

255 governed by the law of simplicity, which is fundamental to Gestalt theory.

256 tablish that the thrombin/fibrinogen axis is fundamental to host antimicrobial defense, offer a possi

257 y to represent and respond to uncertainty is fundamental to human cognition and decision-making.

258 rucially if lithium's effect on the clock is fundamental to its mood-stabilizing effects.

259 oglia play a critical role in many processes fundamental to learning and memory in health and are imp

260 nvolved in many essential processes that are fundamental to life on Earth, including photosynthesis,

261 Protein binding to small molecules is fundamental to many biological processes, yet it remains

262 Linking individual and population scales is fundamental to many concepts in ecology [1], including m

263 g molecular details of these interactions is fundamental to our understanding of amyloid disease.

264 receptors and channels present in neurons is fundamental to our understanding of neural computation.

265 ciated with the observed electroactivity are fundamental to oxygen-reducing microbial cathodes.

266 es played by these drivers of variability is fundamental to predicting near-term climate change and c

267 an populations, infant immunisation has been fundamental to reducing incident infections in children,

268 The regrowth of severed axons is fundamental to reestablish motor control after spinal-co

269 Non-coding RNAs are fundamental to the competing endogenous RNA (CeRNA) hypo

270 on contest processes and outcomes, has been fundamental to the field of dyadic (one-on-one) contests

271 ter and strain-specific amino acid groups is fundamental to the stabilisation of vaterite and that, u

272 replication of pressure/volume relationships fundamental to the study of heart function and remodelin

273 Knowledge of CRC in cancer is fundamental to understanding cancer-specific transcripti

274 rplay between these complementary systems is fundamental to understanding how cone-mediated vision is

275 perovskite nanocrystals, this would add new fundamentals to the insights of crystal growths of nanoc

276 d utility of IFC are severely limited by the fundamental trade-off between throughput, sensitivity, a

277 an emerging antigenic cluster and quantified fundamental trade-offs in our ability to make such predi

278 To break this fundamental tradeoff between acquisition time and MB con

279 The gained fundamental understanding and demonstrated capabilities

280 erapies for prevention and treatment require fundamental understanding and the ability to visualize,

281 However, fundamental understanding into the structural characteri

282 ent time and length scales, are used to gain fundamental understanding of all processes leading to ca

283 photovoltaic and optoelectronic devices, yet fundamental understanding of film formation, key to opti

284 A fundamental understanding of ion transport behavior in w

285 ne transport properties and provide enhanced fundamental understanding of ionization that could enabl

286 as spp. that have substantially improved our fundamental understanding of pathogen biology.

287 f unknown or predicted function, undermining fundamental understanding of pathogenicity and drug susc

288 These results will pave the way for fundamental understanding of phase-specific contribution

289 ds these practical problems and has provided fundamental understanding of plant biology, however not

290 This study advances our fundamental understanding of redox mechanisms in disorde

291 A fundamental understanding of substrate selectivity by SM

292 A fundamental understanding of such relativistic effects o

293 oaches for antigen discovery has limited the fundamental understanding of the antigenic landscape of

294 st interactions will continue to enhance our fundamental understanding of the biology and pathogenesi

295 ic parameters obtained here will advance our fundamental understanding of the surface chemistry and n

296 A fundamental understanding of the unusual properties of w

297 A fundamental understanding of these properties is based o

298 h significant morbidity and mortality, but a fundamental understanding of what regulates FGF23 produc

299 However, the lack of fundamental understanding on charge transport (CT) mecha

300 irreversibly commit to differentiation is a fundamental yet unanswered question.