ライフサイエンスコーパス: fundamental role

1 tiffness or extensible length, unveiling its fundamental role as an activation-dependent spring in co

2 el therapeutic molecule against T2DM and its fundamental role as an immune checkpoint for activated I

3 Due to O-GlcNAc's fundamental roles as a nutrient and stress sensor, it pl

4 Despite the fundamental role biodiversity plays in forest regenerati

5 studied RNA-binding protein (RBP) since its fundamental role both in tumorigenesis and cancer progre

6 Membrane remodeling plays a fundamental role during a variety of biological events.

7 EndMT plays a fundamental role during development, and mounting eviden

8 coded by an immediate early gene and plays a fundamental role during infection, because it enables vi

9 on demanded by low-voltage operation plays a fundamental role, enabling bulk trapping and leading to

10 Here we describe an unexpected fundamental role for ACKR1 in hematopoiesis and provide

11 synaptic autophagy, respectively, implying a fundamental role for Bassoon in the local regulation of

12 numerous cell lines, confirming a novel and fundamental role for cholesterol biosynthesis in regulat

13 vide evidence that this mechanism reflects a fundamental role for DeltaNp63alpha in the normal wound-

14 Here, we define a fundamental role for DNA interstrand cross-link repair i

15 Our study has identified a fundamental role for GDF6 and BMP signaling in governing

16 Together, our findings demonstrate a fundamental role for GPR101 in mediating the leukocyte-d

17 We propose a fundamental role for interoceptive experience and the st

18 Curiosity plays a fundamental role for learning and memory, but the neural

19 Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type

20 sponds to high carbon dioxide, underlining a fundamental role for paleoclimatology in constraining fu

21 form of IT and highlight a hitherto unknown fundamental role for PTPRJ in platelet biogenesis.

22 Thus, we define a fundamental role for ST2(+) T(reg) cells in the lung as

23 drial homeostasis, and establish a novel and fundamental role for Tctp in vertebrate neural circuitry

24 Taken together, our data demonstrate a fundamental role for the ancient 14-3-3 epsilon group me

25 These findings reveal a fundamental role for the chloride ring in the assembly o

26 Together, our results suggest a fundamental role for the glycocalyx in regulating curved

27 Other evidence in support of a fundamental role for the microbiome in patients with IBD

28 early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunit

29 The results suggest a fundamental role for VRN1 in regulating cold acclimation

30 Collectively, our findings uncover a fundamental role for VTA dopaminergic circuitry in the m

31 eir co-dependence on climate, establishing a fundamental role for water transport in the evolution of

32 Taken together, our results suggest a fundamental role for YciB and DcrB in cell envelope biog

33 In animals, fundamental roles for AMT and Rh proteins in the specifi

34 ts and links have been conjectured to play a fundamental role in a wide range of scientific fields.

35 cting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E.

36 the neurogenic niches of the CNS and play a fundamental role in adult neurogenesis.

37 common than currently known, and may play a fundamental role in age-dependent changes in reproductiv

38 Collagen plays a fundamental role in all known metazoans.

39 ese findings indicate that serotonin plays a fundamental role in arthritis through the regulation of

40 Thus, PSGL-1 plays a fundamental role in balancing viral control and immunopa

41 one surface and ligands on another, plays a fundamental role in biology and is key to the infection

42 VEGFR2 plays a fundamental role in blood vessel formation and in life t

43 Circulating tumor cells (CTCs) play a fundamental role in cancer progression.

44 Surgery has played a fundamental role in cancer treatment.

45 es in deep-dentin carious lesions may play a fundamental role in caries etiology.

46 In addition to a fundamental role in cell differentiation, some epigeneti

47 ly investigated since the 1940s due to their fundamental role in cell growth.

48 d factor 2 (NRF2) transcription factor has a fundamental role in cell homeostasis maintenance as one

49 The ribosome plays a fundamental role in cell vitality by the translation of

50 RNA modifications play a fundamental role in cellular function.

51 mal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal hom

52 In addition to their fundamental role in clearance, the kidneys release selec

53 ulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, rew

54 Post-translational modifications play a fundamental role in coordinating replication and repair

55 by the EMT inducers Snail1 and Zeb2 plays a fundamental role in defining embryonic territories in th

56 tential (V (m)) and Ca(2+) transients play a fundamental role in dendritic integration and synaptic p

57 nje neurons generating a signal that plays a fundamental role in dendritic integration.

58 nthalpies (BDEs) of organic molecules play a fundamental role in determining chemical reactivity and

59 We show that the support plays a fundamental role in determining Ga nanoparticle phases,

60 s well as trans acting signals have played a fundamental role in determining NDE1 species specific sp

61 POINTS: Voltage-gated sodium channels play a fundamental role in determining neuronal excitability.

62 y constrained, geometrical properties play a fundamental role in determining the network's behaviour,

63 ing in two-dimensional nanomaterials plays a fundamental role in determining their physical propertie

64 MicroRNAs (miRNAs) have a fundamental role in diabetic heart failure.

65 ic mechanical properties of chromatin play a fundamental role in dictating precatenane formation and

66 activity of nigral dopamine neurons plays a fundamental role in dopaminergic signaling.

67 ies") [1, 2] suggests that they might play a fundamental role in driving the movements and functionin

68 Oxygenic phototrophs have played a fundamental role in Earth's history by enabling the rise

69 ction (HER) is a critical process due to its fundamental role in electrocatalysis.

70 e regulation of synaptic homeostasis plays a fundamental role in ensuring normal and stable synaptic

71 This concept played a fundamental role in establishing the field of cellular m

72 tness effects (DFE) of new mutations plays a fundamental role in evolutionary genetics.

73 Transparent conducting electrodes play a fundamental role in far-field PhotoVoltaic systems, but

74 that temporal psychological distance plays a fundamental role in farsighted decision-making.

75 ansporting metal-rich sulfide cargoes play a fundamental role in fluxing metals into the crust from m

76 Chromatin accessibility plays a fundamental role in gene regulation.

77 ts that duplicated sequences likely played a fundamental role in generating inversions in humans and

78 Snow plays a fundamental role in global water resources, climate, and

79 rain large portions of ice sheets and play a fundamental role in governing their response to atmosphe

80 ories of various types and timescales play a fundamental role in guiding perception and performance a

81 Despite a fundamental role in health and disease, the direct quant

82 The gut microbiome plays a fundamental role in host health and the fecal metabolome

83 ipose tissue bridges body organs and plays a fundamental role in host metabolism.

84 Stories play a fundamental role in human culture.

85 Vitamin D(3) plays a fundamental role in human health; however, it is highly

86 Theory of mind plays a fundamental role in human social interactions.

87 ng immunomodulatory signals, may play a role fundamental role in immune homeostasis.

88 Tregs play a fundamental role in immune tolerance via control of self

89 lular degradative pathway of autophagy has a fundamental role in immunity.

90 , data indicate that biotype does not play a fundamental role in influencing alveolar BT, whereas oth

91 Vinculin plays a fundamental role in integrin-mediated cell adhesion.

92 op-down control of striatal activity plays a fundamental role in linking commitment-induced generosit

93 otective barrier, temporarily, which plays a fundamental role in maintaining a homeostatic environmen

94 results demonstrate that mitochondria play a fundamental role in maintaining bioenergetic homeostasis

95 Cardiac natriuretic peptides (NPs) play a fundamental role in maintaining cardiovascular (CV) and

96 iving biomass in the world oceans and play a fundamental role in maintaining life on our planet.

97 Lymphatic contractions play a fundamental role in maintaining tissue and organ homeost

98 Interfaces play a fundamental role in many areas of chemistry.

99 N-Glycosylation plays a fundamental role in many biological processes.

100 Given that autophagy has a fundamental role in many essential cellular functions, i

101 ative than analyzing single SNPs and plays a fundamental role in many medical applications.

102 r clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the

103 nding between tail and motor domains and its fundamental role in microtubule sliding.

104 hondrial contacts frequently form and play a fundamental role in mitochondrial networks by restrictin

105 s a tumor suppressor, which not only plays a fundamental role in modulation of ECM integrity, but als

106 Epistatic interactions play a fundamental role in molecular evolution, but little is k

107 e, have been repurposed in septins to play a fundamental role in molecular recognition.

108 The striatum plays a fundamental role in motor learning and reward-related be

109 t microtubule (MT) growing ends, which has a fundamental role in MT polymerisation.

110 an activated myofibroblast state and play a fundamental role in myocardial fibrosis and remodeling.

111 Chirality plays a fundamental role in nature, but its detection and quanti

112 structural motifs and length scales plays a fundamental role in nature, enabling unique functionalit

113 e-dependent potassium (K(v)) channels play a fundamental role in neuronal and cardiac excitability an

114 mutations provide evidence that RIP plays a fundamental role in normal bone development.

115 ar communication between lymphocytes plays a fundamental role in numerous immune responses.

116 s9 genome editing to show that optix plays a fundamental role in nymphalid butterfly wing pattern dev

117 D-1 and the LAG-3 exhaustion pathways play a fundamental role in ocular herpes T cell immunopathology

118 plied that rhythmic activity patterns play a fundamental role in odor coding.

119 Medical imaging plays a fundamental role in oncology and drug development, by pr

120 Cellular potassium import systems play a fundamental role in osmoregulation, pH homeostasis and m

121 Cs) are regulated by vitamin D(3) and play a fundamental role in periodontal tissue homeostasis and i

122 We conclude that botanic gardens play a fundamental role in plant conservation, but identify act

123 Abscisic acid (ABA) plays a fundamental role in plant response and adaptation to abi

124 In this way, the I-band spring plays a fundamental role in preventing the development of SL inh

125 ctivated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA.

126 While mTORC1 plays a fundamental role in promoting RBC development, we showed

127 Myelinating glia play a fundamental role in promoting the maturation of the axon

128 from single neuron to network levels, has a fundamental role in proper brain function and its impair

129 The OM plays a fundamental role in protecting Gram-negative bacteria fr

130 ne cathelicidin, induced by infection, has a fundamental role in protection against disease in vivo p

131 ases (aaRSs) are ancient enzymes that play a fundamental role in protein synthesis.

132 heric systems, global climate changes play a fundamental role in regional wave climate.

133 This complex plays a fundamental role in regulating cellular differentiation

134 Circadian (~24 hour) clocks have a fundamental role in regulating daily physiology.

135 Recent studies have shown that KLFs play a fundamental role in regulating diverse biological proces

136 Phenology plays a fundamental role in regulating photosynthesis, evapotran

137 We thus suggest that the ER plays a fundamental role in regulating the assembly and disassem

138 Pre-mRNA splicing factors play a fundamental role in regulating transcript diversity both

139 , we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and t

140 facial and behavioral reactions has played a fundamental role in research on reward but is seldom ass

141 membranous wing that we hypothesize plays a fundamental role in seed establishment in sandy, wave sw

142 Attention plays a fundamental role in selectively processing stimuli in ou

143 have demonstrated that EPAC proteins play a fundamental role in several physiological and pathophysi

144 uts from the hippocampus and amygdala play a fundamental role in shaping the activity of both NAcc D1

145 Consequently, these 'immunoevasins' play a fundamental role in shaping the nature of the immune sys

146 d we propose ways these kinases could play a fundamental role in skeletal muscle mechanotransduction.

147 in ligand TPD1 (TAPETUM DETERMINANT1) play a fundamental role in somatic and reproductive cell differ

148 Crucially, calcium plays a fundamental role in stabilizing cbEGF domains.

149 expansion of regulatory T (Treg) cells has a fundamental role in the achievement of immunological tol

150 inic acetylcholine receptors (nAChRs) play a fundamental role in the attentional circuitry throughout

151 The central melanocortin system plays a fundamental role in the control of feeding and body weig

152 the microbiota and the immune system plays a fundamental role in the control of host physiology.

153 aques and intracellular tangles as playing a fundamental role in the course and progression of the di

154 s one species-expected stimulus that plays a fundamental role in the development of emotion neurocirc

155 ariants alter brain glycosylation and play a fundamental role in the development of schizophrenia.

156 Knots play a fundamental role in the dynamics of biological and physi

157 Animal movement plays a fundamental role in the ecology of migratory species, an

158 metry in non-centrosymmetric materials has a fundamental role in the emergence of a vast number of fa

159 The apical portion of an implant plays a fundamental role in the entire implant stability and is

160 se that a stanna-Brook rearrangement plays a fundamental role in the formation of the polycyclic orga

161 forward in our analysis on the basis of its fundamental role in the function and dynamic regulation

162 microbes voraciously consume H(2) and play a fundamental role in the geochemistry of Earth's ocean-at

163 ethyl sulfide (DMS) to the atmosphere play a fundamental role in the global sulfur (S) cycle and have

164 Macrophages play a fundamental role in the immune system by engulfing forei

165 been defined in dendritic cells and plays a fundamental role in the induction of CD8(+) T cell immun

166 The microbiota plays a fundamental role in the induction, education, and functi

167 Imaging techniques play a fundamental role in the initial diagnosis and follow-up

168 Radiology departments play a fundamental role in the management of COVID-19, both in

169 Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatiti

170 ce and increased neurotoxic cytokines have a fundamental role in the phenotype and treatment of certa

171 Aging processes are ubiquitous and play a fundamental role in the physics of glasses and spin glas

172 a indicate that DEG/ENaC ion channels play a fundamental role in the postsynaptic regulation of excit

173 asing evidence suggests that the CNS plays a fundamental role in the predisposition to develop differ

174 ut we now know that immune signaling plays a fundamental role in the regulation of social interaction

175 me, such as protein phosphorylation, plays a fundamental role in the regulation of stemness and diffe

176 genome structures such as local loops play a fundamental role in the regulation of transcription, alt

177 Altogether, our findings highlight GR's fundamental role in the rhythmic orchestration of hepati

178 crotubules organized by centrosomes - play a fundamental role in the spatial coordination of animal c

179 Electrostatic interactions play a fundamental role in the structure and function of protei

180 nsient structure, so-called channel, plays a fundamental role in the transition.

181 The atmosphere plays a fundamental role in the transport of microbes across the

182 nse research for almost 40 y, both for their fundamental role in the understanding of hydrophobic int

183 cies and electron-phonon interaction plays a fundamental role in their dynamics.

184 ptical emissivity of these compounds plays a fundamental role in their heat balance.

185 ical methods and computational models play a fundamental role in this difficult task, as they allow t

186 scular system is widely accepted as having a fundamental role in this highly complex neurological dis

187 ects midway into the synaptic cleft, plays a fundamental role in this process.

188 ion with regulatory T (Treg) cells playing a fundamental role in this process.

189 While mitochondrial morphology plays a fundamental role in tissue development and homeostasis,

190 Despite their fundamental role in tissue morphogenesis and tissue home

191 Premotor neurons play a fundamental role in transforming physical properties of

192 ze stabilization reflexes, emphasizing their fundamental role in transforming sensory information int

193 s remains inadequate even though they take a fundamental role in transport properties.

194 Endothelial cell motility has fundamental role in vasculogenesis and angiogenesis duri

195 edators, and pollinators, Hymenoptera play a fundamental role in virtually all terrestrial ecosystems

196 d during normal cellular respiration and has fundamental roles in a wide range of cellular processes,

197 culum (ER) and the plasma membrane (PM) play fundamental roles in all eukaryotic cells.

198 otein (RNP) granules are ubiquitous and have fundamental roles in biology and RNA metabolism, but the

199 s components of molecular machines that play fundamental roles in biology.

200 Neutrophils play fundamental roles in both acute and chronic inflammatory

201 Ion channels play fundamental roles in both excitable and non-excitable ti

202 cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and d

203 ulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migratio

204 y is a regulated self-digestion pathway with fundamental roles in cell homeostasis and diseases.

205 NK homeodomain-containing proteins that have fundamental roles in development of sensory structures s

206 The Notch signalling pathway plays fundamental roles in diverse developmental processes in

207 The Notch signaling pathway plays fundamental roles in diverse developmental processes.

208 ually every species and every cell, and play fundamental roles in functions ranging from metabolism t

209 matopoiesis, and they are understood to play fundamental roles in hematological malignancies by actin

210 Calcium (Ca(2+)) signals play fundamental roles in immune cell function.

211 The barrier epithelium plays fundamental roles in immune defenses against enteric vir

212 mplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance.

213 y diverse proteins, including many that play fundamental roles in immunology.

214 sin protein-mediated chromosome looping have fundamental roles in lymphocyte lineage- and development

215 Epigenetic inheritance mechanisms play fundamental roles in maintaining cellular memory of gene

216 ome to trillions of microorganisms that have fundamental roles in many aspects of human biology, incl

217 ls, self-renewing stem cell populations play fundamental roles in many developmental contexts.

218 annels, both ligand- and voltage-gated, play fundamental roles in many physiologic processes.

219 RNA helicases play fundamental roles in modulating RNA structures and facil

220 Although innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality and t

221 tic changes in gene expression profiles play fundamental roles in multistep process of tumorigenesis,

222 tely dividing NG2(+) pericytes and glia play fundamental roles in post-SCI tissue remodeling.SIGNIFIC

223 Epigenetic mechanisms play fundamental roles in regulating numerous biological proc

224 y studied member of the CCC family and plays fundamental roles in regulating trans-epithelial ion mov

225 co/endoplasmic reticulum Ca(2+) -ATPase play fundamental roles in regulation of ion transport in vert

226 hatic vasculature; a system which likely has fundamental roles in renal development, physiology and d

227 Tautomers of the nucleobases play fundamental roles in spontaneous mutations of DNA.

228 bioses are evolutionarily pervasive and play fundamental roles in structuring ecosystems, yet our und

229 A receptors are excitatory ion channels with fundamental roles in synaptic transmission and plasticit

230 amics and flexibility of cell membranes play fundamental roles in the functions of the cells, i.e., s

231 Lipids have fundamental roles in the structure, energetics, and sign

232 her, graviperception and reaction woods play fundamental roles in tree architecture, posture control,

233 They are ubiquitously expressed and play fundamental roles in tumour malignancies, including glio

234 Despite their fundamental role, little is known about the intracellula

235 rcopenia across ethnicities, demonstrating a fundamental role of altered mitochondrial metabolism in

236 The fundamental role of AOX in metabolizing xenobiotics is a

237 Given the fundamental role of associative fear learning in the gen

238 ypes observed in germline BACE1 KO reflect a fundamental role of BACE1 during development while other

239 The fundamental role of bacterial TBDR in nutrient uptake mo

240 Our study uncovers the fundamental role of binocular experience in the formatio

241 Our analyses reveal not only the fundamental role of CBL1 in the adjustment of central tr

242 Our results demonstrate the fundamental role of choroidal MC involvement in GA disea

243 These results highlight the fundamental role of constructive quantum interference (o

244 However, recent evidence points to the fundamental role of contact-dependent reactions, which u

245 Altogether, our results suggest a fundamental role of dendritic spines in shaping Cl(-) di

246 etic flexibly in U. bilobatum highlights the fundamental role of ecological pressures on integrative

247 latory networks to date, and illustrates the fundamental role of enhancers in controlling patterning,

248 Taken together, these data highlight the fundamental role of evidence-based and human-rights affi

249 ponents in the human immune system, with the fundamental role of fighting invading pathogens.

250 Previous studies could prove a fundamental role of FTO (fat mass and obesity-associated

251 This review examines the fundamental role of glia in the regulation of glutamate,

252 Given the fundamental role of HA in the cancer resistance of the n

253 It is argued here that a fundamental role of inter-hemispheric inhibition is to s

254 s are peculiar conducting systems, where the fundamental role of interactions leads to exotic, emerge

255 We also consider the fundamental role of interventional radiology in the trea

256 In this Review, we discuss the fundamental role of mechanical interactions between cell

257 Here, we highlight the fundamental role of microglia as tissue-resident macroph

258 These findings identify a fundamental role of miR-144-3p in the rescue of impaired

259 rgue that such interdependence underlies the fundamental role of mitochondrial activities in the emer

260 Our model reveals the fundamental role of mRNA localization and dendritic mRNA

261 well with current proposals highlighting the fundamental role of neural oscillations in perception an

262 Epidemiological data suggest a fundamental role of non-HLA alloimmunity.

263 Junction sequence analysis suggested fundamental role of nonhomologous end joining mechanism

264 Our studies confirm the fundamental role of osteocytic perilacunar remodeling in

265 f APP, while they also provide support for a fundamental role of PrP(C) to bind to and deliver intran

266 These data unveil a fundamental role of PTX3 in promoting the first wave of

267 These findings support the fundamental role of remote sensing as an effective lens

268 Here, we discovered a fundamental role of S-phase protein kinase 2 (Skp2) in t

269 eric nervous system during inflammation, the fundamental role of serotonin (5-HT) in enteric neuroimm

270 of ocular neovascularization and indicate a fundamental role of TGF-beta signaling in the pathogenes

271 Given the fundamental role of the amygdala in the emergence of emo

272 The fundamental role of the brain-specific myelin transcript

273 ype 1 receptor (CB1R) signaling based on the fundamental role of the endocannabinoid system in synapt

274 Our results reveal a fundamental role of the external pore in the allosteric

275 rent concepts of human sociality highlight a fundamental role of the hypothalamic peptide oxytocin (O

276 g research over the past decade identified a fundamental role of the intestinal microbiome on human h

277 plaque morphology in the cerebellum and the fundamental role of the surrounding tissue in driving th

278 Given the fundamental role of Toll-like receptors (TLRs) and compl

279 These and other findings suggest that the fundamental role of Zip2-Zip4 is to mediate the recombin

280 In this article, we summarize the fundamental roles of microRNAs (miRNAs) in the regulatio

281 These results establish the fundamental roles of myosin filament domains and the ass

282 logy of male mosquitoes but also demonstrate fundamental roles of rhythmic and metabolic genes in the

283 f mammalian heart regeneration and highlight fundamental roles of the extracellular matrix in cardiac

284 lm microstructural analysis demonstrates the fundamental roles of the pi-conjugated core fluorocarbon

285 Soil fauna play a fundamental role on key ecosystem functions like organic

286 Intermolecular interactions play a fundamental role on the performance of conjugated materi

287 same organ and may highlight an independent fundamental role played by each PLN during the establish

288 nal bonds taking into account the increasing fundamental role played by the surface).

289 gun to generate exciting insights about some fundamental roles played by these non-degradative chains

290 cal environment remains limited, despite the fundamental role soil physical structure plays in ensuri

291 for indications where sensory neurons play a fundamental role, such as pain, itch, and asthma.

292 mean-field spin glass models has achieved a fundamental role, thanks to the asymptotic analytic solu

293 ily conserved as CI proteins, indicating the fundamental role that collective influencers in protein

294 nterparts in other organisms, indicating the fundamental role that control analysis of pathways plays

295 This work provides an insight into the fundamental role that membrane-mediated ion-channel coop

296 Here we outline the fundamental role that we believe meta-representations pl

297 e review mounting evidence demonstrating the fundamental role that white matter connections play in c

298 The fundamental roles that peptides and proteins play in tod

299 dinated) as the active sites and attribute a fundamental role to external (and flexible) oxygenated l

300 lation for beta-cells and highlight EIF2B1's fundamental role within this pathway.