ライフサイエンスコーパス: fungicidal

1 ctin-1(-/-) macrophages resulted in impaired fungicidal ability, low nitric oxide production, and ele

2 mycins are peptide-nucleoside compounds with fungicidal, acaricidal, and insecticidal properties beca

3 Echinocandins exert in vitro and in vivo fungicidal action against most Candida species and fungi

4 aromyces cerevisiae to better understand the fungicidal action of fludioxonil and the role of HHK3 in

5 l an important role of CORVET complex in the fungicidal action of fludioxonil downstream of HHK3.

6 nditions are not available for testing their fungicidal activities (minimum fungicidal or lethal conc

7 thway, but the precise mechanisms leading to fungicidal activities in many fungal pathogens are poorl

8 In this study, the fungicidal activities of LL-37 peptide, ceragenin CSA-13

9 is known to have an inhibitory effect on the fungicidal activities of some proteins, parotid secretio

10 study evaluated the in vitro fungistatic and fungicidal activities of voriconazole, itraconazole, and

11 omising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index.

12 polymer with bactericidal, parasiticidal and fungicidal activities.

13 The primary end point was Early Fungicidal Activity (EFA) - the rate of yeast clearance

14 e 2 noninferiority trial examining the early fungicidal activity (EFA) of 3 short-course, high-dose l

15 al meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from

16 acteristics, cerebrospinal fluid (CSF) early fungicidal activity (EFA), and 10-week mortality.

17 from the cerebrospinal fluid (CSF) or early fungicidal activity (EFA), as determined by results of s

18 The primary endpoint was the early fungicidal activity (EFA), which measures the rate of Cr

19 nd point was cerebrospinal fluid (CSF) early fungicidal activity (EFA).

20 Voriconazole showed similar or better fungicidal activity (MFC at which 90% of isolates tested

21 the echinocandins had a broader spectrum of fungicidal activity (MFCs at which 90% of strains are in

22 We have shown previously that amiodarone has fungicidal activity against a broad array of fungi.

23 The antiarrhythmic drug amiodarone has fungicidal activity against a broad range of fungi.

24 ase, but also show effective, broad-spectrum fungicidal activity against a wide range of fungal patho

25 Results confirmed DC lysosome fungicidal activity against all cryptococcal serotypes.

26 ll cationic human salivary peptide with high fungicidal activity against C. albicans, however many st

27 5(+) splenocytes from both mouse strains had fungicidal activity against C. neoformans.

28 an ester to a C22 modified alkyl chain, has fungicidal activity against Candida albicans, Cryptococc

29 gland-secreted cationic peptide with potent fungicidal activity against Candida albicans.

30 5) is a cationic salivary protein with high fungicidal activity against Candida albicans.

31 n-3-yl)acetamide (87), which, in addition to fungicidal activity against Candida species, shows promi

32 nt neutrophils, which are known to have poor fungicidal activity against Candida species.

33 Rustmicin has potent fungicidal activity against clinically important human p

34 cted AM from most donors demonstrated innate fungicidal activity against CN.

35 natural product screen to rescue caspofungin fungicidal activity against Cryptococcus neoformans H99

36 NCR044 peptide also exhibited potent fungicidal activity against multiple plant fungal pathog

37 tion and phagocytosis, galectin-3 has direct fungicidal activity against opportunistic fungal pathoge

38 Several salivary proteins exhibit fungicidal activity against the opportunistic oral patho

39 administered in vivo modulates PMNL-mediated fungicidal activity against the pseudohyphal form of C.

40 We show that both azoles have fungicidal activity and reduce fluidity, but not integri

41 CD40L-deficient patients exhibited defective fungicidal activity and reduced oxidative burst, both of

42 Hence, our data explain the strong, fungicidal activity and selectivity of B. subtilis QST71

43 of microbiological tests and agrees with the fungicidal activity and selectivity of FE.

44 nanoparticles stabilized with gelatin have a fungicidal activity at concentration equivalent 2.5 . 10

45 autophagic factor LC3 demonstrate diminished fungicidal activity but increased cytokine production in

46 This novel process of fungicidal activity by a human salivary protein has high

47 Stimulation of human Mphi fungicidal activity by coculture with chloroquine or by

48 , micafungin, and anidulafungin) exert their fungicidal activity by inhibition of the synthesis of th

49 Loss of fungicidal activity by the addition of CaCl(2) or MgCl(2

50 ural class of amphiphilic peptide with rapid fungicidal activity caused by C. neoformans.

51 ficant reduction, and in most cases loss, of fungicidal activity compared with the uninfected AM.

52 cells and macrophages demonstrated impaired fungicidal activity compared with those from healthy con

53 Early fungicidal activity did not differ (0.42 vs 0.39 log10CF

54 and analgesic agents that together generate fungicidal activity in drug-resistant Candida albicans,

55 ly, LPS priming of human neutrophils rescues fungicidal activity in the presence of pharmacologic inh

56 , attenuated respiratory burst, and impaired fungicidal activity in vitro.

57 microbial membrane is electrostatic, as its fungicidal activity is inhibited by cations.

58 -Candida activity, we sought to determine if fungicidal activity might be regulated by extracellular

59 Moreover, the fungicidal activity of 2H correlates with its inhibition

60 for monitoring of the growth inhibition and fungicidal activity of a drug.

61 The fungicidal activity of amphotericin B (AmB) was quantita

62 the production of superoxide anion, only the fungicidal activity of collagen-adherent monocytes was p

63 Thus, C. albicans Ssa2p facilitates fungicidal activity of Hst 5 in binding and intracellula

64 Fungicidal activity of Hst 5 is initiated by binding to

65 ficantly reduced intracellular transport and fungicidal activity of Hst 5, confirming its importance

66 unity by secreting GM-CSF, necessary for the fungicidal activity of neutrophils.

67 with membranes with MWCOs of >=1000 promoted fungicidal activity of parotid secretion, and this activ

68 e examined patterns of growth inhibition and fungicidal activity of posaconazole and tacrolimus, alon

69 Thus, the innate fungicidal activity of primary human AM is impaired afte

70 The in vitro fungicidal activity of SCH56592 was superior (minimum fu

71 The fungicidal activity of the three agents was similar (G m

72 t, zinc binding had limited effects on Hst 5 fungicidal activity or protease susceptibility.

73 In addition, the enhanced fungicidal activity seen after 18 h of treatment was no

74 sides of carvacrol and thymol exhibited more fungicidal activity than the other compounds.

75 Fungicidal activity varied in duration and effectiveness

76 licidin mCRAMP, killed C. albicans, but this fungicidal activity was dependent on culture conditions.

77 (Deltassa1 and Deltassa2) was observed, and fungicidal activity was further reduced to 20-30% in the

78 The enhancement of monocyte fungicidal activity was maintained over a 4-h period, wh

79 tained over a 4-h period, whereas macrophage fungicidal activity was maximum at 1 h.

80 ed Candida as efficiently as human Mphi, and fungicidal activity was not enhanced by the presence of

81 Little or no fungicidal activity was shown for Fusarium spp. (2 to >8

82 The effects of G-CSF on PMNL-mediated fungicidal activity were evaluated by administration of

83 ssays demonstrate that FK506 has synergistic fungicidal activity with caspofungin against echinocandi

84 major sphingoid bases of fungi, have potent fungicidal activity with remarkably high structural and

85 We compared 10-week survival and CSF early fungicidal activity with the outcomes observed in the AM

86 hat the amphipathic analogs exhibited a high fungicidal activity, a high propensity to form an alpha-

87 olonization through hyphal induction, direct fungicidal activity, and inhibition of candidal adherenc

88 histological evidence of enhanced macrophage fungicidal activity, and resolution of inflammation.

89 olarization macrophages favoring an enhanced fungicidal activity, demonstrated by the decreased CFU r

90 Although each mAb enhanced J774.16 cell fungicidal activity, differences were observed in the ab

91 e neutrophils demonstrates partial rescue of fungicidal activity, including phagocytosis, degranulati

92 etion of CD82 in mice resulted in diminished fungicidal activity, increased C. albicans viability wit

93 his species was relatively resistant to rhBD fungicidal activity, its adherence to oral epithelial ce

94 clearance rate of cryptococcus, termed early fungicidal activity, measured in patients with a first e

95 Compound 1 exhibited rapid fungicidal activity, reducing the burden of C. albicans

96 clinical resolution of talaromycosis, early fungicidal activity, relapse of talaromycosis, developme

97 related strongly with parallel increments in fungicidal activity, suggesting that oxidants did contri

98 ibitory activity toward C. albicans AHAS and fungicidal activity, supporting the hypothesis that AHAS

99 of NO synthase had little to no effect on DC fungicidal activity.

100 lasma-infected DC inhibited PL-fusion and DC fungicidal activity.

101 Ws of approximately 17000 and 4000 exhibited fungicidal activity.

102 plicating these ion movements in the toxin's fungicidal activity.

103 ope binding receptors for Hst 5 that mediate fungicidal activity.

104 ently demonstrated to have novel broad range fungicidal activity.

105 ic ions found in saliva that influence Hst 5 fungicidal activity.

106 id ergosterol results in potent, synergistic fungicidal activity.

107 eaks 1 and 6 had substantial fungistatic and fungicidal activity.

108 in relation to membrane permeabilization and fungicidal activity.

109 onsistent with their fungistatic rather than fungicidal activity.

110 nificant reduction of their microbicidal and fungicidal activity.

111 antifungal with broad-spectrum anti-Candida fungicidal activity.

112 rboring the risk genotype exhibited impaired fungicidal activity.

113 th potent and wide-spectrum bactericidal and fungicidal activity.

114 to 6-month mortality, clinical response, and fungicidal activity.

115 phils recruit pDCs, which promote neutrophil fungicidal activity.

116 gatively through immune exclusion and direct fungicidal activity.

117 luding human beta-defensins 1-3, have direct fungicidal activity.

118 presence of NK cells, resulting in increased fungicidal activity.

119 The extracts had fungistatic rather than fungicidal activity.

120 d reduced rates of PAF26 internalization and fungicidal activity.

121 host directed mechanisms rather than direct fungicidal activity.

122 channel formation is not required for potent fungicidal activity.

123 to activating stimuli and display increased fungicidal activity.

124 Here we found that RTD-1 was rapidly fungicidal against blastospores of fluconazole/caspofung

125 Staphylococcus aureus (especially), and were fungicidal against Candida albicans.

126 al peptide, was recently shown to be rapidly fungicidal against clinical isolates of MDR C. albicans

127 o and in vivo, the echinocandins are rapidly fungicidal against most Candida spp and fungistatic agai

128 st Aspergillus fumigatus, while also being a fungicidal against this organism.

129 xidizing thiocyanate to the bactericidal and fungicidal agent hypothiocyanite.

130 oxo-morpholin-3-yl)-acetamide derivatives as fungicidal agents against Candida species, additionally

131 ay, in part, explain the lack of efficacy of fungicidal agents during clinical disease.

132 ive target for antibacterial, herbicidal and fungicidal agents.We have solved the crystal structure o

133 As a proof of concept, two fungicidal AIs (fludioxonil and cyprodinil) were investi

134 suggest that earlier diagnosis, more rapidly fungicidal amphotericin-based regimens, and prompt immun

135 ood, especially for strawberries, due to its fungicidal and antibacterial effects.

136 Human salivary histatins possess fungicidal and bactericidal activities.

137 has a multitarget mechanism of action: It is fungicidal and bacteriostatic, it induces apoptosis in m

138 Fungicidal and/or fungi static effects proved to be depe

139 explored in the context of bactericidal and fungicidal applications.

140 AMBITION-cm trial regimen is likely to be as fungicidal as the currently recommended 14-day liposomal

141 microm) killed 80% of the wild-type cells in fungicidal assays at room temperature.

142 vities of these constructs were evaluated in fungicidal assays toward Candida albicans blastoconidia

143 tifungal mechanism in vivo, both binding and fungicidal assays were carried out using S. cerevisiae i

144 reas mouse Mphi do require acidification for fungicidal but not fungistatic activity.

145 n synthase inhibitor, has demonstrated broad fungicidal Candida activity and a favorable tolerability

146 Inflammatory microglia have poor fungicidal capacity and significantly expand during infe

147 abolished this activity, indicating that the fungicidal component was salt sensitive.

148 r screening chemical libraries for Nmt-based fungicidal compounds with relatively little activity aga

149 nal growth-based assays; and is specific for fungicidal compounds.

150 m inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) at 250 mug/mL.

151 m inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) varied from 0.28 to 2.25

152 l inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) were established against

153 cytes without eukaryotic cytotoxicity at its fungicidal concentration.

154 peptide is endocytically internalized at low fungicidal concentrations (2.0-5 microM).

155 At high fungicidal concentrations (20 microM), PAF26 internaliza

156 are not available for evaluating the minimum fungicidal concentrations (MFCs) of antifungal agents.

157 Minimum fungicidal concentrations (MFCs) were determined by subc

158 MICs and minimum fungicidal concentrations (MFCs) were determined in each

159 A similar trend was seen with minimum fungicidal concentrations (MFCs), with higher MFCs of th

160 l activity of SCH56592 was superior (minimum fungicidal concentrations [MFCs], 0.25 to 4 microgram/ml

161 he target yeast, with minimal inhibitory and fungicidal concentrations of 1.75 mg/mL.

162 inimum inhibitory concentrations and minimum fungicidal concentrations of each compound were defined

163 internalization and antifungal action at low fungicidal concentrations was energy-dependent, primaril

164 Most existing models for the fungicidal control of plant diseases do not explicitly i

165 Finally, we show that the fungicidal drug amphotericin B can kill intracellular C.

166 of GCN5 also causes hypersensitivity to the fungicidal drug caspofungin.

167 Given the need for fungicidal drugs, we propose that inhibitors of Stp1, Sr

168 s a target for development of a new class of fungicidal drugs.

169 ans and hence is a target for development of fungicidal drugs.

170 ata cells can survive lethal exposure to the fungicidal echinocandin drugs.

171 In this study, we demonstrate the fungicidal effect of these compounds as well as their ki

172 the CFS of X. szentirmaii showed the highest fungicidal effect on growth of S. sclerotiorum.

173 ficity of these responses indicates that the fungicidal effect was Nmt-dependent.

174 ects among the three inhibitors and in their fungicidal effects against pathogenic fungi possibly due

175 are strongly synergistic and exhibit potent fungicidal effects in combination.

176 Importantly, our studies demonstrated fungicidal effects of itraconazole and 25-thialanosterol

177 us, A. terreus was resistant to the in vitro fungicidal effects of safely achievable concentrations o

178 DNA preceded detectable neutrophil-mediated fungicidal effects.

179 susceptible and ABA was least susceptible in fungicidal examination.

180 es the CCR2-mediated massive accumulation of fungicidal ExMs derived from circulating Ly-6C(high) mon

181 lysis of T1/ST2(-/-) mice revealed increased fungicidal exudate macrophages in the lungs and decrease

182 ngal N-acylated cyclic hexapeptides that are fungicidal for candida strains and fungistatic for asper

183 exclusively of D-amino acids) were potently fungicidal for yeast-phase C. albicans.

184 Elevated level of an active fungicidal form of saponin, dAA in the husks possibly in

185 sts that blocking mannose synthesis could be fungicidal in the mammalian host and thus an excellent t

186 for the concerted action of magainin 2, the fungicidal lipopeptide class of surfactins from Bacillus

187 In contrast, the fungicidal lipopeptides surfactin, fengycin, and iturin

188 tatic stunting of hyphal growth and repeated fungicidal lysis of apical tip compartments.

189 ts initial conidial redistribution away from fungicidal neutrophils into the favorable macrophage int

190 is study investigated the mechanism by which fungicidal nitroimidazole compounds modulate AC activity

191 genesis in Candida albicans, notably without fungicidal or fungistatic activity.

192 tant population of fungus, is treated with a fungicidal or fungistatic drug.

193 testing their fungicidal activities (minimum fungicidal or lethal concentrations [MFCs]).

194 may therefore serve as useful antibacterial, fungicidal, or herbicidal agents.

195 oformans, at least in part via generation of fungicidal oxidants.

196 The addition of sodium chloride to dialyzed, fungicidal parotid secretion abolished this activity, in

197 c biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing

198 g, hemolytic, antioxidant, bactericidal and, fungicidal properties, cytotoxicity effects and inhibiti

199 g antimicrobial effects, but did not exhibit fungicidal properties.

200 in the NADPH oxidase that normally produces fungicidal reactive oxygen species.

201 se data extend and corroborate the available fungicidal results for the three agents.

202 From a fungicidal screen, we identified 2-(2-oxo-morpholin-3-yl

203 he expression of EcoPrrC in budding yeast is fungicidal, signifying that PrrC is toxic in a eukaryon

204 view of the trehalose pathway as a selective fungicidal target for use in antifungal development.

205 cumulation of T6P, which makes this enzyme a fungicidal target.

206 isinfectant towelette was significantly more fungicidal than the QAC-alcohol-based disinfectant towel

207 Salivary protein histatin 5 (Hst 5) is fungicidal toward Candida albicans, the causative agent

208 All fungicidal treatments induced an increase in AFB2 produc

209 or less (5b, 6h, 6i), and two (5b, 6i) were fungicidal, unlike a standard antifungal drug fluconazol

210 is an antimicrobial peptide with bacterial, fungicidal, virucidal properties, attacking bacteria and