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1 notations were last updated is not apparent, further complicating a researchers' ability to assess th
2 mple matrix (commonly urine) chemical noise, further complicating accurate identification efforts.
3              This approach, while effective, further complicates an already complex drug formulation
4  challenge as the large size of these tumors further complicates an already difficult procedure.
5 dent 3D topologies in mixed cell populations further complicate analyses.
6  lateral versus depth resolution differences further complicate analysis.
7 tion patterns for many scaffolds is limited, further complicating analysis.
8                                         This further complicates annotation of metagenomic datasets,
9 f a different dosing regimen for RTX and OBZ further complicates any interpretation of clinical resul
10                                 This task is further complicated as biological interactions depend on
11                            This conundrum is further complicated as cytoadherence in the microvascula
12 t the additional lack of normative standards further complicates assessments in pediatric athletes.
13 vant even at small interaction angles and is further complicated at large angles by a non-conservatio
14 tal helping to promote pre-natal development further complicates attempts to identify and quantify th
15 ization/sensitivity, and temperature optima, further complicating attempts to reconstruct the tree of
16                                              Further complicating attempts to understand interactions
17                                      This is further complicated because C3 activation fragments and
18                 This definitional problem is further complicated because neither host nor microbial p
19  particular focus on breast cancer, which is further complicated because of its classification into s
20                      This situation has been further complicated because two other cryptic species fr
21 nd the evaluation of putative communities is further complicated by a lack of known ground truth.
22 nconsistent, and comparing published data is further complicated by a lack of standard processing and
23 teroid therapy and whose clinical course was further complicated by acute tubular necrosis and renal
24                              SL discovery is further complicated by an absence of SL sequences from h
25 zed controlled trial, evaluating survival is further complicated by bias introduced by allowing activ
26                            This situation is further complicated by changing the environmental condit
27                                      This is further complicated by co-morbidities that may alter the
28 y of life might be seriously compromised and further complicated by comorbidities.
29                              These tasks are further complicated by conflicting and proprietary image
30 ons associated with delivered electricity is further complicated by contractual arrangements for dyna
31                                  This may be further complicated by discontinuous domains in the inpu
32 pression abundance of different RNA species, further complicated by divergent cell-type-specific and
33                               The process is further complicated by effects arising from the intracel
34 ation sites with tandem mass spectrometry is further complicated by fragmentation of both the peptide
35 strates that such inter-network dynamics are further complicated by functional fractionation within n
36 nction in pregnancy, and 2%-12% of cases are further complicated by hemolysis (H), elevated liver tes
37  Interpretation of these effect estimates is further complicated by heterogeneity (variation, modific
38 illus Calmette-Guerin therapy is complex and further complicated by high numbers of patients who are
39 dalities, and laboratory report constraints, further complicated by infrequently collected specimen t
40     Their deployment against solid tumors is further complicated by insufficient drug penetration, a
41    The effect of exercise in obese women was further complicated by insurance status.
42                    In diffusion MRI, this is further complicated by intra-voxel inter-subject differe
43                           Thalassemia may be further complicated by iron overload (frequently exacerb
44                           Diagnosing iCCA is further complicated by its limited accuracy, often neces
45 the wing movements of a flying butterfly and further complicated by its motion in and out of shadows.
46 ory inputs across individual cells, which is further complicated by largely observed zero and low exp
47 y (DCM), but the technique is subjective and further complicated by left bundle-branch block (LBBB).
48 ifying how best to design protected areas is further complicated by monitoring programs failing to de
49                                      This is further complicated by our finding that bivalent LRP6 an
50               The transfection experiment is further complicated by PCR errors and the presence of vi
51  as glaucoma remains an unmet clinical need, further complicated by poor patient compliance with topi
52            HLA typing from RNA sequencing is further complicated by post-transcriptional modification
53 f varicella-zoster virus exposure and can be further complicated by postherpetic neuralgia.
54 r HCV, the clinical impact of coinfection is further complicated by reports of HBV reactivation follo
55                                      This is further complicated by societal factors that receive ext
56 e, moisture, and substrate supply, which are further complicated by spatial heterogeneity of the soil
57    Studies of these biomolecules in vivo are further complicated by striking variations between labor
58                                      This is further complicated by studies showing that SK1 and SK2
59 disparities in sex inclusion in research are further complicated by the absence of sufficient reporti
60               Assessing the effect of PEG is further complicated by the aggressively fatal disease, s
61  counterion and water distribution, which is further complicated by the approach and binding of a pro
62 se low-abundance, often unstable proteins is further complicated by the challenge of disentangling th
63                           Decision-making is further complicated by the choice of an invasive (aggres
64               Designing a chiral catalyst is further complicated by the complex mechanism of CuAAC.
65 tremely low gestations is a complex scenario further complicated by the differences in attitudes with
66  therapies for neurodegenerative diseases is further complicated by the difficulty in determining whe
67 -loop control using magnetic actuator coils, further complicated by the diverse requirements across a
68                                      This is further complicated by the dynamics in runoff flows and
69  by germline variants and their detection is further complicated by the effects of tumour purity/subc
70 s is still lacking as data interpretation is further complicated by the emergence of surface-band Lan
71 reover, this somewhat simplistic division is further complicated by the existence of both ectoparasit
72 asis evolved and this simplistic division is further complicated by the existence of both ectoparasit
73                             The situation is further complicated by the existence of six mammalian im
74                            This situation is further complicated by the existence of their multiple s
75                             This decision is further complicated by the fact that a phase III study d
76                              This problem is further complicated by the fact that an intrinsic charac
77                                      This is further complicated by the fact that datasets obtained w
78                        Epitope prediction is further complicated by the fact that multiple epitopes m
79                        These diversities are further complicated by the fact that OSA/PSA spontaneous
80            The study of these adaptations is further complicated by the fact that the changes may be
81        The unreliable variance estimation is further complicated by the fact that the technology-spec
82                           Early diagnosis is further complicated by the fact that there are likely ma
83                      This situation has been further complicated by the fact that two other cytokines
84 y to analyze large numbers of mutants and is further complicated by the high rate of cointegration of
85                             This question is further complicated by the inherently dynamic nature of
86              The detection of the disease is further complicated by the invasiveness of conventional
87 ghly non-linear and dynamic nature, which is further complicated by the issue of non-identifiability.
88 tion of ribonucleotides for DNA synthesis is further complicated by the lack of a ribonucleotide redu
89                             The challenge is further complicated by the large number of genetic varia
90 t for attribution and provenance studies, is further complicated by the low concentrations at which t
91 llenging with current serology assays and is further complicated by the marked decrease in routine vi
92 roduces a complex regulatory picture that is further complicated by the multiple intracellular locati
93                                  Analysis is further complicated by the need for so-called cross-worl
94 d upon laborious germline targeting, and are further complicated by the need to avoid developmental p
95                             The situation is further complicated by the need to separate hydrophobic
96                             Observations are further complicated by the nesting of cells within tissu
97                                     This was further complicated by the observation that changes in t
98                                 Their use is further complicated by the observation that many patient
99                  The recognition of BD-II is further complicated by the overlap of its symptoms with
100                              This pattern is further complicated by the pairwise experience each anim
101 terpretations of amygdala lesion studies are further complicated by the potentially confounded nature
102                                    This gets further complicated by the presence of biophysical facto
103 nd selection of antiepileptic drugs is often further complicated by the presence of comorbidities, po
104 s that are difficult to clean and disinfect, further complicated by the presence of heat sensitive co
105                             Such analysis is further complicated by the presence of hypervariable reg
106  such compounds by chemical synthesis can be further complicated by the presence of multiple nitrogen
107                               The picture is further complicated by the presence of nonfunctional env
108 xpression during mouse development which was further complicated by the presence of several alternati
109 eous subvisible particle characterization is further complicated by the presence of silicone oil drop
110                                      This is further complicated by the prevalence of steatosis in ab
111 s on patients and fertility clinics that are further complicated by the recently evolving US judicial
112                        The second problem is further complicated by the reliance of separation in DQA
113 uires exploration of a complex design space, further complicated by the scarcity of real human livers
114                                  Analysis is further complicated by the steps taken to collect and pr
115                                      This is further complicated by the transcription-coupled incorpo
116 ers considerably between institutions and is further complicated by the transitional physiology of th
117                                This issue is further complicated by the unknown metastasis prevalence
118 ing track of all these proteins, a situation further complicated by the variety of names and identifi
119 ing the individual roles of these factors is further complicated by their ability to cross-regulate o
120                                  This can be further complicated by transfusion, though the contribut
121                             The structure is further complicated by twinning.
122  between diversity and ease of access and is further complicated by uncertainty about the synthesizab
123  resistance is a major public health threat, further complicated by unexplained treatment failures ca
124                                        It is further complicated by variability in nonspecific identi
125 se of fluorescent probes for G4 detection is further complicated by variations of probe uptake into c
126 hailand, limited research exists on suicide, further complicated by varying rates across regions and
127  of consensus regarding treatment thresholds further complicates clinical decision-making.
128                                              Further complicating clinical evaluations are unusual ma
129 s are handled, and how death is incorporated further complicates comparisons across trials.
130 ticity of enzyme functions of these pathways further complicate correct annotation.
131 ng, measurement methods and instrumentation, further complicate data integration.
132 immobilization and screening matrix effects, further complicate data interpretation.
133 e availability of direct oral anticoagulants further complicates decision making and guidance here is
134 n SVG is not always a ctSVG, and vice versa, further complicating detection.
135  polyfungal or bacteria-fungal co-infections further complicates diagnosis and treatment.
136 artly responsible for this transition, which further complicates disease management.
137 ontrasting effects on blood and brain levels further complicates drug dosing.
138 imarily identified, and its broad host range further complicates effective management.
139 rtunities for ignitions and fire spread that further complicate fire management operations.
140 ation in the coreceptor binding domain could further complicate HIV-1 vaccine design.
141              Product selectivity may be even further complicated if n(1)- and n(3)-allyls share a sin
142 mpts to understand mesocrystal formation are further complicated in many systems by the presence of p
143 However, the pharmacology of this series was further complicated in that certain analogs displaying o
144 is limited by the lack of specificity but is further complicated in the benign prostatic hyperplasia
145 ask is when considering cellular life, it is further complicated in the case of viruses.
146                                      This is further complicated in the presence of degradation produ
147                             These issues are further complicated in the study of O-glycosylation, whi
148                         These challenges are further complicated in tropical regions, where despite t
149 nce of multiple conformations of the helices further complicate indexing.
150 n of 3 or more distinct influenza B viruses, further complicating influenza vaccine formulation and h
151 at constitutes elder abuse and neglect, this further complicates instrument development and clinical
152 gly important, while collisions and crowding further complicate inter-particle interactions.
153  with atomic density and multiple scattering further complicates interpretation.
154                                              Further complicating issues is the difficulty in constru
155 for its multidrug resistance to antifungals, further complicating its clinical management.
156 e new tests into existing clinical care, and further complicates many of the economic and ethical dil
157                                           To further complicate matters, recent single-cell RNA seque
158                                              Further complicating matters, differences in life histor
159                                              Further complicating matters, transplant patients have a
160 ction, presents a new set of challenges that further complicate more traditional PCR setups.
161  in loss measurement and angle discontinuity further complicate oriented detection.
162                      This context-dependency further complicates our understanding of mutators in cli
163  laboratories or reproduced in animal models further complicates our understanding of psychiatric dis
164 ss clinical units, and degrading calibration further complicates our understanding of quality.
165                                              Further complicating our grasp of these disorders are am
166 tor tyrosine kinases on the plasma membrane, further complicating our understanding of GREM1 biology.
167 quence context more than previously thought, further complicating our understanding of their contribu
168 iverse patient responses to these conditions further complicate patient management and outcome predic
169 ce of multi-drug-resistant bacterial strains further complicates patient treatment.
170 ticularly liver and kidney, is not uncommon, further complicating perioperative care.
171 ility of the T. pallidum cell envelope which further complicates proteomic identification of rare T.
172 asily in large quantity without resorting to further complicated purification.
173  an emerging spectrum of therapeutic options further complicate PVT management.
174 ticle bursts in resonators on the same chip, further complicating quantum error correction.
175 cy reactivation cycle in sensory neurons may further complicate reproductive failure in pregnant cows
176 ata, while the inherent stochasticity in TFs further complicates result interpretation and reproducib
177  but in the case of complex diseases this is further complicated since genetic factors in affected in
178                      Organ dysfunction often further complicates such toxicities and may even be proh
179 oduce correlation among the samples and thus further complicate the analysis and interpretation of mi
180                                 These errors further complicate the automated identification of EST-r
181 ost patients with severe thalassaemia, might further complicate the clinical phenotype.
182  use, mental illness, and infectious disease further complicate the delivery of care.
183  such as ring saturation and transalkylation further complicate the desired reduction process.
184 osis, which is routine microbiology culture, further complicate the diagnostic and management process
185 i are an emerging threat to human health and further complicate the general problem of treating serio
186 ype and weak genotype-phenotype correlations further complicate the identification of shared cellular
187 pic effects between these two substrates can further complicate the metabolic profile of the enzyme.
188 iability and high noise in ultrasound images further complicate the model training.
189 em and inhibitory tumor microenvironment can further complicate the prospects for successful immunoth
190 crosstalks, and organ-specific architectures further complicate the quest for a faithful human in vit
191 erse functions of TGFbeta in healthy tissues further complicate the search for effective and safe can
192                                           To further complicate the situation, the COVID-19 pandemic
193 lycaemia, weight gain, and drug interactions further complicate the treatment process.
194 iurnal variation, and regression to the mean further complicate the understanding of whether monocula
195          The emergence of novel variants has further complicated the interpretation of much of the av
196                    The COVID-19 pandemic has further complicated the management of cardiometabolic di
197 d and foreground of the suspected sample has further complicated the plant leaf disease detection pro
198 ormation on sexual system in the species has further complicated the situation.
199 ongitudinal design to collect samples, which further complicates the analysis methods needed.
200 tural and chemical diversity of the lipidome further complicates the analysis.
201                         Indeed, this feature further complicates the application of traditional struc
202 vere asthma with fungal sensitization (SAFS) further complicates the correct pheno-endotyping, which
203 ex interplay of signal-transduction pathways further complicates the customization of cancer treatmen
204 ended haplotypes encompassing NCF-1/psiNCF-1 further complicates the detection of A47 degrees CGD car
205 or glaucoma or glaucomatous optic neuropathy further complicates the development of universal diagnos
206 standardized clinical or laboratory criteria further complicates the diagnosis and management.
207 ty of responses targeting different epitopes further complicates the discovery of determinants of pro
208 ventricular cardiomyocytes, skeletal muscle) further complicates the identification of optimal therap
209               Arbitrarily defining genotypes further complicates the interpretation of genotyping res
210                                 Metagenomics further complicates the issue by generating fragmented 1
211 pendence of streamflow trends on flow regime further complicates the issue.
212 uirement to filter noise from the raw signal further complicates the modeling process, as it limits t
213 ecules in all Archaea and in some eukaryotes further complicates the picture of translation initiatio
214 tain significance, often missense mutations, further complicates the risk assessment.
215  of a meaningful protein-encoding transcript further complicates the story.
216 y, increasing antimicrobial resistance (AMR) further complicates the task of effective therapy for UT
217 ria gain resistance to drugs over time which further complicates the treatment.
218 allenge, the current lack of structural data further complicates the use of Gluc for in vitro applica
219  also affect the function of adjacent genes, further complicating the aetiology of the disease.
220 ltiple protein variants from the CASK locus, further complicating the interpretation of experiments u
221 thrombotic risk resides in many specialties, further complicating the issue.
222                                       Though further complicating the measuring procedure and the cor
223                                              Further complicating the process is the existence of pol
224                                              Further complicating the process, myosin binding acceler
225 at should be dealt with carefully to prevent further complicating the situation and should be resolve
226  significantly affect other dihedral angles, further complicating the situation.
227 acity to form stereoisomeric superstructures further complicating the study of this series of compoun
228  different, requirements for their training, further complicating the task of education.
229  antagonistic effects on protein attributes, further complicating the task of outcome prediction.
230                                              Further complicating the utility of fosfomycin is the sp
231 eW binding surfaces near the receptor tip or further, complicating the events at this highly conserve
232 of beta-glucans, soluble versus particulate, further complicate their mechanism of action.
233 ed to as platelet refractoriness (PR), which further complicates their care.
234 teroid use, and variable nutritional support further complicates their management.
235 t RAF autoinhibition underpins this paradox, further complicating therapeutic strategies centered aro
236                             Diploid dynamics further complicate these interactions, showing reduced a
237                        The COVID-19 pandemic further complicated these risks, prompting fire agencies
238                         Kin selection theory further complicates these dynamics: males should avoid c
239  animal models to study age-related diseases further complicates these matters.
240 cation decision is made; commercial bias may further complicate this balance.
241         However, emerging data appear set to further complicate this picture.
242 aurasia in their early evolutionary history, further complicates this picture.
243 dly evolving landscape of systemic treatment further complicates this task, raising significant conce
244                                              Further complicating this challenge is the elusive impac
245                                              Further complicating this issue is increasing evidence t
246                                              Further complicating this process, individuals must perf
247                                              Further complicating this situation, three different PAR
248 n gastrointestinal conditions in early stage further complicates timely detection.
249 cules other than proteins present in tissues further complicate tissue proteomic analysis.
250             Variation unrelated to pathology further complicates transcriptomic, proteomic and metabo
251 rainfall, lead to temporal heterogeneity and further complicate transmission dynamics and the utility
252                                           To further complicate treatment decision-making, many clini
253 yndrome coronavirus 2 variants and mutations further complicates treatment due to their differing sus
254 related to characterizing relevant pathogens further complicates treatment.
255                                              Further complicating variant interpretation, variant imp
256 s in horseweed and may be spreading rapidly, further complicating weed management efforts.
257                            This challenge is further complicated when attempting to make these materi
258                          Interpretations are further complicated when comparing different pepMHC, bec
259           Full-length HIV-1 RNA transport is further complicated when group-specific antigen (Gag) pr
260                             The situation is further complicated when the maggot mass being sampled i
261                             The situation is further complicated when you consider that the genome is
262 ein subunits are quite perplexing, which get further complicated with polyploidy.

 
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