ライフサイエンスコーパス: fused ring

1 tuted cyclooctene to 4.9 kcal mol(-1) in the fused ring).

2 ith 16 fused rings (from a precursor with no fused rings).

3 well as 5-, 6-, and 7-membered rings for the fused ring.

4 ing current in the 6+ state of the partially fused ring.

5 icyclic N-heterocycles: bridged, spiro-, and fused rings.

6 mposed of alternating linearly and angularly fused rings.

7 k]tetraphene-derived oligomers with up to 13 fused rings.

8 our phenyl rings appended to the two central fused rings.

9 ne-like hydrocarbons with the same number of fused rings.

10 linearly extended conjugated core with eight fused rings.

11 motif of three pentagonal and one triangular fused rings.

12 s into a three-dimensional random network of fused rings.

13 fluoromethyl)mercury and sodium iodide] gave fused-ring 2,2-difluorocyclopropane compounds.

14 Deoxypodophyllotoxin contains a core of four fused rings (A to D) with three consecutive chiral cente

15 Promoter sterols have flat, fused rings, a hydroxyl headgroup, an alkyl tail, and a

16 dily from phenylalanine derivatives, but the fused-ring analogues 5 could not be obtained in good yie

17 key dihedral angle was constrained to design fused-ring analogues, substituted N-arylpyrrolopyridines

18 asilanes, possessing up to three consecutive fused rings and differing in relative ring fusion config

19 olizino[8,7-b]indole architectures, with six fused rings and four contiguous chiral centers, is repor

20 sessment of aromatic competition between the fused rings and the central borepin core.

21 sis of complex carbocycles composed of three fused rings and up to five stereocenters with complete s

22 ionalized chiral tetrahydrofurans as well as fused-ring and bridged-ring oxabicyclic products.

23 Fused-ring and bridged-ring tetrahydrofuran scaffolds ar

24 ed DPNDs, these nonplanar dyes bearing eight fused rings are almost nonfluorescent, which is attribut

25 dditional flexibility not available when the fused rings are intact.

26 Arene- and heteroarene-fused rings are pervasive in biologically active molecul

27 s of a Scholl reaction nanographenes with 53 fused rings are realized, which exhibited good solubilit

28 ted against spectra measured for a number of fused-ring aromatic hydrocarbon molecules containing var

29 Well-defined, fused-ring aromatic oligomers represent promising candid

30 These requirements may involve planar fused-ring aryl systems and possibly hydrogen-bonding ca

31 drocarbons (PAHs), ranging from two to seven fused rings, as a result of its large, accommodating cav

32 was found to be similar for chromenes with a fused ring at the 7,8-positions.

33 el anticancer agents, we explored the SAR of fused rings at the 7,8-positions.

34 The largest one shows a 53 linearly fused rings backbone (12.9 nm) and 322 conjugated atoms

35 on involving spontaneous ring expansion of a fused-ring benzazirine into a seven-membered ring cyclic

36 The synthesis of novel fused-ring bicyclic (4-6) and tricyclic (7-10) nicotine

37 ain three stereogenic centers and up to four fused rings can be accessed in two steps from relatively

38 From these results, it is clear that the fused ring carbazoles can bind strongly in the DNA minor

39 om three different structural classes: rigid fused ring compounds [dihydrexidine, dinapsoline, dinoxy

40 -stage modification of complex molecules and fused ring compounds further support the potential broad

41 -stage modification of complex molecules and fused ring compounds.

42 O3) are investigated to reveal how different fused-ring configurations control molecular packing, ele

43 Among the bicyclic fused-ring congeners 17-38, the indole-containing analog

44 Previously undescribed [4.4.0] and [5.3.0] fused-ring-containing products were obtained when santon

45 gent, complex scaffolds bearing heteroatoms, fused rings, contiguous stereocenters, spirocycles, and

46 ed in planar molecular geometry containing a fused-ring core.

47 e the less ordered backbones of the extended fused-ring cores that have recently been utilized (TIF-B

48 3-gh][3,8]phenanthroline-5,11(4H,10H)-dio ne fused-ring derivatives.

49 e first bond, but not with the strain of the fused rings distal to the polymer main chain, suggesting

50 report the synthesis of a novel ladder-type fused ring donor, dithienogermolodithiophene, in which t

51 -1H-inden-1-ylidene)malononitrile to yield a fused-ring electron acceptor (IOIC2) for organic solar c

52 Fused-ring electronic acceptors (FREAs) have transformed

53 Now a superior hydrogen-free 5/6/5 fused ring energetic material, 1,2,9,10-tetranitrodipyra

54 cribes a configuration-dependent [6 + 8 + 5] fused ring formation via a tandem cyclic N-acyliminium n

55 gy for preparing a large variety of aromatic-fused rings from linear simple ketone precursors.

56 lar coupling to form a helical ZrPAH with 16 fused rings (from a precursor with no fused rings).

57 tral or detrimental for inhibition, a rigid (fused) ring generated nM benzobisheterocycle (BBH) inhib

58 This pharmacophore comprises a 6 + 5 fused ring heterocycle linked to an aliphatic substituen

59 The fused-ring heterocycle is stabilized under acidic condit

60 s, and excellent atom economy to obtain four fused ring heterocycles, in a regio- and diastereoselect

61 set up a tandem reaction sequence, providing fused ring heterocycles.

62 Oligomers containing the new fused-ring heterocyclic conjugated building block thieno

63 Fused rings in Vegavis form a well-mineralized pessulus,

64 ed a preference for the formation of the cis-fused rings, in agreement with experimental results.

65 ring was less than 100-fold, suggesting that fused-ring intermediates were not formed.

66 tepwise loss in aromaticity as the number of fused rings is increased from one to two to three.

67 An extensive polycyclic n-system with 23 fused rings is synthesized via a highly efficient boryla

68 Our findings highlight how fused-ring isomerism decisively governs structure-packin

69 ize because of the highly strained 5,6-trans-fused ring junction that had to be formed.

70 yclic enones (7 and 10) that contain A/B-cis-fused ring junctions.

71 of this class is a scaffold of four linearly fused rings, labeled A through D.

72 ogical activities indicate that a variety of fused-ring minor-groove binding agents should be investi

73 The fused-ring monomer enables a broad scope of functionalit

74 from several classes of thia-PAHs with four fused rings, namely, benzo[b]naphtho[2,1-d]thiophene (1)

75 most effective analogues have tryptophan or fused-ring non-natural amino acids at position 4 and ala

76 The fused-ring non-natural amino acids at position 4 contrib

77 nce for activity and that a minimum of a two-fused-ring nucleobase is required for activity to exceed

78 Methyl substitution of the benzo-fused ring of 29 at the 7-, 8-, and 10-positions resulte

79 inal thiophene by selenophene in the central fused ring of BTPSV-4F, for constructing efficient tande

80 vage of the beta-lactam ring, when the rigid fused rings of benzylpenicillin and cephaloridine each f

81 withdrawing fluoro substituents on the benzo fused-ring of the isoselenazolone appear to enhance the

82 associated with furan ring substitution into fused-ring oligothiophenes on the electronic properties

83 A series of fused-ring oligothiophenes were synthesized by a combina

84 6-membered pyrido and the 5-membered pyrrolo fused rings on quinone methide and vinyl quinone formati

85 The longest one comprises 29 linearly fused rings (particularly including 10 pentagonal rings)

86 further insight into the biogenesis of such fused-ring polyether systems.

87 tions 4 and 5, and formation of a hexacyclic fused-ring product with N-phenyltriazolinedione.

88 iyn-1-als, affording the corresponding 5-7-5 fused-ring products bearing a seven-membered lactone moi

89 The size of the fused ring profoundly influences the temperature that is

90 carbon spacer results in the formation of a fused ring rather than the classic methide species.

91 sized consists of an average of 268 linearly fused rings, reaching 65 nm in average length with nearl

92 Hexacene and larger fused rings remain elusive targets for chemists.

93 s (particularly for species with multiple or fused rings) remains uncertain.

94 Although composed of five fused rings, rotenone is a flexible molecule and populat

95 Furthermore, we found that the size of the fused ring significantly influences the signals correspo

96 opore volume, H/C ratio, O/C ratio, aromatic fused ring size, or HTT.

97 defines the conformation of the substrates' fused ring skeleton that ultimately distinguishes betwee

98 xacene-like molecule containing six linearly fused rings, specifically a pentacene molecule fused wit

99 They are assembled from fused-ring spiro-ladder oligomers (spiroligomers) by mod

100 riguing carbocycles, such as highly-strained fused rings, spirocycles or highly-functionalized carboc

101 revious report we showed that, despite their fused ring structure, the carbazoles also bind in A/T se

102 PIM-1, a prototypical PIM material, uses a fused-ring structure to increase chain rigidity between

103 Bioactive triterpenes feature complex fused-ring structures, primarily shaped by the first-com

104 d with CSI, with all examples resulting in a fused ring system except those bearing electron-withdraw

105 tural product architectures led to a complex fused ring system ideally suited to bind to the MDM2 pro

106 nstead resulted in an unexpected tetracyclic fused ring system in high yield (88%).

107 we show how spin density is affected by the fused ring system substituents.

108 matic structural alterations of its complex, fused ring system to synthesize 80 diverse compounds wit

109 reaction for the construction of the bridge-fused ring system was demonstrated.

110 The structure of the tetracyclic spiro-fused ring system was unambiguously confirmed by X-ray d

111 large part by the degree of planarity of the fused ring system whereas functional selectivity was dep

112 -allene [4+3] cycloaddition to build the 5,7-fused ring system with an oxa-bridge in one step, and a

113 The analogous synthesis of the [6 + 7 + 5] fused ring system yielded inseparable diastereomers in a

114 on) and the stereoselectivity (trans- vs cis-fused ring system) of the cyclization process can be con

115 and architectural motifs, including a 6-5-6-fused ring system, 5 stereogenic centers, and a central

116 ummerer cyclization to construct a tricyclic fused ring system, and (c) a diastereoselective ring exp

117 ct the bicyclo[4.3.1]decanedione core from a fused ring system, in which the acetalization step effec

118 trated by efficient synthesis of a different fused ring system, represented by the antihelmintic praz

119 The test systems were constrained in a fused ring system, thus locking the orientation of three

120 e caged structure could arise from a simpler fused ring system.

121 ry or remote stereochemistry in this kind of fused ring system.

122 mediate, which, on hydrogenloysis, gives the fused ring system.

123 a rapid ring closure to the more stable cis-fused ring system.

124 h 2 equiv of diphenylketene afforded a spiro-fused ring system: azoniabenzo[de]fluorine.

125 riation of the N-alkyl chain and of the aryl fused-ring system provides an accounting of bile salt mo

126 ndoloquinoline units incorporated in a seven-fused-ring system.

127 obal aromatic characters of various rings in fused ring systems built upon boron heterocycles.

128 ion mode, and this may be engineered to form fused ring systems by an initial exo-mode nucleophilic c

129 ntaining benzodiazepinone- and quinazolinone-fused ring systems can be assembled by nonribosomal pept

130 us to efficiently forge the intricate 5-8-5 fused ring systems found in numerous complex natural pro

131 nitration reaction sequence leading to trans-fused ring systems have been investigated with density f

132 anidine, and reversed amidine derivatives of fused ring systems have been synthesized from their corr

133 ms because they reflect the inability of the fused ring systems to respond to changes in aromaticity/

134 rpenes with unprecedented 6/11/5 and 6/6/7/5 fused ring systems when transiently co-expressed with a

135 arge methylene-bridged PAHs (mostly 22pi six-fused ring systems).

136 en studied ranging from single aryl rings to fused ring systems, and also styryl substituents, establ

137 n of BTD, ring closing reactions to generate fused ring systems, as well as the generation and captur

138 electron nitrogen bridgehead bicyclic [5,6]-fused ring systems, imidazo[1,2-a]pyridine and imidazo[1

139 may be constrained by setting them into edge-fused ring systems, or extended by conjugation with care

140 provides a method to access spirocyclic and fused ring systems.

141 cess to gamma-lactones, including spiro- and fused ring systems.

142 vides access to isoquinoline- and pyrimidine-fused ring systems.

143 noldiazo compounds that produce cyclopropane-fused ring systems.

144 function of extended conjugation within the fused ring systems.

145 opportunity to easily assemble 5,6- and 6,7-fused ring systems.

146 lustrates a divergent approach to synthesize fused-ring systems by CC activation/functionalization.

147 or the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety.

148 the [5/5] or [5/6] oxygen-containing Indane fused-ring systems in moderate to good yields with excel

149 new benzimidazole and imidazo[4,5-c]pyridine-fused ring templates, represented by compounds 4 and 7,

150 s of this linear intermediate to produce the fused ring tetrahydroxynaphthalene (THN) skeleton.

151 Darobactin has an unusual structure with two fused rings that form post-translationally.

152 active fluorophore and (b) destruction of a fused ring to activate a fluorophore, have been explored

153 formation across a broader range of organic (fused ring to branched aliphatic) and halide (bromide to

154 et of the UV-vis absorption spectra when the fused-ring unit is located nearer to the periphery of th

155 ended conjugation into the electron-donating fused-ring units in nonfullerene acceptors is a promisin

156 ereochemistry of the bridgehead atoms of the fused ring using new MDOs self-assembled from both enant

157 For maximum diversity, the size of the fused ring varied from three to six atoms and contained

158 alkynylation, followed by formation of four fused rings via a zirconacyclopentadiene intermediate, a

159 l systems such as spirocycles, bicycles, and fused rings were excellent substrates, enabling the synt

160 nd thus, larger (11- to 12-membered) diarene-fused rings were obtained via the homo-HIRE and homo(2)-

161 In addition, fully saturated poly-fused rings were prepared from the carboacylation produc

162 ite the presence of the methylene bridge and fused ring, whereas the other showed lower affinity and

163 composed of alternating linear and angularly fused rings, which give rise to an internal cavity and a

164 for compounds with high molecular weight and fused rings while high enrichment factors were obtained

165 netic polycyclic pai-system containing seven fused rings with 27 sp(2)-hybridized atoms and 29 pai-de

166 It consists of 34 pai-fused rings with 96 conjugated sp(2) carbon atoms.