ライフサイエンスコーパス: fusion gene

1 ) and viral entry (the G [attachment] and F [fusion] genes).

2 eukemia (ALL) and gives rise to the TEL-AML1 fusion gene.

3 -retinoic acid receptor alpha (PML-RARalpha) fusion gene.

4 n of miR-99a and enhancing expression of the fusion gene.

5 in vivo in VCaP cells, which express the T/E fusion gene.

6 male patients with lung cancer harboring RET fusion gene.

7 1-platelet-derived growth factor beta(PDGFB) fusion gene.

8 ining 22 base pairs, identified from BCR-ABL fusion gene.

9 genic expression of the Nup98-HoxD13 (NHD13) fusion gene.

10 ome 17, resulting in a classic bcr3 PML-RARA fusion gene.

11 dem duplication leading to an oncogenic BRAF fusion gene.

12 from a green fluorescent protein-beta globin fusion gene.

13 e basis of its molecular lesion, the BCR-ABL fusion gene.

14 from a green fluorescent protein-beta-globin fusion gene.

15 omosomal translocation generating a TEL-AML1 fusion gene.

16 -ALK fusion RNA without forming the EML4-ALK fusion gene.

17 h eosinophilia, which generates a CBFB-MYH11 fusion gene.

18 s of metastatic PCCs/PGLs included the MAML3 fusion gene.

19 em cell (LTHSC) by expression of the BCR-ABL fusion gene.

20 of cancer genomes and often create oncogenic fusion genes.

21 usion isoforms within tumorigenesis-relevant fusion genes.

22 ting to examine the in vivo functions of the fusion genes.

23 exons, discover novel transcripts and detect fusion genes.

24 ngement to generate constitutively activated fusion genes.

25 ed sequencing panel to detect cancer-related fusion genes.

26 sing the MLL-AF6, -AF9, -AF10, -ENL, or -ELL fusion genes.

27 mor specimens, labeled with optical reporter fusion genes.

28 translocations, leading to identification of fusion genes.

29 be helpful to study the functional aspect of fusion genes.

30 CRISPR-mediated inactivation of FGFR3-TACC3 fusion genes.

31 also enabled domain-function studies of BRAF fusion genes.

32 gH genes are main partners in a third of all fusion genes.

33 ticularly in cancers driven by oncogenic ETS fusion genes.

34 read-through transcripts putatively encoding fusion genes.

35 that patients have on average 5.5 expressed fusion genes.

36 DNMT3A is involved in the function of these fusion genes.

37 multiple, independently derived, TRIM5-CypA fusion genes(4,5,15,22-26) pointed to human TRIM5alpha b

38 Notably, EWS-FLI1 fusion genes acted in a positive feedback loop to mainta

39 Full annotation of fusion genes aided by the visualization tool based on tw

40 romosomal translocation 3;21, leading to the fusion gene AML1/MDS1/EVI1 (AME), was observed in an ET

41 ERG gene as the established surrogate of ERG fusion genes among 262 prostate cancer biopsies from the

42 emia, we identified a transforming MLL-NRIP3 fusion gene and biallelic mutations in SETD2 (encoding a

43 (+/56M) mice, which expressed the Cbfb-MYH11 fusion gene and deactivated Chd7 in hematopoietic cells

44 al translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and

45 In CML, the BCR-ABL1 fusion gene and its companion messenger RNA offers a uni

46 determined the importance of the CRTC1-MAML2 fusion gene and its downstream AREG-EGFR signaling in hu

47 Patients were negative for the FIP1L1-PDGFRA fusion gene and required prednisone monotherapy, 20 to 6

48 Increased synaptic and mitochondrial fusion genes and decreased fission genes were found in t

49 Fusion genes and fusion gene products are widely employe

50 study, we analyzed the status of TMPRSS2-ERG fusion genes and interstitial genes in tumors from a lar

51 d imaging have allowed identification of new fusion genes and propelled further characterization of p

52 P complex within rattlesnakes, creating both fusion genes and substantially reduced gene complexes.

53 drial fission genes, decreased expression of fusion genes and synaptic genes were found in the mutant

54 a has been described, landscape of expressed fusion genes and their clinical impact remains unknown.

55 The simulation of events known to create fusion genes and their resulting chimeric proteins is su

56 arrangements involving NUT, usually BRD4-NUT fusion genes and, less commonly, NUT-variant fusion gene

57 n that produces OspC within a tick (from the fusion gene) and during early mammalian infection (from

58 ed VCaP cells, which express the TMPRSS2:ERG fusion gene, and xenografts.

59 Fusion genes are a major cause of cancer.

60 Fusion genes are chromosomal aberrations that are found

61 Beta-alpha subunit fusion genes are found in the choanoflagellates, ichthyo

62 Chimeric fusion genes are highly prevalent in childhood acute lym

63 Oncogenic SS18-SSX family fusion genes are known to alter the composition of the B

64 In this study, we showed that 6 of these fusion genes are present in 7 different types of human m

65 To investigate whether the identified fusion genes are recurrent, we performed fluorescent in

66 hilic MPNs associated with PDGFRA and PDGFRB fusion genes are responsive to imatinib.

67 Although these fusion genes are well characterized as transcription fac

68 Mixed lineage leukemia (MLL) fusion genes arise from chromosomal translocations and i

69 ith t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3.

70 g can be used to investigate the etiology of fusion-gene-associated cancers.

71 ce that carry a modified human rhodopsin-GFP fusion gene at the normal mouse rhodopsin locus.

72 h-throughput data, which allows us to detect fusion genes at both transcript and genomic levels.

73 with the existing tools, IDP-fusion detects fusion genes at higher precision and a very low false po

74 Moreover, we predicted six in-frame fusion genes at sequenced duplication breakpoints; four

75 y the observation that for most known cancer fusion genes, at least one of the fusion partners appear

76 ications introduced to the probe site of the fusion gene-based assay allowed rapid virulence detectio

77 ever, these viruses escaped detection by the fusion gene-based real-time PCR test for virulence.

78 s a proto-oncogene well known as part of the fusion gene BCR-ABL1 in the Philadelphia chromosome of l

79 n established chronic myeloid leukemia (CML) fusion gene (BCR-ABL1) assay down to 0.01% mutant allele

80 a unique entity defined by the presence of a fusion gene between the orphan nuclear receptor, CHN/NOR

81 g use will provide a deeper understanding of fusion gene biology.

82 tary diseases caused by mutations in fission/fusion genes but also by aberrant mitochondrial morpholo

83 We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in mice from condi

84 suggest that the retention of these tmk-dut fusion genes by certain baculoviruses could be related t

85 veral recent studies have reported that some fusion genes can escape microRNA regulation via 3'-untra

86 cular biological approaches to investigate a fusion gene carried by guinea pigs (genus Cavia) that is

87 To provide a comprehensive and detailed fusion gene cartography and suggest new mechanisms of tu

88 Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not su

89 Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma

90 Here we describe methodology permitting fusion gene construction for functional evaluation.

91 d broadly, these tools will facilitate rapid fusion gene construction for subsequent functional chara

92 efore we leveraged the modular design of our fusion gene construction methodology to screen N-termina

93 These unique fusion genes could be related to clinical phenotypes and

94 erences more than the coding sequence of the fusion gene created.

95 he expression of a single bifunctional yeast fusion gene, cytosine deaminase/uracil phosphoribosyltra

96 en implicated in Alzheimer disease, so these fusion gene data could explain a report of spastic parap

97 WWTR1 (protein is known as TAZ)-CAMTA1 (WC) fusion gene defines epithelioid hemangioendothelioma, a

98 roughput RNA sequencing identified recurrent fusion genes defining new molecular subgroups.

99 junction, the duplication allele produces a fusion gene derived from ATAD3A and ATAD3C, the protein

100 cripts that, to our knowledge, are the first fusion genes described in TGCT and may therefore potenti

101 Some highly expressed fusion genes detected by FusionQ are important biomarker

102 mputational features of existing methods for fusion gene detection and suggest directions for future

103 ecimens by Illumina RNA-sequencing, the STAR fusion gene detection pipeline, and GATK RNA-seq variant

104 First, we establish that fusion gene detection with targeted RNAseq is both sensi

105 e that targeted RNAseq will improve clinical fusion gene detection, and its increasing use will provi

106 d sequencing approach, IDP-fusion, to detect fusion genes, determine fusion sites and identify and qu

107 nical patient cohort and improve the overall fusion gene diagnostic rate from 63% with conventional a

108 ve been made in computational approaches for fusion gene discovery over the past 3 years due to impro

109 for testing and benchmarking applications in fusion gene discovery.

110 the Eml4-Alk inversion, express the Eml4-Alk fusion gene, display histopathological and molecular fea

111 Fusion transcripts are formed by either fusion genes (DNA level) or trans-splicing events (RNA l

112 stoma-c-ros-oncogene1 (FIG-ROS1(S); FIG-ROS) fusion gene dramatically accelerates ICC development and

113 ications that aid in the perpetuation of MLL fusion gene driven oncogenic programs are being defined,

114 opment of TCR T cell immunotherapy targeting fusion gene-driven AML.

115 We examine how these fusion genes dysregulate the BCL-2 family of proteins, p

116 ffectors of morphogenesis including the cell fusion gene eff-1.

117 The BRD3-NUT fusion gene encodes a protein composed of two tandem chr

118 The fusion gene encodes a protein with exendin-4 peptide pla

119 This fusion gene encodes for CXCR4/MAML2 protein chimera in w

120 ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep sequencing da

121 karyotes are the result of the two ancestral fusion genes evolving by an assortment of gene fissions,

122 To study the effects of the fusion gene EWS-FLI1 on development and tumor formation,

123 The oncogenic fusion gene EWS-WT1 is the defining chromosomal transloc

124 ndmA, ndmB, and ndmD were cloned as His(6) fusion genes, expressed in Escherichia coli, and purifie

125 hRNA decreases Ser536 phosphorylation in T/E fusion gene expressing cells.

126 inducible system for the fine control of gfp-fusion gene expression and for protein depletion experim

127 Chromosome 6, either entirely or around the fusion gene expression locus, demonstrated a copy number

128 tructural variants (SVs), the breakpoints of fusion genes (FGs) are located in the gene bodies.

129 To date, many fusion genes (FGs) have been established as important bi

130 Expression of the fusion gene FIP1-like 1/platelet-derived growth factor r

131 ma patient carries a novel transmembrane ALK fusion gene: FN1-ALK.

132 male patients with lung cancer harboring RET fusion gene for the first time.

133 njections of adeno-associated virus carrying fusion genes for channelrhodopsin-2 and YFP, in either t

134 The ETV6-RUNX1 fusion gene, found in 25% of childhood acute lymphoblast

135 ced death is suppressed by mutations in cell fusion genes ( FUS1, FUS2, RVS161, CDC42), implying that

136 KT2440 with stable expression of an arsM-gfp fusion gene (GE P. putida), which was inserted into the

137 KIT mutations cooperate with CBFB-MYH11, the fusion gene generated by inv(16), for leukemogenesis.

138 It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in h

139 Moreover, a BCAM-AKT2 fusion gene generated via chromosomal translocation usin

140 ediator of signaling from the FGFR1 chimeric fusion genes generated by translocation in SCLL.

141 Plasmid DNA vaccines encoding the fusion genes generated robust immune responses against o

142 A novel fusion gene, generated by genomic rearrangement, MYB-NHS

143 These fusion genes have a frequency of less than 1% in unselec

144 rangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromo

145 Many tumorigenic fusion genes have retained or lost functional or regulat

146 K3, as well as 20 previously uncharacterized fusion genes identified in The Cancer Genome Atlas datas

147 ctivated in lymphomagenesis induced by FGFR1 fusion genes, implying that Src kinase inhibitors may of

148 (10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients.

149 ecently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leuk

150 ose expression is independent of the EWS-WT1 fusion gene in cultured DSCRT cells.

151 Six-month overexpression of the EAT fusion gene in healthy mice does not lead to any detecta

152 BCAM-AKT2 is the only fusion gene in HGSC that is proven to translate an aberr

153 8 promoter drives expression of the PML-RARA fusion gene in myeloid cells, a Myc allele is gained in

154 arch the functional/regulatory aspect of the fusion gene in the three bio-molecular levels (DNA-, RNA

155 re, coexpression of miR-125b and the BCR-ABL fusion gene in transplanted cells accelerated the develo

156 Finally, knockdown of the fusion gene in VCaP cells resulted in inhibition of prol

157 )(q22.1;q21) translocation, results in a new fusion gene in which a portion of CXCR4 is linked to the

158 gy, we found generation of the Dnajb1-Prkaca fusion gene in wild-type mice to be sufficient to initia

159 ified 58 putative functional and predominant fusion genes in 54.1% of patients (n = 125), 31 of which

160 NA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearr

161 tudy, we modulated the dosage of fission and fusion genes in a Drosophila melanogaster loss-of-functi

162 We have previously identified a panel of fusion genes in aggressive prostate cancers.

163 fication of anaplastic lymphoma kinase (ALK) fusion genes in approximately 50% of IMTs and the role o

164 , there is a growing interest in the role of fusion genes in common epithelial tumors after the disco

165 Surprisingly, expression of fusion genes in E. coli and S.

166 ne, previously shown to be the 3'-partner of fusion genes in endometrial stromal tumors, is also recu

167 d whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3 fusion

168 SNP-chip is a powerful tool to identify fusion genes in human cancers.

169 letions that generate chimeric ATAD3B/ATAD3A fusion genes in individuals from four unrelated families

170 Using FusionMap to characterize fusion genes in K562 chronic myeloid leukemia cell line,

171 Expression of PAX5-fusion genes in murine bone marrow cells blocked develop

172 The precise and distinctive presence of fusion genes in neoplastic tissues and their involvement

173 We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR,

174 e the first independent evolution of TrimCyp fusion genes in rodents.

175 xpression of Mtk and Drs promoter-luciferase fusion genes in S2 cells.

176 prostate cancer highlights the importance of fusion genes in solid tumor development and progression.

177 are characterized by the presence of EWS/ETS fusion genes in the absence of other recurrent genetic a

178 me, and another two lines carrying PVT1-CHD7 fusion genes, indicating that CHD7 may be recurrently re

179 study, we report that expression of the DB7 fusion gene inhibits both intracellular NADH oxidoreduct

180 ell death, while genomic integration of this fusion gene into the liver coupled with somatic Pten del

181 fusion genes and, less commonly, NUT-variant fusion genes involving BRD3 or still-uncharacterized gen

182 nstruction strategy, we validated five novel fusion genes involving MET, NTRK2, and BRAF kinases that

183 al subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively.

184 The BCR-ABL1 fusion gene is a driver oncogene in chronic myeloid leuk

185 The SET-NUP214 (TAF1/CAN) fusion gene is a rare genetic event in T-cell acute lymp

186 Fusion gene is an important class of therapeutic targets

187 al translocation that generates a PAX3-FOXO1 fusion gene is associated with the development of alveol

188 istent with a functional role, the enRep-M9l fusion gene is evolutionarily conserved, broadly transcr

189 A PQN-47::GFP fusion gene is expressed in many neurons, vulval precurs

190 The TMPRSS2/ERG (T/E) fusion gene is present and thought to be an oncogenic dr

191 The TMPRSS2/ERG (T/E) fusion gene is present in the majority of all prostate c

192 The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive inf

193 visualization of the functional features of fusion genes is not available.

194 ugh formation and expression of the PAX-FKHR fusion genes is thought to be the initiating event in th

195 truncated ERG (DeltaERG), encoded by the ERG fusion gene, is stabilized by evading SPOP-mediated dest

196 ion that generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangemen

197 The T/E fusion gene isoforms differentially increase expression

198 We found that T/E fusion gene isoforms differentially increase NF-kappaB-m

199 zation of multiple alternatively spliced T/E fusion gene isoforms which have differential effects on

200 YWHAE-FAM22 fusion gene knockdowns were performed with shRNAs and si

201 roup of patients presented with MLL or NUP98 fusion genes leading to up-regulation of the HOX A clust

202 Expression of a NUP98-HOXD13 (NHD13) fusion gene leads to myelodysplastic syndrome in mice.

203 RNA-mediated knockdown of MEIS1 in human MLL-fusion gene leukemia cell lines resulted in reduced cell

204 Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute myel

205 ception of the presence of the FIP1L1-PDGFRA fusion gene, little is known about predictors of imatini

206 to FGFR-selective agents, the presence of a fusion gene may aid in selection of patients for FGFR-ta

207 Expression of the DB7 fusion gene may reduce protein translation to impair bra

208 y, concomitant deletion of the mitochondrial fusion gene Mfn1 completely rescued heart dysfunction, l

209 nd decreased expression of the mitochondrial fusion genes Mfn1 (mitofusin 1), Mfn2 (mitofusin 2), Opa

210 genes Drp1 and Fis1 were down-regulated, and fusion genes Mfn1, Mfn2 and Opa1 were up-regulated relat

211 rp1 and Fis1 levels; increased levels of the fusion genes Mfn1, Mfn2 and Opa1; and the biogenesis gen

212 clude MLL, AF4, and both MLL-AF4 and AF4-MLL fusion genes; miR-221 down-regulates CDKN1B.

213 and unknown partners, identifying the novel fusion gene MLL-DIAPH2 in the process.

214 the expansion of this information; over 2700 fusion gene mutations are now described.

215 such as the multiple variants of TMPRSS2:ERG fusion gene mutations in prostate cancer (PCa), are prom

216 ally updated, a greater emphasis on curating fusion gene mutations is driving the expansion of this i

217 sed in RMS with PAX3-FOXO1 compared with the fusion gene-negative RMS (t-test; P < 0.0001).

218 ChimerPub includes 2767 fusion genes obtained from text mining of PubMed abstrac

219 muXg elevated the adaptor protein TRAF-6 and fusion genes OC-STAMP and DC-STAMP expression in preoste

220 ALK fusion genes occur in a subset of non-small-cell lung ca

221 The NUP98-HOXD13 (NHD13) fusion gene occurs in patients with myelodysplastic synd

222 y, we demonstrate the use of a newly created fusion gene of exendin-4 and alpha1-antitrypsin to contr

223 , implicating mutations in the mitochondrial fusion genes OPA1 and MFN2 in the pathogenesis of multis

224 by mutations in the canonical mitochondrial fusion genes OPA1 and MFN2, respectively.

225 including gene assessment across pan-cancer fusion genes, open reading frame (ORF) assignment, and r

226 These include the inhibition of the fusion gene or its protein product, and pathways related

227 to TGCT malignancy, such as the existence of fusion genes or aberrant fusion transcript expression, w

228 Genomic deletions can create oncogenic fusion genes or cause the loss of tumor suppressing gene

229 ve breast cancer and underpinned by specific fusion genes or hotspot mutations, which may be of diagn

230 ABL-class fusion genes other than BCR-ABL1 have been identified in

231 ts and identify the first functional TrimCyp fusion gene outside of primates and tree shrews.

232 re available on 83 major cancer genes and 49 fusion gene pairs (19 new cancer genes and 30 new fusion

233 scription and translocation of RUNX1 and ETO fusion gene partners, opening a novel window to understa

234 isease driven by expression of the oncogenic fusion gene PAX3-FOXO1A.

235 poietic stem cells often through preleukemic fusion genes (PFG).

236 Fusion genes play important roles in tumorigenesis.

237 (AR)-regulated expression of the TMPRSS2:ERG fusion gene plays an early role in prostate cancer (PC)

238 itive CRPC are comparable with the levels in fusion gene-positive primary PC, consistent with the con

239 ne(s) that might cooperate with the AML1-ETO fusion gene produced by t(8;21), we developed a set of s

240 EWS/FLI1 is a fusion gene product generated by a chromosomal transloca

241 from two affected individuals shows that the fusion gene product is expressed and stable.

242 Fusion genes and fusion gene products are widely employed as biomarkers a

243 genomic events in human cancer because their fusion gene products can drive the development of cancer

244 nd was successfully applied for non-invasive fusion gene profiling in patient urine samples with subs

245 sistent with the in vitro studies on the DB7 fusion gene, protein translation activity is decreased i

246 The MLL-AF6 fusion gene represents the most common leukemogenic fusi

247 across pan-cancer from three representative fusion gene resources: the improved database of chimeric

248 FOXO1 in RMS cell lines with and without the fusion gene, respectively.

249 e, we found that disruption of mitochondrial fusion genes resulted in the upregulation of multiple st

250 A novel CBFA2T3-GLIS2 fusion gene resulting from a cryptic inversion of chromo

251 lification to simultaneously detect multiple fusion gene RNAs within a short sample-to-answer timefra

252 , we show here that mutation in the myoblast fusion gene rolling pebbles (rols) dominantly suppresses

253 ld facilitate clinical and basic studies for fusion gene screening in clinical specimens, as it can b

254 Using a synthetic BCR-ABL fusion gene sequence target, we examined samples contain

255 ral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect t

256 ix Y short-arm genes and created a Zfy2/Zfy1 fusion gene spanning the deletion breakpoint [4, 5].

257 express chromosomal translocation-generated fusion genes, SS18-SSX1 or SS18-SSX2 in most cases.

258 linicomolecular risk score that incorporated fusion gene status (negative and PAX3/FOXO1 and PAX7/FOX

259 with metastases at diagnosis, independent of fusion gene status and RMS subtype (n = 120; P = 0.039).

260 Discussion continues on the use of fusion gene status to risk stratify alveolar rhabdomyosa

261 tion scheme that incorporated the PAX3/FOXO1 fusion gene status was derived from 287 patients with RM

262 not add new prognostic information over the fusion gene status, which is simpler to assay.

263 eir prognostic value was encapsulated by the fusion gene status.

264 search options and graphic representation of fusion gene structure.

265 ts with translocations that create oncogenic fusion genes such as PML-RARA, RUNX1-RUNX1T1, and MLL-AF

266 enic studies with mice that harbor Plp1-lacZ fusion genes suggest that Leydig cells are the source of

267 ith or without induction of a ubiquitin-APE1 fusion gene suggested that monoubiquitination enhanced t

268 FGviewer gets the input of fusion gene symbols, breakpoint information, or structur

269 cormorant isolate sequence, and the revised fusion gene test successfully identified all 22 isolates

270 or the presence of a prognostically relevant fusion-gene than did seven other OASIS methods in the an

271 everse transcription-PCR assay targeting the fusion gene that is specific for virulent isolates ident

272 ly of tumors expresses aberrant EWSR1- (EWS) fusion genes that are derived from chromosomal transloca

273 We also identify recurrent fusion genes that significantly impact both progression-

274 s in a cancer cell line and identified three fusion genes that were corroborated by RNA-seq data.

275 After translocation, two fusion genes [the DISC1-Boymaw (DB7) and the Boymaw-DISC

276 To detect fusion genes, the current bioinformatics tools heavily r

277 of gene pairs/breakpoints to be involved in fusion genes, the users can search the functional/regula

278 umor, share a common class of tumor-specific fusion genes thought to be key mediators of tumor biolog

279 colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorag

280 anced green fluorescent protein (muDys/eGFP) fusion gene together with a tamoxifen-inducible form of

281 s, real-time quantitative-based detection of fusion gene transcripts or breakpoints, and multiparamet

282 The fusion gene transcripts promoted proliferation, invasion

283 n the 5' region of the alternatively spliced fusion gene transcripts.

284 of pediatric astrocytomas with KIAA1549-BRAF fusion genes typifying low-grade astrocytomas and (V600E

285 Monitoring for PML-RARA fusion gene was conducted after induction and throughout

286 The fusion gene was mutually exclusive with EGFR, PDGFR, or

287 yotic supergroups, suggesting that a subunit fusion gene was present in the last common ancestor of a

288 induced by expression of EWS-FLI1 or EWS-ERG fusion genes was potentiated by PARP1 inhibition in ESFT

289 ansfected with this miRNA cluster and/or MLL fusion gene, we identified 363 potential miR-17-92 targe

290 Two homologs of the tmk-dut fusion gene were separately introduced into the Autograp

291 Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, wi

292 Several expressed in-frame fusion genes were identified but none was recurrent.

293 rons, fission genes were down-regulated, and fusion genes were up-regulated, suggesting that Mdivil d

294 and/or prostate cancers that express the T/E fusion gene, where the NF-kappaB pathway might be target

295 human disease, i.e., activation of Pax3:Fkhr fusion gene with either p53 or Cdkn2a inactivation.

296 the telomeric "half" was reduced to a single fusion gene with functional properties distinct from its

297 al translocations involving PDGFRB result in fusion genes with constitutively activated receptor tyro

298 that were compiled from public resources of fusion genes with experimental evidences.

299 KB represents a knowledgebase including 1066 fusion genes with manual curation that were compiled fro

300 onal in Leydig cells, a battery of Plp1-lacZ fusion genes with partial deletion of Plp1 intron 1 sequ