ライフサイエンスコーパス: futile

1 urrent resuscitation efforts would likely be futile.

2 etter position us to finally make resistance futile.

3 ional cooperators that their efforts are not futile.

4 placebo or with double-blind placebo) nearly futile.

5 tals have received ICU, some of which may be futile.

6 cost, that a predator's further approach is futile.

7 treatment that is medically inappropriate or futile.

8 aflets, possibly rendering its net transport futile.

9 int at which treatment with a statin becomes futile.

10 ment options that were previously considered futile.

11 spond, a Phase III trial would be considered futile.

12 c arrest (CA) has been considered by some as futile.

13 as those in whom mechanical ventilation was futile.

14 hyl diazoacetate catalyzed by Rh2(OAc)4 were futile.

15 tic as further opioid prescribing is largely futile.

16 tochrome P450 oxidoreductase is likely to be futile.

17 me (ie, mRS score of 0-2) at day 90 would be futile.

18 to move to a phase 3 efficacy trial would be futile.

19 n optimal way to hide one's relationships is futile.

20 LCA based on dataset completion will remain futile.

21 on that causes PTEN degradation has remained futile.

22 is setting would have led to 47% (8/17) less futile (131)I treatments, but 29% of patients (5/17) wou

23 Api-mediated translation arrest leads to the futile activation of the ribosome rescue systems.

24 mediate catalysis on membranes and suppress futile adenosine triphosphatase cycles.

25 motility in the absence of cargo results in futile adenosine triphosphate hydrolysis.

26 When continued intensive care is futile, advanced life support should be withdrawn.

27 on (CPR) for >20 minutes has been considered futile after pediatric in-hospital cardiac arrests.

28 ent interruptions who have been treated with futile agents.

29 patient, critical care is often considered "futile." Although futile treatment is acknowledged as a

30 Efforts to minimize nonexistent risks are futile and a major source of persistent radiophobia.

31 clinical features in whom procedures may be futile and affect public reporting of mortality.

32 e care with a therapeutic purpose was deemed futile and brain death (BD) was a likely outcome.

33 s to find evidence of effectiveness to avoid futile and distressing treatment when possible.

34 dA and that MYH-initiated short-patch BER is futile and hence this BER must proceed to long-patch rep

35 rranted and that conservative treatments are futile and may be harmful.

36 f aggressive medical or surgical care may be futile and may unnecessarily prolong the suffering of fa

37 analization of BAO up to 48 hours was seldom futile and produced good outcomes in 50% of patients, wh

38 ) that together control partitioning between futile and productive pathways and their relative rates.

39 he notion that germline transcription is not futile and stress the flexibility in eukaryotic gene usa

40 irst ten patients, the study would be deemed futile and terminated.

41 ciding whether an operative procedure may be futile and the criteria for adequate consent by either a

42 e patients, most potential interventions are futile and transplantation of both an intestine and a li

43 culiar molecules into viable leads are often futile, and much time can be wasted on the characterizat

44 tor activity is precisely regulated to avoid futile ATP consumption and to ensure proper intracellula

45 This feedback mechanism may curtail futile ATP consumption because ADP not only stimulates P

46 monomer along ssDNA with little slippage or futile ATP hydrolysis during translocation.

47 ar semiopen state hints at the origin of the futile ATP hydrolysis of MalFGK(2)-E.

48 ing translocation at low ATP but with little futile ATP hydrolysis.

49 ng that binding of the closed ring induces a futile, ATP-driven, ring-opening cycle.

50 Unexpectedly, in a futile attempt to compensate for the low glutathione, th

51 le inhibitor is upregulated, presumably in a futile attempt to halt proliferation; 6) among the G1/S

52 pensive) is required for every successful or futile attempt.

53 Repetitive, futile attempts at direct current cardioversion should b

54 at inhibits activation of Spo0A and prevents futile attempts to initiate sporulation.

55 In qin mutants, less Ago3 binds Aub, futile Aub:Aub homotypic Ping-Pong prevails, antisense p

56 g constants, concluding that the forward and futile back-electron transfer is in the normal region an

57 ctive dimer ring splitting within 435 ps and futile back-ET in 95 ps.

58 cited flavin moiety and the fast dynamics of futile back-ET without repair.

59 ceptors in two sensory circuits to terminate futile behavioral loops.

60 s its use as a scouting procedure to prevent futile blind (131)I therapy.

61 of this reaction is unstable and generates a futile but harmful cycle (substrate/product/substrate) a

62 esire to proceed with a procedure considered futile by some members of the medical team as a result o

63 ty of ICOD once further treatment was deemed futile by the treating team.

64 10 patients; p = 0.004) and rarely providing futile care (0.26 [0.07-0.95] vs providing futile care o

65 physician assistant ratios and provision of futile care are risk factors for severe burnout.

66 or-performance environment, the provision of futile care can also harm the hospital population as a w

67 e of antibiotics for those who are receiving futile care can be considered unethical by egalitarian t

68 was to examine ways in which the delivery of futile care in the ICU can cause harm to patients other

69 The delivery of futile care is not only an individual patient decision,

70 g futile care (0.26 [0.07-0.95] vs providing futile care often; p = 0.041) were independently associa

71 r 1-5 patients per shift and those providing futile care rarely also had a lower depersonalization sc

72 However, nurses scored higher on futile care than physicians (t = 2.051; p = 0.042), wher

73 posed of 14 items referring to four factors: futile care, poor teamwork, deceptive communication, and

74 m to patients other than those receiving the futile care.

75 with surrogate decision makers and providing futile care.

76 ted in this article, can be used to identify futile cases in which expected outcome is too poor to ju

77 suffering, and limit use of ICU resources in futile cases.

78 ily conserved, even though its potential for futile catalytic cycling is low due to its sluggish cata

79 est that an increased expression of sEH is a futile central nervous system response in protection aga

80 irectional swimming but is at risk of giving futile circular swimming paths in the presence of biolog

81 gene from the chromosome, thereby ending the futile cleavage cycle that otherwise prevents detection

82 Flies avoid futile climbing attempts by processing parallax-motion v

83 ysis (MFA) and the appearance of unrealistic futile co-factor cycles.

84 d flux ranges were tried but did not prevent futile co-factor cycles.

85 of this enzyme, which is necessary to avoid futile competition between synthesis and degradation, is

86 f such systems independently of their use as futile consumers of oxygen.

87 fense against oxygen toxicity through their "futile" consumption of oxygen.

88 Futile critical care was associated with delays in care

89 y providing proper conformation and avoiding futile cross talks.

90 Our studies reveal that the zebrafish gene futile cycle (fue) is required in the zygote for male pr

91 This protein is related to zebrafish futile cycle (Fue), a nuclear envelope (NE) constituent

92 This apparent futile cycle allows eggs to maintain elevated cytoplasmi

93 xperimental conditions and identified a high futile cycle between oxaloacetate and pyruvate, indicati

94 diated lipolysis creates an energy-consuming futile cycle between TG hydrolysis and resynthesis, lead

95 tose-binding site of MalF likely generated a futile cycle by preventing maltose from binding to MalFG

96 Cellular levels of 5fTHF are regulated by a futile cycle comprising the enzymes SHMT and 5,10-methen

97 he model simulations indicate that the 5fTHF futile cycle dampens the stochastic noise in FOCM that r

98 The zebrafish futile cycle gene is shown to encode a maternally expres

99 emingly opposed functions and explains how a futile cycle is avoided-cytoplasmic p300/CBP E4 activiti

100 ional functional modalities on the enzymatic futile cycle mechanism that include stochastic amplifica

101 this phenomenon is not exclusively due to a futile cycle of abortive TLS followed by exonucleolytic

102 involvement of the proofreading subunit in a futile cycle of base insertion/excision with the UmuC st

103 presence of free fatty acids and leads to a futile cycle of Ca(2+) accumulation and release when exo

104 ir target biosynthetic machinery involving a futile cycle of cell wall synthesis and degradation, the

105 persist to the next cell cycle, leading to a futile cycle of centriole formation and disintegration.

106 These findings link a futile cycle of creatine metabolism to adipose tissue en

107 e metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and beta-ox

108 iglycerides to the liver, which results in a futile cycle of enhanced VLDL production and increased k

109 AC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, whic

110 rom the gluconeogenic process and prevents a futile cycle of glucose phosphorylation.

111 gulatory role of GltC may be prevention of a futile cycle of glutamate synthesis and degradation in t

112 phorylation of p31(comet) by Plk1 prevents a futile cycle of MCC assembly and disassembly during the

113 s the mitochondrial inner membrane, create a futile cycle of nutrient oxidation without generating AT

114 sequence are not cleaved, thereby avoiding a futile cycle of removal and readdition of these essentia

115 erted to PC and TAG, and appeared to be in a futile cycle of synthesis and degradation.

116 f enduring lipid droplets that prevented the futile cycle of TAG biosynthesis/lipolysis and instead c

117 Collectively, the data reveal a futile cycle of unregulated transcription, siRNA product

118 MMR-mediated damage tolerance and futile cycle repair processes are discussed, as well as

119 rate, can decompose to produce H(2)O(2) in a futile cycle that consumes NADPH.

120 ith the ferrous heme-NO species is part of a futile cycle that does not directly contribute to NO syn

121 w that a single-player system may escape the futile cycle trap by limiting transfer of reducing equiv

122 rylation of X-5-P by Pho13p might generate a futile cycle with xylulokinase overexpression.

123 ed ultrasensitivity in a kinase/phosphatase "futile cycle" has been a paradigmatic example of collect

124 2014) report that memory T cells activate a "futile cycle" of de novo fatty-acid synthesis and concur

125 birth-death process, an example of enzymatic futile cycle, and a stochastic switch model.

126 3R calcium channel leads to an ATP-depleting futile cycle, resulting in activation of the energy sens

127 ely back to the original quinone, creating a futile cycle, the byproducts of which are deleterious re

128 t bifunctional activities without creating a futile cycle.

129 back to cysteine sulfinic acid and AMP in a futile cycle.

130 sterol actively effluxed by ABC1, creating a futile cycle.

131 if not regulated tightly, could result in a futile cycle.

132 Further experiments confirmed this futile cycle; cells without FepB transported FeEnt acros

133 chastic model of FOCM by including the 5fTHF futile-cycle to explore its effect on the FOCM network.

134 malate into oil is low and that flux through futile cycles (wasting ATP) is low, which contrasts with

135 With the assumption that futile cycles are tightly regulated in reality, the FBA

136 Recent discoveries of other BAT futile cycles based on creatine and succinate have provi

137 on of alternative electron flow pathways and futile cycles in energy rebalancing.

138 urthermore, the ED pathway does not generate futile cycles in organisms that fix CO2 via the Calvin-B

139 evious reported noise-induced bistability in futile cycles is found to have originated from the kinas

140 flux systems, protects cells from continuous futile cycles of Ca(2+) across the inner mitochondrial m

141 Subsequent futile cycles of DNA mismatch repair can lead to a p53-a

142 Viomycin inhibition also promotes futile cycles of GTP hydrolysis by EF-G.

143 We suggest that these result from futile cycles of recombinational elongation and truncati

144 s then cycled back to methionine, leading to futile cycles of SAM synthesis and recycling and explain

145 d therefore to drug resistance by preventing futile cycles of translesion synthesis and mismatch corr

146 It is hypothesized that futile cycles of translesion synthesis past cisplatin-DN

147 e that adipocytes lack GyK and thereby avoid futile cycles of triglyceride breakdown and resynthesis

148 iggering transcription-coupled repair (TCR), futile cycles of which may lead to repeat expansion or c

149 which inhibit modularity, through enzymatic futile cycles that consume energy, typically in the form

150 c regulatory properties for the formation of futile cycles were further considered in the model, resu

151 which has implications for the coherence of futile cycles within an integrated tissue.

152 eschedule metabolic activities, (3) suppress futile cycles, and (4) make ion transport more efficient

153 To avoid infinite futile cycles, folded LRP6 molecules undergo palmitoylat

154 (bio)chemical-reaction mechanisms, enzymatic futile cycles, the external noise may induce a bistable

155 -AT target genes, as NF-ATs are subject to a futile cycling across the nuclear envelope owing to enga

156 yeast glycolysis and the coupled pathways of futile cycling and glycogen and trehalose synthesis (whi

157 duction of beta-lapachone by NQO1 leads to a futile cycling between the quinone and hydroquinone form

158 Calcineurin suppresses this futile cycling by a non-catalytic mechanism involving th

159 Solutions with minimal futile cycling diverted surplus energy and electrons tow

160 osphate-1-kinase coupled with the absence of futile cycling implies an undetermined mechanism of coor

161 and histochemical measurements, we show that futile cycling in roots of barley (Hordeum vulgare) seed

162 g thermogenic brown and beige adipose tissue futile cycling may be an important strategy to increase

163 ell maintenance costs, in agreement with the futile cycling model of ammonium toxicity.

164 e turnover and suggesting that CD36 promotes futile cycling of fatty acids into triglyceride.

165 In conclusion, high futile cycling of fatty acids is important for maintaini

166 Elevated futile cycling of hepatic lipids was also observed.

167 By this mechanism, SLN promotes the futile cycling of SERCA, contributing to muscle heat pro

168 This led to futile cycling the LLO pathway, exacerbated by GDP-manno

169 k(HR) estimates glucose/glucose-6-phosphate futile cycling, along with glucose recycling through the

170 te in the protocol but was timed to minimize futile cycling, since phosphorylase a became inhibited b

171 nesis is achieved through increased rates of futile cycling, which are observed in several systems, m

172 coli, these functions are separated to avoid futile cycling.

173 d neutral invertase, associated with minimal futile cycling.

174 ariant stabilized cob(II)alamin and promoted futile cycling.

175 turnover from strand passage, manifesting in futile cycling.

176 omote uncoupling of the Serca pump and cause futile cycling.

177 t they are coordinately regulated to prevent futile cycling.

178 embrane domains MalF and MalG that generated futile cycling; although interaction with MBP stimulated

179 gulate an activated FBPase in order to avoid futile cycling?

180 Our study fundamentally revises the futile-cycling model by demonstrating that NH3 is the ma

181 The net result was a futile damage-induced DNA synthesis which converted a ga

182 mechanism prevents trapping of the enzyme in futile degradation attempts and ensures that the energy

183 y in access to kidney failure care, avoiding futile dialysis, reducing dialysis costs, shared decisio

184 ch in turn mispairs with thymine, triggering futile DNA mismatch repair (MMR) and ultimately cell dea

185 3-proficient human glioma cells, TMZ-induced futile DNA MMR resulted not in apoptosis but rather in p

186 s-links and reveal that cross-links induce a futile DNA synthesis cycle that may constitute a signal

187 er with the hairpin promotes dissociation of futile EF-G and thus causes multiple EF-G driven translo

188 It is not clear whether these "futile" encounters have a cooperative or competitive rol

189 ast tracking of MLPs for degradation without futile engagement of the cytosolic folding machinery.

190 tory responses including feedback as well as futile "feed-forward" elicitation in the case of fatty a

191 to 49.1%]), both erythropoietin groups were futile (first dosing regimen: 17/35 [48.6%; 95% CI, 31.4

192 deal with telomere damage may be ultimately futile for aging fibroblasts but useful for cancer cells

193 tion under these conditions is assumed to be futile for autophagy.

194 The 'futile' fuel cycle resulting from expression of GyK in a

195 s us that von Pettenkofer was more than this futile gesture.

196 ources, the provision of ICU care, even when futile, has been viewed as an individual patient decisio

197 when the anaesthetist believes surgery to be futile, he or she must consider and understand the basis

198 f Pi from the hydrolysis site, which avoided futile hydrolysis cycles of eIF4AI.

199 helicase either undergoes backward movements/futile hydrolysis or unwinds DNA with a variable bp-step

200 n, thus between productive recombination and futile hydrolysis.

201 dvanced super-resolution microscope would be futile in providing biological insight into subcellular

202 Performing CPR for >20 minutes is not futile in some patient illness categories.

203 Treatment is futile in some patients, but it is difficult to identify

204 Helicobacter pylori incites a futile inflammatory response, which is the key feature o

205 ndent NFkappaB regulation was confirmed with futile inhibition of AP-1 and SP-1 in TNF receptor muted

206 active, inactive, or engaged in assembly of futile initiation complexes.

207 al to and use of hospice, and reduced use of futile intensive care.

208 ppearance on synaptic vesicles could lead to futile interactions with vesicle-SNARE proteins.

209 Clinicians should not provide futile interventions.

210 t the cost of energy expenditure, creating a futile intestine-liver cycle.

211 -positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure.

212 tic evidence indicated that Bcl-x(L) reduces futile ion flux across the inner mitochondrial membrane

213 ciding whether an operative procedure may be futile is examined.

214 Diagnostic laparoscopy reduced the number of futile laparotomies in patients with suspected advanced-

215 Futile laparotomy occurred in 10 (10%) of 102 patients i

216 The primary outcome was futile laparotomy, defined as a PCS with residual diseas

217 of oxidative phosphorylation can result from futile leak conductance through the inner mitochondrial

218 ividuals suggests the presence of augm ented futile lipid cycling, rather than mitochondrial uncoupli

219 t differential diagnosis between HAS and HE, futile LT can be avoided by taking into consideration th

220 ain (PSIDeltaAB mutant) exhibit extended but futile mating attempts.

221 Patients with a devastating brain injury and futile medical prognosis in the ED are an important prop

222 CO to providing potentially inappropriate or futile medical services should not be considered suffici

223 The broader metabolic implications of this futile metabolic cycling are discussed in detail.

224 motes proliferation of NSCLC by limiting the futile metabolism of cysteine to the wasteful and toxic

225 )-methylthioguanine (S(6)mG) in DNA, and the futile mismatch repair triggered by replication-induced

226 ins (UCPs) oppose this phenotype by inducing futile mitochondrial respiration that is uncoupled from

227 rstood, but is proposed to be due to loss of futile MMR activity and/or replication stalling [3] [4].

228 rtially stems from the drug's induction of a futile NQO1-mediated redox cycle that causes high levels

229 Emergency medical service guidelines to stop futile OHCA in the prehospital setting and the strict us

230 ge by inhibiting certain actions, especially futile or dangerous challenges to dominant figures, acti

231 ny ICU admission on a case-by-case basis for futile or inadvisable care, thereby maintaining an open

232 licts that may be inappropriately prolonging futile or unwanted treatments and are perceived to be be

233 aintain viable replication forks or suppress futile origin firing when DNA polymerase is inhibited, l

234 The analysis was focused on futile outcome (3-month or in-hospital mortality) and lo

235 national ALPPS Registry, a risk analysis for futile outcome (defined as 90-day or in-hospital mortali

236 prediction to assess the individual risk of futile outcome after ALPPS surgery and can be used to av

237 Futile outcome occurred in 37 patients (22%).

238 Among 528 ALPPS patients from 38 centers, a futile outcome was observed in 47 patients (9%).

239 comorbidities were independent predictors of futile outcome.

240 educed state and thereby minimizes potential futile oxidation-reduction cycles and may also enhance E

241 E1 species, putatively generated through its futile oxidative cycling, that incurs endoplasmic reticu

242 NQO1 catalyzes a futile oxidoreduction of beta-lap leading to reactive ox

243 eached sufficiently high levels, the use of "futile" oxygen consumption became too bioenergetically c

244 ion of therapy beyond which continued use is futile, particularly in a population of patients admitte

245 eoperative factors may allow differentiating futile patients from those with significant survival ben

246 NK2 interfered with JNK1 activation via its "futile" phosphorylation by upstream kinases.

247 Changes in swimming patterns and in futile predator-predator encounters with viscosity, as r

248 r initial diagnostic laparoscopy can prevent futile primary cytoreductive surgery (PCS) by identifyin

249 tients with a devastating brain injury had a futile prognosis in the ED, without contraindications fo

250 d inefficient thermogenic respiration due to futile proton leak in Fmr1 KO mitochondria caused by coe

251 nucleosome barrier by Pif1 could lead to the futile re-replication of newly synthetized DNA.

252 ted cells, detached kinetochores remain in a futile reattachment/detachment cycle that prevents congr

253 n of only the budget surplus for "costly yet futile" recovery plans can provide sufficient funding to

254 slope, termed the in vivo glucose-dependent futile recycling rate constant k(HR).

255 The futile redox cycle rapidly consumes O2, rendering standa

256 he Dsb oxidizing pathways and thereby avoids futile redox cycles.

257 boquinone lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates

258 ly targets cancer cells through a process of futile redox cycling that decreases intracellular reduci

259 Futile redox cycling, which is suppressed in wild-type h

260 at disrupts redox balance in cancer cells by futile redox cycling.

261 t cardiotoxicity, which may be a function of futile redox cycling.

262 ed NAD(P)H levels that refuel NQO1-dependent futile redox drug recycling.

263 to the corresponding catechol to generate a futile redox-cycle.

264 al trapping of neuronal NOS (nNOS) through a futile regenerating pathway.

265 of 0, 1, 2, 3, 4 and 5 were associated with futile risk of 2.7%, 4.9%, 8.6%, 15%, 24%, and 37%.

266 Our findings support the futile RNA cycle hypothesis, elaborate the mechanism of

267 rgy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an i

268 sed or open complexes, resulting in repeated futile scanning.

269 in cross-cultural research has resulted in a futile search for universal, biological causes of psycho

270 e propose two pruning techniques that remove futile search nodes in the enumeration tree.

271 (3) Use of the term "futile" should be restricted to the rare situations in w

272 together have been proposed to constitute a futile SMM cycle that stops the free Met pool from being

273 k 24--maximized the early discontinuation of futile therapy and minimized premature treatment discont

274 e oxidized to aquo-cob(III)alamin or enter a futile thiol oxidase cycle forming GSH disulfide.

275 y inappropriate" should be used, rather than futile, to describe treatments that have at least some c

276 r the high metabolic cost of this apparently futile transcriptional cycle could be justified by a mor

277 nsolved, resulting in an important amount of futile transfers for thrombectomy.

278 Futile transmembrane NH3/NH4(+) cycling in plant root ce

279 waiting list mortality and to a potentially futile transplant that utilizes an ECD for a critically

280 al should be identified, aiming to eliminate futile transplantation.

281 ize the risk of severe posttransplant BI and futile transplantation.

282 eart transplant failure is required to avoid futile transplants and rationalize donor selection.

283 had a good chance of success, thus avoiding futile transplants.

284 Intriguingly, the significance of these futile transport cycles of VEGFR2 remains unclear.

285 s less likely to contain a patient receiving futile treatment compared with an ICU with available bed

286 care is often considered "futile." Although futile treatment is acknowledged as a misuse of resource

287 bjective was to evaluate delays in care when futile treatment is provided.

288 ility case, and the only clear legal rule on futile treatment is the traditional malpractice test, wh

289 atients of whom 123 were assessed to receive futile treatment.

290 and contained at least one patient receiving futile treatment.

291 ained at least one patient who was receiving futile treatment.

292 disputes about potentially inappropriate or futile treatment.

293 , using family influence (16%), not offering futile treatments (13%), and referring to other physicia

294 ognostication is important to avoid pursuing futile treatments when poor outcome is inevitable but al

295 RNA levels, implying increased turnover in a futile tRNA cycle.

296 otors from individual flagella and prevent a futile tug-of-war.

297 e Arg in developing embryos, thus avoiding a futile urea cycle.

298 after ALPPS surgery and can be used to avoid futile use of ALPPS.

299 sing the underlying causes of the disease is futile; we need to invest in prevention.

300 It is best to consider a situation futile when the patient is terminally ill, the condition