ライフサイエンスコーパス: gain

1 nly FGG exhibited a significantly higher KMW gain.

2 r risk of DM, likely mediated through weight gain.

3 ive of individuals' susceptibility to weight gain.

4 ell as the effects of dolutegravir on weight gain.

5 eurons resulting from modification of neural gain.

6 STIs) has been associated with excess weight gain.

7 rocesses, which further contribute to weight gain.

8 een fine-tuned to maximize inclusive fitness gains.

9 nsidered and evaluated for maximal potential gains.

10 , adding teduglutide cost ${\$}$124,353/QALY gained.

11 below the typical threshold of $100,000/QALY gained.

12 l cost-effectiveness ratio of $4684 per QALY gained.

13 o-pay thresholds of $50 000 or more per QALY gained.

14 More eyes with early DME gained 10 or more letters and fewer eyes lost 10 or more

15 visual acuity and the proportion of patients gaining 15 or more Early Treatment of Diabetic Retinopat

16 0 diabetes mellitus (265 000-274 000) cases, gain 2.44 million quality-adjusted life-years (2.40-2.48

17 GBCL, NOS, high genetic complexity, 1q21-q44 gains, 2p16/REL gains/amplifications, 19p13/CD70 homozyg

18 At 18 months, PLWH on dolutegravir gained 6.0 kg, compared to 2.6 kg for NNRTIs (P < .05),

19 ike WM harbored more deletion 6q (P = .012), gain 6p (P = .033), had increased frequencies of IGHV3 g

20 re costs only, the program cost $25,500/QALY gained (95% CI $12,600-$48,600).

21 track the movements of traffickers, and thus gain a better understanding of illegal trade routes.

22 To gain a better understanding of the regulatory mechanisms

23 Therefore, it is important to gain a better understanding of the relative contribution

24 tructural model of SERCA-PLB interactions to gain a mechanistic understanding of PLB-mediated SERCA t

25 In order to gain a more comprehensive understanding of APOE4's role

26 th genetic diversity, and differentiation to gain a more comprehensive understanding of how habitat l

27 ges of these cellular rewiring mechanisms to gain a new perspective on the molecular underpinnings of

28 und a lossy medium such as the human body to gain a trade-off among power consumption, cost, computat

29 nscriptomics and chromatin accessibility, we gained a better understanding of the pathophysiology und

30 Nitroxyl (HNO) has gained a considerable amount of attention because of its

31 heir regulatory and diagnostic potential has gained a substantial amount of attention, the biogenesis

32 d in the AHHS, with the primary objective of gaining a better understanding of determinants of house

33 As more knowledge is gained about the biology of relapse through comprehensiv

34 2) show intact vestibulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC)

35 rates, seemingly incompatible with nonlinear gain adaptation.

36 With a mass-balance thermodynamic model, we gain additional insights into the composition of copolym

37 , between 7 and 24 weeks, adult-born neurons gained additional dendritic branches, formed a second pr

38 d thermoregulation and lowered average daily gains (ADG) result when livestock graze toxic endophyte

39 However, past evidence suggesting such a gain adjustment rests on subjective measures of color ap

40 y factors independently associated with BCVA gain after 7 monthly ranibizumab treatments were younger

41 h higher childhood IQ whereas greater weight gain after the first year of life was not.

42 activity regulation is not ancestral but was gained after the first subclasses diverged and that RNR

43 that the interaction between sex and weight gain alters the progression of allergic asthma in mice w

44 genetic complexity, 1q21-q44 gains, 2p16/REL gains/amplifications, 19p13/CD70 homozygous deletions, a

45 diverse fitness and virulence mechanisms to gain an advantage in competitive niches.

46 rvovirus infection, including reduced weight gain and 7% mortality.

47 HF diet caused greater weight gain and glucose intolerance in middle-aged females than

48 ut not rGDF8, can reduce diet-induced weight gain and improve metabolic homeostasis.

49 necessary for protection against body weight gain and induction of UCP1 in adipose tissues associated

50 nto an active fibre ring cavity with optical gain and interrogated by the OFDR system for 11 cycles w

51 We also performed target gain and loss analysis of 163 miRNAs and our results sho

52 netic inference of species-specific sequence gain and loss easy for both expert and non-expert users,

53 gene products, and the need to consider both gain and loss of function to develop safe and effective

54 completely resistant to diet-induced weight gain and metabolically normal despite increased food int

55 layed a severe phenotype with reduced weight gain and perinatal lethality.

56 sights into a long-lived excitonic state are gained and discussed.

57 s a linear relationship between mean letters gained and mean number of injections, between 4 and 10 i

58 intervention was used to quantify knowledge gains and knowledge retention.

59 om the same patient with VRL, with extensive gains and losses at the same areas across the whole geno

60 regulatory networks, directly comparing the gains and losses of targets of key TFs across cell state

61 ax designs would generate substantial health gains and savings.

62 irst injection led to less optimistic vision gains and were associated with higher incidence of negat

63 ge (low genomic scar score with chromosome 9 gain) and a superior outcome (100% overall survival at 6

64 and mouse IFITM1, IFITM2, and IFITM3, using gain- and loss-of-function approaches.

65 The C9ORF72 mutation acts through gain- and loss-of-function mechanisms to induce pathways

66 Gain- and loss-of-function studies of HDAC7 in cultured

67 in TKI resistance was determined in in vitro gain-and-loss of function studies and confirmed in subcu

68 iments, showing that significant sensitivity gains are achieved via proton detection under the condit

69 ACATs have gained attention as potential drug targets for the treat

70 eneration, and autoimmune diseases they have gained attention as targets for therapeutic intervention

71 ingolipids and sphingolipid metabolites have gained attention because of their essential role in the

72 versity of scientific areas in which PCs are gaining attention but also the opportunities one can exp

73 ore the importance of avoiding excess weight gain before middle age for preventing this highly fatal

74 and late, both nonimmune and alloimmune, to gain better insight into the causes of graft failure.

75 To gain better separation of the Mn centers and prevent ene

76 Seal mass gain between breeding seasons was (a) negatively associa

77 eater inequity in the distribution of health gains between patients who receive a transplant and pati

78 t size while the larva continues to feed and gain body mass.

79 ing unfavourable conditions, while residents gain breeding benefits from early access to resources.

80 sequently spread through populations tend to gain broader and higher expression levels.

81 s, revealing potential ecological advantages gained by enlarged reserve.

82 Arrhenius equation on modelled daily carbon gain causes a meaningful deviation of c. 18% day(-1) .

83 signature similar to an epithelial cell and gained chromatin accessibility sites correlated with oth

84 h haematological and solid cancers initially gain chromosome arms, while only solid cancers subsequen

85 cardiovascular inflammation are successfully gaining clinical acceptance.

86 ) was characterized by recurrent chromosomal gains, CN-LOH, DAXX mutations, and ALT-positivity.

87 We find that the physical gain coefficients that drive those systems actually play

88 arious countries suggests a possible fitness gain conferred by the type VI signature SNVs.

89 repurposing of a generic stress response to gain considerable gain-of-fitness associated with parasi

90 rms of binocular interactions share a common gain control mechanism in striate and extra-striate cort

91 By adjusting the tile geometry to gain control over the curvature, torsion and the number

92 d were poor mediators of intensity-dependent gain control.

93 Gaining control over polymer self-assembly via molecular

94 Thus, these results elucidates a novel slow gain-control mechanism able to support linear transfer o

95 RR), a smoothing statistic that is gradually gaining currency in modeling literature due to its demon

96 tion-based surveys of diverse microbiomes to gain deeper insights into microbial functioning and life

97 re, we applied a systems biology approach to gain deeper insights into the PCSK6 role in normal and d

98 tended to increase the overall average daily gain, delayed the FI and BW depression for ~ 2 weeks and

99 f-reported grand-maternal gestational weight gain, diet, physical activity, and smoking during pregna

100 GAIN domain-mediated self-cleavage is constitutive and p

101 riftier" metabolic phenotype prone to weight gain during overfeeding and resistant to weight loss dur

102 gardless of whether outcomes involved reward gain, electrical stimulation, or reward loss.

103 different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2

104 between groups are initiated by females, who gain fitness benefits from mating with extragroup males

105 a for both buckthorn species and a potential gain for R. multiflora and A. petiolata.

106 s cost and maximizes efficiency of knowledge gain for the scientific community under a variety of ass

107 In contrast, ICERs were > $175,000 per QALY gained for all strategies for low-risk survivors, repres

108 be thermally controlled, and new insight is gained for the spintronic applications of spin wave mode

109 eries or agricultural sectors achieve income gains for targeted households, but knock-on effects lead

110 gs show that although there is no perceptual gain from avoiding gaze-shifts in this procedure, saccad

111 Mean thickness gain from baseline (S0) to S1, S2, and S3 was 1.31 (95%

112 Crucial understandings gained from early rollout among at-risk populations, suc

113 r emerging methodologies to further insights gained from past climates.

114 Finally, we discuss how the knowledge gained from past domestication processes, together with

115 Loss and gain function study demonstrated that MEndoT-derived cel

116 ifferent time and length scales, are used to gain fundamental understanding of all processes leading

117 The gained fundamental understanding and demonstrated capabi

118 The data and spectra obtained allowed us to gain further insight into accurate identification, concl

119 s using the available datasets might help to gain further insights into the disease process.

120 ed atherosclerosis, of cancer therapies have gained greater recognition.

121 ociation between maternal gestational weight gain (GWG) and preterm birth according to pre-pregnancy

122 Insulators also gain H3K27ac and CCCTC-binding factor (CTCF) in anaphase

123 the community and to identify those who have gained immunity.

124 ground MRI with metal artifact reduction has gained importance in assessment of pain with total hip a

125 solution mass spectrometry (LC/ESI/HRMS) are gaining importance as they enable identification of hund

126 The use of omics is gaining importance in the field of nanoecotoxicology; an

127 Such direct anthropogenic emissions are gaining importance, as those from furnishings and buildi

128 The resulting gain in absolute efficiency exceeds 6 per cent, leading

129 The gain in affinity led to almost equal inhibition of wildt

130 -0.18) and 0.06 (95% CI: 0.04-0.07) years of gain in life expectancy for each death in these cities.

131 uts do not alter the running speed-dependent gain in neuronal firing rates.

132 P can be an important factor influencing CAL gain in OFD.

133 When contrast adaptation reduced the gain in ON-pathway cells, it was accompanied by decrease

134 ary determinant of crop productivity and any gain in photosynthetic CO(2) assimilation per unit of le

135 ic diets were associated with greater weight gain in the first 6 mo postpartum.

136 tric couplings result in maximum information gain in the low-noise, high-signal-correlation limit.

137 Herein, we document the aromaticity gain in two different self-assembly modes of squaramide-

138 s, but also a novel set of taxa consistently gained in disease across all age groups.

139 e functional elements are often consistently gained in jumps into a particular species.

140 The knowledge gained in this study would open new possibilities for th

141 Population-wide gains in average child HAZ and stunting prevalence have

142 reases in yield translated to small absolute gains in global protein production.

143 Although gains in newborn survival have been achieved in many low

144 ghting, and there was some evidence of small gains in precision when using MRP, particularly for smal

145 but this did not translate into demonstrable gains in preservation of renal function, despite an appa

146 Recent gains in the fight against malaria are threatened by the

147 ory capacities synchronously associated with gains in thermoregulatory capacity in amphibious taxa sa

148 Timely treated patients showed larger gains in VA (6.4 letters [SD, 8.1 letters] vs. 1.2 lette

149 s at 6 and 12 months in interdialytic weight gain, in extracellular fluid volume, and in plasma B-typ

150 Predictors of VA gain included number of intravitreal injections (AMD and

151 The risk of poor body weight gain increased in FPIES triggered by cow's milk (adjuste

152 Cardiomyocyte maturation gained increased attention recently due to the maturatio

153 iciency reduced high-fat-diet-induced weight gain, increased energy expenditure and ameliorated insul

154 Cancer immunotherapy has gained increasing attention due to its potential specifi

155 Induced polarization (IP) mapping has gained increasing attention in the past decades, as elec

156 The paracaspase MALT1 has gained increasing interest as a target for the treatment

157 ing risks or lead to long-term morbidity are gaining increasing importance.

158 ently limited by the ability of organisms to gain information about one another.

159 data and intermediate metabolite structures, gaining information about the chemical characteristics o

160 epresent a challenging but valuable model to gain insight into CTL biology.

161 In order to gain insight into the contribution of each somatostatin

162 To gain insight into the evolution of C(4) photosynthesis i

163 To gain insight into the factors underlying different PHD s

164 l for studies on triglyceride metabolism, to gain insight into the genes and physiological mechanisms

165 To gain insight into the influence of HLA-B*57:01 on the de

166 To gain insight into the mechanisms that mediate epigenetic

167 To gain insight into the molecular mechanisms and determina

168 are summarized in a far-IR map, in order to gain insight into the origin of the far-IR localized and

169 th passive and active mobile technologies to gain insight into the role of the circadian system and p

170 From these models, we gain insight into the various mechanisms behind pHLIP tu

171 To gain insight into this dynamic interface, we combined Cl

172 Here we gained insight into the differences between the QC and t

173 orms of diabetes is an important approach to gaining insight and suggest that an insulin sensitizer m

174 me to generate the mutant HVT-DeltavNr-13 to gain insights into its functional roles.

175 To gain insights into the coevolution of this interkingdom

176 ability, and the transition metal L-edges to gain insights into the oxidation/reduction processes of

177 To gain insights into the structure and assembly of Abeta o

178 HPSEC analysis was conducted to gain insights on the effect of OSA-treatment on in vitro

179 ations initiated from Rosetta predictions to gain insights on the interplay of amino acid composition

180 ases, and, more recently, this technique has gained interest in the field of organ transplantation.

181 projections, although caveats remain and the gain is not uniform across all cases.

182 re suite designed to facilitate analysis and gain knowledge from HLA typing, regardless of nomenclatu

183 ropical forest loss currently exceeds forest gain, leading to a net greenhouse gas emission that exac

184 nics, this suggests considering more general gain-loss interactions.

185 e with multiple sclerosis (MS) have recently gained marketing approval.

186 To gain mechanistic insight, follow-up lipid analysis was u

187 To gain mechanistic insights on this unknown, a dynamic roo

188 turally undergoes regression after birth, to gain mechanistic insights that could be therapeutically

189 ium doped zinc selenide (Cr(2+):ZnSe) as the gain medium and is pumped by a commercial nanosecond hol

190 During follow-up, the HIV+ patients gained more body fat (8.6% +/- 0.7%) than the control pa

191 year 2, patients with DR ultra-response had gained more than 5 additional ETDRS letters compared wit

192 PLWH starting dolutegravir also gained more weight at 18 months compared to raltegravir

193 g our capacity across many options-and depth-gaining more information about a smaller number of optio

194 have gained much attention among various other nanocarrier sy

195 was accompanied by the emergence of response gain nonlinearities at the population level.

196 In addition, 28 SNPs were predicted as "stop gained" nonsense SNPs and one SNP was predicted as "star

197 ll become an increasingly important means to gain novel insights into the natural world.

198 -expert users, making it a powerful tool for gaining novel insights into genome evolution.

199 +/- 10.20%) compared with the control (small gain of 0.32% +/- 4.20%) group (P = 0.01).

200 incidence of time to first sustained vision gain of 15 or more Early Treatment Diabetic Retinopathy

201 e number of deaths is projected to produce a gain of 318 million life-years.

202 mV/dec and complementary inverter amplifier gain of 34, the highest among comparable amplifiers.

203 We achieve a metrological gain of [Formula: see text] decibels over the SQL by usi

204 Kupffer cell loss was compensated by gain of adjacent monocyte-derived macrophages that exhib

205 sh, we demonstrate that endothelial-specific gain of function mutations in Kras (G12D or G12V) are su

206 in the first two individuals, resulted in a gain of function, and conversely, the c.73A>G (p.Thr25Al

207 minant negative effects, but also promotes a gain of function.

208 varying demands by dynamically changing the gain of its synapses; however, some tasks require ongoin

209 K4me3 at bivalent regions is associated with gain of methylation.

210 put has separable suppressive effects on the gain of ongoing and evoked visual activity.

211 aled some differences that might explain the gain of potency at alpha3beta2 nAChRs.

212 tor signaling during adolescence enables the gain of prefrontal GABAergic function, which is required

213 tive field properties and improving contrast-gain of retinogeniculate transmission.

214 enzymes evolved from viral proteases through gain of secondary nuclease activity.

215 ces sensitivity to BBDIs, BRD7 loss leads to gain of TEAD-YAP chromatin binding and luminal features

216 ch both NAT tissue and tumor tissue harbor a gain of the same oncogene arising in parallel from disti

217 , an effect known as the offline performance gain of VPL.

218 visual inputs, head movements increased the gain of wing steering responses and coordination between

219 the adult counterpart (eg, SOCS1 and KMT2D), gains of 2p16/REL, and losses of 19p13/CD70.

220 tially marked regions showed both losses and gains of 5hmC after differentiation, despite lower globa

221 RD11, CD79B, and MYD88), losses of 17p13 and gains of chromosome 7, 11q12.3-q25, whereas DLBCL, NOS w

222 peration by enabling recognition of marginal gains of cooperation in the game at stake.

223 th changes in the muscle force, and (ii) the gains of MU-mode involvement co-vary to stabilize the de

224 However, it is unknown whether such gains of viral restriction are rare, or if they incur lo

225 generic stress response to gain considerable gain-of-fitness associated with parasite transmission.

226 In humans, the gain-of-function allele PIEZO1 E756del is highly prevale

227 utational scan scores identified 40 putative gain-of-function and 33 putative loss-of-function varian

228 Gain-of-function and loss-of-function experiments with C

229 The craniofacial consequences resulting from gain-of-function and loss-of-function mutations affectin

230 Genetic gain-of-function and loss-of-function Na(V)1.7 mutations

231 ter of the respective LRR-RK leads to strong gain-of-function brassinosteroid, floral abscission, and

232 Remarkably, all gain-of-function cancer-associated mutations and all los

233 curring STK19 D89N substitution represents a gain-of-function change, allowing increased phosphorylat

234 say and increased v-SNARE binding to exocyst gain-of-function complexes.

235 otic gene programming, whereas analysis of a gain-of-function ETV1 RNA sequencing dataset from neonat

236 onal genetic studies were carried out in the gain-of-function fatty acid oxygenation 2 (fou2) mutant

237 Using genome-wide loss-of-function and gain-of-function genetic technologies, we are able to co

238 CK1alpha mutations observed in tumors cause gain-of-function in cooperating with MDMX and inhibiting

239 reveal that a gain-of-function JAK1 genetic variant results in a mutan

240 tified mutations are demonstrated to exert a gain-of-function mechanism, augmenting transforming grow

241 A gain-of-function mutation implicated a membrane and ESCR

242 The gain-of-function mutation N629D at the outer mouth of th

243 s-of-function CaM mutation, CaM (1-4), and a gain-of-function mutation, CaM-M37Q, into the anterior w

244 l dysplasia and immunodeficiency a germline, gain-of-function mutation, K171R, in IKBKB.

245 lar degeneration and leukodystrophy, whereas gain-of-function mutations cause hyperaldosteronism.

246 Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone

247 Gain-of-function mutations in KCNT1, the gene encoding S

248 Additionally, gain-of-function mutations in NOTCH2 are associated with

249 Using bioinformatics, we identified Glt(Ph) gain-of-function mutations in the flexible helical hairp

250 Recently, gain-of-function mutations in the mechanosensitive ion c

251 The underlying mechanism is a gain-of-function of the RAS-mitogen-activated protein ki

252 850Q, in the human SCN8A channel and present gain-of-function properties of the mutant channel.

253 Here, we report on the results of a gain-of-function screen for modulators of hypotonicity-i

254 We previously reported an in vivo gain-of-function screen that identified ~30 genes with a

255 at the increased cytokinin signaling in ARR1 gain-of-function transgenic lines is associated with inc

256 C7 was represented by copy gains on chromosome 6, and had the highest upregulation

257 rmore, a concordant relationship between the gain or disruption of TF (transcription factor)-binding

258 ified 17 molecular cell types that have been gained or lost during lung evolution and others with sub

259 The author describes perspectives gained over many years of engagement in the field of org

260 ing, resulting in larger offline performance gains over sleep.

261 ed significant reductions in PD, GI, and CAL gain overtime.

262 (P = 0.6) or vascular-sympathetic baroreflex gain (P = 0.85).

263 As the development and translation of GTs gain pace, success can only ultimately be realised for p

264 ulated, exogenous attention yielded response gain-performance benefits in the valid-cue condition and

265 Students and classes gained points and rewards for engaging in any activity i

266 sers that produce high power pulses recently gained popularity for industrial uses.

267 Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty li

268 em cells in biomaterials for cell therapy is gaining popularity but experimental research has overwhe

269 philic interaction chromatography (HILIC) is gaining popularity in metabolomics studies due to its en

270 During development, cells gain positional information through the interpretation o

271 studies to the most relevant tissues and can gain power as fine-mapping resolution and cell-specific

272 ditions have shown few of the desired health gains, raising fundamental questions about current appro

273 e remain poorly understood, although NTA has gained recognition as a key regulator of crucial process

274 and (2) to better identify which factor (CAL gain, residual pocket) mainly contributed to determine a

275 rcept conferred 0.141, 0.141, and 0.164 QALY gains, respectively, with corresponding average CURs of

276 n's disease patients exert similar effort to gain reward but less effort to avoid punishment when com

277 than $100 000 per quality-adjusted life-year gained, screening beginning at age 30 years was preferre

278 specific targets and catalytic activities to gain signals are known to be ideal sensing elements; how

279 P = 0.041).In the highest gestational weight gain strata, especially the third-trimester, the effect

280 Remarkably, fruitless males also gain strong attraction to a live human host, a behavior

281 Various deep learning models have gained success in image analysis including semantic segm

282 wever, applications relying on their optical gain suffer from nonradiative Auger decay due to multi-e

283 ith a "liquid-like" mechanical behaviour and gains superior malleability and deformability against pu

284 maintained through trade-offs where migrants gain survival benefits by avoiding unfavourable conditio

285 ned unchanged and many miRNAs from wild mice gained target site.

286 that by using photoexcitation these enzymes gain the ability to reduce acrylamides through a single

287 e that they function correctly and that they gain the trust of experts.

288 igh-throughput technologies, that scientists gained the ability to profile tumors with a resolution t

289 roach to secondary structure prediction that gains the advantages of both template- and non-template-

290 ing teduglutide cost decreased the cost/QALY gained to below the typical threshold of $100,000/QALY g

291 Toll-like receptor 9 (TLR9) agonists have gained traction in recent years as potential adjuvants f

292 genome is difficult but critical in order to gain understanding of the role noncoding variation plays

293 The event rate for 2-line or more VA gain was 0.49 events/eye-year (95% confidence interval [

294 Maternal gestational weight gain was self-reported in 2007, and breast density by di

295 r 6 or 18 weeks, WT and AIF1L deficient mice gained weight similarly, showed no differences in fat or

296 t treatment-naive patients with nAMD, vision gains were achieved at a slower rate (>6 months), and a

297 bringing an end to Moore's law, performance gains will need to come from software, algorithms, and h

298 nd from pound 9,220 to pound 27,101 per QALY gained with MMRV-MMRV (payer perspective).

299 years) per quality-adjusted life year (QALY) gained with V-MMRV; and from pound 9,220 to pound 27,101

300 physiological behaviour and its evolutionary gain would increase our understanding on how natural sel