ライフサイエンスコーパス: gain access

1 II, are released and/or phagocytic proteases gain access.

2 ror-free because error-prone repair does not gain access?

3 ot gain access to these regions, or does AID gain access, but the resulting uracils are repaired erro

4 suggest that, in these lesions, meningococci gain access from the capillary lumen to the peripheral e

5 ameliorated Nefud Desert interior, possibly gaining access from multiple directions, either using ro

6 trategy that nonenveloped viruses can use to gain access into cells and how viruses usurp disparate h

7 Unlike most intracellular pathogens that gain access into host cells through endocytic pathways,

8 amically controlled way, it is imperative to gain access into the intrinsic dynamics of the supramole

9 To gain access, most enzymes use nucleotide flipping, where

10 directly across the plasma membrane but also gain access through endocytic pathways that are yet to b

11 ther a robotic system and/or laser, surgeons gain access through the mouth via minimally invasive tec

12 ernative mechanism by which tumors cells may gain access to a blood supply.

13 trast two-dimensional objects in particular, gain access to a predominantly left-lateralized language

14 trained to press one lever (seeking; SL) to gain access to a second lever (taking; TL) linked with f

15 ubiquitination of DSL ligands allows them to gain access to a select, Epsin-dependent, endocytic path

16 obesity also showed increased willingness to gain access to a sucrose cue.

17 ty of the SPROUTS database is the ability to gain access to a variety of structural analyses at one p

18 sely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spi

19 ogic mechanism through which SZ chondrocytes gain access to active TGF-beta: the synovium and articul

20 A central question is how nuclear substrates gain access to an enzyme in the ER.

21 external protons permeate TRPM2 channels to gain access to an intracellular site that regulates chan

22 ing that tissues permissive for ERV activity gain access to an otherwise silenced source of regulator

23 chain particle possessed a unique ability to gain access to and accumulate at glioma sites.

24 anochain) that possesses a unique ability to gain access to and be deposited at micrometastatic sites

25 nsport from cells requires that they readily gain access to and function within interstitial fluid.

26 onducting hemichannels that allow protons to gain access to and leave buried carboxyl groups on the p

27 Here we review how viruses gain access to and spread in the well-protected CNS, wit

28 Most compartments that viruses gain access to are under active surveillance by one or m

29 holin-mediated disruption of the membrane to gain access to attack the cell wall, signal anchor relea

30 what stimuli will and what stimuli will not gain access to awareness.

31 roup members is essential for individuals to gain access to benefits from engaging in intergroup conf

32 cles can overcome barriers and allow them to gain access to biological systems.

33 e capacity of this opportunistic pathogen to gain access to BL receptors, leading to a successful col

34 Our results raise a possibility that E1A may gain access to cellular promoters through PLDLS-dependen

35 spindle assembly commences when microtubules gain access to chromatin after nuclear envelope breakdow

36 The mechanism by which pioneer TFs gain access to chromatin remains an important unanswered

37 y factors and transcriptional machinery must gain access to chromatin to extract genetic information.

38 oplasm in interphase cells; thus, it may not gain access to chromosomes until mitosis.

39 functions of antiviral T and B cells as they gain access to CNS compartments.

40 ired rats to solve a new puzzle every day to gain access to cocaine, which they then self-administere

41 requiring animals to solve daily puzzles to gain access to cocaine.

42 where Bcd influences chromatin structure to gain access to concentration-sensitive targets at high c

43 gher-tier cortical areas, including hMST, to gain access to conscious perception.

44 o the nucleolar proteome database and hence, gain access to continually updated results.

45 mechanism whereby pathogenic autoantibodies gain access to cryptic B cell epitopes.

46 ism by which toxins without a binding moiety gain access to cytosolic ribosomes is not known.

47 ery has to overcome this physical barrier to gain access to damaged DNA and repair DNA lesions.

48 hods and technology, we are able to reliably gain access to data in larger quantities, dimensions and

49 where otherwise normal tissue was removed to gain access to deeper hippocampal pathology in patients

50 ol II) must break the nucleosomal barrier to gain access to DNA and transcribe genes efficiently.

51 on requires that RNA Polymerase II (RNAP II) gain access to DNA in the context of chromatin.

52 rations must occur for DNA repair factors to gain access to DNA lesions and restore original chromati

53 roviding the entry port for exogenous DNA to gain access to DNA receptors associated with the cytopla

54 Open states that enable P450 enzymes to gain access to electrons located in the FMN-domain are f

55 How commensals gain access to epithelial soma through densely packed mi

56 ld-type pups, enabled E. coli K1 bacteria to gain access to epithelial surfaces in the distal region

57 ic pathways represents a compelling route to gain access to expanded chemical diversity.

58 Claisen rearrangement is a known protocol to gain access to functionalized allenes through the [3,3]-

59 am innovators may face considerable costs to gain access to gene-oriented technologies.

60 cessing centers where many different enzymes gain access to genomic substrates by exploiting direct i

61 hways by which intracellular aqueous protons gain access to Glu(in).

62 Application of chemical synthesis to gain access to high purity hPTH as well as more stable a

63 echanisms employed by bacterial pathogens to gain access to host iron sources, the role of iron in ba

64 e rapid and widespread RNA decay in order to gain access to host resources.

65 ite on CR1 by which P. falciparum merozoites gain access to human erythrocytes in a non-sialic acid-d

66 ID requires single-stranded DNA and needs to gain access to Ig loci, with RNA pol II transcription po

67 opportunities for academic psychiatrists to gain access to important resources.

68 sure that only fully mature, immunogenic DCs gain access to inductive sites, where they might prime e

69 re, we determined whether antibodies rapidly gain access to integrin overexpressed on the abluminal (

70 -the process by which trainees in any region gain access to international training (electronic or in-

71 has to complex with DNA-binding molecules to gain access to intracellular DNA sensors.

72 viruses have no need for membrane fusion to gain access to intracellular replication compartments.

73 How does the FEF gain access to ipsilateral information?

74 as not available for a LMIC (or we could not gain access to it), we conducted a systematic search for

75 he ability of the recombination machinery to gain access to its chromosomal substrates.

76 cus, to allow the recombination machinery to gain access to its chromosomal substrates.

77 e receives protons from water molecules that gain access to its hydrophobic environment and transduce

78 ter it reaches the nucleus by allowing it to gain access to its target genes.

79 d for an antisense oligonucleotide to enter, gain access to its target mRNA, and exert activity in a

80 y of attachment factors used by the virus to gain access to key cell types involved in pathogenesis a

81 ure suggests that neonatal facilities should gain access to laser technology and laser-trained ophtha

82 model in which core first requires DGAT1 to gain access to LDs, and then LD-localized core interfere

83 dy entry by the ability of CD8(+) T cells to gain access to lesional epithelium.

84 group of aminoaldehydes is also required to gain access to lysosomes where their cytotoxic actions a

85 kine receptor CCR7, how other T cell subsets gain access to medullary areas during their normal devel

86 ntracellular antigens have been described to gain access to MHC class II loading after macroautophagy

87 this study aimed at developing a strategy to gain access to more stable anthocyanins via enzymatic es

88 we examine the mechanism by which antibodies gain access to neuronal tissues to control infection.

89 in determining which blood-borne components gain access to neurons.

90 KV to persistently infect hBMECs and thereby gain access to neurons.

91 Second, the new route was employed to gain access to new alpha,beta-unsaturated ketones and co

92 ine, this new technology can also be used to gain access to not only monobrominated cyclopropanes, in

93 exes that must act on it; how such complexes gain access to nucleosomal DNA is not known.

94 How proteins gain access to nucleosomal DNA target sites in vivo is n

95 le and undertake diel vertical migrations to gain access to nutrient-rich deeper layers at night and

96 its host cell to avoid immune clearance and gain access to nutritional resources.

97 2 and reveal how MDM2-interacting repressors gain access to p53 target promoters and repress transcri

98 t did not label most normal blood vessels or gain access to pancreatic ducts or intestinal smooth mus

99 quiescent CD44(lo)CD62L(hi) T reg cells that gain access to paracrine IL-2 produced in the T cell zon

100 of entry and the adhesive mechanisms used to gain access to PLNs remain poorly defined.

101 ne has raised concerns over their ability to gain access to privileged sites in the body.

102 osit that the first shift enables infants to gain access to redundant audiovisual speech cues that en

103 isotype antibodies that are not expected to gain access to renal cyst lumens.

104 PCNA is not required in vitro for pol eta to gain access to replication complexes at forks stalled by

105 effect terminator read-through, lambdaQ must gain access to RNA polymerase (RNAP) via a promoter-rest

106 lowing nucleotide excision repair enzymes to gain access to sites of damage.

107 frees them to shift attention to the eyes to gain access to social cues.

108 spinal hyperexcitability enables A fibers to gain access to specific spinal circuitry, via heterosyna

109 inding mode of SSB, thereby allowing RecQ to gain access to ssDNA and facilitating DNA unwinding.

110 nsights into the mechanism by which proteins gain access to ssDNA bound by SSB, as demonstrated by ex

111 ract with SSB, could use this interaction to gain access to ssDNA by first interacting with the SSB C

112 , generally due to colonizing organisms that gain access to sterile sites via disrupted epithelial ba

113 ansported to IMS-facing membrane leaflets to gain access to tafazzin, identifying a previously unknow

114 al cells, to cross this thin barrier, and to gain access to target cells and tissues, leading to syst

115 a novel mechanism(s) utilized by B virus to gain access to target cells.

116 These ribosomes appear to gain access to the 3' UTR via a mechanism that does not

117 Thus, AID does not gain access to the 5' and constant regions of Ig genes.

118 s necessary for the lipophilic substrates to gain access to the active site.

119 Microorganisms gain access to the airways and respiratory epithelial su

120 tethered biotin prosthetic group must first gain access to the biotin carboxylase domain and become

121 Viral infections often gain access to the body of their host by exploiting area

122 exist in the sera of AD individuals and can gain access to the brain interstitium.

123 Following acute brain injury, albumin may gain access to the brain parenchyma.

124 ux pump inhibitors, demonstrating that ADEPs gain access to the cell but that export occurs.

125 ng attachment to a cell surface, in order to gain access to the cell interior.

126 limiting cell membrane allowing the virus to gain access to the cellular replication machinery.

127 To gain access to the central nervous system (CNS), GBS mus

128 A major route for peripheral information to gain access to the cerebellum is via ascending climbing

129 phylococcus aureus (S. aureus) bacteria that gain access to the circulation are plucked out of the bl

130 e must be proteolyzed before collagenase can gain access to the cleavage site.

131 Previously, we showed that pneumococci can gain access to the CNS through a nonhematogenous route w

132 Rp must find a way to open it up in order to gain access to the covered template.

133 s viral penetration of cellular membranes to gain access to the cytoplasm and deliver the genome to t

134 iruses must traverse the nuclear envelope to gain access to the cytoplasm and, ultimately, to exit ce

135 From the ER lumen, the toxin must gain access to the cytoplasm, where it enzymatically ina

136 sought to determine how assembled tau seeds gain access to the cytosol and whether this access trigg

137 hagy pathway to defend against microbes that gain access to the cytosol or reside in pathogen-modifie

138 s dislocation or retrograde translocation to gain access to the cytosol.

139 e ER membrane and selective ER components to gain access to the cytosol.

140 somal DNA lesions, the repair machinery must gain access to the damaged DNA in the context of chromat

141 Viruses can gain access to the decidua and placenta by ascending fro

142 ion synthesis (TLS), but how TLS polymerases gain access to the DNA template remains poorly understoo

143 zed at P2 but not at P9, E. coli K1 bacteria gain access to the enterocyte surface in the mid-region

144 ediated reconfiguration of the holoenzyme to gain access to the enzyme during early elongation.

145 To gain access to the gene-containing portion of the barley

146 sis requires that transcriptional activators gain access to the genome and remodel the zygotic transc

147 al RNA-dependent RNA polymerase (vRdRp) must gain access to the genome sequestered in the nucleocapsi

148 advantage of endodermal tissue remodeling to gain access to the gonadal mesoderm and are unable to mi

149 D8+ T cell lines have suggested that Mtb Ags gain access to the HLA-I pathway in an alternate vacuola

150 The mechanisms by which Mtb-derived Ags gain access to the HLA-I-processing pathway are incomple

151 suggests that, as in rodents, external cues gain access to the homeostatic control circuits of the h

152 eal a means whereby intracellular Salmonella gain access to the host cell cytosol from within its mem

153 ses, highlighting the strategies they use to gain access to the host cell cytosol.

154 d pore formation, (ii) innate immune stimuli gain access to the host cytoplasm through the YopBD pore

155 t promoter, thereby allowing the bacteria to gain access to the host cytosol.

156 or proteins traverse eukaryotic membranes to gain access to the host cytosol.

157 Other retroviruses gain access to the host ESCRT components by utilizing a

158 xins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert v

159 The simulation reveals that water molecules gain access to the internal sites by a transient aqueduc

160 biological tools; however, their ability to gain access to the intracellular environment is limited.

161 vated by DAMP/PAMP signals in the colon that gain access to the lamina propria once the mucosal barri

162 breach the intestinal epithelial barrier and gain access to the lamina propria.

163 MC develops when malignant cells gain access to the leptomeningeal space, producing sever

164 ow hydrophobic signals engage the channel to gain access to the lipid bilayer.

165 gest a model in which gammaherpesviruses may gain access to the mature B cell compartment by recurren

166 everal techniques to penetrate the shells to gain access to the meat inside.

167 G and that the PAG uses the NRA as a tool to gain access to the motoneurons generating vocalization.

168 sive pneumococcal disease, S. pneumoniae can gain access to the myocardium, kill cardiomyocytes, and

169 To gain access to the N-RNA template and orchestrate the L(

170 on and suggest that HIV-1 subviral particles gain access to the nucleus by interacting directly with

171 xploits the host nuclear import machinery to gain access to the nucleus, where capsid assembly and ge

172 in to recruit the receptor importin beta and gain access to the nucleus.

173 We demonstrate that TgMYST-B can gain access to the parasite nucleus and acetylate histon

174 ling indicates that the target peptide might gain access to the PDHK active center through the open b

175 dCII is released and/or phagocytic proteases gain access to the periplasm, and SodCII is degraded.

176 ch suggests unfolding as the prerequisite to gain access to the periplasm.

177 A key unresolved issue is how ions gain access to the pore, because the structure reveals t

178 tein DAF to open the tight junction barrier, gain access to the primary receptor CAR, and activate vi

179 d phenotypic characteristics of T cells that gain access to the prostate and induce leukocyte recruit

180 rotation of NADP(+) permits the substrate to gain access to the reactive flavin peroxyanion intermedi

181 the agent crossing an epithelial barrier to gain access to the recipient nervous system.

182 ty that imposes constraints on which enzymes gain access to the recombination intermediate, thereby c

183 tRNA shape-mimicry enables the viral IRES to gain access to the ribosome tRNA-binding sites and form

184 of the polymerase, the large protein (L) to gain access to the RNA.

185 AM fungi colonize root epidermal cells to gain access to the root cortex, and this requires the re

186 In one model, periodontal bacteria gain access to the systemic circulation, and thereby the

187 This suggested that microbiome products that gain access to the systemic circulation, rather than bei

188 corneal epithelial cell-derived exosomes may gain access to the underlying stromal fibroblasts upon d

189 Attempts have been made to gain access to the vinigrol structural framework by way

190 RNA structures become unstable and ribosomes gain access to their binding sites in the mRNAs.

191 ly are relatively hydrophobic molecules that gain access to their blocking site on the sodium channel

192 epair or modify bases in double-stranded DNA gain access to their substrates by base flipping.

193 but the majority of the vascular plants also gain access to these mineral nutrients through endosymbi

194 arget populations in developing countries to gain access to these potentially life-saving medicines.

195 hat amphiphilic and lipophilic molecules may gain access to these receptors by first partitioning int

196 osine deaminase (AID) that initiates SHM not gain access to these regions, or does AID gain access, b

197 ogical analysis coupled with live imaging to gain access to these relationships in ferrets infected w

198 ivores and fungivores that evolve resistance gain access to these resources and can also gain protect

199 s commonly postulated that plasma cells only gain access to these signals within specialized regulato

200 Yet, circulating antibodies must somehow gain access to these tissues to mediate their antimicrob

201 The olefin is mechanistically critical to gain access to this 14-electron, monovalent Ir intermedi

202 o rapidly access the microcirculation and to gain access to this highly anticoagulant environment.

203 ich microbes bypass host iron restriction to gain access to this metal across the host vacuolar membr

204 existing programs and did not help patients gain access to timely PCI.

205 er evidence, suggests that AID may similarly gain access to transcribed S regions and V exons in vivo

206 sm and binds to the 40S ribosomal subunit to gain access to translating mRNAs, MERS-CoV nsp1 was dist

207 ven basic models to explain how odour inputs gain access to transmodal representations required for n

208 es and other macromolecular therapeutics can gain access to tumor cells via leaky tumor vessels.

209 meable to substrate peptide; water molecules gain access to zinc through a polar, central channel tha

210 f smectite veins along which CO2-rich fluids gained access to grain interiors.

211 in major clades such that some lizard clades gained access to new resources, which in turn led to muc

212 eover, in mice, human IgG from the periphery gained access to relevant areas in the hippocampus and b

213 nd blood, demonstrating that instilled ricin gained access to the circulation.

214 acuoles, from which the bacteria escaped and gained access to the cytosol of adjacent cells.

215 on conditions during this transformation, we gained access to the natural products as well as two epi

216 VSV gained access to the nervous system through peripheral n

217 The TiO2 nanotubes were believed to have gained access to the nuclear machinery and caused increa

218 Both AQP2 and AQP3 gained access to the surface plasma membrane in insect l

219 tubular reabsorption of macromolecules, that gained access to the tubular lumen on glomerular filtrat

220 o ascertain why these donors with ESRD never gained access to the waiting list.

221 ses such as HIV have a daunting challenge in gaining access to a new host predominantly through the p

222 both human and mouse lung adenocarcinomas by gaining access to an endosomal compartment within tumor

223 can be challenging due to the difficulty of gaining access to conventional diagnostic matrices of bl

224 nt of shared online informatics resources by gaining access to data where it is being analyzed.

225 r chromatin remodeling may facilitate NER in gaining access to DNA damage in nucleosomes.

226 ocedures, Americans often face challenges in gaining access to health care that may be exacerbated by

227 use of health information and services: (1) gaining access to health information, (2) navigating in

228 sh environment is an efficient mechanism for gaining access to iron.

229 P14 associates with the membrane as a way of gaining access to its membrane soluble substrate.

230 ging speed of deconvolution microscopy while gaining access to missing cone information is thus highl

231 ique "plug-and-play" approach to efficiently gaining access to orphan pathways that may open avenues

232 hat the E1A-12 N terminus prevents PKAc from gaining access to p65 to account for Ser(276) hypophosph

233 ng, aphids inject saliva into plant tissues, gaining access to phloem sap and eliciting (and sometime

234 interacting with health care providers, and gaining access to proper health care.

235 vectors which, although no longer capable of gaining access to receptors on target cells, may be able

236 ocial anointing has functions beyond that of gaining access to resources.

237 hat many SSIs occur as a result of pathogens gaining access to surgical wounds either hematogenously,

238 ractions between PBP 2a and the cell wall in gaining access to the active site in the inhibition proc

239 ency (slope = -0.6 to -1.0), indicating that gaining access to the base lesion provides a substantial

240 brain barrier (BBB) prevents most drugs from gaining access to the brain parenchyma, which is a recog

241 esters Daxx in the nucleus, prevents it from gaining access to the cytoplasm, from binding to and act

242 re more efficient than wild-type bacteria in gaining access to the host cell cytosol and in initiatin

243 a focal individual learns about the world by gaining access to the information possessed by others.

244 e first description of a secreted proteinase gaining access to the inside of a cell and altering intr

245 tablishes a chronic infection in its host by gaining access to the memory B-cell reservoir, where it

246 infections can pose a threat to pregnancy by gaining access to the placenta and fetus, and clinical s

247 ls exiting the intravascular compartment and gaining access to the renal tubular space, we reasoned t

248 e to show that phagocyte-derived H(2)O(2) is gaining access to the Salmonella cytoplasm.

249 ions, thereby inhibiting S. typhimurium from gaining access to the systemic circulation.

250 als can cause proinflammatory responses upon gaining access to the systemic compartment and contribut

251 The "key" to gaining access to this toolbox provided by OEEFs is micr

252 On the other hand, by gaining access to tunneling through individual dopants,

253 h predation to a floral simulation strategy, gaining access to, and visually attracting, a novel reso

254 e receptor-mediated uptake or whether enzyme gains access to brain storage by another route when brai

255 t in retinal disease, mislocalized rod opsin gains access to cAMP signaling, which leads to neuritic

256 e mechanism by which LPS from these bacteria gains access to caspase-11 in the cytosol remains elusiv

257 Condensin I gains access to chromosomes only after the nuclear envel

258 e nucleotide excision repair (NER) machinery gains access to damaged chromatinized DNA templates and

259 Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor ne

260 HIV-1 Gag protein gains access to ESCRT directly by binding Alix, an ESCRT

261 ersists in the salivary epithelium, where it gains access to fluids centrally important for horizonta

262 x1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it driv

263 pus erythematosus, a major route whereby DNA gains access to intracellular TLR9, and thereby activate

264 mechanism by which this virus recognizes and gains access to its target cell is still largely unknown

265 the TCR signal and how the repair machinery gains access to lesions imbedded in stalled RNA polymera

266 not the major route by which blood prolactin gains access to neurons in the brain.

267 tigated the mechanism by which Ty1 integrase gains access to nuclear DNA as a model for how other ret

268 Ibeta (DLAD) but the mechanism by which DLAD gains access to nuclear DNA remains unknown.

269 MRN gains access to occluded DNA ends by removing Ku or othe

270 scular mycorrhizal (AM) symbiosis, the plant gains access to phosphate (Pi) and nitrogen delivered by

271 If AID gains access to the 5' and 3' regions that are unmutated

272 it has not been clear how p-hydroxybenzoate gains access to the buried active site.

273 ure reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive ty

274 ached by blockade by a lipid acyl chain that gains access to the channel cavity through intramembrane

275 X is best characterized by the idea that PAX gains access to the channel through the central cavity o

276 Previous data have shown that the virus gains access to the CNS by infecting olfactory sensory n

277 Precisely how cellular DNA gains access to the cytoplasm remains to be determined.

278 which likely serve as depots from where SV40 gains access to the cytosol.

279 for intrauterine transmission in which ZIKV gains access to the fetal compartment by directly infect

280 Mycobacterium tuberculosis extracellular DNA gains access to the host cell cytosol via the ESX-1 secr

281 ssentially dispensable once L. monocytogenes gains access to the host cell cytosol.

282 human immunodeficiency virus type 1 (HIV-1) gains access to the interior of the target cell, host ce

283 ynamic, providing an explanation of how cAMP gains access to the ligand binding sites that, in the cr

284 infection and persistence proposes that EBV gains access to the memory B cell compartment via GC rea

285 ficient mouse chimeras, we demonstrate HSV-1 gains access to the murine brain stem and subsequently b

286 y, cofactor in the incorrect oxidation state gains access to the mutase active site and is not releas

287 otes reverse transcription before the virion gains access to the new host's RHA.

288 However, it is not clear how Keap1 gains access to the nucleus.

289 nterplay, and how this mitochondrial protein gains access to the proteasome.

290 shed light on how this mitochondrial protein gains access to the proteasome.SIGNIFICANCE STATEMENT Re

291 in concert with the Sec incorporation domain gains access to the ribosomal A site.

292 osed by the nucleosomal structure, integrase gains access to the scissile phosphodiester bonds by lif

293 ng amounts of lipids, we establish that SecA gains access to the SecYEG complex via a lipid-bound int

294 ay be one of the crucial steps by which ZIKV gains access to the site of spermatozoon development and

295 s, little is known about how CHIKV binds and gains access to the target cell interior.

296 state in which the fusion machinery on gp41 gains access to the target cell membrane.

297 a functional uptake pathway in which the SSO gains access to the targeted RNA.

298 ganism that can cause severe disease when it gains access to underlying tissues.

299 sing a wide range of severe diseases when it gains access to underlying tissues.

300 hodopsin was depleted from primary cilia but gained access, without being enriched, with the dual Ax(