ライフサイエンスコーパス: galactomannan

1 time curves (AUCs) to achieve suppression of galactomannan.

2 in a polymer of mannose and galactose called galactomannan.

3 s were studied for expression of circulating galactomannan.

4 n on uniaxial extensions with glucomannan or galactomannan.

5 out on composites containing glucomannan or galactomannan.

6 ificity for Aspergillus plasma cfDNA PCR and galactomannan.

7 us was no longer able to grow on locust bean galactomannan.

8 production of galactosaminogalactan but not galactomannan.

9 on of diagnostic tests based on detection of galactomannan.

10 model for the flow of carbon from sucrose to galactomannans.

11 Galactomannans [(1-->6)-alpha-D-galactose (Gal)-substitu

12 We compared the diagnostic performances of galactomannan, 1,3-beta-D-glucan, and Aspergillus-specif

13 /v), copra meal (38.99% w/v) and locust bean galactomannan (20.94% w/v).

14 /v), copra meal (38.99% w/v) and locust bean galactomannan (20.94% w/v).

15 that makes the beta-1, 4-mannan backbone of galactomannan, a hemicellulosic storage polysaccharide i

16 this antibiotic will demonstrate circulating galactomannan above the threshold considered positive fo

17 re or positive bronchoalvelolar lavage (BAL) galactomannan after transplantation were classified as h

18 ella foenumgraecum) enzyme that has in vitro galactomannan alpha-1,6-galactosyltransferase activity.

19 retion factor and observing the secretion of galactomannan alpha-galactosyltransferase activity.

20 Galactomannan and (1 --> 3)-beta-D-glucan were also meas

21 Galactomannan and (1-->3)-beta-d-glucan assays were not

22 We assessed the performance of galactomannan and (1-->3)-beta-d-glucan in 29 serum samp

23 y scores, mortality, and serum and BAL fluid galactomannan and 1,3-beta-d-glucan concentrations than

24 ificantly higher serum 1,3-beta-d-glucan and galactomannan and BAL fluid galactomannan concentrations

25 Galactomannan and beta-d-glucan detection were evaluated

26 The combination of WB PCR with galactomannan and beta-d-glucan proved optimal (area und

27 the earliest indicator of IA, and increasing galactomannan and beta-d-glucan values were indicators o

28 s of the galactofuranose (Galf) component of galactomannan and contributes galactose to the synthesis

29 highly galactose-decorated viscous guar gum galactomannan and crystalline ivory nut mannan at high e

30 e LFD test for IPA diagnosis (established by galactomannan and culture results) by using bronchoalveo

31 ry aspergillosis with bronchoalveolar lavage galactomannan and cultures performed on admission at 7 d

32 ry aspergillosis with bronchoalveolar lavage galactomannan and cultures performed on admission at 7 d

33 ns two galactose-containing polysaccharides, galactomannan and galactosaminogalactan, whose biosynthe

34 san, shielded by a surface shell composed of galactomannan and galactosaminogalactan.

35 including O-glycans, N-glycans, fungal-type galactomannan and glycosylinositolphosphoceramide, which

36 s barely affected specific activity on carob galactomannan and konjac glucomannan.

37 Galactomannan and relevant cytokine levels were assessed

38 ctions imply that Galbeta1,3-is added to the galactomannans and is then pyruvylated in situ, rather t

39 bility, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin

40 overall sensitivities for WB PCR, serum PCR, galactomannan, and beta-d-glucan were 73%, 65%, 68%, and

41 apsular polysaccharide, histoplasma antigen, galactomannan, and beta-d-glucan, is viewed as being cli

42 It does not bind to xylan, galactomannan, and carboxymethyl cellulose.

43 eceiving piperacillin-tazobactam circulating galactomannan antigen accumulates in vivo to significant

44 The utility of galactomannan antigen for diagnosing invasive aspergillo

45 Aspergillus GM EIA for the detection of the galactomannan antigen in our patient population.

46 ctam expressed a distinctively high level of galactomannan antigen in vitro (P = 0.001).

47 n-tazobactam contains significant amounts of galactomannan antigen in vitro, that in animals receivin

48 itated by assays that can detect Aspergillus galactomannan antigen or DNA in BAL fluid.

49 detecting fungi; microscopy, fungal culture, galactomannan antigen, and aspergillus PCR are useful te

50 to probable or proven mold disease based on galactomannan antigen, culture or histology; or remained

51 residual fungal burden (P</=.05), and serum galactomannan antigenemia (P</=.01), compared with eithe

52 Residual fungal pulmonary burden and galactomannan antigenemia demonstrated persistent infect

53 Glucuronoarabinoxylan, xyloglucan, and galactomannan are noncellulosic polysaccharides found in

54 Galactomannans are hemicellulosic polysaccharides compos

55 CrMan26 exhibited a preference for galactomannan as substrate and the crystal structure of

56 sperm, which accumulates large quantities of galactomannans as a reserve carbohydrate during seed dev

57 The galactomannan assay (GM), a non-culture-based surrogate

58 The presence of a positive serum galactomannan assay (SGM+) has also been associated with

59 Positivity rates for the galactomannan assay in serum and bronchoalveolar lavage

60 iagnostics such as the 1,3-beta-d-glucan and galactomannan assays have emerged as promising adjuncts

61 diagnostic tests (e.g. serum beta glucan and galactomannan assays), and the recent introduction of mo

62 lse positivity for the 1,3-beta-d-glucan and galactomannan assays.

63 ed a dramatic decrease in kcat against carob galactomannan, azo-carob galactomannan, mannotetraose an

64 s included 2,815 mycological tests (culture, galactomannan, B-glucan, and PCR) performed on 475 respi

65 here as a model system to better understand galactomannan biosynthesis and its regulation.

66 ctose substitution of the primary product of galactomannan biosynthesis appear to be regulated by the

67 Galactomannan biosynthesis in vitro is catalysed by memb

68 we identified genes known to be involved in galactomannan biosynthesis, as well as new genes that ma

69 To identify additional genes involved in galactomannan biosynthesis, we previously performed deep

70 Using galactomannan, BoMan26B generated a mixture of (galactos

71 Wall proteins, galactomannan, chitin, and beta-glucan are not the relev

72 Galactomannans comprise a beta-1,4-mannan backbone subst

73 eta-d-glucan and galactomannan and BAL fluid galactomannan concentrations were observed in the group

74 ve dramatically reduced alpha-1,3-glucan and galactomannan content, with a compensatory increase in b

75 gnostic odd ratios differed markedly between galactomannan (cut-off 0.5: optical density index, 0.97,

76 oven IA cases, as well as concordant PCR and galactomannan data in matched broncho-alveolar lavage an

77 The galactomannan Davanat(R) was more active, albeit not a s

78 Dialysate tested negative for galactomannan, demonstrating the inability of treatments

79 fore, at the beginning of, and during active galactomannan deposition.

80 azobactam who were found to have circulating galactomannan detected by the double sandwich enzyme-lin

81 ias, the sensitivity of the LFA outperformed galactomannan detection (0.41 vs 0.31, P = .046).

82 is a fast and effective alternative to serum galactomannan detection for the diagnosis of IA and is e

83 sitivity (0.90 and 0.49, respectively) while galactomannan detection had the highest positive predict

84 Galactomannan detection in bronchoalveolar lavage (BAL)

85 We also prospectively collected data on all galactomannan EIAs performed between 1 September 2003 an

86 this property of piperacillin-tazobactam and galactomannan ELISA is not well understood, we investiga

87 l and spiked sera were blinded and sent with galactomannan enzyme immunoassay (EIA) kits to the parti

88 s studies have reported that the Aspergillus galactomannan enzyme immunoassay (GM EIA) may be a usefu

89 ized and compared the diagnostic yields of a galactomannan enzyme immunoassay (GM EIA), quantitative

90 performance compared to that of the Bio-Rad galactomannan enzyme immunoassay (GM EIA).

91 We evaluated the performance of a galactomannan enzyme immunoassay (GM EIA; Bio-Rad) by us

92 inical information available on inclusion of galactomannan enzyme immunoassay (GM-EIA) (2002) and bet

93 The galactomannan enzyme immunoassay (GM-EIA) is widely util

94 or use in fungal diagnostics, differences in galactomannan enzyme immunoassay (GM-EIA) performance ha

95 gated hepatitis B virus (HBV) antibodies and galactomannan enzyme immunoassay (GM-EIA) positivity.

96 ce of the recently released IMMY Aspergillus galactomannan enzyme immunoassay (IMMY GM-EIA) when test

97 The Platelia galactomannan enzyme immunoassay is a commercially avail

98 mance was comparable to that of both PCR and galactomannan enzyme immunoassay.

99 eported studies evaluating commercial tests (galactomannan enzyme-linked immunosorbent assay).

100 esents a more sensitive alternative to serum galactomannan for noninvasive diagnosis of IA.

101 e of Aspergillus plasma cfDNA PCR with serum galactomannan for the diagnosis of IA during routine cli

102 After omitting serum galactomannan from the definitions to control for incorp

103 Transglycosylation of galactomannan from the membrane to the cell wall is hypo

104 -glucans and one of the strains also grew on galactomannan, galactan, glucomannan and starch.

105 ycosyltransferases, mannan synthase (MS) and galactomannan galactosyltransferase (GMGT).

106 that BoMan26B performs the initial attack on galactomannan, generating oligosaccharides that after tr

107 Positive serum galactomannan (GM) and BDG were associated with increase

108 The utility of Aspergillus galactomannan (GM) and beta-D-glucan (BG) in liver trans

109 In adults, the combination of galactomannan (GM) and fungal DNA detection has proven t

110 dies to assess the diagnostic performance of galactomannan (GM) and polymerase chain reaction (PCR) a

111 sitive (optical density index of >=1.0) BALF galactomannan (GM) and positive BALF Aspergillus culture

112 new methods of Aspergillus detection-sputum galactomannan (GM) and real-time PCR-alongside establish

113 lia Aspergillus enzyme immunoassay (EIA) for galactomannan (GM) antigen detection in bronchoalveolar

114 conate was the factor causing false-positive galactomannan (GM) antigenemia of Plasma-Lyte hydration

115 The benefit of the combination of serum galactomannan (GM) assay and polymerase chain reaction (

116 to investigate the performance of the serum galactomannan (GM) assay in hematology patients with a p

117 were comparable in sensitivity to BAL fluid galactomannan (GM) assay.

118 l-time PCR (targeting the 28S rRNA gene) and galactomannan (GM) detection when testing serum from a E

119 Previous studies have reported that galactomannan (GM) enzyme immunoassay and 1,3 beta-gluca

120 of bronchoalveolar lavage (BAL) in detecting galactomannan (GM) for diagnosing pulmonary aspergillosi

121 tative detection of Blastomyces dermatitidis galactomannan (GM) in urine using an enzyme immunoassay

122 MY (Norman, OK) for detection of Histoplasma galactomannan (GM) in urine using an enzyme immunoassay

123 lying hematological malignancy) who had BALF galactomannan (GM) ordered between 2013 and 2019 at the

124 lying hematological malignancy) who had BALF galactomannan (GM) ordered between 2013 and 2019 at the

125 k factors, positive Aspergillus cultures, or galactomannan (GM) received targeted prophylaxis/preempt

126 Prognostic features of serum galactomannan (GM) remain poorly defined in patients wit

127 , quantitative real-time PCR (qPCR), and the galactomannan (GM) test were used with 32 BAL fluid samp

128 eview the experience at our institution with galactomannan (GM) testing of bronchoalveolar lavage (BA

129 Galactomannan (GM) testing of urine specimens may provid

130 We hypothesize that galactomannan (GM), a component of fungal cell wall, as

131 reviewed and analyzed the available data for galactomannan (GM), beta-D-glucan (BG), and polymerase c

132 immunoassay (EIA), due to contamination with galactomannan (GM).

133 tients is difficult, as Aspergillus antigen (galactomannan [GM]) may have other causes.

134 Galactomannans had the highest effect on reducing the le

135 harides, such as modified citrus pectins and galactomannans, have been shown to have promising anti-i

136 Our findings suggest that the Platelia galactomannan immunoassay has good reproducibility.

137 unction with standard-of-care, including BAL galactomannan.IMPORTANCEInvasive pulmonary infections ar

138 this study was to determine the stability of galactomannan in clinical specimens stored at -20 degree

139 The sensitivity and specificity of serum galactomannan in hematologic malignancies/stem cell tran

140 ance of the serum and bronchoalveolar lavage galactomannan in immunocompromised children is comparabl

141 All 24 patients had positive galactomannan in serum (n = 4), BAL fluid (n = 16), or b

142 We first verified the specific deposition of galactomannans in developing endosperms and determined t

143 are known to accumulate large quantities of galactomannans in the endosperm, and were thus used here

144 gum and the discrimination between different galactomannans in the isolated polysaccharide fraction.

145 systems from transgenic seed endosperms form galactomannans in vitro that are more highly Gal substit

146 sis patients with baseline serum Aspergillus galactomannan index <0.5 and <1.0 had significantly high

147 eracillin-tazobactam into rabbits, the serum galactomannan index (GMI) in vivo changed significantly

148 ative patient specimens showed no decline in galactomannan index (GMI) over 11 months at -20 degrees

149 ng serum samples and to identify the optimal galactomannan index (GMI) positivity threshold for the d

150 sion were used to correlate early changes in galactomannan index (GMI) to mortality and overall respo

151 ensitivity; specifically, a low (0.5 to 0.7) galactomannan index (GMI) value to determine positivity

152 tween serum and bronchoalveolar lavage (BAL) galactomannan index (GMI) values and mortality in alloge

153 structions using a cube reader to generate a galactomannan index (GMI).

154 ys from the first positive serum Aspergillus galactomannan index (s-GMI).

155 rtality (46% vs 59% p=0.30) and reduction of galactomannan index in consecutive samples was observed.

156 ality (46% vs 59%; P = .30) and reduction in galactomannan index in consecutive samples were observed

157 ive clinical utility in conjunction with BAL galactomannan index measurements remains unclear.

158 The height of the serum galactomannan index predicts mortality.

159 mcfDNA-Seq assay was complementary to serum galactomannan index testing; in combination, they were p

160 ion, leukopenia, and the height of the serum galactomannan index were associated with an increased ri

161 n collection, while noninvasive testing with galactomannan is moderately accurate.

162 clinical performance of the sona Aspergillus galactomannan lateral flow assay (GM LFA) was evaluated

163 The Aspergillus Galactomannan Lateral Flow Assay (LFA) is a rapid test f

164 icenter study evaluated the IMMY Aspergillus Galactomannan Lateral Flow Assay (LFA) with automated re

165 aspergillosis and paradoxically rising serum galactomannan levels in the presence of chronic renal fa

166 enal failure and aspergillosis, rising serum galactomannan levels may not necessarily signify progres

167 Galactomannan levels were inextricably tied to fungal in

168 Overall, the Aspergillus Galactomannan LFA showed good performances for CAPA diag

169 kcat against carob galactomannan, azo-carob galactomannan, mannotetraose and 2,4-dinitrophenyl beta-

170 s, it was demonstrated that by using SPH and galactomannan mixtures and controlling the biopolymers'

171 asma antigen-negative and the 32 Aspergillus galactomannan-negative patients varied, but we were unab

172 ections due to Aspergillus, non-Aspergillus (galactomannan-negative), or azole-resistant molds, and d

173 han or equal to 5 acted as acceptors, as did galactomannans of low to medium galactose-substitution.

174 The N-linked galactomannans of Schizosaccharomyces pombe have pyruvyl

175 y or microscopy, positive BAL fluid culture, galactomannan optical index of 1 or more in BAL fluid or

176 on sera that had been tested for Aspergillus galactomannan or Histoplasma antigen.

177 Positive galactomannan or suggestive signs triggered mandatory ev

178 ed in A. thaliana in degradation of mannans, galactomannans, or glucogalactomannans.

179 n-positive patients and 31 of 32 Aspergillus galactomannan-positive patients were also BG positive.

180 Galactomannan positivity correlated with mortality, even

181 Whether galactomannan positivity identifies a subgroup at risk f

182 Galactomannan positivity was associated with mortality (

183 blished by radiographic findings and maximum galactomannan positivity.

184 the substrate-binding cleft, contributing to galactomannan preference.

185 distal negative subsites have a key role in galactomannan preference.

186 a-1,3-glucan, with galactosaminogalactan and galactomannan present in the mobile phase.

187 This indicates that the biosynthesis of galactomannan probably occurs in the lumen of the Golgi

188 oMan26B initially acts on the polysaccharide galactomannan, producing comparably large oligosaccharid

189 ded value to the existing detection of serum galactomannan remain to be investigated.

190 Data indicating that galactomannan remains stable when frozen are scant.

191 nosis of aspergillosis based on detection of galactomannan requires the use of clinical specimens tha

192 radicle emergence, whereas LeMAN1 mobilizes galactomannan reserves in the lateral endosperm.

193 GmtA leads to the absence of galactofuran or galactomannan, respectively.

194 emptive, diagnostic-driven approach based on galactomannan screening and chest computed tomography sc

195 data, we integrated the results of baseline galactomannan serum levels obtained from 249 (65.7%) fro

196 now include consensus cutoff values for the galactomannan test that support the diagnosis of probabl

197 rosol-generating bronchoalveolar lavages for galactomannan testing and microscopic and cultural exami

198 Galactomannan testing from serum and bronchoalveolar lav

199 ludes specific recommendations on the use of galactomannan testing in serum and BAL and for the diagn

200 Bronchoalveolar lavage galactomannan testing showed the highest sensitivity for

201 erum samples were submitted and subjected to galactomannan testing, Aspergillus-specific PCR, and mic

202 evice seems to be a promising alternative to galactomannan testing, which remains the diagnostic gold

203 d included 1,000 (1-3)-beta-d-glucan and 516 galactomannan tests on serum samples.

204 inant HhMAN1 protein hydrolyzes coffee berry galactomannan, the major storage polysaccharide in this

205 days resulted in accumulation of circulating galactomannan to a mean peak GMI of 1.31 and a nadir of

206 In contrast, the xylan backbone, galactomannan-type hemicelluloses, and cellulose were mo

207 The galactomannan utilization locus (BoManPUL) of the human

208 e regression analysis suggested that maximum galactomannan value, Karnofsky score, and baseline plate

209 ues with reduction in bronchoalveolar lavage galactomannan values (7.48-2.15 ng/mL).

210 Serum galactomannan was assayed twice weekly for 60 days, then

211 Galactomannan was used as a biomarker.

212 Galactomannan was used to measure the antifungal effect

213 ition to being used to differentiate between galactomannans, was developed into a selective, quantita

214 tion:MIC values that achieved suppression of galactomannan were 1.68 and 1, respectively.

215 AUC:MIC values that achieved suppression of galactomannan were 55 and 32.1, respectively.

216 s of culture, polymerase chain reaction, and galactomannan were determined.

217 the side chains and backbone of pectins and galactomannans were additionally tested.

218 ackbone synthesis and side-chain addition of galactomannans were previously identified and characteri

219 Galactomannans were ranked first in reducing the levels

220 tion characteristics of arabinogalactans and galactomannans were recovered in all fractions.

221 Galactomannans were the most effective dietary fiber for

222 BoMan26B had higher activity on galactomannan with a high degree of galactosyl substitut

223 enugreek (Trigonella foenum-graecum) forms a galactomannan with a very high degree of Gal substitutio

224 bacco (Nicotiana tabacum) seed are rich in a galactomannan with a very low degree of Gal substitution

225 CBM10-3 and CBM10-2 bound galactomannan with similar affinity (K(d) = 0.2-0.4 mg/m

226 tively in membrane-bound form have endosperm galactomannans with increased average degrees of Gal sub