ライフサイエンスコーパス: galectin 4

1 the first time a structural model for human galectin-4.

2 an adhesion/growth-regulatory galectin-3 and galectin-4.

3 gion between the two CRDs that is present in galectin-4.

4 nt of a distinct gene, Lgals4, which encodes galectin-4.

5 Galectin-4, a member of the galectin family of animal gl

6 otein, identified it as the human homolog of galectin-4, a protein containing two carbohydrate bindin

7 ancer xenografts that express high levels of galectin-4 along with genetic signatures of EGFR-HER2 si

8 Our findings establish galectin-4 and C1GALT1-mediated glycosylation in a signa

9 Expression of both galectin-4 and galectin-6 is confined to the epithelial

10 studies suggest that sugar-binding proteins galectin-4 and galectin-8 bind microbes expressing blood

11 Parallel changes in galectin-4 and O-glycosylation triggered aberrant recept

12 Such different localization of galectins-4 and -3 within T84 cells implies different ta

13 lly expresses two closely related galectins, galectins-4 and -6, each with two carbohydrate recogniti

14 RD) in each monomer, whereas others, such as galectin-4, are isolated as monomers and have two CRDs i

15 Galectin-4 binding to multiple receptor tyrosine kinases

16 ar Worthington, which is recognized by human galectin-4 but not mouse galectin-4, translocated from t

17 ed to specific domains of lamellipodia, with galectin-4 concentrated in the leading edge and galectin

18 Using galectin-4-deficient mice, we aimed to explore whether m

19 l suppression, and the T cell inhibition was galectin-4-dependent.

20 Galectin-4 enchains bacteria during their growth by bind

21 Galectin-4 enhances caspase-1 activation and mature IL-1

22 In vivo investigations established that galectin-4 expression enabled prostate cancer cells to r

23 Galectin-4 expression in clinical specimens of prostate

24 re we report that two innate immune lectins, galectin-4 (Gal-4) and Gal-8, which are expressed in the

25 Galectin-4 (Gal-4), a member of the beta-galactoside-bin

26 ure of tandem-repeat type galectins, such as galectin-4 (Gal-4), modulates their biological activitie

27 Here, we show that intracellular galectin-4 in intestinal epithelial cells (IECs) coats c

28 Our results define a new role for galectin-4 in the modulation of commensal bacteria.

29 We also show that the absence of galectin-4 induces changes in gut microbial composition,

30 Galectin-4 is a tandem-repeat galectin characterized by

31 Galectin-4 is an intestinal lectin that controls pathoge

32 hat can be identified through the binding of galectin-4 is created on local, but not systemic, memory

33 Galectin-4 is expressed at about equal levels in colon a

34 In confluent T84 cells, galectin-4 is mostly cytosolic and concentrated at the b

35 stingly, the reactivity of CD4(+) T cells to galectin-4 is precisely elicited under intestinal inflam

36 The galectin-4-mediated production of IL-6 is MHC class II i

37 The galectin-4-mediated stimulation of CD4(+) T cells is sho

38 In particular, human galectin-4, normally expressed in the healthy gastrointe

39 cident diabetes and 3 proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) with a novel association

40 Our results suggest that galectin-4 plays an important role in host-gut microbe i

41 Notably, these effects of galectin-4 relied upon O-glycosylation mediated by C1GAL

42 The localization of galectin-4 suggests a role in cell adhesion which is als

43 lectin-2 (proto-), galectin-3 (chimera-) and galectin-4 (tandem repeat-type), was selected and analys

44 es, we identify herein an epithelial lectin, galectin-4, that specifically stimulates IL-6 production

45 Furthermore, the binding of galectin-4 to bacterial surfaces restricts intracellular

46 ed by the ability of immobilized recombinant galectin-4 to stimulate adhesion of T84 cells.

47 nteric lymph nodes less effectively in human galectin-4-transgenic mice than in littermate controls.

48 recognized by human galectin-4 but not mouse galectin-4, translocated from the intestines to mesenter

49 Here, we investigate galectin-4 using X-ray crystallography, small- and wide-

50 the course of studying mouse colon mRNA for galectin-4, we detected a related mRNA that encodes a ne

51 Galectin-4, with an increased risk of diabetes, and Para