ライフサイエンスコーパス: gamete

1 line derived clonally from a single parental gamete.

2 s the fertilization checkpoint in the female gamete.

3 d after it matures and receives the paternal gamete.

4 locus, with a mutation rate of up to 5% per gamete.

5 a 50% chance of being included in any given gamete.

6 seed development because of nonviable mutant gametes.

7 s is an integral process for the creation of gametes.

8 and senescence factors into the newly formed gametes.

9 half, sometimes even all, of the functional gametes.

10 cell differentiation, including neurons and gametes.

11 ultrastructure and behavior similar to mt(+) gametes.

12 or mating-type minus gametes but repels plus gametes.

13 ine if shuffled abundances were preserved in gametes.

14 differential DNA methylation inherited from gametes.

15 l alleles to ensure genetic diversity in the gametes.

16 ds of chromosome segregation to form haploid gametes.

17 ting structure at the apical cell surface in gametes.

18 mating frequencies of three-point codominant gametes.

19 gulate Ty3/Gypsy-derived genes in developing gametes.

20 ranscripts, providing early access to future gametes.

21 y, distinct from the one involving unreduced gametes.

22 ic transcriptional states established in the gametes.

23 s complex developmental programs to generate gametes.

24 g underlying the epigenetic reprogramming of gametes.

25 ulminate in the production of mature, viable gametes.

26 are regulated to ensure formation of euploid gametes.

27 umber of replications in lineages leading to gametes.

28 d conceptions in addition to female and male gametes.

29 mologs) is required for formation of haploid gametes.

30 progenitor cells (SSCs) generate adult male gametes.

31 methylation differences observed between the gametes.

32 e segregation errors that generate aneuploid gametes.

33 on and create new combinations of alleles in gametes.

34 cells that contribute to somatic tissues or gametes.

35 t mediates attachment and membrane fusion of gametes.

36 ate towards gonads to mature into functional gametes.

37 mes recombine to create genotypically unique gametes.

38 cycle of all land plants that generate male gametes.

39 d as part of the regular program to generate gametes.

40 " followed by egress of both male and female gametes.

41 s allow diploid organisms to produce haploid gametes: (1) homologous chromosomes (homologs) pair and

42 some organization and accessibility, both in gametes(5-8) and after fertilization(5,8-10).

43 reduce fertility by production of unbalanced gametes, a chromosomal rearrangement may also disrupt or

44 m release from the pollen tube to the female gametes, a critical barrier to interspecific hybridizati

45 Stem cell-derived human gametes, a disruptive technology in waiting, are likely

46 In pregametes, gametes and dark-inactivated gametes, aCRY is localized over the cell body.

47 on SAG1, we show that, within minutes after gamete activation is initiated, cell-surface SAG1 is int

48 d in ectosomes released from flagella during gamete activation.

49 somerase activity which is up-regulated post-gamete activation.

50 are critical for initial interaction between gametes, additional molecules necessary for sperm:egg fu

51 ment interventions to facilitate movement of gametes along short ecological gradients would boost gen

52 Male gametes also develop flagella, which assist in binding f

53 fertilization, is also present in the female gamete and capable of modulating key sperm Ca(2+) channe

54 Each gamete and thus each offspring will inherit only one of

55 Our findings provide important insights into gamete and zygote activity in plants, and our RNA-seq tr

56 uld be deemed "direct exposure" to F1 and F2 gametes and also include subsequent multiple nonexposed

57 aterality determination and the transport of gametes and cerebrospinal fluid.

58 paired, meiotic DSBs can cause aneuploidy in gametes and compromise viability in offspring.

59 In pregametes, gametes and dark-inactivated gametes, aCRY is localized

60 ng organisms use meiosis to generate haploid gametes and faithfully transmit their genome to the next

61 regulate gene expression in developing male gametes and histone retention in mature spermatozoa, pot

62 omes and how they covary across chromosomes, gametes and humans, we developed Sperm-seq, a way of sim

63 is crucial for producing genetically normal gametes and is dependent upon repair of SPO11-induced do

64 ialized cell division that generates haploid gametes and is therefore essential for sexual reproducti

65 n terms of ensuring the production of viable gametes and maintaining the integrity of the genomes the

66 s able to accurately estimate frequencies of gametes and outperformed the EM algorithm in estimating

67 ic index (GSI) as a measure of investment in gametes and proxy for sperm competition, we find that, w

68 chanism to simultaneously differentiate male gametes and reprogram the paternal epigenome.

69 no Y chromosome genes produced haploid male gametes and sired offspring after assisted reproduction.

70 ith recruitment of DNA methyltransferases in gametes and suggestive of unexplored regulatory activiti

71 ergenerational transmission', via changes to gametes and the gestational uterine environment.

72 cal topological-associated domains (TADs) in gametes and their appearance in the embryo(8,9) versus t

73 ated by a small group of cells that includes gametes and their progenitors.

74 ed for correct segregation of chromosomes to gametes and to generate genetic diversity.

75 epigenetic information present in mammalian gametes and whether it is transmitted to the progeny are

76 mbination is essential for producing healthy gametes, and also generates genetic diversity.

77 nas pCRY is down-regulated in pregametes and gametes, and in the pcry mutant, there is altered transc

78 that later contributes to differentiation of gametes, and the second restricts the regulatory influen

79 ) represent the exclusive progenitors of the gametes, and their loss results in adult infertility.

80 the environment changes while hypo-crossover gametes are advantageous in periods of environmental sta

81 the environment fluctuates: hyper-crossover gametes are advantageous when the environment changes wh

82 r transmission through meiosis, when haploid gametes are created from a diploid parent.

83 Male gametes are generated through a specialised differentiat

84 To enact drive, all gametes are poisoned, whereas only those that inherit wt

85 fter fertilization, to initiate development, gametes are reprogramed to become totipotent.

86 Following fertilization in mammals, the gametes are reprogrammed to create a totipotent zygote,

87 Both types of gamete arise from the same precursor, the germ cells.

88 In flowering plants, male gametes arise via meiosis of diploid pollen mother cells

89 is tethered to the chromosomes and passed to gametes at meiosis.

90 gorithm and binomial analysis of three-point gametes (BAT) for estimating gamete frequencies from F2

91 ne: rates of chromosome crossover vary among gametes, between the sexes, and among humans of the same

92 COC and provide new insight into comparative gamete biology as well as metabolism of the COC during i

93 s as a chemoattractant for mating-type minus gametes but repels plus gametes.

94 es were transmitted via both male and female gametes, but homozygous mutants were never recovered.

95 hat are transmitted from parent to child via gametes, but support is gathering for maternal yolk, whi

96 es are attracted to their conspecific female gamete by diffusive molecules, called chemoattractants,

97 t export from the intestine to production of gametes by the germline.

98 a meiotic mishap, we suggest that unreduced gametes can be more explicitly considered as a mechanism

99 rrangement renders the same improved odds of gamete compatibility as direct linkage of the two mating

100 s evolved repeatedly, increasing the odds of gamete compatibility under selfing.

101 pens the "selective arena" within which male gametes compete for fertilization.

102 results suggest that intrasexual gametophyte/gamete competition may play a role in determining mating

103 Gametes constitute a critical stage of the plant life cy

104 Thus, mammalian gametes contain complex patterns of 3D interactions that

105 tified that in the unstressed wild-type male gamete containing pollen of flowering plants, and analog

106 re it is necessary for the disruption of the gamete-containing parasitophorous vacuole membrane, and

107 s ranging from 0.01 to 0.05 aneuploidies per gamete; crossovers partially protected chromosomes from

108 ine the influence of follicular fluid EVs on gamete cryosurvival and the ability to undergo in vitro

109 se findings highlight the importance of male gamete cytoplasmic components to reproductive success an

110 ed microtubules indicates that the increased gamete death after IR is innate to fission yeast.

111 chromosome fragmentation, missegregation and gamete death.

112 fish genes that bias their transmission into gametes, defying Mendelian inheritance.

113 y aberrant development of ovules, leading to gamete degeneration.

114 In eukaryotic meiosis, generation of haploid gametes depends on the formation of inter-homolog crosso

115 If gamete-derived DNA methylation escapes reprograming in e

116 ual dimorphism yet possess self-incompatible gametes determined at mating-type regions of suppressed

117 Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals.

118 ng CRISPR-Cas9 editing had severe defects in gamete development or in spawning both in males and fema

119 DAZL) is an RNA-binding protein critical for gamete development.

120 ar activity on P. falciparum blood stage and gamete development.

121 s the rate of mutation accumulation in human gametes differ across families?

122 Gamete differentiation initiates the transition from the

123 sis but have opposite effects on male/female gamete differentiation.

124 tance signals, (3) adults or their surrogate gamete dispersers are highly mobile, or (4) the two sexe

125 and packaging of the single-copy genome into gametes during the second meiotic division is coordinate

126 Despite being found diversely in male gametes (e.g., Plasmodium falciparum microgametocytes an

127 Instead, MTRAP is essential for gamete egress from erythrocytes, where it is necessary f

128 retion of PfPLP2, reducing the efficiency of gamete egress.

129 s Ca(2+) mobilization, gamete formation, and gametes egress out of erythrocytes.

130 velopment are regulated by a unique maternal-gamete/embryo cross-talk within the oviduct.

131 lly well transmitted through male and female gametes, even though 90% of them were within active gene

132 hought to function solely as spermatia (male gametes), facilitating gene flow between sympatric strai

133 known to be important for P. berghei female gamete fertility, is shown to serve a different function

134 ocytes in the vertebrate host and subsequent gamete fertilization in mosquitoes is essential for the

135 ed role in flagella, SAS6L was absent during gamete flagellum formation.

136 tion levels in plus versus minus mating type gametes followed by chloroplast DNA hypermethylation in

137 ria transmission relies on the production of gametes following ingestion by a mosquito.

138 dividual-level variance of genetic values of gametes for complex traits in large populations.

139 lop flagella, which assist in binding female gametes for fertilization.

140 y which a diploid cell gives rise to haploid gametes for sexual reproduction.

141 Given the differences in 2n gamete formation among Tx623 and Tx631, seed parent sele

142 Specifically, at gamete formation and conception, meiosis ensures random

143 locking potential, as shown by in vitro male gamete formation assays and reduced oocyst infection and

144 ACT-451840 potently prevented male gamete formation from the gametocyte stage with a 50% in

145 Gamete formation is key to survival of higher organisms.

146 Thus, although unreduced gamete formation may be a meiotic mishap, we suggest tha

147 Faithful gamete formation through meiosis requires that kinetocho

148 ellular events, such as Ca(2+) mobilization, gamete formation, and gametes egress out of erythrocytes

149 iosis is the cellular program that underlies gamete formation.

150 d providing a mechanism to prevent aneuploid gamete formation.

151 of three-point gametes (BAT) for estimating gamete frequencies from F2 dominant and codominant marke

152 a powerful method for accurate estimation of gamete frequencies in dominant three-locus system in an

153 ondrial membrane, and it protects the female gamete from oxidative stress.

154 Here we analyse the genomes of 31,228 human gametes from 20 sperm donors, identifying 813,122 crosso

155 ial stem cells to expand the availability of gametes from genetically desirable sires.

156 etazoans do not have a germline but generate gametes from pluripotent stem cells in somatic tissues (

157 germ-cell fate, urogenital development, and gamete functions.

158 gle-pass transmembrane protein HAP2 mediates gamete fusion and is remarkably similar to class II fusi

159 ssed in the egg cell and redundantly control gamete fusion during double fertilization.

160 a eradication, and the biological process of gamete fusion during fertilization is a proven target fo

161 L SPECIFIC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their ex

162 The molecular mechanism triggering gamete fusion is unresolved because both Izumo1 and Juno

163 hat many eukaryotic organisms share a common gamete fusion mechanism.

164 nregulation of Eimeria spp. genes related to gamete fusion, oocyst shedding, mitosis and spermiogenes

165 loop by mutagenesis or by antibodies blocks gamete fusion.

166 velop from vegetative cells rather than from gamete fusion.

167 anisms that regulate plant hybridization and gamete fusion.

168 These results demonstrate that HAP2 is the gamete fusogen and suggest a mechanism of action akin to

169 of taxa and is hypothesized to be an ancient gamete fusogen.

170 Gametocytes differentiation to gametes (gametogenesis) within mosquitos is essential fo

171 ical processes involved in female pregnancy, gamete generation, ovulation cycle, and age at puberty.

172 involving germ cell manipulation, artificial gametes, genetic screening of embryos and gene editing o

173 By reconstructing the gamete genome, MRLR only requires a trio family dataset

174 damage, thereby protecting the integrity of gamete genomes that are passed on to the next generation

175 sible to investigate the effects of specific gamete genotypes.

176 lf of the TEs that were highly methylated in gametes had already undergone CHH hypermethylation in th

177 omes in segregating populations derived from gametes (half-tetrads).

178 Although gametes have a haploid genome (n), most mammalian cells

179 In sexual species, gametes have to find and recognize one another.

180 osha conditional knockout (cKO) mice produce gametes (i.e. sperm and oocytes) partially deficient in

181 in goal of this research was to test whether gamete identity has an effect on the fitness of their di

182 tiology to that of segregation of unbalanced gametes in infertile men harboring a BCA, and provides e

183 Production of healthy gametes in meiosis relies on the quality control and pro

184 an pluripotent stem cells to germline cells (gametes) in vitro.

185 However, understanding of their influence on gametes, including communication with the oocyte, remain

186 hromosome segregation that produce aneuploid gametes increase dramatically as women age, a phenomenon

187 nd transferred to subsequent generations via gametes inheritance.

188 ng of the processes of sperm cell reception, gamete interaction, their pre-fertilization activation a

189 The differentiation of the female gamete into a developmentally competent oocyte relies on

190 efers to events required for transition of a gamete into an embryo, including establishment of the po

191 volves the fusion of male and female haploid gametes into a diploid cell.

192 The merger of two gametes is achieved through a two-step mechanism in whic

193 predictions that reduced investment in male gametes is advantageous in predominantly selfing species

194 The number of male gametes is critical for reproductive success and varies

195 This within-clone movement of gametes is expected to reduce sexual fitness via mate li

196 producing isogamous species, syngamy between gametes is generally not indiscriminate, but rather rest

197 Dimorphism of the two adjacent gametes is mechanistically established in the syncytial

198 umber of pollen grains encompassing the male gametes is widespread in selfing plants.

199 Meiosis, the mechanism of creating haploid gametes, is a complex cellular process observed across s

200 al, overlapping transcripts to encode both a gamete-killing poison and an antidote to the poison.

201 wtf4 as one of these genes that acts to kill gametes (known as spores in yeast) that do not inherit t

202 are genetic parasites that destroy 'sibling' gametes lacking the driver allele.

203 gly, the number of cell divisions within the gamete lineage is nearly independent of both life span a

204 mline ensures the production of high-quality gametes, long-term maintenance of the species and specia

205 Gamete manipulation has yielded haploid embryonic stem (

206 The final stages of female gamete maturation occur in the virtual absence of transc

207 ween diploids and tetraploids, and unreduced gametes may facilitate diploid-tetraploid reproduction.

208 Epigenetic changes in male gametes may therefore impact cancer susceptibility in ad

209 ia of mating type plus and mating type minus gametes mediated by adhesion receptors SAG1 and SAD1 act

210 st cell invasion by the malaria parasite and gamete membrane fusion at fertilization.

211 The fusion of gamete membranes during fertilization is an essential pr

212 o structural information is available on how gamete membranes interact at fertilization, and it is un

213 Following fertilization, the two specified gametes must unite to create an entirely new organism.

214 jor advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelia

215 his result demonstrates the compatibility of gametes of these two species and the viability of result

216 ence and systematically pair the recombinant gametes of two intercrossed natural genomes into an arra

217 g nuclear and mitochondrial DNA mutations in gametes or preimplantation embryos have now been develop

218 e as vectors, delivering signals not only to gametes or the zygote but also to tissues of the materna

219 differentially methylated regions (DMRs) in gametes or their maintenance in early embryogenesis.

220 d wind- or water-driven passive dispersal of gametes, or sluggish or sedentary adult life habits in t

221 generates four genetically distinct haploid gametes over the course of two reductional cell division

222 We also consider how oogamy (a large female gamete packed with mitochondria) alters selection on the

223 In flowering plants, two pairs of gametes participate in double fertilization.

224 In both gametes, patterns of CHH methylation, typically a strong

225 re, their interactions with promoters in the gametes persist during early development.

226 Importantly, this gamete phenotypic plasticity was adaptive: thermal trans

227 nd plants, including important roles in male gamete physiology.

228 In warmer environments, gamete plasticity enabled males to double their reproduc

229 triploid, the tetraploids resulting from 2n gametes present in the sorghum female parent.

230 lization events, it is unknown whether plant gametes prevent polyspermy by a fast block.

231 tep-wise cohesin removal result in aneuploid gametes, preventing the generation of healthy embryos.

232 an epigenetic phenomenon established in the gametes prior to fertilization that causes differential

233 stitutive heterochromatin is disassembled in gametes prior to formation of the zygote and then subseq

234 Unreduced gametes produced by first division restitution mechanism

235 ecifies conditions favoring the evolution of gametes producing ligand and receptor asymmetrically and

236 seasons in the north and reduced periods for gamete production in the south certainly have the potent

237 s and epididymal sperm counts (indicators of gamete production) contained a higher P:C ratio (1:1) th

238 ount of genetic shuffling that occurs during gamete production.

239 two randomly chosen loci are shuffled during gamete production.

240 ins involved in the formation of flagellated gametes; proteins involved in DNA replication, chromatin

241 es variation, allowing selection to optimize gamete quality through somatic gametogenesis.

242 tween early-sequestered oocytes, undermining gamete quality.

243 totic selection that ultimately improves the gamete quality.

244 pool of SAG1 on the plasma membrane of plus gametes rapidly becomes enriched in the peri-ciliary mem

245 er these findings suggest nonrandom union of gametes rather than meiotic drive or preferential lethal

246 , the mechanism elucidating species-specific gamete recognition likely exists in mammals.

247 The sperm gene bindin encodes a gamete recognition protein, which plays an important rol

248 n be used to create in vitro models to study gamete-related diseases in humans.

249 eted from heterochromatin boundaries in both gametes relative to vegetative tissues, reminiscent of s

250 lock mechanisms to ensure accurate timing of gamete release are largely unknown.

251 strongly supports the hypothesis that coral gamete release is achieved by a complex array of potenti

252 signaling cascades that ultimately result in gamete release.

253 ation is inherited from both male and female gametes, remodelled during mid-blastula transition, and

254 The formation of healthy gametes requires pairing of homologous chromosomes (homo

255 through adult development, we found opposing gamete responses, with males producing shorter sperm and

256 esults suggest that selection for asymmetric gamete signaling could be the first step in the evolutio

257 responsiveness, sperm dispersal capacity and gamete size all contribute to the mediation of the direc

258 stive of unexplored regulatory activities of gamete small RNAs.

259 blue light of the strictly light-dependent, gamete-specific gene GAS28 pCRY acts as a negative regul

260 Motile male gametes (sperm cells) are an ancestral eukaryotic trait

261 myces pombe, an organism containing numerous gamete (spore)-killing wtf drivers, offers a tractable s

262 n among sperm/pollen or meiotic drive during gamete/spore production.

263 By contrast, in infected mice, male gametes successfully fertilize female parasites, which l

264 s a specialized cell division that generates gametes, such as eggs and sperm.

265 roband, whereas mosaicism also affecting the gametes, such as germline or gonosomal mosaicism, is tra

266 2, prevent fertilization tubule formation in gametes, suggesting that polymerization of F-actin for f

267 the ongoing search for additional gametocyte/gamete surface antigens, as well as antigens on the surf

268 the most robust hit, DDD01035881, as a male-gamete targeted compound.

269 oid embryonic stem cells (hESCs) from female gametes that also outlines how to maintain the cells onc

270 their own chances of transmission by killing gametes that do not inherit them.

271 it gene of the ATP synthase generated viable gametes that fuse and form ookinetes but cannot progress

272 sed gsm1 and gsp1 mutants and examined fused gametes that normally undergo the multiple organellar fu

273 erm cells (PGCs), precursors of sex-specific gametes that produce an entire organism upon fertilizati

274 interact and fuse with two dimorphic female gametes (the egg and the central cell) forming the major

275 g plants produce two highly dimorphic female gametes, the egg cell and central cell.

276 a possible role in flagella assembly in male gametes, the only flagellated stage.

277 Meiosis produces gametes through a specialized, two-step cell division, w

278 Meiosis produces haploid gametes through a succession of chromosomal events, incl

279 nd produce millions of genetically identical gametes throughout a population.

280 unction of these maternal factors during the gamete to embryo transition remains poorly understood.

281 a prominent "zinc spark." The ability of the gamete to mount a zinc spark response was meiotic-stage

282 with the fusion of the haploid egg and sperm gametes to form the genome of a new diploid organism.

283 Epigenetic marks are reprogrammed in the gametes to reset genomic potential in the next generatio

284 is transition from terminally differentiated gametes to totipotent blastomeres, but the identity of t

285 d chromosome alignment/segregation in female gametes to try to understand the origin of errors of ooc

286 ral role in early development as the site of gamete transport, syngamy, and early development; hence,

287 edentary adult life habits in the absence of gamete vectors, appear to be incompatible with sustained

288 f rearranged chromosomes associates with low gamete viability, which compromises fruit set and decrea

289 pment, indicating that TAF1 is important for gamete viability.

290 dvancing age exerts detrimental effects upon gametes which can have serious consequences upon embryo

291 scale redistribution in both male and female gametes, which is not correlated with recruitment of DNA

292 a crucial step for the production of haploid gametes, which occurs from anterior to posterior in feta

293 ategies to increase the genetic diversity of gametes, which should prove useful in plant breeding and

294 mens produce pollen grains that contain male gametes, while the carpels contain the ovules that when

295 s on the prospect of stem cell-derived human gametes with an eye toward minimizing potential untoward

296 n concomitantly increases the frequencies of gametes with especially high, or especially low, numbers

297 e chromosome segregation in meiosis leads to gametes with incorrect chromosome numbers.

298 germline genome editing on human embryos and gametes, with appropriate oversight and consent from don

299 ion between individuals, differences between gametes within individuals have been less frequently exp

300 generated RNA-seq transcriptome profiles of gametes, zygotes, and apical and basal daughter cells.