ライフサイエンスコーパス: gamma-chain

1 ta chain and IL-2/IL-7/IL-15 receptor common gamma chain.

2 ein composed of one alpha, one beta, and one gamma chain.

3 imulation and is not DAP10/12 or Fc receptor gamma chain.

4 ic chain, and JAK3 is appended to the common gamma chain.

5 d the gammaA/gamma' variant with an extended gamma-chain.

6 of transcription factor PLZF and Fc receptor gamma-chain.

7 f the IL-21 receptor (IL-21R) and the common gamma-chain.

8 at expressed the IL-7Ralpha-chain and common gamma-chain.

9 lls expressing the IL-15Rbeta and the common gamma-chain.

10 d3 was dependent on expression of the common gamma-chain.

11 a has a substitution of Arg375 to Trp in the gamma-chain.

12 cells bearing the IL-2Rbeta-chain and common gamma-chain.

13 to form intricate lattices together with the gamma-chain.

14 on protein and mRNA level of both alpha- and gamma-chain.

15 the C-terminal halves of fibrinogen beta and gamma chains.

16 e or four ion pairs between thrombin and the gamma' chain.

17 vels of the alternatively spliced fibrinogen gamma' chain.

18 M) even though it does not interact with the gamma'-chain.

19 roxidase, MBP, and fibrin alpha-, beta-, and gamma-chains.

20 ated signaling subunits, such as FcepsilonRI gamma-chains.

21 th cells bearing human IL-15Rbeta and common gamma-chains.

22 ht multimer formations that can also contain gamma-chains.

23 mobilization via association with the common gamma-chain, a subunit that transmits signals upon ligat

24 As expected, fibrinogen alpha, beta, and gamma chains accounted for many of the most significant

25 mal (rFgn) and a deletion mutant lacking the gamma-chain AGDV sites (rFgn gammaDelta408-411).

26 nizing the HLA-A2-restricted T-cell receptor gamma-chain alternate reading-frame protein (TARP)(4-13)

27 an 90% of the constituent Aalpha, Bbeta, and gamma chain amino acid sequences.

28 IL-2 receptor subunit alpha (IL-2Ralpha) and gamma chain and also endogenous serine/threonine phospha

29 the regions between CDR2 and CDR3 of the TCR gamma chain and modulated by the affinity of the CDR3 re

30 ine that shares the common cytokine receptor gamma chain and plays important roles for normal Ig prod

31 pansion of lymphocytes expressing the common gamma chain and the development of CD3(+) T lymphocytes.

32 r consisting of the common cytokine receptor gamma chain and the IL-21 receptor (IL-21R).

33 utant JAK3 (M511I) for binding to the common gamma chain and thereby suppresses its oncogenic potenti

34 al electrostatic complementarity between the gamma' chain and exosite II or if there are critical cha

35 Thrombin binds to the gamma'-chain and forms a higher affinity interaction wit

36 tion of the FcepsilonRI alpha-chain with the gamma-chain and beta-chain was markedly reduced.

37 ed with tyrosine phosphorylation of GPVI-FcR gamma-chain and CLEC-2.

38 ites in fibrin are not confined to its known gamma-chain and RGD motifs.

39 receptor complex glycoprotein VI (GPVI)-FcR gamma-chain and the C-type lectin-like receptor 2 (CLEC-

40 teins belongs to fibrinogen (alpha, beta and gamma chains), and this protein showed the maximum frequ

41 ontaining collagen receptor complex GPVI-FcR gamma-chain, and the von Willebrand factor receptor comp

42 gen (gamma'-Fg), a variant with an elongated gamma-chain, are resistant to lysis when compared with c

43 une receptors, but the common use of the FcR gamma-chain as their signaling subunit challenges the co

44 s IL-2, IL-7, and IL-15, while IL-4, another gamma-chain-associated cytokine, is thought to primarily

45 re regulated by the cytokine receptor common gamma-chain-associated cytokines IL-2, IL-7, and IL-15,

46 ylation events downstream of the Fc receptor gamma-chain-associated immunoreceptor tyrosine-based act

47 uences of the ligand-binding alpha-chains of gamma-chain-associated receptors.

48 In the absence of FcR gamma-chain association in P388D1 cells, the Ser(248)-Fc

49 y a single amino acid mutation in the common gamma-chain binding site on IL-15.

50 Taken together, our data suggest that common gamma-chain binding-dependent activation of the shared I

51 ion of negatively charged amino acids in the gamma' chain, both individually and collectively, to thr

52 w that Fcgr3-rs interacts with the common Fc-gamma chain but that Fc receptor-mediated phagocytosis a

53 a3 binds to a KQAGDV motif at the fibrinogen gamma-chain C terminus and to RGD motifs present in loop

54 The fibrinogen gamma-chain C-terminal (residues 144-411) fusion protein

55 of fibrinogen contains a differently spliced gamma chain called gamma', which presents itself mainly

56 e middle of each coiled-coil adjacent to the gamma chain carbohydrate attachment site.

57 The common gamma chain (CD132) is a subunit of the interleukin (IL)

58 -17 cells express IL-15Ralpha and the common gamma chain (CD132), yet lack the IL-2/15Rbeta chain (CD

59 mRNA for IL-7R alpha (CD127) and its common gamma chain (CD132).

60 iable speed with a few members of the common gamma-chain (CD132) family of cytokines, the speed of pr

61 omposed of IL-7Ralpha (CD127) and the common gamma-chain (CD132) to transmit its signal.

62 ls expressing IL-2/IL-15Rbeta and the common gamma-chain (CD132), but did not block IL-15 action in c

63 The glycoprotein (GP) VI/Fc receptor gamma-chain complex is a central regulator of these proc

64 plays an important role in GPVI-Fc receptor gamma-chain complex-mediated platelet activation, and is

65 ich is expected to block signaling involving gamma chain-containing cytokines including interleukins

66 deficiency in IL-7 receptor alone, a common gamma chain-containing receptor required for ILC develop

67 though each of the individual charges in the gamma' chain contributes only incrementally to the overa

68 Our results show that gamma-chain cross-linking contributes significantly to c

69 To study the contribution of FXIIIa-induced gamma-chain cross-linking on fibrin structure and functi

70 /Q399N/K406R and gammaK406R) that modify the gamma-chain cross-linking process.

71 rations that primarily block alpha-, but not gamma-, chain crosslinking decreased RBC retention in cl

72 n in clots formed with fibrinogen that lacks gamma-chain crosslinking sites, but not in clots that la

73 through T cell antigen receptors and common gamma chain cytokine receptors.

74 genes associated with type I IFN and common gamma chain cytokine signaling in CD4 T cell subsets and

75 by effector T cells was dependent on common gamma-chain cytokine activation of the mTOR pathway, whi

76 p is provided via IL-21 production, a common gamma-chain cytokine closely related to IL-2.

77 most recently described member of the common gamma-chain cytokine family, is produced by activated CD

78 has indicated that CD8 T(mem) use the common gamma-chain cytokine IL-15 for their steady-state mainte

79 at IL-2-mediated up-regulation of the common gamma-chain cytokine receptor and perforin, and activati

80 he need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thus STAT5

81 ral signaling mediators activated via common gamma-chain cytokine receptors.

82 IL-21, a common gamma-chain cytokine secreted by activated CD4+ T cells,

83 f ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrease CD8

84 This report addresses the role of gamma-chain cytokine signals in regulating CD4(+) T cell

85 ycle proteins are independent of Jak3/common gamma-chain cytokine signals.

86 s of Foxp3 induction in Treg precursors upon gamma-chain cytokine stimulation.

87 response is induced via IL-2 receptor common gamma chain cytokines and a Janus kinase 3 (JAK3)-depend

88 The common gamma chain cytokines interleukin (IL)-2 and IL-7 are im

89 For example, common gamma-chain cytokines (CGCC), such as interleukin-7 (IL-

90 bryostatin 1/ionomycin and sequential common gamma-chain cytokines (IL-7/IL-15 + IL-2).

91 cells during homeostatic expansion driven by gamma-chain cytokines and exerted a durable, yet reversi

92 The common gamma-chain cytokines IL-15 and IL-7 have been shown to

93 All gamma-chain cytokines signal through JAK-3 and JAK-1 act

94 signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 exp

95 ant, but IL-4, IL-7, and IL-15, other common gamma-chain cytokines, could sustain Foxp3 expression.

96 GVHD, caused by T cells activated by common gamma-chain cytokines, each represent therapeutic target

97 Other common gamma-chain cytokines, IL-4, IL-7, or IL-15, do not shar

98 Foxp3(-) cells to IL-2, but not other common gamma-chain cytokines, resulted in Stat5 phosphorylation

99 tion with physiologic stimuli such as common gamma-chain cytokines, Toll-like receptor (TLR) 2 ligand

100 te peptide stimulation or exposure to common gamma-chain cytokines.

101 ion of NKG2C(bright) NK cells was FcepsilonR gamma-chain defective and highly responsive to Ab-driven

102 ID gamma (with interleukin-2 (IL-2) receptor gamma chain deficiency) mice also revealed the ATRA plus

103 In CD132 (common gamma-chain)-deficient hosts, pmel-1 CD8(+) T cells unde

104 OD) wild-type or SCID/NOD Fc receptor common gamma chain-deficient (FcRgamma(-/-)) mice.

105 this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(-/-) mi

106 betic severe combined immunodeficient common gamma chain-deficient stem cell factor (huNSG) mice exhi

107 trol B16F10 tumor growth, but only in common gamma-chain-deficient host mice.

108 Therefore, we used alymphoid Rag- and common gamma-chain-deficient mice as recipients and observed ho

109 s but lacking their own activating FcgammaR (gamma-chain-deficient mice).

110 ruitment, synovitis, and bone destruction in gamma-chain-deficient mice.

111 al microbiota, adaptive immunity, and common-gamma chain-dependent signaling.

112 activation of these cells in the absence of gamma-chain-dependent cytokine signals induces an altern

113 we examine in detail the role of Jak3/common gamma-chain-dependent cytokines in promoting cell cycle

114 direct impact of IL-2 and IL-15, two common gamma-chain-dependent cytokines, on CD8(+) T-cell exhaus

115 The gamma' chain differs from the gammaA chain in its C-term

116 ain to the shared IL-2/IL-15Rbeta and common gamma-chains displayed on the surface of T cells and NK

117 ollowing IRI in immunodeficient RAG-2/common gamma-chain double-knockout mice, suggesting that the ch

118 plasmic region of the CD3zeta or Fc receptor gamma chain, effectively redirected T cell cytotoxicity

119 ion motif (ITAM) adaptor protein Fc receptor gamma-chain, even though the canonical ITAM signaling wa

120 DCs from mice lacking the Fc receptor gamma chain exhibited an activated phenotype in vitro.

121 Approximately 7-15% of the fibrinogen gamma chain exists as the highly anionic gamma' variant

122 gamma chain expression was very low in tumors expressing

123 showed increased IL-17A and T cell receptor gamma chain expression, and IL-17 production by intestin

124 These erythrocytes demonstrated 60%-70% gamma-chain expression (vs. < 10% for negative control)

125 d protection from infection all required FcR gamma-chain expression on DC.

126 IL-2 and IL-15 are common gamma-chain family cytokines involved in regulation of T

127 IL-7, a member of the common gamma-chain family of cytokines, is essential for B and

128 MyD88 and FcR common gamma-chain (Fcer1g, FcRgamma) elicit proinflammatory re

129 Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid artery

130 ceptor signaling, which utilizes Fc-receptor gamma-chain FcRgamma-Syk.

131 in Mincle or its adapter protein Fc receptor gamma chain (FcRgamma) produced severely reduced amounts

132 yrosine-based activation motif on the common gamma chain (FcRgamma).

133 ying a homozygous mutation in the fibrinogen gamma chain (Fibgamma390-396A) had a striking 50% reduct

134 FcgammaRIII, required association of the FcR gamma-chain for optimal expression and function on myelo

135 ceptor beta-chain CD122, forming with common gamma-chain functional high-affinity IL-2 receptors.

136 on in this interaction and the C-terminus of gamma chain (gamma(377-394)), located in D-domain, showe

137 which IL-7Ralpha or common cytokine receptor gamma chain (gamma(c)) genes were deleted in thymocytes

138 vgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by the ga

139 merization with the common cytokine receptor gamma chain (gamma(c)), the protein whose expression is

140 completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts.

141 cells expressing IL-15/IL-2Rbeta and common gamma chain (gamma(c)).

142 IL-2Rbeta, and the common cytokine receptor gamma chain (gamma(c)).

143 The common gamma-chain (gamma c) cytokines IL-2, IL-7, IL-15, and I

144 rystal structures of complexes of the common gamma-chain (gamma(c)) cytokine receptors and their cyto

145 The common gamma-chain (gamma(c)) cytokines signal through the Janu

146 cuses on the role of cytokines of the common gamma-chain (gamma(c)) family in the determination of th

147 unliganded receptor structure in the common gamma-chain (gamma(c)) family of receptors and cytokines

148 he receptor subunit IL-2Rbeta and the common gamma-chain (gamma(c)).

149 The common cytokine receptor gamma chain, gamma(c), is a component of the receptors f

150 21, IL-2 shares the common cytokine receptor gamma chain, gamma(c), which is mutated in humans with X

151 ghly related to the common cytokine receptor gamma chain, gamma(c).

152 nd IL-15 shares the common cytokine receptor gamma chain, gamma(c).

153 ine that shares the common cytokine receptor gamma-chain, gamma(c), with IL-2, IL-4, IL-7, IL-9, and

154 Cytokines that use the common gamma chain gammac are critical for lymphoid development

155 nt mice lacking the cytokine receptor common gamma chain (gammac(-/-)) and carrying a human stem cell

156 tion-activating gene 2 (Rag2) and the common gamma chain (gammac) (Rag-gammac(-/-)), which lack gut-a

157 2 (IL-2) and IL-15 signal through the common gamma chain (gammac) and through IL-2 receptor beta-chai

158 Gamma chain (gammac) cytokines (interleukin [IL]2, IL4,

159 IL-2 and IL-15, members of the gamma chain (gammac) family of cytokines, are prominentl

160 cy (XSCID) is due to mutations in the common gamma chain (gammac) gene and is identical clinically an

161 Interestingly, common gamma chain (gammac) knockout mice have been shown to ha

162 ations in the IL2RG gene encoding the common gamma chain (gammac) of receptors for interleukins 2 (IL

163 cted to interleukins that recruit the common gamma chain (gammac) receptor, including IL-9.

164 The common gamma chain (gammac)-binding cytokine interleukin (IL)-2

165 ver, Foxp3 lethality was prevented by common gamma chain (gammac)-dependent cytokine signals that wer

166 Common gamma chain (gammac)-receptor dependent cytokines are re

167 We show that common gamma chain (gammac)-using cytokines, namely IL-2, IL-7,

168 L-7 is heterodimeric, consisting of a common gamma chain (gammac, encoded by Il2rg) and an alpha subu

169 rus vector expressing interleukin-2 receptor gamma-chain (gammac) complementary DNA successfully rest

170 CID caused by mutations affecting the common gamma-chain (gammac) cytokine signaling pathway and mice

171 T and NK cell populations relative to other gamma-chain (gammac) cytokines has not been fully define

172 Tim-3 was induced by the common gamma-chain (gammac) cytokines IL-2, IL-7, IL-15, and IL

173 ciated with hyporesponsiveness of T cells to gamma-chain (gammac) cytokines known to influence T cell

174 -gamma) response and upregulation of several gamma-chain (gammac) cytokines known to promote the acti

175 in mice lacking both the Rag2 and the common gamma-chain (gammac) genes (Rag2(-/-)gammac(-/-)), indic

176 The common gamma-chain (gammac) is a key component of multiple cyto

177 The common gamma-chain (gammac) plays a central role in signaling b

178 TGF-beta) that did not signal via the common gamma-chain (gammac) receptor but that, like IL-7 and IL

179 f natural killer (NK) cells relies on common gamma-chain (gammac)-dependent cytokines, in particular

180 ignals through the type I (IL-4Ralpha/common gamma-chain [gammac]) and the type II (IL-4Ralpha/-13Ral

181 a (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors.

182 T-cell receptor-gamma chain gene rearrangement identified a clonal popul

183 here they recombine their TCR beta-chain and gamma-chain gene loci.

184 ed by expressing a hybrid TCR containing TCR-gamma chain germ-line complementarity determining region

185 Because Hep II C3 PEA substitution and gamma-chain GlcNAc OAc addition have been reported to ne

186 Approximately 50% of gamma-chain GlcNAc was present in its 3-OAc-substituted

187 The Fc receptor (FcR) gamma-chain has been shown to be up-regulated in T cells

188 The gamma-chain Hep II contains two phosphoethanolamine (PEA

189 unlike GHRPam, not at all to the homologous gamma-chain hole.

190 We generated immunodeficient Rat Rag-/- Gamma chain-/- human signal regulatory protein alpha-pos

191 In human platelets, Fc receptor gamma-chain IIa (FcgammaRIIa) has been identified as an

192 the gene encoding the Interleukin-2 receptor gamma chain (IL-2Rgamma), leading to a lack of functiona

193 al knockout of interleukin 2 receptor common gamma chain (IL-2Rgammac) from adaptive immunity-deficie

194 ends on expression of interleukin-2 receptor gamma chain (IL-2Rgammac), IL-15, and the major histocom

195 mously or in collaboration with other common gamma chain (IL-4 and IL-7) and IL-6/IL-12 family cytoki

196 The IL-2R common gamma-chain (IL-2Rgamma) is shared by receptors for seve

197 questioned whether the restriction of IL-2R gamma-chain (Il-2rgamma)-dependent cytokine signaling on

198 s interleukin (IL)-2R beta , common gamma (C gamma ) chain, IL-7R alpha , IL-15R alpha; and prolifera

199 bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, investigat

200 in the interleukin 2 (IL-2) receptor common gamma chain (IL2rg(null)) into mice that were already de

201 ding the human interleukin 2 receptor common gamma chain (IL2RG) gene and the efficient derivation of

202 ressing mutations in the IL2-receptor common gamma chain (IL2rg) gene, including NOD-scid IL2rgamma(n

203 e report that the germ-line gene for the TCR gamma chain in a chondrichthyan, the sandbar shark (Carc

204 ory and effector memory subsets and of the C gamma chain in all maturation subsets of CD8+ T cells.

205 which is involved in increased expression of gamma chain in HepG2 cells that are transfected with Bbe

206 y of hnRNP A1 leads to the overexpression of gamma chain in HepG2 cells that overexpress the Bbeta ch

207 tion of interleukin 2 (IL-2) receptor common gamma chain in Rag-deficient mice did rescue mutant colo

208 nals through receptors containing the common gamma chain, induced expression of IL-10 in the IL-2-dep

209 harges plays a profound role in the thrombin-gamma' chain interactions.

210 In Q398N/Q399N/K406R, cross-links with any gamma-chain involvement were completely absent, and only

211 The cross-linking of gamma chains is known to involve the reciprocal linkages

212 ts genetically deficient in mature NK cells (gamma-chain knock out) also showed decreased severity of

213 e as well as humanized NOD Scid IL2 receptor gamma chain knockout (NSG) human leucocyte antigen (HLA)

214 etic severe combined immunodeficiency common gamma chain knockout-bone marrow-liver-thymus humanized

215 KO]) or only the inhibitory FcgammaRIIb (FcR gamma-chain KO).

216 e T cell activation, which was absent in FcR gamma-chain KO, but strikingly more pronounced in Fcgamm

217 odels that tonic signals derived from the Fc-gamma chain lead to Syk-dependent activation of STAT3 an

218 The presence of the gamma' chain modulates thrombin and FXIII activity, infl

219 without gamma-chain or by coexpression with gamma-chain mutants, was associated with significant imp

220 ing of IL-13 to IL-13Ralpha1, neither common gamma-chain nor IL-13Ralpha1 contributed significantly t

221 ocompromised NOD/SCID interleukin-2 receptor gamma chain null (Il2rg(-/-)) mice, can increase the det

222 unodeficient NOD/SCID/interleukin 2 receptor gamma chain null mice.

223 kedly higher level in NOD/SCID/IL-2 receptor gamma chain-null (NSG) mice compared with cytokine-induc

224 c cells and binds specifically to the common gamma chain of a subfamily of cytokine receptors that in

225 osine kinase that associates with the common gamma chain of cytokine receptors and is recurrently mut

226 ntegrin alpha(M)beta(2)-binding motif on the gamma chain of fibrin(ogen).

227 The cell surface-expressed gamma chain of the high affinity receptor for IgE (Fceps

228 s-links between Gln(398) and Lys(406) on the gamma chains of fibrin (the positive control of the stud

229 methionine residues on the alpha, beta, and gamma chains of fibrinogen.

230 Animals lacking both the signal-transducing gamma-chain of IgG receptors and SHIP or Ig and SHIP pro

231 ve therapeutic gene IL2RG, which encodes the gamma-chain of the interleukin-2 receptor, in a mouse mo

232 ombination activating gene 2 [Rag2], and the gamma-chain of the receptor for IL-2 [Il-2rgamma]) with

233 The degradation of the alpha-, beta-, and gamma-chains of fibrin and the appearance of peptide fra

234 ulation factor XIII (FXIIIa) cross-links the gamma-chains of fibrin early in clot formation.

235 The equivalent position in gamma-chains of human fibrin(ogen) is occupied by a lysi

236 noncovalent association with the Fc receptor gamma chain on human and murine platelets and serves as

237 s to study the effects of fibrinogen and its gamma' chain on APC resistance.

238 ing competency, either by expression without gamma-chain or by coexpression with gamma-chain mutants,

239 ts segregated on the basis of use of the TCR gamma-chain or delta-chain indicated the existence of th

240 complex of IL-4Ralpha with either the common gamma-chain or the IL-13R chain alpha1 (IL-13Ralpha1).

241 maRI, FcgammaRIII, FcgammaRIV, or FcR common gamma chain, or inhibitory FcgammaRIIB.

242 The gamma chain "out loop" contained within each coiled-coil

243 tation as observed for the clumping factor A.gamma-chain peptide complex.

244 experiments were performed using immobilized gamma' chain peptides with charged-to-uncharged amino ac

245 64H and gammaD364A, which have nonfunctional gamma-chain polymerization sites to prevent the dominant

246 A motif in the Fg gamma chain previously shown to be central to the alpha(

247 More importantly, common cytokine receptor gamma-chain(-/-)RAG(-/-) animals deficient in NK cells,

248 , and gamma intact chain contents; the gamma/gamma' chains ratio; the N-glycosylation; and the post-t

249 D bearing a null mutation in the IL-2 common gamma chain receptor (NSG) mice as animal models of huma

250 Nonobese diabetic (NOD)-scid interleukin-2 gamma chain receptor (NSG) readily engraft with human im

251 Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis

252 sed and functions in synergy with the common-gamma chain receptor family.

253 cell differentiation defect in interleukin-2 gamma-chain receptor (IL2RG)/JAK3 severe combined immuno

254 erleukin-21 (IL-21) is a recently identified gamma-chain receptor cytokine family member that promote

255 IL-33 is a gamma-chain receptor-independent cytokine of the IL-1 su

256 ry, possibly by repressing the expression of gamma-chain receptors and the downstream effector of the

257 R1 expression by signals via TCRs and common gamma-chain receptors was essential for naive CD4(+) T c

258 tissue in unconditioned allogeneic RAG2(-/-) gamma-chain(-/-) recipients.

259 ite, identified previously within fibrinogen gamma chain residues 207-235, is a high-affinity site an

260 y apo(a)-binding site within the sequence of gamma chain residues 287-411.

261 exosite II or if there are critical charged gamma' chain residues involved.

262 of FXIII-A2B2 to murine fibrinogen that has gamma-chain residues 390-396 mutated to alanines (Fibgam

263 ains, 226KDa for beta chain and 338.5KDa for gamma chain, respectively.

264 stals showed mostly intact native alpha- and gamma-chain sequences (the native beta chain is blocked)

265 e-arginine interaction can also occur in the gamma-chain setting.

266 erotrimeric receptor IL-2/IL-15Rbeta and the gamma chain shared with IL-2 and the cytokine-specific I

267 Conversely, C57BL/6 mice lacking the gamma-chain shared by activating FcgammaR had enhanced s

268 atures are induced in CTCL T cells by common gamma chain signaling cytokines such as IL-2 and do not

269 interleukin 15 and common cytokine receptor gamma chain signaling for their development.

270 RI effector functions, including Fc receptor gamma-chain signaling and intracellular calcium mobiliza

271 IL-21 is a member of the common gamma-chain signaling family of cytokines.

272 penic mice deficient in interleukin (IL)-2/7 gamma-chain signaling.

273 2(-/-) splenocytes but not Rag2(-/-) common gamma chain(-/-) splenocytes.

274 mine and lysine residues on fibrin alpha and gamma chains stabilize the fibrin clot and protect it fr

275 motif (ITAM) incorporated into the accessory gamma-chain subunit that associates with FcgammaRIA and

276 Cytokines that signal through the common gamma-chain suppressed T(reg) cell-induced apoptosis.

277 nding from the central region, and the short gamma chain "tail" extending from each distal globular r

278 -21R in conjunction with the common receptor gamma-chain that is also shared by members of the IL-2 f

279 mice deficient in both apolipoprotein E and gamma-chain, the common subunit of activating Fcgamma re

280 Independently of the FcepsilonRI gamma-chain, this single-chain FcepsilonRI was internali

281 ombin binds to the highly anionic fibrinogen gamma' chain through anion-binding exosite II.

282 In addition, the binding of the gamma' chain to thrombin was weakened in a dose-dependen

283 isease and associates with either the common gamma-chain to form the type I IL-4R or with the IL-13R

284 obial exposure after birth, we monitored the gamma-chain (TRG) and delta-chain (TRD) repertoires of p

285 ncing platform, we sought to analyze the TCR gamma-chain (TRG) repertoire of gammadelta T cells withi

286 igen-induced FcepsilonRI-Lyn association and gamma-chain tyrosine phosphorylation were both impaired

287 mic profile analysis identified ATP synthase gamma chain, ubiquinol-cyt-C reductase, heat shock prote

288 une deficiency in HIV-infected patients, and gamma -chain-utilizing cytokines may play an important r

289 Other common gamma-chain-utilizing cytokines were unable to induce Fo

290 signal correlative microscopy, we found that gamma-chain variable region 5 (V(gamma)5) TCRs expressed

291 T cells expressing the TCR containing the gamma-chain variable region 9 and the delta-chain variab

292 actor XIIIa-catalyzed dimerization of fibrin gamma chains was selected to represent the D-dimer antig

293 s behind clearance of the aberrant Aguadilla gamma-chain, we expressed the mutant gammaD domain in ye

294 ased activation motif receptors: Fc receptor gamma chain, which is noncovalently associated with the

295 IL2RG encodes the common gamma chain, which is part of several interleukin recept

296 e mimicking the C-terminus of the fibrinogen gamma' chain, which binds thrombin and inhibits its acti

297 bulin (Ig) receptor GPVI and the Fc receptor gamma-chain, which has an immunoreceptor tyrosine-based

298 d with the shared IL-2/IL-15Rbeta and common gamma-chains, which activate signaling pathways on NK ce

299 press IL-7 receptors, which share the common gamma chain with IL-2 receptors, IL-7 cannot initiate li

300 enitors lacking the cytokine receptor common gamma-chain yields leukemogenic pre-B cells that exhibit