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1 s a rare disorder associated with monoclonal gammopathy.
2 ry amyloidosis with a concomitant monoclonal gammopathy.
3 marrow and the presence of an IgM monoclonal gammopathy.
4 racutaneous manifestations, and a monoclonal gammopathy.
5 me (FS) is a rare complication of monoclonal gammopathy.
6 era of individuals with a form of monoclonal gammopathy.
7 ge, 42-80 years) of the IBM patients without gammopathy.
8 ogy in patients who do not have a monoclonal gammopathy.
9 of patients will have persistent monoclonal gammopathy.
10 al reorganization of AL and other monoclonal gammopathies.
11 amate than patients with indolent monoclonal gammopathies.
12 ) cells across the progression of monoclonal gammopathies.
13 implicated in the pathogenesis of monoclonal gammopathies.
14 ed gammopathies and some sporadic monoclonal gammopathies.
15 disease have an increased risk of monoclonal gammopathies.
16 replication in the persistence of monoclonal gammopathy.1 It has been known for some time that patien
19 ropoietin and erythrocytosis; (3) monoclonal gammopathy; (4) perinephric fluid collections; and (5) i
20 Further investigation revealed a monoclonal gammopathy, a unique patterning of subcutaneous fat reti
21 rized by urticarial exanthema and monoclonal gammopathy accompanied by systemic symptoms such as feve
22 ) are preceded by an asymptomatic monoclonal gammopathy (AMG), classified as either monoclonal gammop
23 y underlie both Gaucher's disease-associated gammopathies and some sporadic monoclonal gammopathies.
25 alignancy characterized by an IgM monoclonal gammopathy and bone marrow (BM) infiltration with lympho
26 e always preceded by a detectable monoclonal gammopathy and by elevated biomarkers of organ involveme
27 (21%) patients were positive for monoclonal gammopathy and had a faster rate of recurrence and graft
28 ew the causal association between monoclonal gammopathy and neuropathy, and critically review the rec
29 unknown, but in many patients the monoclonal gammopathy and other B-cell abnormalities can be reverse
30 on have an increased incidence of monoclonal gammopathy and plasma cell dyscrasias.2,3 The exact mech
31 a causal relationship between the monoclonal gammopathy and the renal damage and because the signific
32 ambda J lambda rearrangements in lambda-type gammopathies, and that of other Abs to thymus-dependent
33 ogic workup revealed an IgG kappa monoclonal gammopathy, and bone marrow biopsy confirmed smoldering
34 cterized by an urticarial rash, a monoclonal gammopathy, and clinical, histological, and biological s
35 with C3G had GN unrelated to the monoclonal gammopathy, and one with PGNMID did not complete the fir
36 hy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare
37 current urticarial rash and a monoclonal IgM gammopathy, and two of the following minor criteria: rec
43 by recurrent urticarial rash and monoclonal gammopathy, associated with clinical and biological sign
48 group of patients with ISCLS have monoclonal gammopathy-associated SCLS (also known as Clarkson disea
50 stics of human disease, including monoclonal gammopathy, BM infiltration with lytic bone lesions, and
52 2% of age-matched controls, had a monoclonal gammopathy characterized as IgG lambda in 9 patients, Ig
53 (MIDD) is a rare complication of monoclonal gammopathy characterized by deposition of monoclonal Ig
54 ain human sera from patients with monoclonal gammopathies contain factors that induce myelin repair i
57 ion in the immunoglobulin M (IgM) monoclonal gammopathy disease spectrum remains poorly understood.
58 In conclusion, FS associated with monoclonal gammopathy does not appear to confer an additional risk
59 in 305 patients with asymptomatic monoclonal gammopathy enrolled in S0120 under the auspices of SWOG.
60 ical and laboratory findings with monoclonal gammopathy evaluation and, if indicated, TTR gene testin
61 an screen subjects who have known monoclonal gammopathy for amyloid organ dysfunction and damage, all
62 pheral neuropathy associated with monoclonal gammopathies has been advanced by recent clinical studie
63 t not nonprogressive myeloma or premalignant gammopathy, have a marked deficiency of ligand-dependent
64 iated skeletal destruction, serum monoclonal gammopathy, immune suppression, and end-organ sequelae.
65 Ophthalmologists should consider monoclonal gammopathies in unexplained bilateral interstitial kerat
67 tor in child GP patients and with monoclonal gammopathy in adult GP patients, who frequently showed I
70 rasias.2,3 The exact mechanism of monoclonal gammopathy in patients with HIV infection is unknown, bu
72 lification was detected in 67% of monoclonal gammopathies, including monoclonal gammopathy of undeter
73 globulin in 33% of sporadic human monoclonal gammopathies is also specific for the lysolipids LGL1 an
74 ical progression in patients with monoclonal gammopathies is associated with an acquired but potentia
75 l disease, the persistence of the monoclonal gammopathy is associated with high rates of recurrence a
77 mouse models of Gaucher's disease-associated gammopathy is reactive against lyso-glucosylceramide (LG
81 on, the presence of non-malignant monoclonal gammopathy (MG) can be causally associated with kidney d
83 predictors of finding lesions of monoclonal gammopathy (MG) of renal significance (MGRS) on kidney b
86 Detection of light chain (LC) monoclonal gammopathies (MGs) traditionally relies on serum free LC
87 ls compared with the marrow in preneoplastic gammopathy (monoclonal gammopathy of undetermined signif
88 ere we show that patients with preneoplastic gammopathy mount a vigorous T cell response to autologou
89 tudies might seek to identify, with biclonal gammopathy multiple myeloma as an investigative model, t
90 study, we identified patients with biclonal gammopathy multiple myeloma by central laboratory analys
93 results show that, in patients with biclonal gammopathy multiple myeloma, anti-multiple myeloma thera
95 d tumor bed in 23 patients with premalignant gammopathy, nonprogressive myeloma, or progressive multi
96 only 15% of patients, included 21 monoclonal gammopathies of renal significance; 15 multiple myelomas
97 bone marrow trephine samples from monoclonal gammopathies of undetermined significance (MGUS) and fro
98 paraprotein target (paratargs) in monoclonal gammopathies of undetermined significance (MGUS), multip
100 tients (29 AL, 23 MM, and 9 MGUS [monoclonal gammopathies of undetermined significance]) were studied
101 light-chain (AL) amyloidosis, and monoclonal gammopathy of clinical significance (MGCS), all of which
102 It focuses on the concept of monoclonal gammopathy of clinical significance, which can have a la
104 M-protein concentrations at the monoclonal gammopathy of indeterminate potential (MGIP) level were
107 und in 89% of patients, including monoclonal gammopathy of renal significance (65%) and symptomatic l
115 bone marrow biopsy which revealed Monoclonal Gammopathy of renal significance, triggering a HUS and t
116 as determined in 63 patients with monoclonal gammopathy of uncertain significance (MGUS) and 198 pati
117 s of normal plasma cells (PCs) to monoclonal gammopathy of uncertain significance (MGUS) and multiple
118 human controls and patients with monoclonal gammopathy of uncertain significance expressed higher le
120 bjects representing premalignant (monoclonal gammopathy of uncertain significance), early, and advanc
121 CGH on 25 cases of MM, 4 cases of monoclonal gammopathy of uncertain significance, and 1 case of Wald
122 cal study in a person with advanced ALS, IgA gammopathy of unclear significance, and B lymphopenia, C
123 ent course of disease that mimics monoclonal gammopathy of undermined significance, whereas others ha
124 oma (SMM) bridges the gap between monoclonal gammopathy of undetermined significance (a mostly premal
127 58 patients with WM, 77 with IgM monoclonal gammopathy of undetermined significance (IgM-MGUS), 84 w
128 othelial cells from patients with monoclonal gammopathy of undetermined significance (MGECs) and endo
129 s from subjects with MM (n = 16), monoclonal gammopathy of undetermined significance (MGUS) (n = 6),
130 somes from multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS) and healt
131 4+ CD25+ T cells in patients with monoclonal gammopathy of undetermined significance (MGUS) and in pa
132 arly pathogenesis of premalignant monoclonal gammopathy of undetermined significance (MGUS) and malig
134 rrow specimens from patients with monoclonal gammopathy of undetermined significance (MGUS) and multi
135 ignant non-immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) and multi
136 ly expressed in plasma cells from monoclonal gammopathy of undetermined significance (MGUS) and multi
137 eceded by the precursor states of monoclonal gammopathy of undetermined significance (MGUS) and smold
139 (MM) is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS) and smold
140 ant plasma cell dyscrasia such as monoclonal gammopathy of undetermined significance (MGUS) and smold
143 ering of the precursor condition, monoclonal gammopathy of undetermined significance (MGUS) has been
144 lls in the blood of patients with monoclonal gammopathy of undetermined significance (MGUS) has been
145 r et al showed that patients with monoclonal gammopathy of undetermined significance (MGUS) have incr
146 e reported a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS) in Africa
161 Whether this dichotomy exists in monoclonal gammopathy of undetermined significance (MGUS) is uncert
162 The association of obesity with monoclonal gammopathy of undetermined significance (MGUS) is unknow
165 to quantitate adverse outcomes of monoclonal gammopathy of undetermined significance (MGUS) of the im
166 pathy (AMG), classified as either monoclonal gammopathy of undetermined significance (MGUS) or asympt
168 At diagnosis, most patients had monoclonal gammopathy of undetermined significance (MGUS) or smolde
169 nditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smolde
170 eceded by precursor states termed monoclonal gammopathy of undetermined significance (MGUS) or smolde
171 (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients
172 in 90% of immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) patients.
175 ith AL-amyloidosis secondary to a monoclonal gammopathy of undetermined significance (MGUS) referred
176 ation from immunoglobulin-M (IgM) monoclonal gammopathy of undetermined significance (MGUS) remain un
178 patients is more consistent with monoclonal gammopathy of undetermined significance (MGUS) than with
179 study the risk of progression of monoclonal gammopathy of undetermined significance (MGUS) to lympho
180 y a role in the transformation of monoclonal gammopathy of undetermined significance (MGUS) to MM.
182 cogenic drivers of progression of monoclonal gammopathy of undetermined significance (MGUS) to multip
183 s that determine progression from monoclonal gammopathy of undetermined significance (MGUS) to multip
184 dering multiple myeloma (SMM) and monoclonal gammopathy of undetermined significance (MGUS) to multip
185 hat the clinical progression from monoclonal gammopathy of undetermined significance (MGUS) to multip
186 leading the transformation of the monoclonal gammopathy of undetermined significance (MGUS) to myelom
187 ple myeloma (MM) and premalignant monoclonal gammopathy of undetermined significance (MGUS) tumors: a
188 ate the outcomes of patients with monoclonal gammopathy of undetermined significance (MGUS) with COVI
189 untreated active myeloma, 14 had monoclonal gammopathy of undetermined significance (MGUS), 10 had d
191 om two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precur
192 re suggested to jointly influence monoclonal gammopathy of undetermined significance (MGUS), a precur
194 detected in 5 of 5 patients with monoclonal gammopathy of undetermined significance (MGUS), an early
195 sed multiple myeloma (MM), 5 with monoclonal gammopathy of undetermined significance (MGUS), and 31 h
196 multiple myeloma, three cases of monoclonal gammopathy of undetermined significance (MGUS), and five
197 da immunoglobulin light chains in monoclonal gammopathy of undetermined significance (MGUS), as detec
198 ones of a subset of patients with monoclonal gammopathy of undetermined significance (MGUS), asymptom
199 ties to multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), but its
200 tions have been identified in the monoclonal gammopathy of undetermined significance (MGUS), but thei
202 l clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have bee
203 Plasma cell dyscrasias, including monoclonal gammopathy of undetermined significance (MGUS), multiple
204 n plasma cells from patients with monoclonal gammopathy of undetermined significance (MGUS), smolderi
205 eloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS), which is
206 myeloma to a benign form known as monoclonal gammopathy of undetermined significance (MGUS), which re
217 myeloma and its precursor state, monoclonal gammopathy of undetermined significance (MGUS); however,
218 than 500 untreated patients with monoclonal gammopathy of undetermined significance (MGUS; n = 14),
219 s relatively common and occurs in monoclonal gammopathy of undetermined significance (MGUS; n=17), sm
220 l [CI], 1.31-17.86; P = .018) and monoclonal gammopathy of undetermined significance (OR, 5.94; 95% C
222 acroglobulinemia [WM], 6 with IgM monoclonal gammopathy of undetermined significance [MGUS], and 5 no
223 ls (B cells, normal plasma cells, monoclonal gammopathy of undetermined significance [MGUS], presenta
225 ypic profiles between AL and both monoclonal gammopathy of undetermined significance and MM PCs.
226 te potential (CHIP), analogous to monoclonal gammopathy of undetermined significance and monoclonal B
227 luding asymptomatic states called monoclonal gammopathy of undetermined significance and smoldering m
228 precursor states of MM, including monoclonal gammopathy of undetermined significance and smoldering M
229 m precursor conditions, including monoclonal gammopathy of undetermined significance and smoldering m
230 oreover, analyses of samples from monoclonal gammopathy of undetermined significance and smouldering
232 one marrow involvement similar to monoclonal gammopathy of undetermined significance at diagnosis, th
233 criteria were newly diagnosed MM, monoclonal gammopathy of undetermined significance at high risk for
236 healthy donors and patients with monoclonal gammopathy of undetermined significance or other plasma
237 ment cells in transformation from monoclonal gammopathy of undetermined significance or smoldering mu
238 s who were 18 years or older with monoclonal gammopathy of undetermined significance or smouldering m
239 matic precursor conditions-either monoclonal gammopathy of undetermined significance or smouldering m
240 rum adiponectin concentrations in monoclonal gammopathy of undetermined significance patients who sub
241 terials and Methods Patients with monoclonal gammopathy of undetermined significance prospectively un
242 nt disease stages, from 23.66% in monoclonal gammopathy of undetermined significance to 3.23% in MMs
246 Plasma cells in 10 patients with monoclonal gammopathy of undetermined significance were not stained
247 s can help identify patients with monoclonal gammopathy of undetermined significance who are developi
248 y be the presenting feature); and monoclonal gammopathy of undetermined significance with atypical cl
249 characteristics that evolves from monoclonal gammopathy of undetermined significance, a highly preval
250 S from neuropathy associated with monoclonal gammopathy of undetermined significance, additional crit
251 in amyloidosis, multiple myeloma, monoclonal gammopathy of undetermined significance, and non-parapro
252 Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clon
253 n from the non-malignant disorder monoclonal gammopathy of undetermined significance, are poorly unde
254 amyloidosis, multiple myeloma and monoclonal gammopathy of undetermined significance, immunoreactive
255 reexisting plasma cell disorders, monoclonal gammopathy of undetermined significance, or smoldering m
256 plasma cells from healthy donors, monoclonal gammopathy of undetermined significance, smoldering MM,
257 f paraproteinemia in a setting of monoclonal gammopathy of undetermined significance, smoldering plas
258 on to delineate the complexity of monoclonal gammopathy of undetermined significance, smouldering MM
259 in both multiple myeloma (MM) and monoclonal gammopathy of undetermined significance, suggesting that
260 tients with IgG/IgA (but not IgM) monoclonal gammopathy of undetermined significance, supporting a ro
261 MM, whereas nonprogressor SMM has monoclonal gammopathy of undetermined significance-like characteris
266 rease in MM cell proliferation in monoclonal gammopathy of undetermined significance/smoldering MM co
268 tion of SOCS1 and SYK; (5) MM and monoclonal gammopathy of unknown significance (MGUS) had infrequent
269 ients with MM, chronic leukemias, monoclonal gammopathy of unknown significance (MGUS), PBC, and heal
272 Although the high prevalence of a monoclonal gammopathy of unknown significance in SCLS suggests a pa
273 the limited plasma cell disorder monoclonal gammopathy of unknown significance or in nonmyeloma hema
274 patients with multiple myeloma or monoclonal gammopathy of unknown significance sequentially underwen
275 5 with smoldering MM, and 4 with monoclonal gammopathy of unknown significance) and 20 individuals w
280 s through a premalignant state of monoclonal gammopathy of unknown significance; however, the molecul
281 ere at high risk for developing a monoclonal gammopathy on the basis of Black race or a family histor
282 onstellation of lambda-restricted monoclonal gammopathy, plasma cell rimming around lymphoid aggregat
285 unexpected low rate of detectable monoclonal gammopathy, questioning the reality of an underlying clo
288 xenografts from patients with preneoplastic gammopathy showed progressive growth, suggesting that th
289 Its differentiation from other IgM-producing gammopathies such as Waldenstrom macroglobulinemia (WM)
290 tiple myeloma (MM) are 2 distinct monoclonal gammopathies that involve the same cellular compartment:
291 RS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney di
292 s, a form of renal involvement by monoclonal gammopathy that mimics immune-complex glomerulonephritis
293 iple myeloma is the most frequent monoclonal gammopathy to involve the kidney; however, a growing num
294 ge renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchest
295 nt somatic mutation in benign monoclonal IgM gammopathy, Waldenstrom's macroglobulinemia, and diffuse
299 ge, is frequently associated with monoclonal gammopathies, which often recognize various muscle compo
300 focused on defining differences between IgM gammopathies (WM/IgM-MGUS) compared with controls, and s