ライフサイエンスコーパス: ganglioside

1 condensation of the layer at small mol % of ganglioside.

2 only pramlintide increased the level of GM2 ganglioside.

3 the differentiation of a, b, and c series of gangliosides.

4 ion in toxicity in mice deficient in complex gangliosides.

5 y the sialic acid, but not other moieties in gangliosides.

6 d class of the cell's plasma membrane called gangliosides.

7 lceramide synthase (GCS) (gene Ugcg)-derived gangliosides.

8 first biosynthetic enzyme of a- and b-series gangliosides.

9 in sialic acid-containing glycolipids termed gangliosides.

10 on of sialic acid moieties in virus membrane gangliosides.

11 h engage LSTc as well as multiple sialylated gangliosides.

12 saccharides of mono-, di-, and trisialylated gangliosides.

13 lycans (GAGs), and secondary accumulation of gangliosides.

14 the ion abundances of labile lipids such as gangliosides.

15 human tumors produce and shed high levels of gangliosides.

16 MS was applied to NDs containing mixtures of gangliosides.

17 sequently cross-react with lower affinity to gangliosides.

18 ion nor by the global expression of a-series gangliosides.

19 late neuronal function by catabolizing brain gangliosides.

20 ch represents the highest number of reported gangliosides.

21 ssive RT112 cells by reducing (p < 0.01) Gb3 ganglioside (-50 +/- 3%) and sphingosine 1-phosphate (S1

22 the synthesis and extracellular shedding of gangliosides, a class of biologically active cell surfac

23 afts as Lrch4 silencing reduces cell surface gangliosides, a metric of raft abundance, as well as exp

24 ID MS/MS, applied here for the first time to gangliosides, a novel, tetrasialylated O-GalNAc modified

25 eral studies have implied that specific anti-ganglioside Abs induce neuropathy in patients with axona

26 ies indicate that, in this mouse model, anti-ganglioside Abs induce sequential nodal and axonal injur

27 d inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact ner

28 To study the mechanisms of anti-ganglioside Abs-induced neuropathy, we established a new

29 eptors (FcgammaRs) were involved in the anti-ganglioside Abs-mediated nodal and axonal injury in this

30 s model) and systemic administration of anti-ganglioside Abs.

31 For example, either ganglioside addition or human glucosylceramide synthase

32 Some animals received daily GM1 ganglioside administration for 6 weeks, beginning 24 hou

33 rotavirus, VP8* interacts with cell surface gangliosides, allowing engulfment into a membrane vesicl

34 Gangliosides also affect the aggregation of Abeta (Alzhe

35 ng, this work suggests that complex neuronal gangliosides also modulate hypothalamic IR signaling and

36 PD-MS strategy allowed the elucidation of 27 gangliosides among five different classes.

37 hermal titration calorimetry, a screening of ganglioside analogues together with a detailed character

38 tolysosomes and lowered their content of GM2 ganglioside and Abeta-immunoreactivity without detectabl

39 nockout mice also have reduced levels of GM1 ganglioside and myelin in neuronal axons.

40 weeks substantially reduced brain levels of ganglioside and oligosaccharide substrates and reversed

41 weeks substantially reduced brain levels of ganglioside and oligosaccharide substrates and reversed

42 Abeta oligomers become sequestered onto GM1 ganglioside and presumably other lipids on neuronal memb

43 Labile compounds such as gangliosides and cardiolipins are detected in the negati

44 P(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane rafts surroun

45 Relative contributions of gangliosides and glycoproteins to CTB binding depend on

46 not easily controlled or in assays where the gangliosides and MAG are not presented as part of fluid

47 erefore likely to cooperate with each other: gangliosides and members of the synaptic vesicle glycopr

48 ne derivatives, human milk oligosaccharides, gangliosides and N-glycans.

49 ure, where an upper aqueous layer containing gangliosides and other polar lipid subclasses is further

50 The identification of gangliosides and other polar lipids is based on accurate

51 ortant roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin

52 ers efficiently into neurons lacking complex gangliosides and shows no reduction in toxicity in mice

53 insights into the functional roles of brain gangliosides and sialoglycoproteins consistent with rela

54 e UGCG-depleted cells show reduced levels of gangliosides and significantly elevated levels of rhEPO

55 enes responsible for terminal sialylation of gangliosides and some glycoproteins.

56 validates the use of ESI-MS for cell-derived gangliosides and supports the further development of lip

57 accumulation of glycolipids like GM2 and GM3 gangliosides and unesterified cholesterol in surviving P

58 ; ether lipids, sphingolipids (notably GM(3) gangliosides) and lipid classes previously associated wi

59 Abeta oligomers bound strongly to GM1 ganglioside, and blocking the sialic acid residue on GM1

60 increased levels of B4GALNT1 enzyme and GM1 ganglioside, and only pramlintide increased the level of

61 ic acid-containing glycosphingolipids called gangliosides, and its mRNA overexpression and the gangli

62 imaging of acidic lipids such as sulfatides, gangliosides, and phosphatidylinositols in the negative

63 ostinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated wit

64 To examine fine specificities of anti-ganglioside antibodies and develop a more robust platfor

65 xonal forms of Guillain-Barre syndrome, anti-ganglioside antibodies bind gangliosides on nerve surfac

66 stigated whether endocytic clearance of anti-ganglioside antibodies by nerve terminals might also be

67 Although lectins and anti-ganglioside antibodies did not differentiate the ganglio

68 itter recycling, are able to endocytose anti-ganglioside antibodies from the cell surface so rapidly

69 The typical AMAN-associated anti-ganglioside antibodies were rarely present.

70 unexpected pathway by which pathogenic anti-ganglioside antibodies, and potentially other gangliosid

71 amine binding specificities of lectins, anti-ganglioside antibodies, and serum antibodies of GBS pati

72 oblems, they were exposed to anti-disialosyl ganglioside antibodies, including those derived from a p

73 uch signalling and the pathogenic effects of ganglioside antibodies.awx012media15372351982001.

74 Remarkably, systemically delivered anti-ganglioside antibody in mice was so avidly cleared from

75 of neuromuscular junctions, from where anti-ganglioside antibody was retrogradely transported to the

76 Gangliosides are a family of glycosphingolipids characte

77 Within the intracellular milieu, gangliosides are constituents of the autophagosome membr

78 Gangliosides are extracted by chloroform-methanol-water

79 Gangliosides are important cellular membrane components

80 Gangliosides are major cell-surface determinants on all

81 IGNIFICANCE STATEMENT Sulfatides and complex gangliosides are membrane glycolipids with important rol

82 or engagement, while the more weakly binding gangliosides are not required for productive infection.

83 leaflet, distinct nanodomains consisting of gangliosides are observed.

84 Sulfatides and gangliosides are raft-associated glycolipids essential f

85 GM2/GD2 gangliosides are surface glycolipids mainly found on bra

86 t sialic acid-containing glycosphingolipids (gangliosides) are also ligands for human NoVs.

87 including flotillin-1, cholesterol, and GM1 ganglioside, are altered.

88 membranes, and their sialylated derivatives, gangliosides, are the major class of glycoconjugates exp

89 erotypes of BoNTs (BoNT/A-G) require complex gangliosides as co-receptors.

90 9/Siglec-1(+) antigen-presenting cells using gangliosides as targeting ligands.

91 membrane with their glycans facing outward, gangliosides associate laterally with each other, sphing

92 -oligosaccharide (LOS) that cross-react with gangliosides at peripheral nerves causing polyneuropathy

93 loglycoconjugates and a comprehensive set of ganglioside-based glycoconjugates.

94 erdependent roles for sulfatides and complex gangliosides because double (but not single) deficiency

95 deteriorates as the physiological profile of gangliosides becomes progressively and distinctively abn

96 transferase knock-out, CST (-/-)) or complex gangliosides (beta-1,4-N-acetylegalactosaminyltransferas

97 Release of ganglioside binding may enhance GluR2-containing AMPAR a

98 l-cell recognition by trans interaction with ganglioside binding proteins on apposing cells.

99 anglioside antibodies, and potentially other ganglioside binding proteins, are cleared from the syste

100 able ATP (ATPgammaS) significantly disrupted ganglioside binding, whereas it enhanced AMPAR associati

101 of ganglioside functions, affinity-captured ganglioside-binding proteins from rat cerebellar granule

102 ase, because of defects in the first step of ganglioside biosynthesis (GM3 synthase), results in a se

103 Inherited defects in ganglioside biosynthesis causing fatal neurodegenerative

104 Human congenital disorders of ganglioside biosynthesis invariably result in intellectu

105 Disrupting ganglioside biosynthesis may result in reduced synaptic

106 Human congenital disorders of ganglioside biosynthesis result in paraplegia, epilepsy,

107 L5, which codes for an enzyme early in brain ganglioside biosynthesis, result in an early-onset seizu

108 stem are revealed by congenital mutations in ganglioside biosynthetic genes.

109 In the absence of gangliosides, both virion types are efficiently internal

110 Furthermore, in the plasma membrane, CD81-ganglioside bridges arising from preformed glycolipid pa

111 y reconstitution studies indicated that GD1a ganglioside, but not other gangliosides, could restore P

112 ice by neuron-specific expression of complex gangliosides, but not by their glial-specific expression

113 rted to interact with sialic acid-containing gangliosides, but the role of these glycans in JCPyV inf

114 rtant roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues i

115 rted to sphingomyelins and glucosylceramides/gangliosides by the addition of polar head groups.

116 9/Siglec-1, an I-type lectin that recognizes gangliosides, captures the virus.

117 engineered to express a CAR against the GD2 ganglioside (CAR.GD2), which is highly expressed by neur

118 n mouse models, whereas inherited defects in ganglioside catabolism causing various clinical forms of

119 n (heavy chain receptor binding domain) with ganglioside co-receptors orients the translocation domai

120 by tethering of TeNT to the membrane through ganglioside co-receptors prior to acidification.

121 pitope formed by two different gangliosides (ganglioside complex) in the acute-phase sera of some pat

122 Moreover, these gangliosides conferred partial protection in the context

123 Gangliosides consist of a backbone of sphingoid base and

124 resence of a monoclonal IgM reacting against gangliosides containing disialosyl epitopes.

125 We found that GPR37(tGFP) partitioned in GM1 ganglioside-containing lipid rafts in the plasma membran

126 molecular dynamics simulations performed on ganglioside-containing nanodiscs suggest that the partic

127 ) mice is due to a reduced level of neuronal ganglioside content and lack of interactions between the

128 ut CNS resulted in a 36-76% reduction in GM1-ganglioside content in the brain and 75-86% in the spina

129 eraction kinetics as a function of vesicular ganglioside content.

130 Ganglioside conversion by Neu3 sialidase further activat

131 al sialic acid (SA) on the cell surface GD1a ganglioside could be used for PSV binding and infection

132 dicated that GD1a ganglioside, but not other gangliosides, could restore PSV binding and infection, f

133 unctional interactions between sulfatide and gangliosides, CST (-/-) and GalNAc-T (-/-) genotypes wer

134 gangliosides on various cells, we show that ganglioside D3 (GD3) is overexpressed on eight neurosphe

135 provide convincing evidence linking b-series gangliosides deficiency and neurogenesis defects to beha

136 we report that tumor cells engineered to be ganglioside deficient exhibit impaired tumorigenicity, s

137 g myeloid-derived suppressor cells (MDSC) in ganglioside-deficient tumors, in contrast with the large

138 ences from the alpha subunit that confer GM2 ganglioside-degrading activity and protease resistance.

139 The initial step was ganglioside dependent, while the subsequent step involve

140 tained the interchain disulfide bond, showed ganglioside-dependent binding to neurons, required acidi

141 ed tumorigenicity, supporting a link between ganglioside-dependent immune escape and tumor outgrowth.

142 precursor analogs to modulate the sialylated ganglioside-dependent interaction of MLV particles with

143 al sclerosis, conduritol B epoxide preserved ganglioside distribution at the neuromuscular junction,

144 evaluate the temporal expression profiles of gangliosides during the course of neurodegeneration in r

145 racts with alpha2-3-sialyllactose-containing gangliosides enriched in lipid rafts to inhibit raft-dep

146 Our results identify ganglioside-enriched lipid rafts to be receptors that me

147 Our study demonstrates that the b-series gangliosides, especially GD3, play a crucial role in the

148 eared from the circulation by endocytosis at ganglioside-expressing plasma membranes that it was rapi

149 of the CaR-ESI-MS assay using NDs containing gangliosides extracted from porcine brain led to the dis

150 To probe the mechanisms of ganglioside functions, affinity-captured ganglioside-bin

151 Dutch mutant APP(E693Q)) form complexes with gangliosides (GAbeta).

152 nformational epitope formed by two different gangliosides (ganglioside complex) in the acute-phase se

153 For example, the complex ganglioside GD1a interacts dynamically with the IRs on a

154 nce of fibronectin aggregates in MS lesions, ganglioside GD1a might act as a potential novel therapeu

155 re we demonstrate that exogenous addition of ganglioside GD1a overcomes the inhibiting effect of aggr

156 Recently, we identified the ganglioside GD2 as a novel breast cancer stem cell marke

157 Ganglioside GD2 is highly expressed on neuroectodermal t

158 We previously showed that ganglioside GD3 plays a crucial role in the maintenance

159 study, IMS MS was introduced in human brain ganglioside (GG) research.

160 GCases and was able to efficiently hydrolyze gangliosides, globosides, (n)Lc-type GSLs, and cerebrosi

161 chemoenzymatic method for accessing complex ganglioside glycans and should be useful for the synthes

162 The ganglioside (glycolipid) GM1 is thought to be the sole C

163 Gangliosides GM(3) and GD(3) are located in the apical a

164 ney were positive for the lipid raft markers ganglioside GM1 and Caveolin-1.

165 preferential localization of sphingomyelin, ganglioside GM1 and cholesterol in the monolayer region

166 l-dependent cohesive phase separation of the ganglioside GM1 into nano- and microscale assemblies in

167 ra toxin causes diarrheal disease by binding ganglioside GM1 on the apical membrane of polarized inte

168 In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE)

169 of the cholera toxin B subunit, which binds ganglioside GM1, to the Golgi apparatus.

170 a comparative study of the lateral motion of ganglioside GM1, which is a glycosphingolipid residing o

171 ycero-3-phospho-l-serine (sodium salt)), and ganglioside GM1.

172 sults revealed that CTB5 binds to six of the gangliosides (GM1, GM2, GM3, GD1a, GD1b, and GT1b), whil

173 nstrate the reliability of the method, seven gangliosides (GM1, GM2, GM3, GD1a, GD1b, GD2, and GT1b)

174 bind GT1b, but bound specifically to another ganglioside, GM1.

175 beta-hexosaminidase deficiency in which the ganglioside GM2 and other glycolipids accumulate intrace

176 lethanolamine, phosphatidylinositol, and the gangliosides GM2 and GM3.

177 encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2.

178 Ganglioside GM3 mediates adipocyte insulin resistance, b

179 The ST3GAL5 enzyme synthesizes ganglioside GM3, a glycosophingolipid enriched in neural

180 Ganglioside GM3, a host-derived glycosphingolipid incorp

181 s including several sphingolipids (ceramide, ganglioside GM3, GM2, GM1, GD3 and GD1a), cardiolipin, c

182 ids, such as ceramide, glucosylceramide, and ganglioside GM3, have been implicated in various aspects

183 SSEA3) and SSEA4 in hiPSCs toward the simple gangliosides GM3 and GD3 in hiPSC-CMs.

184 osylceramide, globotriaosylceramide, and the gangliosides GM3 and GM1 were significantly elevated in

185 Gangliosides (GMs) form an important class of lipids fou

186 ns that bound selectively to the major brain ganglioside GT1b (GT1b:GM1 > 4; p < 10(-4)), three regul

187 The binding involved gangliosides GT1b and GD1a and a few membrane lipids.

188 -deficient) mice expressing only GM3 and GD3 gangliosides had normal auditory structure and function.

189 Presence of these gangliosides has previously been shown to correlate with

190 iosides were used to determine the effect of ganglioside headgroup charge and geometry on its interac

191 aim at elucidating whether exogenously added gangliosides (i.e., cell surface lipids with a potential

192 ncreasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vi

193 id analysis confirmed a complete lack of GM3 ganglioside in patient fibroblasts, while microarray ana

194 agal deficiency leads to accumulation of GM1-ganglioside in the central nervous system (CNS).

195 important for understanding the role of this ganglioside in the flexibility of neuronal membranes.

196 ed for the identification of a wide range of gangliosides in biological samples.

197 ctures of amphiphilic glycosphingolipids and gangliosides in comparison to collision induced dissocia

198 Binding to alpha2-3-sialyllactose moiety of gangliosides in lipid rafts and inhibition of raft-depen

199 rgets lipid rafts we show that clustering of gangliosides in lipid rafts is important.

200 rane interactions mediate the recognition of gangliosides in membranes by BoNT/DC.

201 lysosomes, thereby impairing the turnover of gangliosides in myelin.

202 of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help

203 ass signals from intact cardiolipin (CL) and gangliosides in normal brain and the effect of a control

204 l alterations in response to loss of complex gangliosides in patient fibroblasts and in zebrafish emb

205 d GT1b-represent the vast majority (>90%) of gangliosides in the brains of all mammals and birds.

206 We report here altered levels of gangliosides in the cerebrospinal fluid of amyotrophic l

207 The functions of gangliosides in the human nervous system are revealed by

208 oral deficits, and support a crucial role of gangliosides in the long-term maintenance of NSCs in adu

209 The molecular functions of brain gangliosides include regulation of receptors in the same

210 Mutations in the ganglioside-induced differentiation associated protein 1

211 Mutations in ganglioside-induced differentiation-associated protein 1

212 We further demonstrate how MAG-ganglioside interactions can be disrupted by antiganglio

213 , we present an approach to characterize MAG-ganglioside interactions in real time, where MAG, GD1a,

214 provided additional confirmation of the NoV-ganglioside interactions.

215 Since the GM1 ganglioside is a major constituent of mammalian lipid ra

216 The GM2 ganglioside is an antigen expressed in the majority of m

217 GT1b ganglioside is axonally transported to the spinal cord d

218 raminidase 3 and 4 double-knockout mice, GM3 ganglioside is stored in microglia, vascular pericytes,

219 , causing conversion of GD1a and GT1b to GM1 ganglioside, is an essential step in regeneration occurr

220 obopentaosylceramide (DSGb5 Cer), a dominant ganglioside isolated from malignant renal cell carcinoma

221 iosides, and its mRNA overexpression and the gangliosides it generates are linked to tumor progressio

222 d sensitive method can be applied to monitor ganglioside levels in plasma from normal people and neur

223 n addition to studies suggesting that simple gangliosides like GM3 regulate peripheral IR signaling,

224 hereas transient nanodomain incorporation of ganglioside lipid GM1 is apparent in both the live-cell

225 As a striking exception, vesicles containing ganglioside lipids GM1 or GM3 accelerate the process.

226 Vs preferentially coordinate domain-favoring ganglioside lipids within host membranes to enhance curv

227 Ganglioside-liposomes specifically bound to CD169 and we

228 dimensional reduction analysis revealed that ganglioside-liposomes specifically targeted CD14(+) CD16

229 in cancer patients and efficiently captured ganglioside-liposomes.

230 of densely packed autofluorescent material, gangliosides, lysozyme, phosphorylated tau, and amyloid-

231 Systemic delivery of an anti-ganglioside mAb was used for selective intraneuronal/axo

232 emic injection of fluorescently labeled anti-ganglioside mAb.

233 tudy are that fluorescent conjugates of anti-ganglioside mAbs are valuable delivery vectors to visual

234 Ganglioside-MAG interactions are often studied in cellul

235 these changes may be due to dysregulation of ganglioside-mediated oligodendroglial precursor cell pro

236 NEU3 sialidase, a key enzyme in ganglioside metabolism, is activated under hypoxic condi

237 of the LOS of C. jejuni extended by various ganglioside mimics.

238 erum samples bound much more strongly to the ganglioside mimics.

239 n B subunit homopentamer (CTB(5)) binding to ganglioside mixtures in model membranes (nanodiscs) usin

240 ents because less DPPC is needed to condense ganglioside molecules with larger cross-sectional areas.

241 We examine the use of an anti-ganglioside monoclonal antibody (mAb) as selective neuro

242 ganglioside-monosialic acid 3 synthase (GM3S) is a known

243 Here, we identified two mammalian gangliosides-namely monosialoganglioside GM3 and disialo

244 ysis kinetics of CUPRA substrates containing ganglioside oligosaccharides by the glycosyl hydrolase h

245 binding specificities of these proteins for ganglioside oligosaccharides.

246 s and were recovered in part as bound to GM1 ganglioside on membranes.

247 e syndrome, anti-ganglioside antibodies bind gangliosides on nerve surfaces, thereby causing injury t

248 findings suggest that sulfatides and complex gangliosides on opposing axo-glial membranes are respons

249 interactions are those between GD1a and GT1b gangliosides on the axon and myelin-associated glycoprot

250 indicate that sulfatide and complex b-series gangliosides on the glial and neuronal membranes, respec

251 By analysis of gangliosides on various cells, we show that ganglioside

252 es are deformed similarly, regardless of the ganglioside or its mole fraction.

253 N-glycosylation or the synthesis of specific gangliosides or displaying Neu5Gc-terminated, as opposed

254 tococcus, and with sialoglycans presented as gangliosides or in the form of sialoglycan microarrays,

255 lated by different facilitator lipids (e.g., gangliosides or phosphoinositols), revealing a plausible

256 rat oligodendrocytes to GD1a, but not other gangliosides, overcomes aggregated fibronectin-induced i

257 We analyzed ganglioside pattern on four melanoma and two neuroblasto

258 ting of the optimal lipid moiety and the GM1 ganglioside pentasaccharide yielded affinities similar,

259 Increased levels of GM1 and GM2 gangliosides play an important role in regulating amyloi

260 n TgCRND8 mice where abnormally abundant GM2 ganglioside-positive granules are detected in neuronal l

261 onize insulin signaling in myotubes, whereas ganglioside precursors do not.

262 We show that gangliosides-preferentially disialogangliosides-function

263 able to remove sialic acid residues from the gangliosides present on adjacent cells, thus creating ce

264 tion, supporting a direct connection between ganglioside production by tumor cells and the recruitmen

265 ical, and genetic tools advance, research on gangliosides promises to reveal mechanisms of molecular

266 ture, and block its interaction with the GM1 ganglioside receptor in the outer leaflet of the plasma

267 gen, Campylobacter jejuni, can mimic the GM1 ganglioside receptor of CT and LT.

268 B subunit homopentamer (CTB5) and its native ganglioside receptor, beta-D-Gal-(1 --> 3)-beta-D-GalNAc

269 We here propose that the glycan part of the ganglioside receptors mainly provides abundance and spec

270 n of cholesterol-rich domains and associated ganglioside receptors prefer to occur in the monolayer a

271 Transient ganglioside reconstitution of the tumor cell inoculum wa

272 e internal Gal-linked Neu5Ac residues of the gangliosides relative to the membrane surface.

273 Gangliosides relieve this block, binding to the capsid a

274 bolic blocks in processing and catabolism of gangliosides result in the development of severe neurolo

275 de on the basis of the correlation among the ganglioside retention, the number of saccharide units, a

276 IL-2Ralpha/IL-15Ralpha colocalized with GM1 ganglioside-rich lipid rafts, but MHC I clusters retract

277 rast with the large MDSC infiltrates seen in ganglioside-rich littermate control tumors.

278 The glycan motifs of gangliosides serve as initial coreceptors for these prot

279 eficiency in GD3 and the downstream b-series gangliosides showed a progressive loss of NSCs both at t

280 Gangliosides, sialic acid-containing glycosphingolipids,

281 eral novel acid glycosphingolipids, like the gangliosides sialyl-lactotetraosylceramide and sialyl-gl

282 Gangliosides (sialylated glycolipids) play an essential

283 Gangliosides, sialylated glycosphingolipids, found on al

284 species, and ESI-MS was used to quantify the ganglioside species expressed within these injured neuro

285 sulting in unambiguous identification of 145 ganglioside species from 19 subclasses, which represents

286 reas two monosialodihexosylganglioside (GM3) ganglioside species were associated with future AF.

287 The most prominent candidates are ganglioside synthesis and impaired addition of O-linked

288 GM3, a lipid raft ganglioside synthesized by GM3 synthase (GM3S), regulate

289 eramide synthase and other components of the ganglioside synthetic pathway are crucial host factors t

290 evidence of CTB(5) binding to the other five gangliosides tested, alone or present together with GM1

291 Externally applied sialidase converted GD1a ganglioside to GM1 and rescued axon regeneration in CNS

292 e the signals from the low-abundance CLs and gangliosides to allow their GCIB-SIMS detection at 8 and

293 ains containing either sulfatides or complex gangliosides to localize and function effectively.

294 tion-resistant saturated and monounsaturated gangliosides) to regions including the CA1 and CA3 of th

295 Loss of neuronal rather than glial complex gangliosides underpins the GalNAc-T (-/-) phenotype, as

296 Gangliosides were altered and enriched within an expande

297 Otherwise, phospholipids and gangliosides were pointed as healthy volunteers' skin li

298 lo-(GA1), disialo-(GD1b) and trisialo-(GT1b) gangliosides were used to determine the effect of gangli

299 GD3 is a well-studied ganglioside which is known to have roles in the developm

300 gCTB retained nanomolar affinity to GM1-ganglioside with only marginal reduction of physicochemi

301 HCR (HCR/T) and TeNT(RY) were found to bind gangliosides with similar affinities and specificities,