ライフサイエンスコーパス: ganglioside GM1

1 site comprised of cholesterol and saturated ganglioside (GM1).

2 iation constant for cholera toxin binding to ganglioside GM1.

3 (CTB) and the corresponding membrane ligand, ganglioside GM1.

4 pic phase behavior, and their high levels of ganglioside GM1.

5 to the lipid raft-associated natural product ganglioside GM1.

6 nce of NANA in a LOS structure mimicking the ganglioside GM1.

7 ycero-3-phospho-l-serine (sodium salt)), and ganglioside GM1.

8 e dependent upon binding of the B subunit to ganglioside GM1.

9 as controlled by doping different content of ganglioside GM1.

10 bind GT1b, but bound specifically to another ganglioside, GM1.

11 are the surface-exposed sugar groups of the gangliosides GM1.

12 Inasmuch as the anionic ganglioside GM1, a compound structurally dissimilar to a

13 derived from Escherichia coli that binds to ganglioside GM1, a glycosphingolipid on the surface of m

14 tested whether CT's apical membrane receptor ganglioside GM1 acts specifically in toxin action.

15 ) and an internally esterified derivative of ganglioside GM1 (AGF2) upon ethanol-induced changes in t

16 he thermotropic and structural properties of ganglioside GM1 alone and in a binary system with 1,2-di

17 ney were positive for the lipid raft markers ganglioside GM1 and Caveolin-1.

18 preferential localization of sphingomyelin, ganglioside GM1 and cholesterol in the monolayer region

19 ns and lipid rafts, however, examined mainly ganglioside GM1 and glycosylphosphatidylinositol-linked

20 The caveolar markers ganglioside GM1 and H-ras were found concentrated in the

21 ex structures, such as the fucosylated human ganglioside GM1 and Lewis(a) antigen.

22 CT and LTIIb distinguish between gangliosides GM1 and GD1a at the cell surface by virtue

23 particles, we demonstrate that both alpha2-3 gangliosides GM1 and GM3 are capable of mediating this i

24 n 6 inhibition decreased the delivery of GM1 ganglioside (GM1) and glycosylphosphatidylinositol (GPI)

25 ich specifically binds to the raft component ganglioside GM1, and an antibody against CTX.

26 XCR4 colocalized with raft-resident markers, ganglioside GM1, and glycosylphosphatidylinositol-anchor

27 toxin, with their natural GSL receptors, the ganglioside GM1, and the globotriaosylceramide Gb3, resp

28 cetylene lipid and the cell surface receptor ganglioside GM1 are utilized to construct an amperometri

29 labile enterotoxin from Escherichia coli and ganglioside GM1 as a paradigm, we developed a modeling p

30 virus simian virus 40 (SV40), which uses the ganglioside GM1 as a receptor that mediates cell binding

31 , CD9 and alpha(3) integrin colocalized with ganglioside GM1 as seen by double staining of fixed cell

32 The ganglioside GM1, as the recognition unit for cholera tox

33 Finally, the upregulation of caveolin-1 and ganglioside GM1 at the plasma membrane of E5-expressing

34 on in its B subunit, which binds in vitro to ganglioside GM1 but not to ganglioside GD1b, was unable

35 ipid analogs of glucosylceramide, sulfatide, ganglioside GM1, ceramide 1-phosphate, sphingosine 1-pho

36 The lipid raft marker, ganglioside GM1, co-localizes with CD44 on the plasma me

37 ed CFTR (GFP-CFTR) and the lipid raft marker ganglioside GM1 colocalized at sites of P. aeruginosa co

38 Patches of cross-linked raft resident ganglioside GM1 colocalized with ULBP1, 2, 3, or MICA, b

39 d that alpha-synuclein specifically binds to ganglioside GM1-containing small unilamellar vesicles (S

40 ganglioside GM3, and the non-binding ligand, ganglioside GM1, for their capacity to target antigens t

41 cifically binds with monosialo-tetra-hexosyl-ganglioside (GM1) found on the exterior cell membrane of

42 The mechanism(s) by which ganglioside GM1 functions in signal transduction likely

43 The ganglioside GM1 (Gal 1beta1, 3GalNAcbeta1, 4Gal-NeuAcalp

44 Here, the terminal sugar of ganglioside GM1, galactose, was chosen as a lead in desi

45 s gangliosides, and is selective for certain gangliosides (GM1, GD1a, and GD1b), whereas others (GM3)

46 Exogenous addition of mixed gangliosides (GM1, GD1a, and GT1b) as well as GD1a itsel

47 dies (mAbs) against the major nervous system gangliosides GM1, GD1a, GD1b and GT1b to test whether an

48 ide antisera, three monoclonal antibodies to ganglioside GM1 (GM1) and of the cholera toxin B subunit

49 sults revealed that CTB5 binds to six of the gangliosides (GM1, GM2, GM3, GD1a, GD1b, and GT1b), whil

50 nstrate the reliability of the method, seven gangliosides (GM1, GM2, GM3, GD1a, GD1b, GD2, and GT1b)

51 rafts by targeting the sialic acid moiety of gangliosides, GM1/GM3.

52 ientation relative to a membrane surface) of ganglioside GM1 in biologically relevant membrane enviro

53 e (Gal-T-II) is responsible for synthesis of ganglioside GM1 in the ganglioside biosynthetic pathway.

54 crosslinking a minor membrane component, the ganglioside GM1, in simple lipid models of the plasma me

55 We report that intraventricular infusion of ganglioside GM1 induces phosphorylation of mutant huntin

56 l-dependent cohesive phase separation of the ganglioside GM1 into nano- and microscale assemblies in

57 robe linked to the membrane-imbedded tail of ganglioside GM1 is not influenced by pH in a range from

58 The complex of cholera toxin and ganglioside GM1 is one of the highest affinity protein-c

59 Ganglioside GM1 is the natural receptor for cholera toxi

60 entavalent binding between cholera toxin and ganglioside GM1 is used as a model system to demonstrate

61 GM1-ganglioside (GM1) is a major sialoglycolipid of neuronal

62 ing antigen uptake because the CTB receptor, ganglioside GM1, is a glycolipid present in apical membr

63 icate that the expression of raft-associated ganglioside, GM1, is increased in T cells from SLE patie

64 covalently attached sugar molecules such as ganglioside GM1, lactosyl phosphatidylethanolamine, and

65 ination of a completed genome sequence and a ganglioside GM1-like LOS structure makes C. jejuni NCTC

66 n subunit B binding protein (BODIPY)-labeled ganglioside GM1 lipid after Fas-L induction of apoptosis

67 ACE2 to move from PIP(2) lipids to endocytic ganglioside (GM1) lipids, where the virus is optimally l

68 Results with positively curved lipids (ganglioside, GM1; lysophosphatidylcholine, LPCs) and neg

69 palmitoyl-sn-glycero-3-phosphocholine (DPPC)-ganglioside GM1 monolayers to probe Abeta-GM1 interactio

70 oth fluorescence donor and acceptor)-labeled ganglioside GM1 on a biomimetic membrane surface (suppor

71 These findings show that ganglioside GM1 on T84 cells is not a functional recepto

72 ra toxin causes diarrheal disease by binding ganglioside GM1 on the apical membrane of polarized inte

73 olocalization between IK1 and the lipid raft ganglioside GM1 on the plasma membrane, which subsequent

74 0-fold increase in the lipid raft component, ganglioside GM1, on the cell surface and mediates a dram

75 targeted to the transferrin receptor (TfR), ganglioside GM1 or ICAM1, associated to the clathrin, ca

76 d when GM3 was absent or replaced with other gangliosides GM1 or GD1a, or with LacCer.

77 osphatidylinositol-linked protein Thy-1, the ganglioside GM1, palmitoylated LAT, and cross-linked IgE

78 Finally, nuclear membrane-associated ganglioside GM1 plays a pivotal role in Ca(2+) homeostas

79 luorescent dendriplexes co-localize with the ganglioside GM1 present into membrane rafts in both an i

80 lex of the cholera toxin B-pentamer with the ganglioside GM1 receptor pentasaccharide diffract to nea

81 n, the addition of increasing amounts of the ganglioside GM1 reduced the potency of the inhibitor dra

82 In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE)

83 several other oligosialogangliosides and to ganglioside GM1, the functional receptor for cholera tox

84 Ganglioside GM1, the receptor for CT, is predominantly c

85 of the cholera toxin B subunit, which binds ganglioside GM1, to the Golgi apparatus.

86 gulated localization of a lipid raft marker, ganglioside GM1, to the leading edge.

87 ays utilized a ganglioside-"capture" format: ganglioside GM1, utilized for capture of analyte, was im

88 t analysis showed that the "raft" associated ganglioside GM1 was enriched in the detergent-insoluble

89 Binding to ganglioside GM1 was essential for suppression, since rLT

90 The ganglioside GM1 was tagged with the fluorescent dye tetr

91 Ganglioside GM1 was used to prepare the liposomes by spo

92 esult in cDNA amplification when a different ganglioside (GM1) was used for coating of the microtiter

93 a (CTbeta), which binds to the raft-enriched ganglioside GM1, was selected to label rafts.

94 ilayers containing various concentrations of ganglioside GM1 were addressed along the length of indiv

95 resence of Nef, viral envelopes contain more ganglioside (GM1), which is a major component of lipid r

96 The natural receptor for LT is the complex ganglioside GM1, which has galactose as its terminal sug

97 a comparative study of the lateral motion of ganglioside GM1, which is a glycosphingolipid residing o

98 nked proteins Thy-1 and CD59, as well as the ganglioside GM1, which is known to partition preferentia

99 Cross-linking of raft gangliosides GM1 with cholera toxin (CTxB) was shown to