ライフサイエンスコーパス: gastrin-releasing peptide

1 -containing SCN cells are immunopositive for gastrin-releasing peptide.

2 re localized to the SCN subregion containing gastrin-releasing peptide.

3 ducing vasoactive intestinal polypeptide and gastrin-releasing peptide.

4 ombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide.

5 transient receptor potential subtype V1 and gastrin-releasing peptide.

6 nes stably transfected with the receptor for gastrin releasing peptide, a physiologic stimulant of NT

7 g neurons respond to histamine and coexpress gastrin-releasing peptide, a peptide involved in itch se

8 of the mitogenic neuropeptide receptors for gastrin-releasing peptide and arginine vasopressin.

9 ed release of the pruritogenic neuropeptides gastrin-releasing peptide and atrial natriuretic peptide

10 Gastrin cells respond to both gastrin-releasing peptide and carbachol but not to chole

11 lease of the itch and analgesia transmitters gastrin-releasing peptide and leucine-enkephalin.

12 ropeptides of the bombesin family, including gastrin-releasing peptide and neuromedin B, which are fo

13 r, although two low affinity antagonists for gastrin-releasing peptide and NMB receptors, [D-Arg1,D-T

14 Gastrin-releasing peptide and other bombesin-like peptid

15 ranscription that regulate these parameters: gastrin-releasing peptide and the small conductance, cal

16 ide, neuropeptide Y, NBNP, endothelin 1, and gastrin-releasing peptide), and neurotrophins (eg, nerve

17 gastrin, chromogranin A and normal levels of gastrin-releasing peptide, and 9 other hormones.

18 opressin, vasoactive intestinal polypeptide, gastrin-releasing peptide, and corticotropin-releasing f

19 on of ASH1, the neuroendocrine growth factor gastrin-releasing peptide, and neuroendocrine markers sy

20 uitary adenylate cyclase-activating peptide, gastrin-releasing peptide, and substance P is reviewed.

21 , via activation of antral neurons secreting gastrin-releasing peptide, and that the antral innervati

22 ve agonist stimulated scratching behavior by gastrin-releasing peptide- and opioid-dependent mechanis

23 A gastrin-releasing peptide antagonist inhibited the post-

24 We identified the Grp gene, encoding gastrin-releasing peptide, as being highly expressed bot

25 3], which binds to the cell surface bombesin/gastrin-releasing peptide (BBN/GRP) receptor, was conjug

26 tagonists, JV-1-65 and JV-1-63, and bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC-3940-II

27 Antagonists of bombesin/gastrin-releasing peptide (BN/GRP) have been developed t

28 cers, treatment with antagonists of bombesin/gastrin-releasing peptide (BN/GRP) produces a reduction

29 rian cancer, or therapeutic utility, such as gastrin-releasing peptide/bombesin in lung carcinomas.

30 ts, blocking calcium mobilization induced by gastrin-releasing peptide, bradykinin, cholecystokinin,

31 label immunohistochemistry reveals that most gastrin-releasing peptide cells (approximately 70%) cont

32 Gastrin-releasing peptide-containing cells do not expres

33 reated with BBS, the amphibian equivalent of gastrin releasing peptide, demonstrated a similar MARCKS

34 nd genetic silencing shows the importance of gastrin releasing peptide-expressing neurons in mediatin

35 IP(+)), neuromedin S-expressing (NMS(+)) and gastrin-releasing peptide-expressing (GRP(+)) cells.

36 Gastrin-releasing peptide fragment 14-27 and gastrin 17,

37 We previously reported that a gastrin-releasing peptide/gastrin-releasing peptide rece

38 We generated gastrin-releasing peptide gene knockout (Grp(-/-)) mice

39 Gastrin, histamine, gastrin-releasing peptide, ghrelin, orexin, and glucocor

40 of 125I-labeled [Tyr4]BN to receptors for BN/gastrin releasing peptide (GRP) on Swiss 3T3 cells was d

41 taining either arginine vasopressin (AVP) or gastrin releasing peptide (GRP) were also compared betwe

42 nthesize GABA, CALB, VIP, calretinin (CALR), gastrin releasing peptide (GRP), and neurotensin (NT), a

43 Gastrin releasing-peptide (GRP) is a potent growth facto

44 483 cells with siRNA causes an inhibition of gastrin-releasing peptide (GRP) -induced phosphorylation

45 halocyanine-peptide conjugates targeting the gastrin-releasing peptide (GRP) and integrin receptors i

46 The G cell is activated by acetylcholine and gastrin-releasing peptide (GRP) and is inhibited by soma

47 Gastrin-releasing peptide (GRP) and its amphibian homolo

48 The gastrin-releasing peptide (GRP) and its receptor (GRPR)

49 for the oncogenic transformations induced by gastrin-releasing peptide (GRP) and its receptor, GRP-R,

50 of a cohort of itch-sensing genes, including gastrin-releasing peptide (GRP) and MAS-related GPCR mem

51 Two related (bombesin-like) peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) h

52 The mammalian bombesin peptides [gastrin-releasing peptide (GRP) and neuromedin B (NMB)]

53 NeuroD2 that contribute to these processes: gastrin-releasing peptide (GRP) and the small conductanc

54 al horn excitatory interneurons that express gastrin-releasing peptide (GRP) are part of the circuit

55 Here we identify gastrin-releasing peptide (GRP) as a new angiogenic mole

56 We demonstrate that gastrin-releasing peptide (GRP) can inhibit the prolifer

57 Bombesin (BN) or gastrin-releasing peptide (GRP) can stimulate the growth

58 Gastrin-releasing peptide (GRP) causes multiple effects

59 only vasoactive intestinal polypeptide (VIP)/gastrin-releasing peptide (GRP) cells located ventrally

60 We next found that the gastrin-releasing peptide (Grp) expressing neurons in th

61 The bombesin/gastrin-releasing peptide (GRP) family of neuropeptides

62 Gastrin-releasing peptide (GRP) functions as a neurotran

63 ctions of spinal opioid-related peptides and gastrin-releasing peptide (GRP) in awake, behaving monke

64 ies showed that antagonists of bombesin (BN)/gastrin-releasing peptide (GRP) inhibit the growth of va

65 Brief light pulses or microinjection of gastrin-releasing peptide (GRP) into the third ventricle

66 Gastrin-releasing peptide (GRP) is a mitogen and morphog

67 Gastrin-releasing peptide (GRP) is a neuropeptide that a

68 Gastrin-releasing peptide (GRP) is a spinal itch transmi

69 Previous studies suggested that gastrin-releasing peptide (GRP) is an itch-specific neur

70 Gastrin-releasing peptide (GRP) is localized to the SCN

71 Gastrin-releasing peptide (GRP) is proposed to be a key

72 Gastrin-releasing peptide (GRP) is synthesized by pulmon

73 ed the effect of the number of receptors for gastrin-releasing peptide (GRP) on ligand affinity and o

74 The effects of antagonists of bombesin/gastrin-releasing peptide (GRP) on the growth of human m

75 ning the adult colon do not normally express gastrin-releasing peptide (GRP) or its receptor (GRPR).

76 plication of the bombesin-like neuropeptides gastrin-releasing peptide (GRP) or neuromedin B (NMB) pr

77 Overexpression of gastrin-releasing peptide (GRP) receptor (GRPR) in both

78 as cloned based on its homology to the human gastrin-releasing peptide (GRP) receptor and neuromedin

79 known human BLP receptor subtypes [i.e., the gastrin-releasing peptide (GRP) receptor, neuromedin B (

80 Gastrin-releasing peptide (GRP) receptors (GRPr) are fre

81 Gastrin-releasing peptide (GRP) receptors have been show

82 tides have demonstrated high affinity toward gastrin-releasing peptide (GRP) receptors in vivo that a

83 We have previously shown that gastrin-releasing peptide (GRP) stimulates neuroblastoma

84 The gastrin-releasing peptide (GRP) system in the lumbosacra

85 amino acid peptide, is an analogue of human gastrin-releasing peptide (GRP) that binds to GRP recept

86 al for high affinity binding of bombesin and gastrin-releasing peptide (GRP) to the GRP-R.

87 Previously, we determined that gastrin-releasing peptide (GRP) was elevated within days

88 Two probes for gastrin-releasing peptide (GRP), a known stimulatory ago

89 Gastrin-releasing peptide (GRP), a selective agonist for

90 , including the bombesin (BBS)-like peptide, gastrin-releasing peptide (GRP), and its cognate recepto

91 Although cyclooxygenase-2 (COX-2), gastrin-releasing peptide (GRP), and its receptor, GRP-R

92 epolarization and a second SCN neuropeptide, gastrin-releasing peptide (GRP), can acutely enhance and

93 hetamine-related transcript (CART), galanin, gastrin-releasing peptide (GRP), neuropeptide Y (NPY), n

94 approach with four prominent neuropeptides: gastrin-releasing peptide (GRP), oxytocin (OT), substanc

95 we reveal that a bombesin-like neuropeptide, gastrin-releasing peptide (GRP), recruits disinhibitory

96 Gastrin-releasing peptide (GRP), secreted by pulmonary n

97 oxide, vasoactive intestinal peptide (VIP), gastrin-releasing peptide (GRP), substance P, and calcit

98 a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct syn

99 Exemplified by gastrin-releasing peptide (GRP), these neuropeptides tra

100 Gastrin-releasing peptide (GRP), which is found within c

101 ied 5-HT1A as a key receptor in facilitating gastrin-releasing peptide (GRP)-dependent scratching beh

102 PAR-4 was also found on gastrin-releasing peptide (GRP)-positive neurons (pruric

103 s at 0.4 nM and was 30-fold more potent than gastrin-releasing peptide (GRP).

104 embrane domains of diphtheria toxin fused to gastrin-releasing peptide (GRP).

105 VIP), peptide histidine isoleucine (PHI) and gastrin-releasing peptide (GRP).

106 ry afferent-derived "itch" neurotransmitter, gastrin-releasing peptide (GRP).

107 ibutions from arginine vasopressin (AVP) and gastrin-releasing peptide (GRP).

108 A gastrin-releasing peptide (GRP)/GRP receptor-mediated au

109 ne neurons express mRNA for the neuropeptide Gastrin-releasing peptide (GRP); however, its functional

110 ptor subtypes (neuromedin B [NMB]) receptor, gastrin-releasing peptide [GRP] receptor, and bombesin r

111 Normally, levels of mammalian bombesin (gastrin-releasing peptide [GRP]) drop postnatally, but t

112 e NMBR over the closely related receptor for gastrin-releasing peptide (GRPR), we used a chimeric rec

113 ry adenylate cyclase-activating peptide, and gastrin-releasing peptide have shown how these peptides

114 areas of the stomach, about one-third of all gastrin-releasing peptide immunoreactive (GRP-IR) neuron

115 al peptide-IR (VIP-IR), but not with that of gastrin-releasing peptide-IR (GRP-IR).

116 Furthermore, the findings suggest that gastrin-releasing peptide is a potential mediator of int

117 We found that gastrin-releasing peptide is specifically expressed in a

118 These neuropeptides, including gastrin-releasing peptide, neuromedin B, neurotensin, ga

119 e compounds demonstrated that antagonists of gastrin-releasing peptide/neuromedin B receptors (BB/BB)

120 r support for a critical role of dorsal horn gastrin-releasing peptide neurons in itch circuits, but

121 e in pain.SIGNIFICANCE STATEMENT Dorsal horn gastrin-releasing peptide neurons serve a well-establish

122 ed by activation of cholinergic and bombesin/gastrin-releasing peptide neurons, acts mainly by releas

123 Bombesin, gastrin-releasing peptide, NMB, and a bombesin receptor

124 receptors: the neuromedin B-preferring, the gastrin-releasing peptide-preferring, and the bombesin-r

125 Pro-gastrin releasing peptide (pro-GRP) was identified as a

126 says are in high demand, and analysis of pro-gastrin releasing peptide (ProGRP) as a small cell lung

127 Bioconjugate affinity for the gastrin releasing peptide receptor (GRPR) as determined

128 The gastrin releasing peptide receptor (GRPr) has a high aff

129 Gastrin releasing peptide receptor (GRPR) is an attracti

130 , we show that the spinal neurons expressing gastrin releasing peptide receptor (GRPR) primarily comp

131 into tumor cells, their affinity toward the gastrin releasing peptide receptor (GRPr), metabolic sta

132 e been proposed for diagnosis and therapy of gastrin releasing peptide receptor (GRPR)-expressing tum

133 lls transfected with the Gq-coupled bombesin/gastrin releasing peptide receptor, bombesin stimulated

134 The gastrin-releasing peptide receptor (BB2r) is overexpress

135 Receptor-targeted agents, such as gastrin-releasing peptide receptor (BB2r)-targeted pepti

136 ed by cells expressing the G-protein-coupled gastrin-releasing peptide receptor (GRP-R) and is curren

137 The gastrin-releasing peptide receptor (GRP-R) is a neuropep

138 The gastrin-releasing peptide receptor (GRP-R) is one of thr

139 imilar rationale, radioligands targeting the gastrin-releasing peptide receptor (GRP-R) might offer a

140 ll lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor

141 receptors (neuromedin B receptor (NMB-R) and gastrin-releasing peptide receptor (GRP-R)).

142 s by the bombesin receptor family, including gastrin-releasing peptide receptor (GRP-R), neuromedin B

143 -coupled receptors currently consists of the gastrin-releasing peptide receptor (GRP-R), neuromedin B

144 udy we demonstrate that for the G(q)-coupled gastrin-releasing peptide receptor (GRP-R), phosphorylat

145 ceptor subtypes have been characterized: the gastrin-releasing peptide receptor (GRP-R), the neuromed

146 of G-protein-coupled receptors includes the gastrin-releasing peptide receptor (GRP-R), the neuromed

147 mutagenesis to address these issues with the gastrin-releasing peptide receptor (GRP-R).

148 al, G-protein coupled receptors includes the gastrin-releasing peptide receptor (GRP-R, or bb2), neur

149 However, the limited expression of gastrin-releasing peptide receptor (GRPR) and integrin a

150 We recently introduced the potent gastrin-releasing peptide receptor (GRPR) antagonist (68

151 e treatment of prostate cancer, radiolabeled gastrin-releasing peptide receptor (GRPr) antagonists ha

152 e spinal cord to establish that NK1R and the gastrin-releasing peptide receptor (GRPR) are coexpresse

153 romosome occurred in the first intron of the gastrin-releasing peptide receptor (GRPR) gene and that

154 Because overexpression of the gastrin-releasing peptide receptor (GRPR) has been repor

155 Theranostic applications targeting the gastrin-releasing peptide receptor (GRPR) have shown pro

156 eraction between u-opioid receptor (MOR) and gastrin-releasing peptide receptor (GRPR) in spinal GRPR

157 MOR1D heterodimerizes with gastrin-releasing peptide receptor (GRPR) in the spinal

158 The role of gastrin-releasing peptide receptor (GRPR) in various dis

159 The overexpression of gastrin-releasing peptide receptor (GRPR) in various tum

160 These NK1R neurons comprise a subset of gastrin-releasing peptide receptor (GRPR) interneurons a

161 The gastrin-releasing peptide receptor (GRPR) is a well-know

162 Although our previous study suggested that gastrin-releasing peptide receptor (GRPR) is an itch-spe

163 The gastrin-releasing peptide receptor (GRPR) is found to be

164 The gastrin-releasing peptide receptor (GRPR) is overexpress

165 The gastrin-releasing peptide receptor (GRPR) is overexpress

166 The gastrin-releasing peptide receptor (GRPr) is overexpress

167 Gastrin-releasing peptide receptor (GRPR) is overexpress

168 The gastrin-releasing peptide receptor (GRPr) is overexpress

169 The gastrin-releasing peptide receptor (GRPR) is overexpress

170 Gastrin-releasing peptide receptor (GRPr) is phosphoryla

171 The use of PET/CT with gastrin-releasing peptide receptor (GRPR) ligand [(68)Ga

172 We have recently developed a novel gastrin-releasing peptide receptor (GRPR) ligand with im

173 A growing body of evidence suggests that gastrin-releasing peptide receptor (GRPR) might be a val

174 Consistently, ablation of gastrin-releasing peptide receptor (GRPR) neurons, which

175 Ablation of gastrin-releasing peptide receptor (GRPR) or GRPR neuron

176 Here we describe that the gastrin-releasing peptide receptor (GRPR) plays an impor

177 In this study, we demonstrate that gastrin-releasing peptide receptor (GRPr) regulates ERK

178 he Trpv1-Cre population, depends on CGRP and gastrin-releasing peptide receptor (GRPR) transmission b

179 ckbones to generate bivalent ligands for the gastrin-releasing peptide receptor (GRPR) with a fixed d

180 -expression of Shh and BBS-cognate receptor (gastrin-releasing peptide receptor (GRPR)).

181 Gastrin-releasing peptide receptor (GRPR), a member of t

182 BBN) is a peptide with high affinity for the gastrin-releasing peptide receptor (GRPr), a receptor th

183 tion of the mammalian bombesin (Bn) peptide, gastrin-releasing peptide receptor (GRPR), is an excepti

184 Its receptor, gastrin-releasing peptide receptor (GRPR), is expressed

185 Because expression of the gastrin-releasing peptide receptor (GRPR), somatostatin

186 peptide that binds with high affinity to the gastrin-releasing peptide receptor (GRPR), which is over

187 isplay very high selectivity/specificity for gastrin-releasing peptide receptor (GRPR)-/prostate-spec

188 nd antagonistic pharmacophores targeting the gastrin-releasing peptide receptor (GRPR).

189 ptor (VIPR), substance P receptor (SPR), and gastrin-releasing peptide receptor (GRPR).

190 ith a population of neurons that express the gastrin-releasing peptide receptor (GRPR).

191 ic bombesin receptor antagonist that targets gastrin-releasing peptide receptor (GRPr).

192 resents a subset of neurons that express the gastrin-releasing peptide receptor (GRPR).

193 g very high selectivity and affinity for the gastrin-releasing peptide receptor (GRPr).

194 The human gastrin-releasing peptide receptor (hGRP-R) is aberrantl

195 The murine gastrin-releasing peptide receptor (mGRP-R) is a member

196 c bacteriophage P1 clones encoding the mouse gastrin-releasing peptide receptor (mGRP-R).

197 Results: Gastrin-releasing peptide receptor affinity was high for

198 Blocking gastrin-releasing peptide receptor and natriuretic pepti

199 compared the preclinical performance of the gastrin-releasing peptide receptor antagonists RM2 (DOTA

200 is and to use bombesin analogs to target the gastrin-releasing peptide receptor for the diagnosis and

201 The bombesin (Bn)/gastrin-releasing peptide receptor GRP-R, which is coupl

202 kinase is dependent on the expression of the gastrin-releasing peptide receptor in rat 1A fibroblasts

203 By contrast, gastrin-releasing peptide receptor is overexpressed in E

204 icals, such as prostate-specific membrane or gastrin-releasing peptide receptor ligands for the imagi

205 FITC-labeled bombesin-like peptide with the gastrin-releasing peptide receptor on PC-3 and HT-29 cel

206 BON cells or BON cells stably expressing the gastrin-releasing peptide receptor treated with either p

207 between an agonist and an antagonist for the gastrin-releasing peptide receptor were found to have ex

208 ceptors (m3 muscarinic, V1a vasopressin, and gastrin-releasing peptide receptor) were coexpressed (in

209 different neuropeptides for itch, including gastrin-releasing peptide receptor, natriuretic peptide

210 Gastrin-releasing peptide receptor, targeted by the copp

211 We compared the gastrin-releasing peptide receptor-targeting (68)Ga-RM2

212 3 and neuromedin-B receptor (NMB-R), but not gastrin-releasing peptide receptor.

213 ed independently of neurons that express the gastrin-releasing peptide receptor.

214 of patients, demonstrating the potential of gastrin-releasing-peptide receptor imaging.

215 Gastrin releasing peptide receptors (GRPR) have been sho

216 Gastrin-releasing peptide receptors (GRP-R) are upregula

217 the spinal dorsal horn (SDH) that expresses gastrin-releasing peptide receptors (GRPR) is critical f

218 specificity of coupling interactions between gastrin-releasing peptide receptors (GRPrs) and their co

219 rostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptors (GRPRs) are both ove

220 Gastrin-releasing peptide receptors (GRPrs) are overexpr

221 Gastrin-releasing peptide receptors (GRPRs) are potentia

222 Gastrin-releasing peptide receptors (GRPRs) expressed on

223 (68)Ga-RM2 targets gastrin-releasing peptide receptors (GRPRs), which are o

224 rostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptors are both overexpress

225 rostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptors are both overexpress

226 ded to understand the expression of PSMA and gastrin-releasing peptide receptors in different types o

227 Peptides such as gastrin-releasing peptide receptors targeting radiopharm

228 Gastrin-releasing peptide receptors, part of the bombesi

229 ic bombesin receptor antagonist that targets gastrin-releasing peptide receptors.

230 B, neurotensin, neuropeptide Y, peptide YY, gastrin-releasing peptide, somatostatin, and [Met5]enkep

231 expressing cells, but a second neuropeptide, gastrin-releasing peptide, still induced strong response

232 ase a number of peptides such as gastrin and gastrin-releasing peptide that could cause acid hypersec

233 ied two TMs (neuron-specific enolase and pro-gastrin-releasing peptide) that differentiate the risk o

234 cholecystokinin antagonists, carbachol, and gastrin-releasing peptide were monitored using video ima

235 Further, we demonstrate that gastrin-releasing peptide, which activates a Gq-coupled